Medicine and Health Sciences Commons^™

Zo1 As A Factor In The Remodeling Of Myocardial Gap Junctions, Ralph John Barker

MUSC Theses and Dissertations

The remodeling of connexin43-containing gap junctions (GJs), as defined by changes in size, distribution, or function, is a prominent feature of both the developing and diseased myocardium. During postnatal development of the mammalian ventricle, there is a progressive remodeling of GJs into intercalated disks. This change in GJ quantity and distribution is correlated with alterations in the velocity and anisotropy of impulse spread within differentiating myocardium. Orderly distribution of GJs is perturbed in many cardiac diseases, and reemergence of immature patterns of myocyte coupling may be a factor in the arrhythmogenic potential attending such pathologies. Although mechanisms responsible for this …

Regulation Of Proto-Oncogenes Expression In Developmental Epilepsy, Mahnoush Shafiei

Seton Hall University Dissertations and Theses (ETDs)

Seizures cause selective neuronal cell loss in vulnerable regions such as the hippocampus, cortex, thalamus or substantia nigra (SN) in human or experimental animals. While the HF can propagate seizures, the SN pars reticulata (SNR) regulates the spread ol seizures in an age-dependent fashion, and the pars compacta (SNC) affects extrapyramidal motor control. In mature animals, both structures are wlnerable to seizure-induced damage. In prepubescent rats, seizure susceptibility is reduced and CA 1 region rs primarily affected. The proto-oncogenes, Bcl-2 and Bax, encode specific proteins that inhibit and promote programmed cell death, respectively. In order to determine whether proto-oncogenes are …

The Effects Of Practice Under Conditions Of Contextual Interference On The Interjoint Kinematics Of Lifting, Beth S. Norris

Seton Hall University Dissertations and Theses (ETDs)

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The Cost Of Implementing Hipaa In Private Physicians' Offices In South Carolina, Gary E. Bell

MUSC Theses and Dissertations

HIPAA - the Health Insurance Portability and Accountability act of 1996 is the largest government action in healthcare since Medicare. Since the passage of the HIPAA legislation, estimated cost of implementation has ranged from $3.8 billion to $45 billion for the implementation of the privacy rules. This study examines the cost on implementing HIPAA in private physicians' offices in South Carolina. The study selected the medical specialties of family practice, general practice, obstetrics & gynecology, and pediatrics. The study compares and analyzes cost of rural vs. urban physician practices, by specialty, and by type of entity when implementing privacy rules.

Rethinking Pegram : Why Erisa Health Benefits Administrators Should Have A Comprehensive Legal Requirement Of Fiduciary Duty, Bradley Ray Helfand

Public Health Theses

In the 2000 case Pegram v. Herdrich, the U.S. Supreme Court decided that administrators of health benefits plans covered by the Employee Retirement Income Security Act (ERISA) of 1974 do not have a fiduciary duty towards beneficiaries when making "mixed decisions" involving treatment and eligibility components. This thesis, Rethinking Pegram: Why ERISA Health Benefits Administrators Should Have a Comprehensive Legal Requirement of Fiduciary Duty, challenges the Court's opinion on grounds of legal precedent and public health ethics. While the legal critique of Pegram is an elaboration of earlier scholarship, the public health ethics critique represents a unique contribution …

The Role And Regulation Of Heat Shock Protein 27 In Retinal Ischemic Preconditioning, Norris Andrew Whitlock

MUSC Theses and Dissertations

Introduction: Vision loss resulting from retinal ischemia is associated with several systemic and ocular diseases. In the retina, ischemia is thought to lead to neuronal cell death by initiating a series of events that include oxidative stress, glutamate excitotoxicity, and intracellular Ca2+ overload. Attempts to prevent ischemic retinal degeneration have included the use of NMDA receptor antagonists, Ca2+ channel blockers, and antioxidants. These treatments have had limited success due to incomplete retinal protection and development of adverse side-effects. This has caused researchers to look toward endogenous protective mechanisms, such as ischemic preconditioning (IPC) in order to identify new strategies to …

Emg And Motion Analysis Of Swiss Ball Abdominal Exercises And Pilates Multi-Chair Exercises, Kelly L. Almquist, Ember M. Bopp, Chet R. Yoder

Physical Therapy Scholarly Projects

As the second most common reason for visits to primary care doctors, and a symptom that affects 80% of the general United States population, low back pain and its' treatment is a burdening cost on the American economy every year. Various spinal stabilization exercises have emerged as a means to treat low back pain. One of the most recent fonns of these stabilization exercises used in the physical therapy arena is Pilates, a fonn of dynamic spinal stabilization. Although numerous electromyographic (EMG) studies have been completed on abdominal exercises for spinal stabilization, minimal scientific research can be found on the …

Emg Analysis Of Lower Extremity Muscle Activity During Wall Slides With Varying Foot Positions, Jon Beach, Neil Feist, Mike Hiscock, Ryan Stromme

Physical Therapy Scholarly Projects

Knee injuries are among the most common injuries seen in a physical therapy clinic. Nearly all rehabilitation programs following a knee injury involve quadriceps muscle strengthening. One popular and safe method of quadriceps strengthening often used is the wall slide. There is, however, debate and little research indicating whether or not changing the foot position used during wall slides alters the muscle activity during this exercise.

