Medicine and Health Sciences Commons^™

Critical Incident Debriefing: Impact On Oncology Nurses And The Infusion-Related Reaction Care Bundle, Megan A. Corbett

DNP Scholarly Projects

Background: A critical incident is a sudden, unexpected, emotionally distressing event commonly experienced by oncology nurses. Debriefing is an evidence-based best practice that facilitates communication, reflection, and learning to identify quality improvement opportunities to enhance clinical practice, patient safety, and quality of care. However, debriefing within oncology care settings is inconsistent despite the demonstrated benefit and availability of frameworks. Infusion-related reaction management follows an algorithm that directs care delivery, aligning with a care bundle approach. Care bundles, when consistently and reliably applied, help identify connections between the critical incident (i.e., infusion-related reaction) and opportunities for improvement to ensure clinicians follow …

Design And Implementation Of A Nursing Peer Practice Case Review Program In An Academic Surgical/Trauma Icu, Natalie Tredway

DNP Scholarly Projects

Background: Peer review has been in use in healthcare for many years, primary by physicians. Recently, however, nursing has adopted a framework for peer review within the profession. According to the American Nurses Association (admin, 2011), organizations are required to maintain a systematic peer review process aimed at evaluating nursing care and nursing care providers to obtain/maintain Magnet designation. According to Foster (2015) nursing peer review (NPR) is “process by which practicing registered nurses systematically assess, monitor, and make judgments about the quality of nursing care provided by peers as measured against professional standards of practice”. The focus is on …

Promoting Rapid Identification Of Oncological Emergencies In The Emergency Department : A Quality Improvement Project, Christine Hart Brown

DNP Scholarly Projects

BACKGROUND: The American Cancer Society estimates 2,041.90 new cases of cancer in the U.S. (1 in 18 Americans) with a global projection of thirty-five million new cases annually by 2050. With this alarming increase, early recognition of oncological emergencies in the Emergency Departments is essential. Life-threatening conditions require rapid assessment, accurate diagnosis, and immediate interventions. Qualified emergency nurses must understand the effects that cancer and treatment have on the immune, metabolic, and hematologic systems. This quality improvement (QI) project focuses on assessing emergency nurses’ oncological knowledge of acute emergencies and providing a resource for rapid identification.

PROBLEM STATEMENT: …

Empowering Reproductive Health & Access To Enhance College Student Well-Being: A Mixed Methods Community Engaged Proposal, Allison Maladore

CGU Theses & Dissertations

This study is a proposal developed in response to the need for the expansion of reproductive health services in institutions of higher education. College-age young adults in the age group of 18 to 24 are particularly vulnerable to unintended pregnancies, sexually transmitted infections, and participate in risky behaviors such as alcohol usage and illicit drug consumption which can increase the likelihood of unsafe sexual behaviors. Reproductive healthcare access is linked to academic success, improved health outcomes, and holistic well-being. The proposal utilizes a community-engaged socioecological approach to create a roadmap and implementation plan to expand reproductive services and access to …

Evaluation Of Genetic Testing For Thoracic Aortic Disease, Adrian Ricardo Acuna Higaki

Yale Medicine Thesis Digital Library

AimsThoracic aortic disease (TAD), including aneurysms and dissections, present a significant global health challenge due to its typically asymptomatic nature until the onset of critical complications that come with high morbidity and mortality. Effective risk stratification is crucial for early identification and management of patients and their families who are at heightened risk of disease progression. This study aims to evaluate the effectiveness of current genetic testing guidelines for patients with thoracic aortic aneurysms. Methods The study evaluated genetic tests for TAD from 2012 to 2023 in patients aged 18 and older with a thoracic aorta diameter greater than 4 …

Impacts Of Early/Mid-Gestation Shearing On Umbilical Blood Flow And Lamb Birth Weight, Mara Johnson

