Medicine and Health Sciences Commons^™

Effects Of Aging On Pressure-Induced Mapk Activation In The Rat Aorta, Kevin M. Rice

Theses, Dissertations and Capstones

With age, the cardiovascular system experiences substantial alterations in cellular morphology and function. The factors regulating these changes are unknown; however, the mitogen activated protein kinase (MAPK) pathways have emerged as critical components for mediating numerous cellular responses including control of cell growth, differentiation and adaptation. Here we compare the expression, basal activation and the ability of increased pressure to activate the MAPK pathways in adult (6 month old), aged (30 month old) and very aged (36 month old) Fischer 344 x Brown Norway F1 Hybrid rats. Histochemical analysis demonstrated an age-related increase in tunica media thickness of approximately 11% …

The Effectiveness Of Memory Training Programs In Improving The Subjective Memory Characteristics Of Healthy Older Adults With Memory Complaints : A Meta-Analysis, Kimilee Y. Wilson

Theses, Dissertations and Capstones

The focus of this study was to examine the effectiveness of memory training programs in improving the metamemory (i.e., subjective memory characteristics) of healthy older adults by integrating recent research findings in a meta-analysis. In particular, the following research questions were proposed: (a) How effective are memory training programs in improving the subjective memory characteristics of healthy older adults with memory complaints? (b) Which components of the memory training programs increase the effectiveness of memory training (in terms of metamemory characteristics)? (c) How do the results of this meta-analysis compare to those reported by Floyd and Scogin (1997)? Studies that …

Mechanisms Of Growth Hormone Enhancement Of Excitatory Synaptic Transmission In Hippocampus, Ghada Saad Zaglool Ahmed Mahmoud

Theses, Dissertations and Capstones

Growth hormone (GH) deficiency is associated with impaired learning and memory. One possible target for GH effects on memory is the hippocampus, a brain region containing GH receptors (GHRs). To determine if GH acutely alters hippocampal function, recombinant human GH (rhGH) was applied to in vitro rat hippocampal brain slices. Extracellular recordings were used to assess effects of GH on the field EPSP (fEPSP) and long-term potentiation (LTP) of the fEPSP. GHR expression was measured in GH-treated and control rat hippocampal slices using RT-PCR. The GH signaling pathway was investigated by studying the effect of GH on the fEPSP after …

Discovering The Barriers To Health-Promoting Lifestyles Among Appalachian Veterans With Uncontrolled Hypertension, Tara L. Porter

Theses, Dissertations and Capstones

Introduction: The purpose of this study was to discover the barriers to health promoting lifestyles among the Appalachian veteran population with uncontrolled hypertension.

Design: A quantitative research study was conducted over five months using a non-experimental, descriptive research design. Pender’s Health Promotion Model served as the study’s framework. Subjects were recruited from a primary care setting through advertisement within the hospital. A convenience sample of thirty-two subjects was obtained.

Method: The Health Promotion Lifestyle Profile (HPLP) II survey assessed for barriers to controlled hypertension in the following areas: health-promoting lifestyle, health responsibility, stress management, spiritual growth, interpersonal relationships, nutrition, and …

Effects Of Tamoxifen On Mitochondrial Nos Activity: Alteration In The Intramitochondrial Ca2+ Homeostasis, Sandeep S. Joshi

Theses, Dissertations and Capstones

Tamoxifen (Tam) is an anticancer drug that induces oxidative stress and apoptosis via mitochondria- and nitric oxide (NO)-dependent pathways. Here, we report that therapeutic concentrations of Tam stimulate the mitochondrial NO synthase (mtNOS) activity of isolated rat liver mitochondria by increasing the intramitochondrial ionized Ca²⁺ concentration ([Ca²⁺]_m). Tam decreases transmembrane potential (∆ψ) due to increased [Ca²⁺]_m that neutralizes the negative charges of the inner mitochondrial membrane. Thus, the present study reports a novel mechanism for the widely used anti- caner drug, Tam.