The purpose of this study was to provide a better understanding of the muscle activity during wall slides with feet in various positions so that more accurate rehabilitation protocols may be developed in the …

The Effects A Total Knee Arthroplasty Has On Static And Dynamic Balance, Connie Christensen, Nicole Riddle, Nicole Sukut, Cara Uyema

Physical Therapy Scholarly Projects

In the United States today, the total knee arthroplasty (TKA) has become one of the most commonly performed surgeries of the lower extremity. A generous amount of information exists regarding joint proprioception after a joint replacement, however no studies have been done testing postural control after a TKA. With the increasing popularity of the TKA procedure, a need appears for research evaluating static stability and functional mobility of TKAs.

The purpose of this study was to determine the effects a TKA, 6 months postoperative or beyond, has on static and dynamic balance. The balance of 8 female volunteers and 4 …

Internet Health Promotion: Designing Guidelines, Jane Burns

Theses : Honours

The aim of this research was to investigate the factors which facilitate the communication of health promotion on the Internet and to produce guidelines for developing web pages for health promotion. Health communication in general is a growing field, however there appears to be limited infom1ation in the literature on how the factors of communication on the Internet (such as sender, message, channel, medium, receiver and their subsets), can be incorporated into the design of an

Internet health promotion intervention. Draft guidelines were developed from a critical analysis of the literature. These draft guidelines were used in the production and …

Individual Phonological Awareness Training For Speech/Language Impaired First Graders, Sarah Weaver

Masters Theses

The purpose of the present study is to determine the effects of individual phonological awareness and phonics training emphasizing auditory, motoric, and alphabetic properties of phonemes with 3 children who did not make substantial gains following classroom phonological awareness intervention. Subjects were enrolled in the first grade and exhibited speech and/or language impairments. The individual phonological awareness program contained 3 parts: (1) phonological awareness, (2) phoneme-grapheme correspondence, and (3) decoding and spelling and employed a single subject multiple probe baseline across behaviors design. Results indicated that individual treatment was successful for teaching phonological awareness, phoneme-grapheme correspondence, and decoding and spelling. …

The Relationship Between Thigh Muscle Size And 1rm Squat Strength Among Bodybuilders, Powerlifters, And Olympic Weightlifters, James Dinaso

Masters Theses

The purpose of this study was to determine if a significant difference exists in the relationship between measures of muscle size and strength among elite bodybuilders, powerlifters, and Olympic weightlifters. Fifteen male subjects between the ages of 16 and 48 years participated in the study. All three subject groups, Olympic weightlifters (OWL, n=5), powerlifters (PL, n=5), and bodybuilders (BB, n=5), were highly trained and currently involved in competition training. All test subjects were of similar body weight and weighed between 76-96 kilograms. Measures of body weight, body composition (bioelectrical impedence), shoulder width, thigh circumference (proximal, distal, and mid-thigh), and thigh …

Factors Influencing Substance Abuse/Dependence And Treatment Outcome Of Adolescents In A Residential Substance Abuse Program: An Exploratory Study, Melissa L. Moody

Masters Theses

Previous research examining the risk factors associated with alcohol and other drug use has primarily focused on the adult population. Few studies have investigated the factors which influence adolescent substance abuse and the respective effects on treatment outcome. This in spite of the considerable decline in the age-of-onset for problematic substance use that could, if gone untreated, escalate into dependence and a variety of other interpersonal problems which extend across the lifespan. Effective interventions targeting the adolescent population would therefore seem to be of utmost importance to both researchers and clinicians. It has been suggested that individualized treatment programs focusing …

Effects Of Information Display On The Construction Of Clinician Mental Models, Constance M. Johnson

Dissertations and Theses (Open Access)

Objective: To determine how a clinician’s background knowledge, their tasks, and displays of information interact to affect the clinician’s mental model. Design: Repeated Measure Nested Experimental Design Population, Sample, Setting: Populations were gastrointestinal/internal medicine physicians and nurses within the greater Houston area. A purposeful sample of 24 physicians and 24 nurses were studied in 2003. Methods: Subjects were randomized to two different displays of two different mock medical records; one that contained highlighted patient information and one that contained non-highlighted patient information. They were asked to read and summarize their understanding of the patients aloud. Propositional analysis was used to …

