Medicine and Health Sciences Commons^™

Gastric Myoelectrical Activity In Patients With Diabetes, Sandra Luberata Holmes

Theses and Dissertations (ETD)

This descriptive, correlational study investigated the associations among gastric myoelectrical activity (GMA), upper gastrointestinal (GI) symptoms, and glucose control. The study also attempted to determine whether any relationship existed between upper GI symptoms, glucose control, age, or length of diagnosis and pattern of GMA identified using electrogastrography (EGG). A total of 25 persons participated in the study. The sample was comprised of 7 healthy controls, 5 patients diagnosed with type 1 diabetes, and 13 patients diagnosed with type 2 diabetes. Electrogastrography was performed for 30 minutes in the fasting state and continued at 30-minute intervals for a total of 1-1/2 …

Molecular Mechanism Of Tetraspanin Cd9 Mediated Cell Motility, Jayaprakash Kotha

Theses and Dissertations (ETD)

CD9, a member of the tetraspanin superfamily of proteins participates in the regulation of cell adhesive functions such as cell migration. The mechanisms underlying CD9 mediated cell migration are not known. In the current study, we investigated the molecular basis for the CD9 promoted cell migration. Our findings show that the phosphatidylinositol-3 kinase (PI-3K) inhibitors, wortamannin and LY294002 inhibited CD9 promoted cell motility in Chinese hamster ovary (CHO) cells. In contrast, inhibitors targeting protein kinase C or mitogen-activated protein kinase had no effect on CD9 driven CHO cell motility. Furthermore, inhibition of PI-3K activity in CHO cells by dominant/negative PI-3K …

Novel Carbopol-Wax Blends For Controlled Release Oral Dosage Forms, Natarajansoundarapandian Mariageraldrajan

Theses and Dissertations (ETD)

Carbopol is crosslinked acrylic acid. Carbopol can be used in developing formulations for transdermal, oral, rectal use. It is forms strong gel in low concentration. Therefore, it can be used in low concentration in developing controlled release formulations. This increases the cost effectiveness and number of formulation options. In spite of its effectiveness, carbopol is one of the most efficient however underutilized polymer in oral controlled drug delivery system development. This is attributed to the difficulty in processing the carbopol. Carbopol has poor flow characteristics and stickiness. Objective of our research is to eliminate processing difficulties of carbopol using hot …

Effects Of Tricalcium Phosphate Coated Titanium On Adjacent Early Bone Formation, Bristol Williams

Theses and Dissertations (ETD)

Dental implants are the gold standard of restorative dentistry today. Implants have been used for several years in Orthopedics. Dental implants are an important treatment option for several patients today. When a patient is fully or partially dentate, they are given the opportunity to restore their dentition in ways similar to their natural oral cavity. The past literature states that titanium is one of the first metals used in implant placement. There have been many improvements made on this material. Most modifications have been used in order to promote more bone growth around these implants. Several different coating materials have …

Silver Doped Hydroxyapatite Coating On Titanium Surfaces And Its Effect On Early Bone Response And Osseointegration, Nicole Besu

Theses and Dissertations (ETD)

The clinical success of dental implants is determined mostly by surface properties of implants and interactions with surrounding tissues. Furthermore, clinical success of dental implants is directed by implant surfaces and bone cell responses that promote osseointegration and long-term stability. Hydroxyapatite (HA)-coated Titanium (Ti) implants have been widely used due to its effect on bone response. However, microbial infection is common. One material known to have anti-microbial properties is silver (Ag). However, the effects Ag has on osteoblastic activity as well as decrease bacterial load has yet to be determined.

