Medicine and Health Sciences Commons^™

A Perceptual Evaluation Of The Effect Of A Pseudopalate On Voiceless Obstruent Production And Motor Adaptation, Megan Ann Cannon Williams

Theses and Dissertations

Electropalatography (EPG) has proven to be a useful clinical and research tool for measuring tongue-to-palate contact. Research has shown sensorimotor adaptation to an EPG device may be possible following a short period of speech practice. This study was developed in order to better understand how a listeners' perception of speech clarity is effected by the presence of a relatively thin artificial pseudopalate in the speakers' oral cavity. Twenty listeners rated 220 speech stimuli on a visual analog scale ranging from normal to very distorted speech clarity. The stimuli included two different American English sentences. Speech clarity ratings were looked at …

The Effects Of Intensive Lower Limb Training On The Speech Of Patients With Parkinson's Disease, Lauren Fjeldsted Allen

Theses and Dissertations

Research has documented the positive effects of physical therapy as a treatment for limb motor symptoms associated with Parkinson's disease (PD). Previous studies have shown that speech and voice measures can be reflective of overall cardiovascular health and fitness in young, middle-aged, and older adults. In healthy individuals, increased respiratory drive has been found to influence vocal function and speech articulation. The rationale for the present study was that improved lower limb function might lead to improvements in overall fitness, which then may influence speech in individuals with Parkinson's disease. To investigate this premise, 10 participants diagnosed with mild to …

The Effect Of Fatigue On Acoustic Measures Of Diphthongs In Individuals With Multiple Sclerosis, Kristi Lee Hollis

Theses and Dissertations

Although recent literature suggests that fatigue influences the communication of people with multiple sclerosis (MS), its relationship to acoustic measures of speech, specifically formant transitions during diphthongs, has not been explored. In the present study, 11 participants diagnosed with MS, two of whom were perceptually dysarthric, and 12 control subjects were recorded as they performed selected speech tasks in both the morning and the afternoon. Before each recording session, participants rated their fatigue level. The participants with MS gave significantly higher ratings of fatigue than the control group. The speakers with MS had longer diphthong durations in a non-fatigued state, …

Finish-A-Rhyme-Story: A Rhyme Cloze Assessment For Preschool Children, Kimberly Jeanne Condie

Theses and Dissertations

Educators need measurement tools to determine phonological awareness in young children. This study investigated the appropriateness of rhyme cloze tasks, referred to as Finish-a-Rhyme-Story items, which were designed to measure preschool and kindergarten children's early rhyme development. The rhyme cloze tasks required children to verbally complete a sentence by filling in a final rhyming word that matched a rhyme pattern highlighted in a short story that was read aloud to them. The task required rhyme awareness as well as comprehension of the language in the story. Twenty-four items were individually administered to preschool (n = 207) and kindergarten (n = …

Investigating The Response Of Oligodendrocyte Progenitor Cells To The Cuprizone Model Of Demyelination, David Moffatt

Theses and Dissertations

Multiple sclerosis and other myelin diseases affect the quality of life many people. In the United States alone, multiple sclerosis afflicts as many as 400,000 individuals. Myelin, which is attacked by multiple sclerosis, plays a critical role in maintaining the healthy function of the adult nervous system. There are many model systems that study myelin and its formation and loss. Our lab investigates the cuprizone model of demyelination and remyelination. The cuprizone model is commonly believed only to affect adult oligodendrocytes, which it kills. The current study investigates whether other cells in the oligodendrocyte line, such as oligodendrocyte progenitor cells, …

Role Of Fdcs And Fdc Activation In Promoting Humoral Immunity Including Responses To T-Dependent Antigens In The Absence Of T Cells, Sayed Rania El

Theses and Dissertations

Follicular dendritic cells (FDCs) reside in primary B-cell follicles and in the light zones of germinal centers (GCs) in secondary follicles, where their dendrites interdigitate forming extensive networks intimately interacting with B-cells. In GCs, FDCs can be found at the edges attached to the supporting reticular fibers. They trap and arrange immune complexes (ICs) in vivo and in vitro in a periodic manner with 200–500Å spacing and provide both antigen-specific and non-specific accessory signals to B-cells. FDCs exist in resting and activated states, with two characteristically different phenotypes. In their activated state, FDCs upregulate the expression of accessory molecules and …

