Medicine and Health Sciences Commons^™

An Exploration Of The Relationship Between Stress Physiological Signals And Stress Behaviors In Preterm Infants During Periods Of Environmental Stress In The Intensive Care Unit., Niang-Huei Peng

Dissertations

The purpose of this descriptive study was to examine relationships between stress physiological signals and stress behaviors in preterm infants during periods of environmental stress. The study used a repeated-measures design to examine the relationships between environmental stressors, sleep-wake states, and both stress physiological signals and stress behavioral responses in one group of preterm infants. Measurements of these variables for each preterm infant were recorded every two minutes during four 60-minute observation periods (two in the morning and two in the afternoon) conducted over two days (one morning and one afternoon observation each day). The sample was 37 preterm infants …

Health And Nutritional Need Assessment Of Hispanics In South Carolina, America Chavez-Martinez

All Dissertations

From 1990 to 2000, South Carolina's Hispanic population increased 211%. Now, states such as South Carolina have the fastest growing Hispanic population in the U.S. Hispanics have a high incidence of obesity and related chronic diseases such as diabetes, stroke, hypertension and heart disease, these diseases could be avoided through diet. Meanwhile, nutrition education interventions help to reduce weight and to change behaviors, leading to better health. This study used qualitative and quantitative methods to examine Hispanics health and nutritional needs to develop a cultural compatible nutrition program for this audience. The qualitative methods explored predisposing, enabling and reinforcing factors …

Identification Of Virulence Determinants For Streptococcus Sanguinis Infective Endocarditis, Lauren Turner

Theses and Dissertations

Streptococcus sanguinis is the second most common causative agent of bacterial infective endocarditis (IE). Risk of S. sanguinis IE is dependent on pre-disposing damage to the heart valve endothelium, which results in deposition of clotting factors for formation of a sterile thrombus (referred to as vegetation). Despite medical advances, high mortality and morbidity rates persist. Molecular characterization of S. sanguinis virulence determinants may enable development of prevention methods. In a previous screen for S. sanguinis virulence determinants by signature-tagged mutagenesis (STM) an attenuated mutant was identified with a transposon insertion in the nrdD gene, encoding an anaerobic ribonucleotide reductase. Evaluation …

Reliability Generalization Of The Alcohol Use Disorders Identification Test., Chandni Patel

Electronic Theses and Dissertations

The Alcohol Use Disorder Identification Test (AUDIT) is a brief screening instrument for assessing alcohol use problems among adults. This instrument is widely used and continued evaluation of its psychometric performance is needed. Reliability and validity are the primary psychometric characteristics of interest when evaluating psychological instruments. The focus of the present study is on reliability, which reflects the consistency or repeatability of the scores produced by a given instrument. Using meta-analytic methods, results showed that approximately 65% of previously published studies using the AUDIT did not appropriately report reliability estimates. Among the remaining studies, weighted reliability estimate centered on …

Sex Differences In Nicotine-Conditioned Hyperactivity In A Model Of Dopamine D2 Receptor Priming: Roles Of Dopamine D2 And D3 Receptor Subtypes., Ashley Brianna Sheppard

Electronic Theses and Dissertations

The aim of this investigation was to determine the effect of a nicotine-conditioned context on locomotor hyperactivity in an animal model of D2-priming, and whether conditioned hyperactivity could be blocked by the D2 antagonist eticlopride or the D3 antagonist nafadotride. D2-primed male rats showed enhanced nicotine sensitization as evidenced by statistically significant differences in horizontal activity. D2-primed female rats administered nicotine demonstrated an increased hypoactive response after initial sensitization and increased stereotypy. Eticlopride and nafadotride blocked sensitization to nicotine in both D2-primed and non D2-primed males and females. Eticlopride blocked conditioned hyperactivity in females but not in males. D2-primed female …

An Epidemiological Study Of Maternal Depression: Findings From The National Institute Of Child Health And Human Development Study Of Early Child Care And Youth Development., Liang Wang