In this study, the effect of Ag-doped HA coatings on …

Root Morphology And Sexual Dimorphism : Size Standards For Crown And Root Dimensions In Adolescents, William Max Couch

Theses and Dissertations (ETD)

“Early” or two-phase orthodontic treatment of Class II malocclusions is a highly debated topic in the orthodontic literature. We report here on a retrospective cephalometric study of patients with Class II, division 1 malocclusions. One group consisted of 32 consecutively treated patients who received “early” treatment with a Fränkel II appliance followed by treatment with full fixed appliance. These subjects were “matched” by sex and cephalometric value, to a subject treated with standard edgewise appliances in a single phase. Matching criteria focused on the bony facial characteristics, notably ANB, NAP, Y Axis, AOBO, FMA, overjet, and overbite. The question was …

Health Barriers, Health Perceptions, And Cardiovascular Risk Factors Of Adolescent Black American Males, Desmarie Jackson Decuir

Theses and Dissertations (ETD)

Area of Investigation: Cardiovascular (CV) diseases are the leading cause of death among Black American adult males. Health behaviors that contribute to CV disease are probably learned during adolescence yet few researchers have studied the factors that influence health promotion behaviors in adolescent Black American males. This study described the health barriers, health perceptions (health self-efficacy and health status), and CV risk factors reported by and the influence of these variables on health promotion behaviors of a sample of Black American adolescent males without known CV disease.

Methods and Procedures: A descriptive correlation study design was used to …

Probing The Role Of Nascent Helicity In Protein Function: P27kip1 As A Regulator Of The Cell Cycle, Steve Otieno

Theses and Dissertations (ETD)

p27^kip1 binds to and regulates the activity of cyclin-dependent kinases (Cdks) which are the master timekeepers of the cell division cycle. Members of the p27 family of proteins, also including p21 and p57, are called cyclin-dependent kinase inhibitors (CKIs). The amino terminal domain of p27 inhibits Cdk activity and is referred to as the kinase inhibitory domain (KID). The KID is comprised of a cyclin-binding domain (D1) and a Cdk binding domain (D2) joined by a 22 residue linker domain (LH). Structural analysis of the KID in solution before binding its Cdk targets revealed that D1 and D2 are …

Morbidity And Mortality Ofvery Low Birth Weight Infant Graduates Of A Level Three Neonatal Intensive Care Unit, Maria Cortes

Master's Projects

Purpose: To describe the morbidity and mortality of very low birth weight (VLBW) infant graduates of a level three neonatal intensive care unit (NICU) in a medically underserved population. Design: A retrospective chart analysis of 181 live born infants at a regional tertiary center between 2004-2006. Sample: Infants born with a birth weight of 425-1489 grams and gestational age of23-40 weeks (n=127). Main outcome variable: Descriptive statistics were used to describe the incidence of associated VLB W morbidities presenting after discharge along with hospital readmissions and mortality rates. Results: VLBW infants discharged from the NICU had chronic lung disease (24.4%), …

Cultural Self-Efficacy Of Graduating Baccalaureate Nursing Students In A State Funded University In The Silicon Valley, Lihua Liu

Master's Projects

The purpose of the study was to examine the level of cultural self-efficacy of graduating baccalaureate nursing students, who care for diverse populations, in a state funded university in the Silicon Valley, California. The level of cultural self-efficacy was measured using Bernal and Froman's Cultural Self-Efficacy Scale (CSES). A convenience sample of 48 nursing students completed an 8-item demographic questionnaire and a 26-item CSES. The subjects of this study were found to have an increased level of cultural confidence in comparison with previous studies. This study suggests nurse educators continue to incorporate cultural concepts and skills in the nursing curriculum.

Screening For Postpartum Depression At Well-Baby Visits, Suzanne Mello

Master's Projects

Objective: To assess the prevalence of postpartum depression among mothers who attend first-year well-baby visits. Methods: A convenience sample of 33 women was screened during first year well-baby visits using the Edinburgh Postpartum Depression Scale (EPDS) at three pediatric offices in Northern California. Measures included demographic data, history of depression, tobacco use, strength of support system, breast/bottle feeding, and child's health. EPDS scores were collected to calculate the prevalence of postpartum depression. Results: The EPDS was administered to 33 women at first year well-baby visits. Thirty-two were completed. Sixty-six percent of women had scores < 10 indicating no depression. Thirty-four percent reported scores of>=l 0 during the postpartum year …