Factors Influencing Placental Transfer Of Lopinavir: Binding, Uptake And Efflux, Abhishek Gulati

Theses and Dissertations

HIV protease inhibitors are an important component of Highly Active Antiretroviral Therapy used to treat HIV infected pregnant women. They have a low placental transfer and are highly plasma protein bound. The purpose of this thesis was to characterize the factors limiting placental passage and fetal exposure to lopinavir. These factors include lopinavir plasma protein binding and uptake, cellular binding, and efflux of lopinavir in the placental trophoblast cells. First, we determined the unbound fraction of lopinavir in cord blood and characterized the binding of lopinavir to α1-acid glycoprotein (AAG) and human serum albumin (HSA), and displacement by ritonavir. Serum …

Exercise Motivation For Breast Cancer Risk Reduction, Maureen Elaine Wood

Dissertations

According to The International Agency for Cancer Research (IARC), 25% of worldwide breast cancer cases are due to having a sedentary lifestyle and being overweight or obese (2002). Unfortunately, less than 50% of women participate in physical activity as recommended by the Centers for Disease Control (CDC) and the American College of Sports Medicine and more than 25% do not participate in any physical activity at all (CDC, 2005). Perceptions of increased personal risk and self-efficacy have been shown to promote exercise participation, and as such, are key elements of protection motivation theory, used as the theoretical framework to guide …

Roles Of Krüppel Like Factors Klf1, Klf2, And Klf4 In Embryonic Beta-Globin Gene Expression, Yousef Alhashem

Theses and Dissertations

Krüppel like factors (KLFs) are a family of 17 proteins whose main function is gene regulation by binding to DNA elements in the promoters of various genes. KLF transcription factors recognize CACCC-elements and act as activators or repressors of the gene expression. Among the 17 family members, KLF1, KLF2, and KLF4 share high homology to each other. KLF1 is the founding member of the family and is an erythroid-specific protein. KLF2 is expressed in erythroid, endothelial, and other cells. KLF4 is expressed in endothelial, smooth muscle, and other cells. In this thesis, the functions of these KLFs were reviewed in …

The Effect Of Chronic Constriction Injury On Cellular Systems Within Nociceptive Pathways In The Mouse, Michelle Hoot

Theses and Dissertations

Chronic neuropathic pain is often difficult to treat due to its resistance to therapeutic intervention. This is due in part to the poor understanding of the physiological mechanisms involved in the establishment and maintenance of neuropathic pain states. The neuropathic pain model, chronic constriction injury of the sciatic nerve, produced robust pain hypersensitivity in our mice. It also induced significant changes in the mitogen activated protein kinase family, and the cannabinoid and µ-opioid systems in three different brain areas involved in the modulation or regulation of pain states. CCI induced a 2.5 fold increase in mRNA of the kinase Raf-1 …

Validity Of Seven Syntactic Analyses Performed By The Computerized Profiling Software, Stacy Lynn Minch

Theses and Dissertations

The Computerized Profiling (CP) software extracts several quantitative measures from a transcribed sample of a client's language. These analyses include the Mean Length of Utterance in Words (MLU-W) and in Morphemes (MLU-M), the Mean Syntactic Length (MSL), the Syntactic Complexity Score (SCS), Developmental Sentence Scoring (DSS), the Index of Productive Syntax (IPSyn), and the Picture-Elicited Screening Procedure for LARSP (PSL). The validity of these measures was examined by comparing them to the number of finite nominal, adverbial, and relative clauses contained in samples from 54 first-, 48 third-, and 48 fifth-grade students and 24 young adults. The DSS and SCS …

Psychometrically Equivalent Monosyllabic Words For Word Recognition Testing In Mongolian., Valarie Nicole Haslam

Theses and Dissertations

The purpose of this study was to record a set of Mongolian monosyllabic word lists that could be used to obtain a word recognition score. A word list was developed of 190 frequently used monosyllabic words which had been selected by a group of raters. Native male and female Mongolian talkers were utilized to make digital recordings. The 190 words were divided into 10 lists of 19 words. The lists were presented to 20 normally hearing subjects at 10 different intensity levels ranging from -5 to 40 dB HL in 5 dB increments. An S-curve distribution was used to divide …