Electronic Theses and Dissertations

Studies outside the USA have reported that shearing pregnant ewes during mid to late gestation increases lamb birth weight. Our hypothesis was that shearing pregnant ewes on day 50 of gestation would increase umbilical blood flow (UBF), fetal size, lambing and placental weights. Twenty-eight Polypay ewes were randomly assigned to two treatments: shorn (S) and sham-shorn (Control, CON) and divided in singleton (S: n=4; CON: n=4), twins (S: n=5; CON: n=5) and triplets (S: n=5; CON: n=5). Umbilical BF and fetal and placental measurements were obtained via ultrasonography every 10 days from day 50 to 110 of gestation. Lamb birth …

Investigating Antimicrobial Efficacy Of Turmeric And Rosemary Oil Against Staphylococcus Aureus, Aishwarya Tripathi

Selected Full-Text Master Theses 2021-

This study investigates the antimicrobial efficacy of turmeric (Curcuma longa) and rosemary essential oil (Rosmarinus officinalis) against Streptococcus aureus, with a comparative analysis to phenoxyethanol, a widely used synthetic preservative. The growing consumer demand for natural cosmetic formulations have intensified the search for plant-derived alternatives to synthetic preservatives. Turmeric and rosemary oil were selected based on their documented antimicrobial, antioxidant, and anti-inflammatory properties. The objective of this research was to evaluate whether these natural agents can serve as effective preservatives in topical gel formulations, either individually or in combination, and how their efficacy compares to phenoxyethanol.

Eight gel-based formulations were …

Critical Appraisal Of Language Assessment Tasks For African American Children, Tamara Diana Jacobs

Selected Full-Text Master Theses 2021-

Language assessment is a fundamental aspect of the speech-language therapist's role. However, a critical examination of standardized assessments reveals their historical association with constructing disability and exerting control over individuals with a disability, often rooted in the medical model of disability (Nair et al., 2023). As a result, there has been a growing interest in developing alternative methods for evaluating language and speech, particularly in diverse populations (Hyter, 2022). This interest has extended to the study of assessment methods within urban communities, including African American English (AAE) speakers.

Language assessment is a fundamental aspect of the speech-language therapist's role. However, …

College Health Provider Experiences With Inclusive And Affirming Care Of Sexual And Gender Minorities, Somatra Lynn Connolly

Open Access Dissertations

Increasing numbers of individuals in the U.S. are identifying as sexual and gender minorities (SGM). Approximately 17-21% of U.S. college students identify as SGM, comprising a sizable portion of minoritized groups on college campuses. College students who identify as SGM are at significant risk for physical and mental health issues, experiences of victimization, and poorer health outcomes. It is essential that colleges and universities ensure their campuses are meeting the needs of their entire student body, including SGM students. This study aims to: (1) obtain an in-depth understanding of college healthcare provider (HCP) experiences and their perceptions with inclusive and …

Real-World Clinical And Cost Effectiveness Of Osteoporotic Treatments In Men, Yu Ren

Open Access Dissertations

Osteoporosis is a condition characterized by the loss of bone mass, which increases the risk of fractures. In 2017-2018, the age-adjusted prevalence of osteoporosis among adults aged 50 and over was 12.6%, with 19.6% in women and 4.4% in men. Untreated osteoporosis can lead to a cycle of recurrent fractures that severely impact quality of life and place significant emotional, physical, and financial strain on patients, families, and healthcare resources. Approximately 50% of women and 20% of men will experience at least one fracture in their lifetime. In the United States, an estimated 1.5 million osteoporotic fractures occur each year, …

Reprogramming Of Immunometabolic Functions In Brain Microvascular Endothelial Cells During Neuroinflammation: Insights From Ischemic Stroke And Sepsis, Shokofeh Rahimpourkaldeh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ischemic stroke and sepsis-associated encephalopathy (SAE) are two distinct conditions that share common pathophysiological mechanisms affecting brain microvascular endothelial cells (BMECs). Ischemic stroke results from an acute reduction in cerebral blood flow due to thrombosis or embolism, leading to energy failure, oxidative stress, and blood-brain barrier (BBB) dysfunction. SAE, a neurological complication of sepsis, arises from systemic inflammation, endothelial activation, and BBB disruption, leading to cognitive impairment and neuroinflammation. Despite their different etiologies, both conditions involve BMEC dysfunction as a central mediator of neurovascular injury. This dissertation aims to investigate the immunometabolic dysfunction of BMECs in ischemic stroke and sepsis, …