Barriers To Mammograms Among Women Who Are Homeless, Lucinda M. Ramirez

Master's Projects

Purpose: The purpose of the study was to identify barriers to mammogram screening among women who are homeless. Knowing the barriers to mammogram screening will be useful to advanced practice nurses for it provides insight to understanding the perceived susceptibility, benefits, and barriers of women potentially amendable to intervention. Data sources: A descriptive survey was used with a convenience sample of 41 women who were homeless, between the ages of 20-70 years, and agreed to participate in this study. The research was conducted at two homeless shelters in an urban county in Northern California. Findings: Findings reflected positive perceptions recognizing …

Does Glutamine Supplementation Contribute To The Incidence Of Diarrhea In Ventaltor Dependent Patients?, Justin Johnson

Undergraduate Honors Capstone Projects

In this project we investigated the incidence of diarrhea and its possible causes in ventilator dependent patients in the intensive care unit (ICU) at McKay-Dee Hospital. Chronic diarrhea has been a long time problem in the ICU, but the etiology has never been fully explored. High dose antibiotic therapy has been thought to be a potential risk factor. Another proposed risk has been the use of glutamine, a conditionally essential amino acid contained in some enteral products. Glutamine is commonly used in feeding critically ill patients because of its immune enhancing properties.

Currently, we have not established a correlation between …

Infant Feeding Practices: History, Nutrient Needs, Assessment Of Nutriture, And Special Concerns, Katy Lynn Bodily

Undergraduate Honors Capstone Projects

Ideas regarding infant feeding practices have changed drastically over the past 100 years. Research discovered the composition of human milk, followed by the invention of human milk substitute (HMS). These discoveries lead to many changes in the way people feed infants. The macro and micronutrient needs of infants have been determined, and are used to develop ideal feeding practices for infants. There are many choices available for feeding infants including human milk, HMS, and solid foods. There are many guidelines available that provided suggestions on what to feed an infant, and at what age. Assessing the adequacy on infant feeding …

Malnutrition In The Elderly In Long-Term Care Facilities, Cindy L. Pitcher

Undergraduate Honors Capstone Projects

In 2000, there were 17,000 nursing homes in the United States housing about 1.5 million residents over the age of 65. Approximately 75% of long-term residents are women. The average length of stay for residents is 2.5 years, so in essence the nursing home becomes their home. Those who are in these long-term care facilities are generally characterized as frail elderly adults who suffer from a host of chronic and acute diseases and conditions. They are most likely cognitively impaired and have a great number of limitations in their activities of daily living (ADL). In addition, data collected by the …

Celiac Disease: What Dietitians Can Do To Effectively Treat A Growing Problem, Meagan Roxanne Wade

Undergraduate Honors Capstone Projects

The symptomology of celiac disease, also known as gluten-sensitive enteropathy or celiac sprue, was first described in AD 50 by Aretaeus, a noted ancient Greek physician who specialized in isolating and explaining disease states. Clinical manifestations of the disease were distinctly defined by Samuel Gee in 1888 who theorized that diet therapy was likely the treatment for the disease: "the allowance of farinaceous must be small, but if the patient can be cured at all, it must be by means of diet." Farinaceous foods included those rich in starches or mealy in texture. Treatment at the time consisted of a …

Efficacy Of Heart Health Claims Regarding Trans Fat, Unsaturated Fat, And Stanols/Sterols, Elaine Watkins

Undergraduate Honors Capstone Projects

In the United States, nearly 80 million people have some form of cardiovascular disease (CVD). This amounts to one in three adults, making it the number one cause of death each year for over a century. Because of the high prevalence of CVD, it is a priority in the U.S. to decrease its morbidity and mortality. Extensive research has been dedicated to pinpointing risk factors, determining preventive techniques, and developing treatments. A major focus in this research is the role of nutrition in the pathogenesis of CVD. Quality of diet is an important factor in health and disease progression. To …

The Association Between Sleep And Body Mass Index (Bmi) In College Freshmen At Utah State University, Mary-Marie Austin Sullivan

Undergraduate Honors Capstone Projects

Background: Obesity has become a major health problem with increasing prevalence in the United States. Cases of obesity have increased at alarming rates and have almost doubled over the past 40 years. During this same period of time, sleep duration for all age groups has significantly declined. Because sleep duration is a potential mediator of energy metabolism and body weight, it is an important aspect of health. An association between short habitual sleep time and increased body mass index (BMI) has been reported in large population studies for US young adults. Freshmen college students may encounter many environmental and emotional …

