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Full-Text Articles in Medicine and Health Sciences

Assessment Of Parenting Skills Of Mothers In Court Ordered Substance Abuse Treatment, Barb Pieske Jan 2009

Assessment Of Parenting Skills Of Mothers In Court Ordered Substance Abuse Treatment, Barb Pieske

All Graduate Theses, Dissertations, and Other Capstone Projects

Objective of this project was for me to search for an assessment tool that gives an understanding of mothers who are court ordered to substance abuse treatment. Methods: Search scholarly literature and consult with field supervisor. Results: Adoption of an assessment tool that identifies the strengths and weakness of parenting skills. Conclusion: A structured interview assessment allows the therapist to gather data on the parent with a person centered perspective with a holistic approach.

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Implementation And Data Tracking Of School-Linked Mental Health Services At A Rural Mental Health Agency, Jim Redmond Jan 2009

Implementation And Data Tracking Of School-Linked Mental Health Services At A Rural Mental Health Agency, Jim Redmond

All Graduate Theses, Dissertations, and Other Capstone Projects

In late December of 2007 Tom McNeely, the clinical director for the Sioux Trails Mental Health Center, received a Request for Proposals (RFP) from the Minnesota Department of Human Services soliciting grant applications for a new school-linked mental health program. The school-linked program would provide students (K-12) attending public schools full therapeutic services in an effort to reduce mental health issues as a barrier to learning. This approach mirrored Sioux Trails’ belief that a holistic philosophy incorporating prevention and early intervention is the most effective healthcare service. Since the RTF seemed a good fit for the agency, Mr. McNeely, along …

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Social Work Ethics Computer-Based Training Minnesota State University, Mankato Department Of Social Work, Rebecca Robinson-Wargelin Jan 2009

Social Work Ethics Computer-Based Training Minnesota State University, Mankato Department Of Social Work, Rebecca Robinson-Wargelin

All Graduate Theses, Dissertations, and Other Capstone Projects

At the Community Behavioral Health Hospital, St.Peter (CBHH),a discussion was held regarding Ethics Continuing Education Hours(CEUs). The Minnesota Board of Social Work(MNBSW)and Minnesota State Statute 148D.130 require that Licensed Social Workers receive two hours of ethics-specific CEUsper licensure renewal. Through this discussion,it appeared that it would be beneficial to create an ethics computer-based training(CBT), which would be of no expense to State Operated Services(SOS)Social Workers.This option would also provide convenience for social workers, who as a majority,reside within rural areas.The CBT created is in accordance to requirements of the MNBSW and has an emphasis to include the National Association of …

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From A Consumer’S Perspective: What Is Helpful For Residents Of Four Bed Group Homes To Maintain Good Mental Health, Ronna R. Severson Jan 2009

From A Consumer’S Perspective: What Is Helpful For Residents Of Four Bed Group Homes To Maintain Good Mental Health, Ronna R. Severson

All Graduate Theses, Dissertations, and Other Capstone Projects

The population with mental illness has faced many changes in the services provided to them throughout the years. And fortunately, in recent years there has been many progressions in the field that have made the services even better. This transformation all began with the gradual process of closing mental health hospitals and the opening of community based alternatives, otherwise known as deinstitutionalization (Brunt & Hansson, 2002, p. 611). The main objective of the deinstitutionalization movement was to create more humane services for the individuals with mental illness (Searight& Handal, 1987, p. 8). Through this process one of the community based …

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Pervasive Developmental Disorder, Electric Training Modules, Jennifer Stuehrenberg Jan 2009

Pervasive Developmental Disorder, Electric Training Modules, Jennifer Stuehrenberg

All Graduate Theses, Dissertations, and Other Capstone Projects

The South Central Crisis Center is a State Operated Services mental health facility in Mankato, Minnesota. The center is designed to offer people suffering an acute mental health episode, such as suicidal thoughts, or who need a medication adjustment or other psychiatric services, up to a few days in a safe, secure environment. The center accepts referrals from law enforcement, county or health care professionals in these participating counties: Blue Earth, Brown, Faribault, Freeborn, Le Sueur, Martin, Nicollet, Rice, Sibley and Watonwan. Recently, the program has been serving a larger amount of clients who have a diagnosis of Asperger’s Disorder …

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Parent Training, Support And Psychoeducational Groups As Evidence Based Practice In Children's Mental Health, Dorothy Wagner Jan 2009

Parent Training, Support And Psychoeducational Groups As Evidence Based Practice In Children's Mental Health, Dorothy Wagner

All Graduate Theses, Dissertations, and Other Capstone Projects

The evidence base for programs in children’s mental health has expanded significantly in the last decade (Burns, 2003), yet the implementation of these programs has lagged behind (Walrath, Sheehan, Holden, Hernandez & Blau, 2005). The purpose of this project is to research current evidence based practices and programs that could improve and/or update services that are provided to children and adolescents diagnosed with severe emotional disturbance (SED) in Steele County. Research and analysis of the feasibility of implementing a group intervention to provide support, psychoeducation and/or skills training to families was conducted.