Expression Of Hepatitis C Viral Non-Structural 3 Antigen In Transgenic Chloroplasts, Anubhuti Bhati

Electronic Theses and Dissertations

Hepatitis C viral infection is the major cause of acute hepatitis and chronic liver disease and remains the leading cause of liver transplants (NIH). An estimated 180 million people are infected globally (WHO). There is no vaccine available to prevent hepatitis C. The treatment with antiviral drugs is expensive, accompanied with various side effects and is limited only to those at risk of developing advanced liver disease. The treatment is also effective in only about 30% to 50% of treated patients and still a high percentage of patients are resistant to therapy. Therefore, there is an urgent need for the …

Expression Of Cholera Toxin B Subunit-Rotavirus Nsp4 Enterotoxin Fusion Protein In Transgenic Chloroplasts, Anila Kalluri

Electronic Theses and Dissertations

Rotavirus, the major cause of life-threatening infantile gastroenteritis, is a member of the Reoviridae family and is considered to be the single most important cause of virus-based severe diarrheal illness in infants and young children particularly 6 months to 2 years of age in industrialized and developing countries. Infection in infants and young children is often accompanied by severe life threatening diarrhea, most commonly following primary infection. Diarrhea is the major cause of death among children around the world. Responsible for 4 to 6 million deaths per year according to the World Health Organization (WHO), diarrhea is especially dangerous for …

Thyroid Hormone-Regulated Skeletal Muscle Glut4 Glucose Transporter Trafficking During Fasting In Diet-Induced Obesity And Insulin Resistance, Lucy Soo Yon Jun

Theses Digitization Project

This thesis project will investigate the effects of fasting on the serum levels of two key regulatory hormones, insulin and thyroid hormone (T3) and the effects of these hormones on the trafficking of Glut4 on soleus muscle.

Body Image And Depression, Alicia Sue Boggio

Theses Digitization Project

The purpose of this study was to examine the link between body image and depression in young women. This study intended to examine a correlation between body image dissatisfaction and depressed mood.

The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca

Theses Digitization Project

Examines whether the reinforcing properties of drugs of abuse were altered in adulthood by methylphenidate, more commonly known as Ritalin. Subjects were 108 rats of Sprague-Dawley descent (Harlan). Methylphenidate, or saline was administered daily to the subjects from the postnatal period (11-20 days old). The rats preference for morphine during early adulthood was measured using conditioned place preference. The number of dopamine D₂ receptors was measured in each rat and the correlation between receptor number and morphine preference was determined. Results indicate that rats pretreated with methylphenidate showed greater preference for morphine than saline pretreated rats and suggests that exposure …

Evaluation Of The Family Nurturing Program: The Family Education Component Of The Riverside County Dependency Recovery Drug Court Program, Lila Massoumi Samady

Theses Digitization Project

This project assesses the need for evaluating the Family Nurturing Program for its effectiveness with the Riverside County Dependency Recovery Drug Court (DRDC) participants and their children.

Parental Perceptions Of Their Child's Weight And Health, Julie Vy Pham

Theses Digitization Project

Childhood obesity is a major health problem facing children in the United States. How parents view their children's weight is an important consideration for health care professionals. The purpose of this study was to explore parental perceptions of their children's weight and health.

The Geo-Spatial Analysis And Environmental Factors Of Narcotics Hot Spots, Stefanie Wrae Balchak

Theses Digitization Project

A mixed methodological approach with two different analytic procedures and multiple data sources was used to examine narcotics hot spots. The first phase compares two methods of hot spots identification; the prediction model and the actual crimes. The second phase involves an intensive study to better understand the phenomenon of drug hot spots areas consistently shown to be repeat hot spots.

Attitudes Towards The Use Of Computers By Registered Nurses, M Luther Borgardt

Theses Digitization Project

The purpose of this study was to describe the attitudes of a group of nurses towards the use of computers in a Southern California Veterans Affairs hospital.