Electronic Theses and Dissertations

This study examined maternal depression status from month 1 to 36 after birth using data from the NICHD Study of Early Child Care and Youth Development. Maternal depression was assessed with the Center of Epidemiological Studies Depression Scale. The prevalence of maternal depression was highest at 1 month, decreased at 6 months, and then kept fairly stable to 36 months. The prevalence was higher in blacks than other races, in 18-24 than 25-46 years old, and in single mothers than non-single mothers. Mothers with better physical health, social support, or employed had a lower prevalence than their counterparts. Mothers in …

The Effects Of A Season-Long Relaxation Program On Anxiety And Performance In Female High School Track & Field Throwers, Jeremy Walker

Graduate Theses

The purpose of this study was to examine the effects of a season-long relaxation breathing program on anxiety and performance in track and field throwers. It was hypothesized that the relaxation breathing technique would help to reduce anxiety and increase overall performance. Use of a single-subject research design was used to allow ongoing monitoring of each athlete’s anxiety levels and performance. Results indicated that 2 of the 3 participants had improved performance and reduced trait anxiety over the course of the season. Additional results indicated that there was no significant difference in performance between participants and non-participants and that the …

Positioning Hospice Care Within The Black And Hispanic Communities, Carol Armstrong

Graduate Theses

Nationally, hospice care and the signing of advance directives are underutilized by minority populations. Research on this phenomenon includes cultural differences, access to medical care and language barriers. A retrospective study of 1,817 closed patient charts from a local hospice was conducted to determine significant differences among the White, Black and Hispanic patient populations. The number of White patients admitted to both hospice homecare and to the hospice inpatient was significantly greater than the number of admissions of either the Black or Hispanic patients. There were no significant findings in the total number of services provided to each of the …

Relationship Of Lactobacillus Casei To Prevention Of Antibiotic Associated Diarrhea Due To Clostridium Difficile, Kayal K. Chandramohan

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this research was to study the effectiveness of Lactobacillus casei in preventing the occurrence of antibiotic associated diarrhea related to Clostridium difficile. Twenty-six patients, above the age of sixty years, who were prescribed antibiotic therapy and admitted to the Rehabilitation or Orthopedics Units at Union Hospital and who met the eligibility criteria were recruited for the study. Equal numbers of patients (13 in each group) were assigned to the Control and the Experimental group based on their admission date to the hospital and their willingness to consume a probiotic yogurt type drink. The patients in the experimental …

Characterization Of Kaposi's Sarcoma-Associated Herpesvirus Orf11 As A Possible Dutpase, Christina N. Ramirez

Seton Hall University Dissertations and Theses (ETDs)

A dUTPase is a crucial enzyme that hydrolyzes dUTP to dUMP. This reaction prevents the mutagenic or lethal misincorporation of uracil into DNA. For that reason, the enzyme is required for efficient DNA replication. Previous studies have shown that has ORFl l dUTPase-like motifs and thus may be a dUTPase. Generally, gammaherpesviruses contain six characteristic dUTPase motifs. In particular ORFl 1 and contains motifs 1, 2, 4, 6. While the characteristic motifs of gamroaberpesviruses include motifs 1, 2, 3, 4, 5, and 6, the number of dUTPase-like motifs in ORFl 1 's protein sequence is substantial. Thus, ORFl 1 may …

Combined Cognitive Behavioral Treatment Plus Caregiver Sessions For Childhood Depression, Dikla Eckshtain

Dissertations

Childhood depression is intimately related to the family context and caregiver-child relations, but only a limited number of treatment outcome studies for depressed youth have formally included members of the family in the intervention. To address this discrepancy the present study evaluated the efficacy of adding caregiver sessions to individual cognitive behavioral therapy (CBT) for the treatment of depressed youth. The treatment included 16 individual sessions and 7 caregiver sessions administered in the child's school to promote accessibility. Fifteen children (10 females and 5 males ranging in age from 8-13), who met inclusion criteria based on self-report and interview measures …

Perceptions Of Quality Of Life Of Latinos With Diabetes Living In The U.S.: Variations By Geographic Region Of Origin, Janice M. Long

Dissertations

The Latino population, the largest ethnic minority in the United States, is a diverse group originating from numerous geographic regions of Latin America. Latinos vary in the risk for type 2 diabetes, a condition that exacts a costly burden on those who suffer with it. With the Latino population diversity, diverse strategies are needed. One strategy is to improve outcomes of life quality by improving knowledge of those who deliver health services to Latinos with type 2 diabetes. Through measurement of quality of life (QOL), the more precious aspects of living, how one feels about living with diabetes, can be …