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Structural And Functional Studies On Heat Shock Protein Hsp40-Hdj1 And Golgi Er Trafficking Protein Get3, Junbin Hu Jan 2009

Structural And Functional Studies On Heat Shock Protein Hsp40-Hdj1 And Golgi Er Trafficking Protein Get3, Junbin Hu

All ETDs from UAB

Molecular chaperones are a large group of proteins that bind and stabilize nascent polypeptides and facilitate protein folding. One major function of chaperones is to bind hydrophobic segments of nascent polypeptides to prevent them from aggregating. How chaperone Hsp40 recognizes and interacts with polypeptides and cooperates with chaperone Hsp70 is a fundamental question. The crystal structure of the putative peptide-binding fragment of Hdj1, a human member of the type II Hsp40 family was determined, suggesting the domain I of Hsp40 may possess significant flexibility which is important for Hsp40 to regulate the size of the cleft. The flexibility may be …

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The Effects Of Bisphenol A (Bpa) On Erbb2-Positive Breast Cancer, Sarah Jenkins Jan 2009

The Effects Of Bisphenol A (Bpa) On Erbb2-Positive Breast Cancer, Sarah Jenkins

All ETDs from UAB

Bisphenol A (BPA) is a synthetically made compound used to produce a myriad of consumer goods. Recent studies have shown BPA to leach from these products in appreciable amounts, resulting in nearly ubiquitous exposure. In this study, we assessed whether chronic administration to a range of low concentrations of BPA could accelerate spontaneously developing mammary cancer using a transgenic model that over-expresses wild type ErbB2/neu transgene (MMTV-erbB2). MMTV-erbB2 mice were provided drinking water containing 0 (control), 2.5 (BPA 2.5), 25 (BPA 25), 250 (BPA 250), or 2500 (BPA 2500) µg BPA/L from eight weeks of age until sacrifice. This range …

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Understanding The Regulatory Mechanisms Of Ubp-M And H2a Deubiquitination In Chromatin And Cellular Functions, Heui Yun Joo Jan 2009

Understanding The Regulatory Mechanisms Of Ubp-M And H2a Deubiquitination In Chromatin And Cellular Functions, Heui Yun Joo

All ETDs from UAB

Posttranslational modifications of histones regulate important chromatin and cellular functions. Among them, ubiquitination of histone H2A is correlated to transcriptional repression, such as HOX gene silencing and X chromosome inactiviation. Little was known about the removal of ubiquitin from histones, the enzyme(s) involved and its function in chromatin dynamics. We have identified the protein Ubp-M (USP16) to be the H2A- and nucleosome-specific deubiquitinase. We also demonstrated that Ubp-M-mediated H2A deubiquitination is involved in cell cycle progression to M-phase, HOX gene expression, and posterior development in Xenopus laevis. Furthermore, we have also purified USP12 and USP46 which contain an Ubp-M independent …

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A System Genetics Analysis Of Energy Metabolism Traits In Drosophila Melanogaster, Patricia Paola Jumbo-Lucioni Jan 2009

A System Genetics Analysis Of Energy Metabolism Traits In Drosophila Melanogaster, Patricia Paola Jumbo-Lucioni

All ETDs from UAB

Obesity is emerging as a global public health problem and it has shown to precede and predict the development of type 2 diabetes, a complex disease that has also reached epidemic proportions in the US and worldwide. Despite that obesity-related traits are highly heritable, the genetic basis underlying their natural variation and the loci playing pleiotropic roles among organismal traits have not been fully elucidated. The overall goals of these present studies were: to shed light on the architecture of the genetic co-expression networks regulating variations in obesity-related traits, elucidate the extent to which they are regulated by pleiotropic loci, …

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Sustained Pupil Constriction Following Brief Light Exposure: Relation To Retinal Health, Laxmikanth Kankipati Jan 2009