Prevalence Of White Spot Lesions During Orthodontic Treatment, Julian Dixon

Theses and Dissertations

The reported prevalence of decalcification in orthodontic patients varies from 2 to 96% mainly due to the lack of a standard examination technique. The aims of this study were: 1) to determine the prevalence of white spot lesions around brackets using visual examination and the DIAGNOdent; 2) to determine which teeth were the most susceptible to decalcification; and 3) to test the accuracy of the DIAGNOdent by comparing to the visual examination. The presence of white spot lesions was determined in two groups of patients who were 6 and 12 months into orthodontic treatment, respectively. The control group consisted of …

The Effect Of Single Nucleotide Polymorphisms (Snps) In Toll-Like Receptors -2, -4, -9, And Cd14 Genes In An African-American Population With Chronic Periodontitis, Willard Maughan

Theses and Dissertations

AIM: to determine if a relationship exists between TLR-2, TLR-4, TLR-9, or CD14 polymorphisms and risk for developing chronic periodontal disease in an African-American population. This is the first study conducted to determine role of SNPs in TLR genes and CD14 gene in a periodontally-diseased African-American population. Additionally, this is the first study to assess the role of TLR-9 polymorphism in periodontitis patients. METHODS: A total of 130 subjects were involved in the study. The chronic periodontitis (CP) group contained 73 subjects, and the healthy control (NP) group 57subjects. Genotyping was performed in TLR2 (G2408A), TLR4 (A896G),TLR9 (T1486C) and CD14 …

Frequency Of Tlr-2, 4, 9 And Cd14 Polymorphisms In Aggressive Periodontitis Population In African-Americans, Melanie Chou

Theses and Dissertations

Aim: The aim of this study is to determine the frequency of single nucleotide polymorphisms (SNPs) in various pattern recognition receptor (PRR) genes, including Toll like receptors (TLR) -2, -4, -9, and CD14 in chronic (CP), localized (LAP) and generalized aggressive (GAP) periodontitis and periodontally healthy (NP) patients in an African American population. Methods: A total of 205 subjects were involved in the study. The LAP group consists of 25 subjects, the GAP group 50 subjects, the CP group 73 subjects and the NP group 57subjects. Genotyping was performed in TLR2 (G2408A), TLR4 (A896G),TLR9 (T1486C) and CD14 (C260T) genes by …

A Comparison Of Seven Automated Measures Of Syntactic Complexity, Laura Elizabeth Wilde

Theses and Dissertations

This study compared seven syntactic measures which can be automatically generated by the Computerized Profiling (CP) software: Mean Length of Utterance in morphemes or words (MLUm or MLUw), Mean Syntactic Length (MSL), the Index of Productive Syntax (IPSyn), the Picture Elicited Scoring Procedure (PESP) for the Language Analysis Remediation and Screening Profile (LARSP), the Syntactic Complexity Score (MSC) scoring of LARSP, and Developmental Sentence Scoring (DSS). Language samples came from 192 children, 106 typically developing children, ages 5;6 to 11;2 and 86 children with language impairment, ages 5;6 to 11;1. Patterns of correlation were consistent for children with or without …

Phonemic Categorization Of Eight-To-Ten Year Old Children With An Articulation Disorder, Marjorie A. Smith

Theses and Dissertations

Phonemic categorization is the ability to discriminate and organize speech sounds into categories. This ability begins soon after birth and continues to refine as an individual matures. An association between categorical labeling and phonological awareness has been reported. A strong link between perception and production has been established. The present study examined phonemic categorization of two groups of four listeners. Eight-to ten-year-old children with an articulation disorder were compared with typically speaking peers to determine if the two groups differed in their ability to categorize speech sounds. Behavioral and electrophysiological measures were used to ascertain if any differences existed. These …

Weathering The Storm: Climate Change, Vulnerability, And Adaptation In Bangladesh, Justin Guay

Electronic Theses and Dissertations

The world is guaranteed a certain level of climate change due to the emissions already released into the atmosphere. Therefore, adaptation to climate change is necessary. Increases in diarrheal disease and malnutrition due to climate change are analyzed for Bangladesh. Relative risks determined by the World Health Organization, estimates obtained from agricultural models, and migration estimates are utilized to determine the costs associated with each of these diseases, as well as reductions in rice production and increases in urban migration. It is found that climate change will create additional costs for treating each of these diseases that equal .05% of …

The Effect Of Auxiliary Preparation Elements On The Resistance Form Of Complete Metal Crowns, Mostafa Nazari

Loma Linda University Electronic Theses, Dissertations & Projects

This study measured the resistance to dislodgment of complete metal crowns when they were fabricated for tooth preparations lacking resistance form. These preparations were modified with four different auxiliary preparation features.