The Relationship Between Perceived Personal Risk Of Getting Prostate Cancer And Prostate-Specific Antigen (Psa) Screening, Yeatoe G. Mcintosh

Theses and Dissertations

Abstract Title: The Relationship between Perceived Personal Risk of getting Prostate cancer and Prostate-Specific Antigen (PSA) Screening Yeatoe G. McIntosh, MPH Candidate Advisor: Emmanuel Anum, MBChB, MPH, PHD Preceptor: Emmanuel Anum, MBChB, MPH, PHD Background: Prostate cancer is one of the most common cancer diagnoses in the United States. The American Cancer Society estimates that in 2008 28,660 deaths would be attributed to prostate cancer, projecting it to be the leading cause of cancer deaths in U.S. men. Despite the potential threat this cancer presents to men and the potential for improved disease outcomes from early detection, guidelines for screening …

The Association Of Maternal Intention To Breastfeed, Early Skin-To-Skin Mother/Infant Contact, And Exclusive Breastfeeding During The Maternity Hospital Stay, Leslie Mary Bramson

Loma Linda University Electronic Theses, Dissertations & Projects

Breastfeeding is the optimal method to nourish and nurture an infant. Exclusive breastfeeding rates in the United States have reached the goal of Healthy People 2010 that 75% of mother's breastfeed in the immediate postpartum period. Yet, less than 35% of San Bernardino county mothers and 47.7% of Riverside county mothers are exclusively breastfeeding during their maternity hospital stays, with as many as 50% of the infants being weaned from the breast in the first 14 days of life.

This prospective study examined archived data collected by Perinatal Services Network (PSN) of Loma Linda University Medical Center/Children's Hospital for the …

Infectious Keratitis Associated With Contact Lens Use, Misty Dawn Harvey

All-Inclusive List of Electronic Theses and Dissertations

In March 2006, ophthalmologists noticed increased Fusarium keratitis in patients wearing soft contact lenses; the etiology was that of Fusarium solani. By May of 2006, CDC reported receiving a total of 130 confirmed cases of Fusarium keratitis across 26 states and one territory; of the 118 who could identify the lens solution they had used, 64% reported using Bausch & Lomb's ReNu with Moistureloc ©,while 18% reported using only non-Bausch & Lomb products. The association between Fusarium keratitis and ReNu with Moistureloc was not clear. Nevertheless, Bausch & Lomb withdrew Moistureloc solutions worldwide. In earlier laboratory tests using standard methods …

Intergenerational Communication: Its Effect On Early Screening Activities In African-American Adult Daughters Of Mothers With Breast Cancer, Rita R. Callahan Phd, Ma, Bsn, Rn

Dissertations

Health communication at numerous levels is vital to sustainability of healthy individuals. The notion of African-American mothers and adult daughters sharing breast health and breast cancer knowledge openly and honestly could be the initial step in addressing the high morbidity and mortality that continues to affect this population. Communication is a variable that has yet to be studied between African-American mothers diagnosed with breast cancer and their adult daughters. This study first examined whether this relationship existed, and secondly if it was strong enough in supporting and encouraging one another towards consistent breast health and breast cancer screening activities. The …

The Multiple Location Time Weighted Index: Using Patient Activity Spaces To Calculate Primary Care Service Areas, Jennifer Lynn Rankin

Dissertations and Theses (Open Access)

Geographic health planning analyses, such as service area calculations, are hampered by a lack of patient-specific geographic data. Using the limited patient address information in patient management systems, planners analyze patient origin based on home address. But activity space research done sparingly in public health and extensively in non-health related arenas uses multiple addresses per person when analyzing accessibility. Also, health care access research has shown that there are many non-geographic factors that influence choice of provider. Most planning methods, however, overlook non-geographic factors influencing choice of provider, and the limited data mean the analyses can only be related to …