Transforming The Athlete Through Occupational Therapy-Facilitated Mentorship Programming, Cecelia D. Simons

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is a high prevalence of role strain experienced among collegiate athletes with increased attention and awareness surrounding its impact on the transition out of sport and into the next phase of their lives. Many colleges and universities throughout the United States have developed career readiness programs focused on mental health, career transitions, and resilience training preparation for life after sport. However, these programs are often delivered in a group format, making it difficult to provide individualized support to student-athletes. This project elaborated on the role occupational therapy serves in both program development and the transition out of sport. This …

Using Visual Prompts To Analyze Ejection Fraction In Echocardiograms, Kevin Reisch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Left ventricular ejection fraction (LVEF) is a critical biomarker for heart failure, but manual estimation from echocardiograms is time-consuming. Artificial intelligence can be used to accelerate this process, allowing clinicians to focus on other critical tasks. Current methods typically train models from scratch on echocardiogram datasets; however, this approach is limited by the scarcity of large medical imaging datasets, which are expensive and difficult to acquire. We present a transfer learning approach that leverages pretrained models from massive datasets, enabling continuous improvement as foundation models advance. Our method employs visual prompting to generate trainable masks for echocardiogram videos, transforming the …

Comparative Analysis Of Safety, Accuracy, Comprehensiveness, And Organization In Endodontic Patient Education Material: American Association Of Endodontics (Aae) Vs. Ai-Generated Content., Fabiola M. Salgado Reyes

Graduate Theses, Dissertations, and Problem Reports (ETD)

Comparative Analysis of Safety, Accuracy, Comprehensiveness, and Organization in Endodontic Patient Education Material: American Association of Endodontics (AAE) vs. AI-Generated Content. Fabiola Salgado Reyes, DMD Introduction: With patients increasingly using AI chatbots like ChatGPT4o and Copilot, it is essential to assess whether these tools can effectively support patient understanding of complex endodontic procedures. AI-generated responses may occasionally provide inaccurate, unsafe, disorganized, or content that is not comprehended. The purpose of this study is to examine if dental experts and patients can determine if patient education materials (PEMS) were 1) generated by AI; 2) medically safe; 3) accurate; 4) can be …

Improving Neuromuscular Blockade Surveillance In Anesthesia Care With Quantitative Train Of Four Monitoring, Carley S. Blair

Graduate Theses, Dissertations, and Problem Reports (ETD)

Problem Statement: Despite the availability of quantitative train of four (TOF) monitoring, anesthesia providers more frequently rely on tactile (qualitative) TOF monitoring, which is associated with underestimation of recovery from muscle relaxation. Inadequate recovery from muscle relaxants results in residual weakness and its associated complications in the postoperative period, including compromised respiratory function (Thilen et al., 2023).

Background: Neuromuscular blockade (NMB) drugs are required to facilitate endotracheal intubation and allow for surgical manipulation. When these drugs are used, train of four (TOF) stimulations are used to monitor and assess the depth and recovery from NMB. TwitchView monitors (quantitative monitoring) is …

Developing A Simplified Method Of Measuring Ultrafine Particulate Matter Dose Concentrations For Diesel Emissions, Nafisat Ohunene Isa

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Developing a Simplified Method of Measuring Ultrafine Particulate Matter Dose

Concentrations for Diesel Emissions

Ultra-fine particulate matter (UFP), particularly from diesel emissions, poses significant health and environmental risks due to its small size and potential to penetrate deep into the respiratory system. Accurate measurement of UFP concentrations is essential for assessing exposure and mitigating health impacts. However, current methods for measuring UFP can be complex, time-consuming, and costly. This study aims to develop a simplified method for efficiently measuring UFP concentrations from diesel emissions, which will enable easier and more widespread monitoring of air quality and public health impacts. …

Towards Developing Glut2 Specific Probes For Biochemical And Biomedical Applications, Abdelrahman Ismail