Regulation Of Alpha-1-Adrenoceptor-Mediated Contractions Of The Uterine Artery By Pkc, Hongying Zhang

Loma Linda University Electronic Theses, Dissertations & Projects

Pregnancy is associated with a significant decrease in uterine vascular tone and a striking increase in uterine blood flow, which ensures normal fetal development. Multiple mechanisms are involved in the adaptation of uterine artery contractility during pregnancy. Both protein kinase C (PKC) and activation of ai-adrenoceptors play important roles in the regulation of uterine artery contractility. In addition, PKC mediates the pregnancyassociated decrease in myogenic tone of the uterine artery, and interacts with ajadrenoceptors leading to modulation of ai-adrenoceptor-mediated contractions of vascular smooth muscle. Yet, whether or to what extent PKC regulates ai-adrenoceptormediated contractions of the uterine artery and their …

Immunoadjuvanticity Of Chlorophyll, Jocelyn Helen Parks Ramos

All-Inclusive List of Electronic Theses and Dissertations

Background: Vaccines are formulations containing antigenic determinants (from non-self organic matters) and immuno-enhancers called adjuvants. Together, they evoke protective immune responses in hosts. Adjuvants are substances that further vaccines' capability to induce a robust immune response. Common side effects with conventional adjuvants used in most vaccines are toxicity, inflammation and granulomas. In this study we investigated the pigment chlorophyll (Chl) for immunoadjuvanticity. The selection of chlorophyll is based on the fact that it is a component in foods such as spinach, and that it contains an isoprenoid structure that is a feature of many conventional adjuvants, Pristane and Squalene. Chl …

Graduate Art Therapy Experience Of Students Of Color, Keena Tarrant

EVMS School of Health Professions Theses & Dissertations

This narrative inquiry explored the perspectives of three professional art therapists of color. This study explored the past experience of being a graduate art therapy student of color on several levels. It also explored the impact of cultural competency course in relation to the experience of being a student of color. This experience is important in terms of how being an ethnic minority can affect the learning environment in relation to graduate experience of students of color and how cultural competency is taught to all students. This study explored the art recommendations of therapy professionals of color for cultural competency …

College Athletes’ Human Figure Drawings, Kaitlin Taggart

EVMS School of Health Professions Theses & Dissertations

The demands of both lean and non-lean sports upon male athletes can lead to body image dissatisfaction and eating disorders. This study explored whether the Human Figure Drawing (HFD) is a valid method for assessing male college athletes’ body image. A total of 86 male athletes who were competitive on a lean (cross-country or wrestling) or non-lean (football or ice hockey) sport participated in the study. The score recorded on the Male Body Attitude Scale (MBAS) (Tylka, Bergeron, & Schwartz, 2005), a 24-question survey administered to each participant, focused specifically on assessing muscularity, body fat, and height attitudes of these …

A Study On The Effects Of Wheel Throwing And A Child Diagnosed With Attention Deficit/Hyperactivity Disorder, Jennifer Evans

EVMS School of Health Professions Theses & Dissertations

It has been estimated that 3-7 percent of children are diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD) (Barkley, 2005). Research has found many treatment options to be effective; however, the most efficacious treatment is a combination treatment of medication and cognitive/behavioral therapy. Some art therapists have discussed the treatment of ADHD; however, few studies have large enough samples and repeatable results to provide empirical support. It was hypothesized that an eight week ceramic/wheel-throwing intervention in individual art therapy sessions would help calm and focus a child diagnosed with ADHD. This study consisted of a six week, six sessions, ceramic wheel-throwing intervention …

Adults’ Responses To The Art Process And Interaction With Art Media, Madeline Couch

EVMS School of Health Professions Theses & Dissertations

The art materials are a major component in art therapy. Their actual usage in sessions with clients, especially with adults, has rarely been the topic of investigation. The ideas about the qualities and purposes that the art materials bring to art therapy sessions are based on older theories, which were created without evidence-based research. The purpose of this study was to gain an understanding of how adults interact with and react to art media. Five adult volunteers, who were not formally trained as artists and who did not regularly engage in artistic processes, participated in the study. The participants experimented …