Modeling Pure Vasogenic Edema In The Rat Brain, Charles Nottingham

Theses and Dissertations

Targeted drug delivery to the brain is difficult to achieve using conventional techniques, largely due to the blood-brain barrier’s (BBB) impediment to drug diffusion into the brain parenchyma. In response, development of convection-enhanced delivery (CED) offers the ability to circumvent the BBB and target specific areas of the brain. Predictability of infusate movement in pathological brain states during CED will maximize the effectiveness of this treatment, and therefore modeling of infusate movement must be characterized. Previous work from our lab effectively modeled CED in rats using the middle carotid artery occlusion model of cytotoxic edema. However, previous models examined for …

Developing A Medically Informative And Socially Supportive Interactive Online Network (Mission), Katherine Adams

All Theses

This thesis discusses virtual communities and social networks and their current and potential uses in health and medicine, proposing a novel virtual health network called a 'Medically Informative and Socially Supportive Interactive Online Network' (MISSION). The purposes of a MISSION are to 1) serve as an information resource for patients, 2) to facilitate conversation between patient and provider, 3) to potentially aid in office tasks (such as scheduling, billing, etc.), and 4) to aid in community-building acts in patients' own local, physical communities. In this thesis, the concept of virtual communities and social networks are explored, the legal and ethical …

Manipulations Of Macrophage Activation Through Targeted Delivery Of Interferon Regulatory Factor Genes Mediated By Recombinant Adenovirus-Conjugated Zymosan, Mengmeng Zhang

All Theses

According to the different phenotypes and distinct patterns of gene expression, macrophages can be subdivided into two types: M1 and M2. The M1 macrophages, which are activated through the classical pathway, have a proinflammatory characteristic, providing an in-front defense line against different kinds of pathogens as well as malignant cells. On the other hand, the M2 macrophages are immunosuppressive and instead can promote tumor growth and dissemination. The solid tumor tissues are often infiltrated with a large number of macrophages, the so-called tumor-associated macrophages (TAMs). TAMs, which are polarized into M2 phenotype under the tumor microenvironment, promote tumor progression by …

Physiological And Molecular Characterization Of Genetic Competence In Streptococcus Sanguinis, Alejandro Rodriguez

Theses and Dissertations

The ability of bacteria to assimilate free DNA from the environment is known as competence. Though many studies have focused on competence regulation in Streptococcus pneumoniae and Streptococcus gordonii, Streptococcus sanguinis has yet to be examined. Physiological characterization of competence in S. sanguinis strain SK36 and its comC mutant, JFP41, led to the genome-wide transcriptional analysis of cells induced to competence via addition of competence-stimulating peptide (CSP). A total of 128 genes were induced at least 2-fold, 74 of which were classified as either “early” or “late” based on their induction patterns. Expression patterns were verified using qRT-PCR. This study …

Development Of Thai Speech Audiometry Materials For Measuring Speech Recognition Thresholds, Lauren Alexandra Hart

Theses and Dissertations

Speech audiometry materials are essential for thorough audiological testing. One aspect of speech audiometry is evaluating an individual's speech recognition threshold (SRT). Recorded materials for SRT are available in many languages; however there are no widely published recorded SRT materials available in the Thai language. The goal of this study was to develop relatively psychometrically equivalent SRT materials for evaluating the hearing abilities of native speakers of the Thai language. To accomplish this, 90 commonly used bisyllabic Thai words were digitally recorded by a male and a female talker and evaluated by 20 native Thai listeners. Twenty-eight words with relatively …

Recognition Of Emotion In Facial Expressions By Children With Language Impairment, Dorthy A. Stott

Theses and Dissertations

Recent research has shown that children with language impairment (LI) have increased social difficulties. This study examined the relationship between language skills and emotion understanding through recognition of facial expressions of emotion in children with LI and their typically developing peers. It is a replication of the research of Spackman, Fujiki, Brinton, Nelson, and Allen (2005) and Atwood (2006). Participants consisted of 22 children with LI and 22 age- and gender-matched peers with typically developing language, from the age range of 7:0 to 10:11 years. They were shown photographs of faces conveying one of the following emotions: happiness, sadness …

The Effect Of A Pseudopalate On Voiceless Obstruent Production: A Spectral Evaluation Of Adaptation, Karie Lindsay Dean