The Relationship Between Self-Esteem And Glycemic Control In 13-17 Year Old Adolescent Girls With Type 1 Diabetes Mellitus, Annabelle Lucia Sandoval Esparza

Theses Digitization Project

The purpose of this study was to explore the psychosocial phenomena of self-esteem in relation to gucose control in diabetic adolescent girls living in the Inland Empire. Three central themes emerged: body image, peer acceptance, and stress.

A Developmental Care Program In The Neonatal Intensive Care Unit At Arrowhead Regional Medical Center, Shirley Marie Farr

Theses Digitization Project

The purpose of this project is to develop a self-administered developmental care program that will be utilized by the staff of the neonatal ICU at Arrowhead Regional Medical Center, Colton, CA.

Educational Curriculum For Obesity In School Aged Youth, Carmen Vieyra Kemp, Melody Ann Mendiola

Theses Digitization Project

The purpose of this project was to develop an educational program to assist educators in keeping school children healthy. This program is designed to support professionals who are working to reduce the problem of oobesity in children and adolescents in elementary and middle school setting.

The Effects Of Childhood Obesity On Elementary School Absenteeism, Sarah Diane Schoonover, Wyona Marie Lagomarsino

Theses Digitization Project

The purpose of this study was to determine if a relationship existed between body mass index and school absence. The research was a retrospective study of school nurse height and weight reports and attendance reports for 2nd grade Hispanic students at an elementary school in Riverside, California.

Compliance With Dialysis Regimens: The Effects Of Coping And Social Support, Toyoko Yagi

Theses Digitization Project

The purpose of this study was to identify determinants of compliance behavior. Since compliance among dialysis patients increases survival rate, it is important for social workers to identify patients who are at risk of noncompliance.

Spirituality And Compliance Correlates Of Hemodialysis Patients, Paula Luz Ferro, Gloria Del Fernandez

Theses Digitization Project

The purpose of a study of spirituality and its relationship to the compliance of hemodialysis patients is to consider changing the approach of the treatment team in the dialysis setting. The interdisciplinary treatment team at the dialysis center consists of physicians, nurses, dietitians, and social workers. One of the many roles of the dialysis social worker is to facilitate the adjustment to and acceptance of the patient's need for dialysis.

Korean Americans And Barriers To The Use Of Mental Health Services, Kimberly Joy Steiner

Theses Digitization Project

Based on data concerning Korean Americans affected by mental health problems, it is apparent that current methods of providing mental health services are not adequate. The purpose of this study was to examine the perceptions of various mental disorders and barriers keeping Korean Americans from utilizing mental health services.

Cultural Factors Affecting Latino Diabetics, Maud Danitza Garcia

Theses Digitization Project

This study addressed cultural factors that prevent Hispanic diabetics from getting diagnosed early, controlling their glycemic levels, and obtaining appropriate transportation, health insurance, and better education on nutrition.

Prevalence Of Type 2 Diabetes Among Minority Groups, Patricia Elizabeth Sanchez

Theses Digitization Project

The purpose of this study was twofold. First, the study evaluated Loma Linda University Medical Center's (LLUMC) Diabetes Treatment Center's (DTC) effectiveness in providing diabetes education and services to high risk minority populations. Second, the results of the study helped the DTC determine the need for expanding its present efforts in the form of community health prevention services to San Bernardino County residents.

Levels Of Social Intimacy Among Women In Substance Abuse Treatment, Jean Emiko Ishihara

Theses Digitization Project

This study found that women in substance abuse treatment have higher levels of social intimacy than women with no history of substance abuse (treatment). Other factors examined in relation to level of intimacy were: type and number of substances used, length of use, length of treatment, participation in mental health treatment, substance abuse in the home when the subject was a child, and a history of the subject being a survivor of abuse.