Sustained Pupil Constriction Following Brief Light Exposure: Relation To Retinal Health, Laxmikanth Kankipati

All ETDs from UAB

The pupillary light reflex (PLR) is an indispensable clinical measure of visual, neurological and autonomic function which, until recently, was thought to be driven by only rods and cones. In 2000, a novel subset of retinal ganglion cells (RGCs) was discovered that express melanopsin and are intrinsically photosensitive (ipRGC). These ipRGCs contribute to the PLR and are responsible for the sustained pupilloconstriction observed following light offset (the post-illumination pupil response (PIPR)). The primary goal of this project was to examine the PIPR in a broad sample of the general human population. Using a newly-developed, wide-field optical system, we demonstrate that …

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Effects Of Daily Versus 30-Day Continuous Contact Lens Wear On Tear Cytokine Levels, Lucy Ebunoluwa Kehinde Jan 2009

Effects Of Daily Versus 30-Day Continuous Contact Lens Wear On Tear Cytokine Levels, Lucy Ebunoluwa Kehinde

All ETDs from UAB

The purpose of this investigation was to determine if 30 days of continuous contact lens wear produces a different ocular inflammatory response compared to 30 days of daily wear of Bausch & Lomb® PureVisionTM silicone hydrogel contact lenses. Eighty-five individuals wore these lenses for 30 days continuously in one eye and daily in the contralateral eye. Relative concentrations of 27 cytokines were measured in tear samples collected from the subjects using cytometric bead-based assays. Clinical tests were also conducted to correlate changes in cytokine levels to changes in clinical profiles. This study contributes to a greater understanding of the impact …

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Role Of Syndecan-1 As Key Regulator Of Multiple Myeloma Pathogenesis, Yekaterina Borisovna Khotskaya Jan 2009

Role Of Syndecan-1 As Key Regulator Of Multiple Myeloma Pathogenesis, Yekaterina Borisovna Khotskaya

All ETDs from UAB

Syndecan-1 (CD138), a transmembrane heparan sulfate-bearing proteoglycan, is expressed at high levels on most myeloma cells and is shed into the microenvironment. In patients, high levels of serum syndecan-1 are indicative of poor prognosis and elevation of shed syndecan-1 in animal models dramatically enhances tumor growth, angiogenesis and metastasis. Because syndecan-1 is a key regulator of myeloma pathogenesis, we hypothesized that reduction of syndecan-1 levels expressed by the myeloma cells will block their growth and dissemination. Syndecan-1 knockout and knockdown variants of two human myeloma cell lines, CAG and RPMI-8226, were developed using short hairpin RNA (shRNA) technology. In vitro, …

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Impact Of Genetic And Epigenetic Variability In Response To Two Test Drugs 5-Fluorouracil And Lansoprazole, Adam Michael Lee Jan 2009

Impact Of Genetic And Epigenetic Variability In Response To Two Test Drugs 5-Fluorouracil And Lansoprazole, Adam Michael Lee

All ETDs from UAB

Pharmacogenetics has proven to be an invaluable tool in predicting variability in drug response; however, there are numerous incidences where genetics cannot fully explain interindividual drug variability. Other factors, such as the epigenetic mechanism of DNA methylation, may offer an alternate explanation. Therefore, this dissertation focuses on both genetic and epigenetic regulation in order to gain a better understanding of the molecular basis behind drug response variability. Initial investigations focused on the antineoplastic agent 5-Fluorouracil (5-FU), which can produce severe toxicity in patients with deficiency in dihydropyrimidine dehydrogenase (DPD). Genotypic studies have identified >32 sequence variants in the DPYD gene; …

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Parental Attitudes Of Human Papillomavirus Vaccination Of Adolescent Girls In Alabama, Allison G. Litton Jan 2009

Parental Attitudes Of Human Papillomavirus Vaccination Of Adolescent Girls In Alabama, Allison G. Litton

All ETDs from UAB

Human papillomavirus is the most common sexually transmitted infection in the United States. This study examined racial and socio-demographic differences between African Americans and non-Hispanic Whites in Alabama regarding HPV vaccine acceptability. This cross sectional study employed a statewide survey of Alabama parents using a random digit dial phone method conducted through the Survey Research Unit at UAB. Participants were female caregivers of adolescent girls between the ages of 10-14 years. The final sample size was 403. Analyses included descriptive statistics, cross tabulations and odds ratios to assess race/ethnicity and other subgroup differences and logistic regression of intention to vaccinate …