An Ivorine mandibular first molar was prepared on a milling machine with the following characteristics: 20 degrees of total occlusal convergence (TOC), 360 degrees shoulder finish line of 1.0 mm width, and axial wall of reduced height offering no geometric resistance form. The following tooth preparation modifications were studied:

1. Two proximal grooves (two lingually positioned grooves, one on the mesial and one on the distal surface) (design B) (Figures …

Fetal Cocaine Exposure Causes Epigenetic Changes In The Rat Heart, Kurt D. Meyer

Loma Linda University Electronic Theses, Dissertations & Projects

Cocaine abuse continues to be prevalent in the United States and other industrialized nations, in addition to the negative health effects that cocaine abuse has on the user, a mother who uses cocaine while pregnant also exposes the developing fetus to cocaine. Although there have been many studies of the effects of cocaine on the adult heart, studies of cocaine on the fetal heart and its potential delayed pathophysiological effects on cardiac function in adult offspring are extremely limited. The studies of the present project sought to enhance the understanding of the effect of cocaine exposure on the fetal heart …

Localization And Expression Of The Aer Receptor In Escherichia Coli, Daniel Salcedo

Loma Linda University Electronic Theses, Dissertations & Projects

In Escherichia coli, chemotactic movement towards an energetically-favorable environment is mediated by five transmembrane chemoreceptors. These sensory proteins respond to numerous environmental signals, including amino acids, sugars, and pH. The aerotaxis receptor, Aer, is an intracellular sensor that responds to oxygen concentration and other parameters affecting cellular energy levels. Bacterial chemotaxis receptors form dimeric signaling units that organize into tetramers and hexamers and form large clusters at the cell poles. A cluster arrangement could increase receptor sensitivity by lateral communication between dimers, thus amplifying the signal from one dimer. We have shown that Aer forms dimers, trimer of dimers, …

Tuberculosis In San Bernardino County, 1993-2004 : Lifestyle And Environmental Factors, Anuj Bhatia

Loma Linda University Electronic Theses, Dissertations & Projects

An observational retrospective study was conducted for tuberculosis (TB) cases between San Bernardino County (SBC), Riverside County, and the state of California from 1996 to 2004. A univariate comparison between San Bernardino County and California indicated a higher proportion of U.S. born cases in SBC. Additionally, it was found that San Bernardino had a higher proportion of non-injection drug using TB cases, compared with California in 1996. Further comparisons were made along country of birth between TB cases in San Bernardino County from 1993 to 2004. Notable differences were observed for injection drug use, non injection drug use, alcohol abuse, …

A Psychoeducational Group Intervention For Fibromyalgia Patients, Derek O. Bacchus

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined the effect of a multidisciplinary psychoeducational treatment group on Fibromyalgia Syndrome (FMS) pain, depression, catastrophizing, and quality of life. The Short-Form McGill Pain Questionnaire (SF-MPQ), Center for Epidemiologic Studies Depression Scale (CES-D), Coping Strategies Questionnaire (CSQ), and the World Health Organization Quality of Life Assessment—Abbreviated Version were used to assess these constructs in 15 participants. The sample was composed entirely of female participants and was predominantly middle aged, which is typical of the FMS population. Two separate groups of FMS patients—seven in Group 1, eight in Group 2—completed a 10-week psychoeducational intervention where they were presented with …

Mnte-2-Pyp And Radiation In A Prostate Cancer Model: Implications For Radiotherapy, Adeola Y. Makinde

Loma Linda University Electronic Theses, Dissertations & Projects

A major limitation of successful radiation therapy in cancer treatment is the increase in normal tissue damage as higher doses are used to achieve greater tumor destruction. Radiation dose optimization in cancer therapy requires achieving maximum tumor destruction with minimal damage to normal tissue Antioxidants have been shown to protect normal tissues against radiation damage, as radiation-induced tissue damage results predominantly from reactive oxygen species that directly damage cellular components. However, for effective use as normal tissue radioprotectants in radiotherapy, these antioxidants must not protect the tumors. Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP) is a metalloporphyrin antioxidant that has been …