Survey Of Camera Phone Awareness In Outpatient Community Behavioral Health Facilities, Tara Lynn Overton

Community & Environmental Health Theses & Dissertations

The purpose of this study was to determine the level of camera phone awareness in outpatient community behavioral health facilities in a medium sized Mid-Atlantic state. Camera phones have been shown to have a detrimental effect on the protection of privacy in areas such as corporations, gym locker rooms, and court houses, but privacy issues have not yet been addressed in behavioral health. Privacy is an important issue in healthcare as shown through the implementation of the Health Insurance Portability and Accountability Act (HIPAA). This study used Rogers' (1995) Diftbsion of Innovations Theory as a framework for determining the stage …

Convergence Analysis Of Mcmc Method In The Study Of Genetic Linkage With Missing Data, Diana Fisher

Theses, Dissertations and Capstones

Computational infeasibility of exact methods for solving genetic linkage analysis problems has led to the development of a new collection of stochastic methods, all of which require the use of Markov chains. The purpose of this work is to investigate the complexities of missing data in pedigree analysis using the Monte Carlo Markov Chain (MCMC) method as compared to the exact results. Also, we attempt to determine an association between missing data in a familial pedigree and the convergence to stationarity of a descent graph Markov chain implemented in the stochastic method for parametric linkage analysis.

In particular, we will …

Effect Of Dna Base Modification On Polymerase Chain Reaction Efficiency And Fidelity, Jan A. Sikorsky

Theses, Dissertations and Capstones

Polymerase stop assays, used to quantify DNA damage, assume single lesions are sufficient to block thermostable DNA polymerase progression. To explore this assumption, 90 base oligonucleotides containing normal or modified DNA bases were amplified using real-time PCR. Data implied that the PCR efficiency was influenced to differing degrees depending on which base lesion was present on the input oligonucleotide; specifically, while reactions with templates containing a single 8-oxo-7,8-dihydro-2í-deoxyguanosine (8-oxodG) were not noticeably altered, the presence of a single 8-oxo-7,8-dihydro-2í-deoxyadenosine, an abasic site, or a cis-syn thymidine dimer (TT dimer) dramatically delayed amplification. In addition, the presence of two tandem 8-oxodGs …

Accuracy Of Parental Report On Phonological Inventories Of Toddlers, Kristin Marie Teske

Electronic Theses and Dissertations

Considering the diminishing availability of professional resources, increasing costs, and time requirements involved in early childhood mass screenings, parents are an essential source of information. In this study, the Survey of Speech Development (SSD) (Perry-Carson & Steel, 2001; Steel, 2000) was used to determine the accuracy of parents in reporting the speech sound inventories of their toddlers. Parents of 30 children, who were between the ages of 27 to 33 months old, completed the SSD prior to a speech and language assessment session. Based on assessment results, the children were classified as normal developing or language delayed. A 20-minute play …

Electromyographic (Emg) Analysis Of Trunk Muscles At The Point Of Puck Contact During Slap And Wrist Shots Of Female Ice Hockey Athletes, Lon Donald, Kristi Kjellgren, Jodi Young, Michael Young

Physical Therapy Scholarly Projects

The number of female hockey players has increased significantly in the last decade. The first recorded female hockey game was in Ottawa in 1889. Since that time, hockey has spread into the United States .. Today, USA Hockey, Inc. reports 40,000 registered females and the Canadian Hockey Association has 55,000 female hockey players. Despite the rising popularity of the sport among females, there is little research specifically related to female hockey players.

Golf, tennis, and hockey swings utilize similar rotational components about the trunk. Trunk rotation is controlled and produced by the erector spinae, external oblique and rectus abdominus muscles. …

The Effects Of Childhood Obesity On Self-Esteem, Heather L. Paxton

Theses, Dissertations and Capstones

Obesity is a growing health problem affecting children in the United States. The prevalence of obesity has increased dramatically over the past 10 years across virtually all populations and age groups. Recent data suggest that 15 percent of U.S. children are severely overweight or obese (National Center for Health Statistics, 2002) . Obese children are at risk for significant health problems, but also face many psychological and social consequences, including low self-esteem. Children who are obese face an increased risk of emotional problems lasting well into adulthood. Factors such as peer rejection, weight-related teasing, and internalized social standards play a …