Theses and Dissertations

Many studies in speech communication have provided valuable findings concerning the kinematic nature of speech articulation. This type of research often involves introducing an oral device to the vocal tract such as lingual pellets, magnets, and different forms of pseudopalates to track the movement and placement of the articulators. This study examined the effect of an electropalatography (EPG) pseudopalate on the production of five voiceless obstruents (/p, t, k, s/ and /sh/). Acoustic recordings from 20 adult speakers with typical speech production were made during three different speaking conditions: prior to pseudopalate placement, immediately after placement, and following 20 minutes …

Promotion Of Tumor Cell Death Through The Induction Of, Tuyen Nguyen

Theses and Dissertations

Microtubule poisons have proven to be effective in the treatment of a variety of malignancies. Although taxol-based derivatives promote microtubule stabilization, there is continuing interest in compounds that, like colchicines, act as microtubule destabilizing agents. Previous work from this laboratory showed that the novel microtubule poison, JG- 03-14, was active against breast tumor cells, promoting autophagic cell death. In the current work, we studied the influence of JG-03-14 on p53 wild type HCT116 colon carcinoma cells. A crystal violet sensitivity assay indicated that JG-03-14 induced growth inhibition, with 75% suppression of growth evident at a concentration of 500 nM. Time …

Recognizing The Need To Dissemble Emotions In Hypothetical Social Scenarios: Differences In Children With Language Impairment, Emily Rowberry Jones

Theses and Dissertations

This study investigated the ability of children with LI to recognize the need to dissemble emotions. Participants included 22 children with LI and 22 typically developing peers, ages 7;1 to 11;0 years. Children were presented with 10 hypothetical social scenarios in which the main character experienced an emotion which should be dissembled for social purposes. The participant's responses were categorized as dissemblance or display. Children with LI reported that they would hide the experienced emotion significantly less often than their typical peers. Children in both groups reported higher levels of dissemblance when asked what their parents would want them to …

Promoting Healthy Development: Educating Somali Mothers And Children On The Importance Of Outdoor Physical Activity, Rebecca S. Wawra

Theses and Graduate Projects

This paper describes an educational program that was designed to provide education and awareness for Somali mothers and children about the importance of outdoor physical activity on healthy child development. The program is based on Margaret Newman's nursing theory of Health as Expanding Consciousness and Hartrick-Doane & Varcoe's concept of walking with. A comprehensive literature review was completed to exemplify the need for outdoor physical activity education in the immigrant population.

Spirituality And Symptom Self Management Of Osteoarthritis, Lois M. Kannan Phd

Dissertations

Healthcare providers need to identify holistic self-care techniques that are endorsed by patients as effective strategies for symptom management of osteoarthritis, which is the single most common cause of disability in older adults. Research in this area may direct the development of interventions to ensure that older adults are afforded every opportunity to remain active and productive, with an improved health related quality of life, despite age related musculoskeletal conditions. The purpose of this study was to describe the relationships among symptom experience, symptom management, and symptom outcome based on spiritual well-being. A quantitative, descriptive, correlational, and noninterventional study design, …

Research Utilization Barriers Perceived By Nurses In The Emergency Department, Yen Hai Nguyen

Nursing Theses - Archive

The purpose of this quantitative, descriptive study is to explore and describe Emergency Department nurses' perceived barriers to research utilization. The setting of this study takes place in the Emergency Department of a community hospital in North Central Texas. The BARRIERS to Research Utilization Scale (Funk, Champagne, Wiese, & Tornquist, 1991a) was the questionnaire used in this study. Sixteen completed questionnaires were obtained. The greatest barrier identified by this sample was that nurses do not feel they have enough authority to affect change, which is the same primary barrier found by Funk, Champagne, Wiese, and Tornquist in 1991. Implications for …

Primary Health Care Providers’ Knowledge And Practices On Asthma Management Within Dar Es Salaam Region Health Facilities, John C. Rwegasha

Master of Medicine in Family Medicine

Background: Asthma is a common chronic health problem worldwide with considerable variation in the way it is managed. In the sub- Saharan Africa there is substantial gaps in asthma care; countries like Tanzania with inadequate health care structure are lagging far behind in both correct diagnosis and management of asthma. The increasing prevalence of asthma within populations is attributed to a number of the following factors; Patient behavior, Health service structure and access, Environmental factors and Provider's knowledge and practices. There is lack of required standard asthma care under provider's factors, hindering effective control of the disease. This could be …