Toward An Understanding Of Serial Killers Through Their Artwork: Implications For Forensic Art Therapy, Kelly Macionis

EVMS School of Health Professions Theses & Dissertations

This research study explored the formal elements and content of 258 images of artwork created by 47 serial killers to see if common themes or content could be discovered. The images were found on five Internet websites containing serial killer artwork. The 47 serial killer artists were all male and it was assumed they were imprisoned when they created their art. The artwork gathered was viewed on a laptop and analyzed using the methods of content analysis. After categories of content and formal elements in the images were entered into a spreadsheet, frequencies and percentages of each category and subcategory …

A School Art Therapy Group: Helping Eighth Grade Students Decrease Disruptive Behaviors And Increase Coping Skills Before The Transition To High School, Erin Spier

EVMS School of Health Professions Theses & Dissertations

The transition to high school can be difficult for adolescents, especially those exhibiting disruptive behaviors and poor coping skills. This study was concerned with developing conducting a group art therapy intervention that would help increase coping skills and decrease disruptive behaviors in eighth grade students preparing for the transition to high school. Two girls and four boys from a private school in southeastern Virginia participated in the study after the start of their final semester in eighth grade. The study consisted of 8 sessions conducted on alternating days, twice a week for a four-week period.

During the group art therapy …

A Group Art Therapy Intervention To Increase Self-Efficacy In Battered Women, Sheryl Marie Morrison

EVMS School of Health Professions Theses & Dissertations

Domestic violence is a problem that affects an estimated six million women every year (Berry, 1998). There are many theories that attempt to explain the phenomenon such as, learned helplessness and battered woman syndrome. It is clear that the affects of domestic violence can leave lasting damage in the survivor’s ability to cope and function. One aspect that might be hindered in battered women is self-efficacy. Self-efficacy is the degree to which one believes he or she has the ability to be successful. The Self-Efficacy Scale (SES) created by Sherer, et al. (1982) was used to assess the clients’ self-efficacy. …

Exploring The Applicability Of Visual Thinking Strategy To Group Art Therapy With Adolescents, Jessica Rae Hirsh Angle

EVMS School of Health Professions Theses & Dissertations

Because adolescence is a time marked by physical, psychological, and cognitive changes and stressors, group art therapy with teens can be difficult. Art history enriched art therapy has proven effective with adults to aid in overcoming treatment difficulties. The Visual Thinking Strategy (VTS) is a research supported approach to art history which emphasizes group dynamics and student-directed art discussion. Therefore, this study explores the applicability of VTS to adolescent group art therapy.

In this study, a group of four 13 to 14-year-old girls participated in a three session workshop. Session one included personal art-making and an open discussion of the …

Mandala As A Measure Of Change With Adult Residents Of A Homeless Shelter, Mary W. Cochran

EVMS School of Health Professions Theses & Dissertations

Homelessness in the United States is a problem that continues to be addressed at the local, state, and federal levels. Diverse solutions to the problem of homelessness include emergency shelters, transitional shelters, and long-term housing. Shelters for families have become a common shelter type, offering diverse programs and types of services. Art therapy with the homeless has concentrated on the aspect of building self-efficacy through the creative process, however, there is limited research concerning the use of art products as a measure of change for the homeless. This study explores the use of mandala drawings to assess changes occurring in …

The Development Of A Gc/Ms Protocol For The Analysis Of Polysaccharides In Echinacea Purpurea, Michaela Knapp

Undergraduate Theses and Capstone Projects

Echinacea purpurea is an herbal supplement used to reduce symptoms of common colds and flu-like illnesses. As of right now, it is not well understood what chemical components in the plant are immunologically active. The four main potentially immunologically active chemical components in E. purpurea are caffeic acid derivatives, alkamides, polyacetylenes, and polysaccharides. In this investigation, a protocol was developed in an attempt to identify polysaccharides present in Puritan’s Pride E. purpurea (aerial) “non-irradiated” herbal supplement First, an estimate of the crude total polysaccharide content in Puritan’s Pride and in a ChromaDex certified botanical standard (E. purpurea -powdered root) was …