Dissertations, Master's Theses and Master's Reports

Facilitated Glucose transporters (GLUTs) are membrane proteins responsible for the uptake of simple sugars and other structurally similar metabolites in all mammalian cells. One of the hallmarks of cancer is dysfunctional sugar metabolism, known as the Warburg effect, and one of the manifestations of that effect is abnormal GLUT expression. There are 14 known GLUT proteins with different expression patterns in different tissues, and tumors tend to express certain GLUTs that are not present in surrounding healthy tissue. Therefore, selective targeting of GLUTs presents a potentially powerful tool for diagnostics and treatment of cancer and other diseases. This has been …

Cyanine-Based Dual-Emission Sensor For Ratiometric Nad(P)H Imaging In Cells, Renal Tissues, And Entire Organisms, Peter Agyemang

Dissertations, Master's Theses and Master's Reports

Monitoring the dynamic fluctuations of NADH and NADPH, key coenzymes in Intracellular redox homeostasis and bioenergetics, are essential for understanding both normal physiology and disease pathology. However, precise, real-time imaging of NAD(P)H levels in complex biological systems remains a major challenge due to interference from endogenous fluorescence and the limitations of intensity-based sensors. We present a newly engineered dual-emission fluorescent sensor, sensor A, which overcomes these obstacles by offering ratiometric detection with high specificity and sensitivity. The sensor features a 3-quinolinium moiety conjugated to a cyanine dye scaffold via an amine linker, enabling selective reactivity toward NAD(P)H. Upon reduction, …

Design And Development Of Fluorescent Probes For Sensing And Bioimaging Of Nad(P)H, Intracellular Viscosity, And So2, Dilka Liyana Arachchige

Dissertations, Master's Theses and Master's Reports

Understanding the dynamic biochemical and biophysical changes within living systems is vital for advancing disease diagnosis and therapeutic development. This work presents the design and development of innovative fluorescent probes, based on cyanine and coumarin scaffolds, for the highly sensitive and selective detection of key metabolic and biophysical markers, NAD(P)H, mitochondrial viscosity, and sulfur dioxide (SO₂) in live cells and fruit fly larvae. A series of cyanine-based probes were engineered to undergo strong fluorescence enhancement upon reduction by NAD(P)H, enabling real-time visualization of metabolic fluctuations in cancer cells and Drosophila larvae. These probes exhibit excellent sensitivity, mitochondrial targeting capability, and …

Faculty And Student Perspectives On Course Collaborations Within The Communication Sciences And Disorders Discipline, Shanna R. Morrison

Master's Theses and Doctoral Dissertations

Collaborative course (re)design (CCRD) allows faculty and students to redesign a course together that the faculty teaches and the student has previously taken. This process amplifies student voices and helps faculty better understand students’ perspectives. However, barriers such as faculty’s feelings of ownership, students’ hesitations to share feedback, and logistical challenges often discourage participation. This qualitative study explores the perspectives of students and faculty in the communication sciences and disorders discipline following their engagement in CCRD. Findings include shifts in participants’ teaching and learning perspectives, insight into partnership dynamics, logistical challenges of CCRD, and ideas for future CCRD implementation. This …

Diabetes Device Knowledge And Confidence Among School Nurses: A Mixed Methods Study, Cassandra F. Moffitt

Nursing Theses and Dissertations

Problem: Type 1 diabetes is one of the most common chronic medical conditions in childhood. While manageable, these children may spend half of their day in the school setting and often need assistance from a school nurse to manage their care.

Theory: Bandura’s Social Cognitive Theory (1977) served as the theoretical framework for this study.

Research Questions: The research questions explored knowledge, confidence, and additional predictors of confidence related to diabetes devices.

Design/Methods: An explanatory sequential mixed methods design was used. The Diabetes Device Confidence Scale (DDCS) was used to measure device confidence, while Subscale 10 of the KAT-1 instrument …

Resilience And Its Effects On Psychological Well Being During The Covid-19 Pandemic, Taylor Reinsel

Honors Theses

Stressors and trauma in life are unavoidable. However, the way we respond and adapt to them can be within our control. This response differs from person to person, but there are factors that can influence the likelihood of an individual rebounding from a crisis, as well as factors that can put them at a higher risk of developing mental illness. One of the main factors that influences Psychological Well Being is the presence of Resilience.