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Regulation Of Vh Replacement In Human Immature B Cells By B Cell Receptor (Bcr) - Mediated Signaling, Jing Liu Jan 2009

Regulation Of Vh Replacement In Human Immature B Cells By B Cell Receptor (Bcr) - Mediated Signaling, Jing Liu

All ETDs from UAB

VH replacement occurs through RAG-mediated secondary recombination to change unwanted IgH genes. In this dissertation, I focused on studying the molecular mechanism that regulates VH replacement in human immature B cells. In part I, our results show that VH replacement is regulated by B cell antigen receptor (BCR) mediated signaling. Using the human EU12 mHC+ cells as an experimental model system, crosslinking BCR with F(ab')2 anti-IgM antibodies results in BCR internalization, cell proliferation arrest, and induction of VH replacement. Pretreatment of human EU12 mHC+ cells with the protein tyrosine kinase inhibitor Genistein, Syk kinase inhibitors, and a Src kinase inhibitor …

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The Antecedents And Consequences Of The Niche Approach To Healthcare Delivery, Lejon Poole Jan 2009

The Antecedents And Consequences Of The Niche Approach To Healthcare Delivery, Lejon Poole

All ETDs from UAB

ABSTRACT OBJECTIVE: Niche hospitals represent a growing segment in the health care industry. A niche strategy is an approach that focuses on a narrow market segment that its resources and capabilities can exploit (Porter, 1980; Powers and Khan, 2004). The purpose of the proposed study was to provide an understanding of the antecedents and consequences of the niche approach to healthcare delivery. The interaction of the niche strategy and the physician-owner as a unique bundle of resources was also examined. The subsequent model tested the relationships among generic strategies, market effects, firm effects, and financial performance. RESEARCH DESIGN AND METHODS: …

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Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) Modulators And Their Mechanistic Basis: Relevance To Emerging Therapies For Cystic Fibrosis, Louise Clare Pyle Jan 2009

Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) Modulators And Their Mechanistic Basis: Relevance To Emerging Therapies For Cystic Fibrosis, Louise Clare Pyle

All ETDs from UAB

Cystic fibrosis (CF) is a lethal genetic disorder leading to pulmonary decline and premature death. The gene responsible for CF, the cystic fibrosis transmembrane conductance regulator (CFTR), serves as a chloride and bicarbonate channel situated at the apical cell surface of epithelia. The discovery of small molecules that augment channel gating of mutant CFTR (so-called `potentiators') represents a major theme of CF research, and offers hope for new therapeutic interventions. High-throughput screening (HTS) provides a means to test millions of agents in an unbiased manner for CFTR potentiating properties. New agents identified by HTS have undergone extensive pre-clinical and clinical …

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The Role Of Mitochondria And Plasma Membrane Ca2+ Transport Systems In Ca2+-Dependent Glutamate Release From Rat Cortical Astrocytes, Reno Cervo Reyes Jan 2009

The Role Of Mitochondria And Plasma Membrane Ca2+ Transport Systems In Ca2+-Dependent Glutamate Release From Rat Cortical Astrocytes, Reno Cervo Reyes

All ETDs from UAB

Astrocytes, a type of glial cell in the central nervous system, are recognized for their support roles to neurons. They supply neurons with metabolites, maintain ion homeostasis and clear the synaptic space of neurotransmitters. However, it has been found that some astrocytes have receptors for neurotransmitter and neuroligands, exhibit Ca2+ excitability when stimulated via these receptors, and secrete gliotransmitters as an output of this Ca2+ excitability. In the Ca2+-dependent release of glutamate, it has been shown that the endoplasmic reticulum is the predominant source and the extracellular space is the auxiliary source of free Ca2+ necessary for triggering exocytosis. Because …

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The Role Of Transforming Growth Factor Beta-1 In Bone Remodeling, Yi Tang Jan 2009

The Role Of Transforming Growth Factor Beta-1 In Bone Remodeling, Yi Tang

All ETDs from UAB

Bone remodeling depends on the precise coordination of bone resorption by the osteoclasts and bone formation by the osteoblasts. It is proposed that osteoclastic bone resorption releases factors to initiate bone formation, thereby, coupling the bone resorption and formation. Mesenchymal stem cells (MSCs) are progenitors of osteoblasts. Recruitment of MSCs in response to osteoclastic bone resorption may be an initial step for bone formation during bone remodeling process. Therefore, we have established an in vitro osteoclastic bone resorption system. Bone resorption condition medium have been tested to identify the factor inducing the migration of human bone marrow mesechymal stem cells …