The Effects Of A Psychoneuroimmunology Based Lifestyle Intervention In Modifying The Progression Of Major Depression In Clinically Depressed Adults, Ruth A. Tanyi

Loma Linda University Electronic Theses, Dissertations & Projects

Chronic stress can lead to poorly controlled upsurges of cortisol and dysregulation of the hypothalamic pituitary-adrenal axis, thereby contributing to major depression. Hence, researchers have begun to examine the effects of individual psychoneuroimmunology (PNI) interventions and their impact on modifying stress and depression. However, there is a lack of studies that have examined the composite effect(s) of a PNI-based lifestyle intervention and major depression. Thus, this randomized interventional study examined the composite effect(s) of a PNI-based lifestyle intervention: combined progressive muscle relaxation and spiritual guided imagery and humor as an adjunct therapy to modifying the progression of depression. Participants were …

Anthropometric Parameters Of Under-Five Years Old Children With Different Dietary Habits In Ukambani Region : A Study In Eastern Rural Kenya, Hellen M. Ndiku

Loma Linda University Electronic Theses, Dissertations & Projects

The objective of this descriptive cross sectional study was to assess dietary intake and nutritional status of children under-five years in two rural sites of Eastern Kenya where the staple cereals may differ. A modified rapid, knowledge, practice and coverage (KPC) questionnaire and a 24-hr dietary recall form were used to collect the data. A total of 403 households were surveyed from four randomly selected divisions. This yielded 629 surrogate 24-hr dietary recalls of children < 5 years with 314 from Mwingi district and 315 from Makueni district (49 % boys and 51 % girls).

Statistical analysis was done using SPSS and SAS. Comparison of means was done using t- test and chi square was used for proportions. The 24-hr …

Quality Of Life And Depression: Outcome Markers For A Weight Management Program, Cecilia Dueñas

Loma Linda University Electronic Theses, Dissertations & Projects

Pediatric obesity has become a national epidemic and current trends suggest a continued increase. Obese children have been found to have higher incidences of depression and a lower quality of life (QOL) than children from other often more severe medical populations. As a result, weight management programs are on the increase with the majority measuring outcome success through weight loss and decreased body mass index (BMI). It is evident however, that health factors are not the only factors associated with obesity, and that psychosocial components are important as well. The Loma Linda University Growing Fit Program is unique in that …

Accuracy Of A Rationally-Derived Method For Predicting Failure In Residential Treatment, Jennifer Pester Grattan

Loma Linda University Electronic Theses, Dissertations & Projects

Recent studies of adult mental health treatment have used patient-focused research methods to improve outcomes, by tracking treatment response and comparing it with expected recovery patterns. One such line of research has used rationally-derived and empirically-derived methods to analyze data gathered by the OQ-45 and identify patients who are not responding as expected to treatment. This allows for adjustment of treatment, which results in improved outcomes and lower overall costs.

Similar but less extensive research has provided evidence that these approaches may also improve outcomes in outpatient treatment for children and adolescents. These approaches might be particularly useful in residential …

Postprandial Effects Of Pecans Ingestion On Plasma Level Of Nutrients, Polyphenolic Compounds And Biomarkers Of Antioxidant Status In Human Volunteers, Chatrapa Hudthagosol

Loma Linda University Electronic Theses, Dissertations & Projects

Pecans (Carya illinoinensis) are rich sources of polyphenolic compounds and nutrients, which have antioxidant capacity results in favorable reductions in plasma lipids and lipoproteins. However, the health benefits of pecans may not be limited to blood lipid changes. There has been very little investigation into the contribution of bioactive components found in nuts to antioxidant protection. The purposes of the study were 1) to determine the impact of pecan consumption on concentration of total plasma polyphenols and their peak concentration over time. 2) to measure the effect of a pecan diet on postprandial levels of plasma lipid peroxidation …

Body Weight Perceptions And Weight Control Behavior Among Adult Bermudians, Kyla J. Raynor

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Overweight and obesity is a serious public health concern that has major consequences on health and quality of life. As of 2006, 64% of adults in Bermuda were overweight or obese. There remains a gap in the literature related to how adult Bermudians perceive their body weight and body image, and if perceptions of being overweight or obese are associated with weight control behaviors.

Purpose. This study was undertaken to develop a better understanding of the perceptions of ideal body weight, level of overweight, body image and weight control behavior in adult Bermudians.

Methodology. This was a cross-sectional observational …