A Process For Achieving Comparable Data From Heterogeneous Databases, Rachel L. Richesson

Dissertations and Theses (Open Access)

The current state of health and biomedicine includes an enormity of heterogeneous data ‘silos’, collected for different purposes and represented differently, that are presently impossible to share or analyze in toto. The greatest challenge for large-scale and meaningful analyses of health-related data is to achieve a uniform data representation for data extracted from heterogeneous source representations. Based upon an analysis and categorization of heterogeneities, a process for achieving comparable data content by using a uniform terminological representation is developed. This process addresses the types of representational heterogeneities that commonly arise in healthcare data integration problems. Specifically, this process uses a …

The Effects Of Partial Body Weight Support For Gait For Patients With Neurological Dysfunction: A Case Study Approach, Larae Haas, Beth Millage, Becky Sorenson

Physical Therapy Scholarly Projects

The purpose of this study was to determine the effects of partial body weight support during gait for individuals with neurological dysfunction. Body weight support (BWS) training provides a safe environment in which the individual can perform and practice mechanics of normal gait at a variety of speeds with or without body weight support, depending on the level of function. The subjects who participated in this study were community ambulators older than 20 years of age with a neurological diagnosis. Each subject was tested initially and at the conclusion of the study to compare data using a battery of balance …

An Electromyographic And Motion Analysis Of Forward And Backward Walking, Sarah Dekrey, Lori Guderian, Kerry Hendricksen, Glenda Scott

Physical Therapy Scholarly Projects

Backward walking is a common intervention in the rehabilitation of lower extremity injuries. Despite its popularity, there is limited research available on the EMG activity during backward walking at an incline when compared to forward walking. In this study, we recorded EMG activity in four muscles of the lower extremity and utilized motion analysis to evaluate the knee range of motion when walking forward and backward on a treadmill at 0 and 15 percent grade inclines.

Overall, our results indicated a greater increase in muscle activity during backward walking than forward walking. Walking backward at a 15 percent grade incline …

A Single Case Study: Occupational Therapy Home Program For A Child With Congenital Cataracts, Melissa R. Edwards

Occupational Therapy Capstones

No abstract provided.

The Effects Of Partial Body Weight Support For Gait In Patients With Neurological Dysfunction: A Case Study Approach, Sarah Hammers, Alecia Herring, Amanda Olson, Mandy Runyan

Physical Therapy Scholarly Projects

Cerebrovascular accident (CV A) is the primary cause of disability in the United States. l It is estimated that 75% of those who have a CVA survive and function with multiple degrees of impairments. These impairments impact their activities of daily living in a variety of ways. One of the goals of rehabilitation is to minimize the negative effects a CVA has on the functioning of an individual and allow each person to reach his or her maximum potential. Limited research has been conducted exploring the positive outcomes of partial body weight support treadmill training (PBWSTT) in those who have …

An Electromyographic Analysis Of The Abdominal Musculature In The Production Of Vocalization Intensity During Singing, Chris Huravitch, Nyle Relay, Kristine Schulte

Physical Therapy Scholarly Projects

The purpose of this study was to determine if a relationship existed between electromyographical (EMG) activity in the abdominal muscles and the intensity of sound production. Currently, no consensus existsin the music profession regarding the appropriate use of the abdominal muscles during singing, even though it is known that the abdominal muscles playa significant role in sound production. As musicians strive to improve performance and therapists work to rehabilitate musicians and others who suffer from vocal deficits, understanding the basic muscular requirements of this activity/profession is essential to affect positive outcomes.

Eleven subjects with choral experience were recruited from the …

University Of North Dakota Physical Therapy Alumni Preferences For A Transitional Doctorate Of Physical Therapy Degree, Nolan Lubarski, Jessica Mcdougall, Steven Panos, Heidi Sites

Physical Therapy Scholarly Projects

The purposes of this study are to assess whether University of North Dakota Physical Therapy (UND-PT) graduates desire a transitional Doctorate of Physical Therapy (t-DPT) degree and to determine their preferences regarding this proposed educational program.