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Characterizing The Role Of Primary Cilia In The Hair Follicle And Skin, Jonathan Merle Lehman Jan 2009

Characterizing The Role Of Primary Cilia In The Hair Follicle And Skin, Jonathan Merle Lehman

All ETDs from UAB

Primary cilia have been established as a nearly ubiquitous microtubule based signaling organelle, yet their function in many organs, including the hair and skin, is unknown. We hypothesized that the primary cilium would play vital roles in the hair follicle and skin based on the cilium's well characterized interactions with the Shh and Wnt developmental signaling pathways. This dissertation describes our efforts to determine the localization of the primary cilia in the murine hair follicle and assess the function of this organelle in the hair and skin. We used confocal immunofluorescence microscopy to virtually section the entire hair follicle and …

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Regulation Of The Human Heme Oxygenase-1 Gene By Nitro-Linoleic Acid, Macienne M. Wright Jan 2009

Regulation Of The Human Heme Oxygenase-1 Gene By Nitro-Linoleic Acid, Macienne M. Wright

All ETDs from UAB

Nitro-fatty acids (NO-FA) exert anti-inflammatory effects in the vasculature. Heme oxygenase-1 (HO-1) degrades heme into iron, biliverdin, and carbon monoxide and is up-regulated as an adaptive and protective response to inflammatory processes. This dissertation examined whether nitro-linoleic acid (LNO2) induced HO-1 gene expression and evaluated the molecular mechanism of induction in human aortic endothelial (HAEC), human embryonic kidney 293 (HEK 293) and mouse embryonic fibroblast (MEF) cells. LNO2 induced HO-1 mRNA and protein in HAEC at the level of transcription. NO scavenging by carboxy-PTIO partially reversed LNO2–mediated induction of HO-1, suggesting that LNO2 acts via NO-dependent and NO-independent mechanisms of …

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Protective Mechanisms Of Apoa-I Mimetic Peptide Action In Sepsis-Induced Tissue Injury, Zhenghao Zhang Jan 2009

Protective Mechanisms Of Apoa-I Mimetic Peptide Action In Sepsis-Induced Tissue Injury, Zhenghao Zhang

All ETDs from UAB

Sepsis is among the top ten causes of death in the US, and it is associated with severe inflammatory tissue damage and organ dysfunction. Reduced plasma high density lipoprotein (HDL) is associated with increased mortality in septic patients. Since raising plasma apolipoprotein (apo) A-I and HDL may reduce sepsis complications, we tested the hypothesis that the apoA-I mimetic peptide 4F confers similar protective effects in two animal models of sepsis, and explored the possible mechanisms. In endotoxemic rats, inflammatory mediators were significantly induced while blood pressure was significantly reduced by 6hr. The impaired arterial response to vasoconstrictors was related to …

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Molecular Characterization Of Neural Apoptosis, Ken C. Walls Jan 2009

Molecular Characterization Of Neural Apoptosis, Ken C. Walls

All ETDs from UAB

Neural cell death plays a critical role in normal nervous system development and dysregulated neural stem cell death contributes to brain malformation, tumorgenesis, and possibly, neurodegenerative disease. The two major forms of cell death in the nervous system are apoptotic and autophagic. Altered clearance of proteins may lead to neuronal dysfunction and neuron loss via apoptotic and/or autophagic pathways. The research presented here examined the molecular regulation of the autophagic and apoptotic pathways in vivo and in vitro by using models of lysosome dysfunction and hypoxia. In vivo investigation of lysosome dysfunction-induced death utilized the cathepsin D (CD)-deficient mouse model. …

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Analysis Of Cystic Kidney Disease-Related Genes In Caenorhabditis Elegans, Corey L. Williams Jan 2009

Analysis Of Cystic Kidney Disease-Related Genes In Caenorhabditis Elegans, Corey L. Williams

All ETDs from UAB

Cilia are evolutionarily conserved, membrane-bound, microtubule-based organelles found on a diverse array of cell types in eukaryotic organisms. Inherited diseases of cilia protein dysfunction include Nephronophthisis (NPHP), Joubert Syndrome (JBTS), Meckel-Gruber Syndrome (MKS), and Bardet-Biedl Syndrome (BBS). Important insight in the basic cell biological functions of BBS and NPHP proteins has been gained from analysis in the nematode Caenorhabditis elegans. My goal in this dissertation was to model MKS protein function in cilia biology utilizing the powerful genetic malleability of C. elegans. mks-1 and mks-3, the C. elegans homologs of two MKS-associated proteins in humans, were selected for this analysis. …

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Factors Associated With Sleep Disruption Among Community-Dwelling Older Adults In The Health And Retirement Study, Laura L. Williams Jan 2009

Factors Associated With Sleep Disruption Among Community-Dwelling Older Adults In The Health And Retirement Study, Laura L. Williams

All ETDs from UAB

Introduction: The purpose of this study was to examine behavioral outcomes and sleep disruption in aging adults using data from the 2004 wave of the longitudinal Health and Retirement Study (HRS). It was hypothesized that sleep disruption is associated with behavioral outcomes and sociodemographic variables in a population-based sample. Methods: The 2004 HRS data (N=20,129) represents a cross-sectional analysis of community dwelling aging adults born in the US at or before 1923 through 1953. Data are stratified by date of birth to provide five cohorts of aging elderly. The HRS Psychosocial Leave-Behind Participant Lifestyle Questionnaire (PLBQ) was given to a …

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The Acute Onset Of Insulin Resistance In Adipose Tissue Following Trauma And Hemorrhage, Vanessa L. Williams Jan 2009

The Acute Onset Of Insulin Resistance In Adipose Tissue Following Trauma And Hemorrhage, Vanessa L. Williams

All ETDs from UAB

Insulin resistance and hyperglycemia are common findings in patients following acute illnesses or injuries, such as surgical trauma, thermal injury, infection, hemorrhage, and sepsis. Insulin has three main target tissues: liver, skeletal muscle, and adipose tissue. Insulin resistance in the liver results in an increase in gluconeogenesis. In skeletal muscle, insulin resistance causes a decrease in insulin-stimulated glucose uptake. However, little is known about the contribution that adipose tissue makes to the insulin resistant state. The goals of the research presented in this dissertation were to: 1) determine whether insulin resistance developed in adipose tissue following acute trauma and hemorrhage; …

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The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler Jan 2009

The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler

All ETDs from UAB

Members of the ß2-integrin family of adhesion molecules, CD11a, CD11b, and CD11c, have all been shown to play a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). CD11d had yet to be studied in demyelinating disease and its functions remained unclear. We report here that CD11d is the only member of the ß2-integrin family of adhesion molecules that fails to protect against the development of EAE. Surprisingly, the EAE studies suggested that CD11a, CD11b, and CD11c were all contributing to T cell activity during disease development by mechanisms beyond the migration of these cells into the CNS. However, the …

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Oxidation Of Mercury During Selective Catalytic Reduction Of Nitric Oxide, Giang Tong Jan 2009

Oxidation Of Mercury During Selective Catalytic Reduction Of Nitric Oxide, Giang Tong

All ETDs from UAB

A promising method for mercury removal from the gaseous products of coal combustion is the catalytic oxidation of elemental mercury to water-soluble mercuric chloride during selective catalytic reduction of NOx by ammonia, followed by removal of the oxidized mercury during wet flue gas desulfurization. Measurements of the mercury species distribution and sulfate formation at the outlet of a 310 mm long square cell monolithic V2O5-WO3/TiO2 commercial SCR catalyst showed the following trends: (1) Mercury oxidation was highly sensitive to HCl at the low levels characteristic of Powder River Basin subbituminous coals (0-5 ppmv). (2) Mercury oxidation was inhibited by NH3, …

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Modification Of Adenovirus Capsid Proteins For Gene Therapy Applications, Yizhe Tang Jan 2009

Modification Of Adenovirus Capsid Proteins For Gene Therapy Applications, Yizhe Tang

All ETDs from UAB

Adenovirus (Ad) is the most commonly used viral vector in gene therapy applications to date for a broad range of diseases. Although Ad-based viral vectors have many advantages in a variety of gene therapy designs, the commonly used adenoviral vectors have several key shortcomings. Those shortcomings include (1) inefficient transduction in cell types devoid of Ad’s native receptors and the incapability of gene delivery to targets behind physical barriers; (2) restricted accessibility to the central nerve system due to the existence of the blood-brain barrier (BBB); (3) lack of a useful strategy and platform to generate multi-functionality displaying Ad vectors …

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