The survey was sent to 1136 alumni of the UND-PT program spanning from its first graduating class in 1970 to the class of 2002. It consisted of 8 demographic questions and 12 questions regarding areas such as curriculum content, program implementation, and personal views about the Doctorate of Physical Therapy degree. Frequencies for all responses were determined. The respondent data were also analyzed for …

Electromyographic And Motion Analysis Of The Trunk And Lower Extremity Muscle Recruitment Comparing A Maximal Voluntary Contraction To The Plyo Press And Agaton Max Series Leg Press, Lee Nagle, Thayne Bosh, Tonya Kunze, Kelly Jorschumb

Physical Therapy Scholarly Projects

Numerous studies have been done on the Plyo Press, with focus on the concentric phase of the exercise. However, for athletes eccentric training has always been a topic of interest. Most leg press machines have a concentric and an eccentric phase involved with the exercise. However, during the eccentric phase of the leg press the muscles are underloaded because of the force-velocity relationship of the human skeletal muscle and the fact that eccentric contractions require fewer motor units for the same force and workload. This means that the leg press exercise is limited by the concentric phase. A new machine …

Structure And Functional Effects Of Age-Related Posttranslational Modifications Of Aquaporin 0 In The Normal Human Lens, Lauren Elizabeth Smith-Ball

MUSC Theses and Dissertations

Aquaporin 0 (AQP0, MIP), a water channel protein found in the ocular lens fiber cells, has been proposed to maintain osmotic homeostasis by contributing to an internal circulatory system within the avascular lens. The formation of cataracts in patients with mutations in the AQP0 gene and in heterozygous AQP0 deficient mice suggests that AQP0 is necessary for establishing and preserving lens transparency. Previous structural characterization of AQP0 revealed that the C-terminus, a putative regulatory domain, is subject to many age-related posttranslational modifications. The goal of the present study was to map the spatial distribution of posttranslationally modified forms of AQP0 …

Constraint-Induced Therapy: Remediation Of The Upper Extremity And Its Application In Occupational Therapy, Amanda J. Hively

Occupational Therapy Capstones

No abstract provided.

Investigation Of The Role Of Self-Efficacy In Postoperative Outcomes In Spinal Fusion Patients, Karen Roberts Burritt

Masters Theses

A descriptive correlational design was utilized to explore the relationship between preoperative self-efficacy and the postoperative outcomes of distance ambulated, brace application, discharge disposition and length of stay in surgical spinal fusion patients. Social cognitive theory and the concept of self-efficacy were used to provide the theoretical framework. A novel self-efficacy questionnaire was developed to measure the independent variable, it was tested for reliability and validity in a 16 patient pilot study. The pilot study was followed by a study of 52 post-operative patients. Preoperative self-efficacy significantly correlated to distance ambulated in the entire sample. Females in this sample demonstrated …

Adolescents With Epilepsy: The Relationship Between Perceptions Of Parenting, Self-Concept, And Self-Assessment Scores Of Depression, Alison Z. D. Hofheinz

Masters Theses

Adolescents with chronic diseases must accomplish the management of their healthcare decisions and practices; those with epilepsy also deal with the uncertainty of seizure disorders and the stigma linked to this disease. This secondary analysis of data examined psychosocial variables for adolescents with epilepsy within the developmental-contextual framework proposed by Hohnbeck and Shapera (1999). No statistically significant differences were found between the mean Piers-Harris scores, self-assessment scores on the Children's Depression Inventory (CDI) or the Revised Family APGAR for the subgroups of males, females, younger (9 to 11.44 years) or older (11.45 to 14 years) adolescents. Perceptions of parenting, length …

Pre-Verbal Trauma, Dissociation And The Healing Process, Dorothy Dreier Scotten

Educational Studies Dissertations

This qualitative research study examines some of the ways in which the healing process takes place in adults who have experienced dissociation, and who have most likely been psychologically traumatized before full language development. The impact of early trauma on human cognitive, socio-emotional, and spiritual development are explored within the context of participant narratives in order to develop an understanding of what may be helpful in developing effective teaching strategies for clinical and teacher education. In-depth interviews were conducted with four adult persons who had been diagnosed with Dissociative Identity Disorder. All had histories of infant psychological trauma and all …

Trace Analysis Of Organic Substances, Alan Giltinan

Theses

One of the major challenges facing the pharmaceutical industry is the control of the amount of trace contaminants during the manufacture of organic substances. Lowering the level of contamination improves the quality of the product and reduces possible side effects.

One of the main techniques used to detect trace contaminants is UV-VIS spectroscopy, where the unique absorption fingerprint of a chemical reveals its presence. UV-VIS absorption is based upon the Beer-Lambert Law. The critical point to note about this law is that the absorption is exponentially dependent on both the concentration of the absorber and the pathlength traversed by the …

Protocol To Enhance Psychosocial Treatment Intervention For Clients With Reflex Sympathetic Dystrophy, Breezy L. Sykes

Occupational Therapy Capstones

No abstract provided.

An Advanced Inquiry Of Occupational Therapy Treatment In The Neonatal Intensive Care Unit Focusing On The Sensory Systems Of The Infant, Summer J. Van Rooyen

Occupational Therapy Capstones

No abstract provided.