The main goal of this study was to examine how factors of Resilience relate to Psychological Well Being and COVID-19 Well Being during the COVID-19 …

Negotiating With-Ness: Midwives' Lived Experiences Of Gender, Inclusive Language, And Professional Identity., Kimberley-Ann De Wet

Theses

This research investigated midwives lived experiences of using gender-inclusive language in public maternity care, examining how linguistic practices intersect with professional identity, ethical commitment, and institutional constraint. Informed by feminist theory and guided by descriptive phenomenology with a constructivist paradigm, the study explored how midwives navigate the profession’s foundational ethos of being ‘with woman’ while responding to the ethical imperative to provide inclusive care in an increasingly diverse society. Semi-structured interviews were conducted with eight practising midwives in Western Australia, generating rich descriptions of how inclusive language is enacted, negotiated, and constrained in practice. Reflexive thematic analysis produced three overarching …

Adapting The Minority Stress Model Among Middle-Aged And Older Adults With And Without Hiv: Understanding The Interplay Between Minority Stress, Mental Health, And Sexual Risk Behaviors, Alexis R Long Thompson

All ETDs from UAB

This dissertation aims to adapt Meyer’s Minority Stress Model to understand the interplay between minority stress, mental health, and sexual risk behaviors among middle-aged and older adults with and without HIV. The study utilizes data from the MACS WIHS Combined Cohort Study, focusing on adults aged 40 and older. It examines the relationships between perceived stress, psychosocial factors (depression, substance use, social support), and sexual risk behaviors, considering the impact of minority identities such as race, gender, sexual orientation, and HIV status. The findings highlight significant differences in perceived stress, depressive symptoms, substance use, and social support across different intersectional …

Automated Thermo-Mechanical Therapy For Immediate Relief In Chronic Non-Specific Lower Back Pain (Cnslbp): A Randomized Controlled Trial, Kyle V. Donnery

Dissertations and Theses

Objective: Chronic non-specific lower back pain (cNSLBP) is a prevalent and disabling condition, imposing a substantial socioeconomic burden due to high healthcare costs and productivity losses, with limited accessible and effective long-term treatment options. Automated Thermo-mechanical Therapy (ATT) is a promising, non-drug intervention that leverages innovative technical advances to provide multimodal pain relief, offering accessibility and low-cost delivery. This study tested ATT for immediate pain relief in individuals with cNSLBP in a single-session, double-blind, randomized controlled trial.

Methods: Forty participants with cNSLBP were randomly assigned to receive either active ATT (n=20) or control ATT (n=20) in a 40-minute session. The …

Lis1 Depletion In Adult Mouse Projection Neurons Causes Neurodegeneration And Severe Neurological Phenotypes, Anne Ventrone

Theses and Dissertations

Proper LIS1 function is crucial for human brain development, as mutations in LIS1 lead to lissencephaly, a severe neurodevelopmental disorder caused by defective proliferation, differentiation and migration of neural precursors. Our understanding of LIS1's functions after brain development is limited. LIS1 regulates cytoplasmic dynein 1 (dynein), an essential microtubule motor protein in cell division and migration, but also a cellular transport motor. We previously showed that tamoxifen (TX)-induced global knockout of LIS1 using a Cre/Lox system (Act-Lis1iKO) in young adult mice results in severe neurological defects and rapid lethality. This strongly supports LIS1's critical post- developmental role, but the underlying …

Sexual And Reproductive Health Access Among Racial/Ethnic Minority College Students, Srithanvi Pasunuri

Honors Undergraduate Theses

Sexual and reproductive health (SRH) is critical for individual well-being, yet significant disparities in access persist among racial and ethnic minority college students in the United States. These inequities, driven by systemic barriers such as financial constraints, cultural stigmas, and inadequate campus resources, contribute to higher rates of unintended pregnancies, sexually transmitted infections (STIs), and poor health outcomes within these populations. This systematic review aims to identify and synthesize existing literature on the barriers to SRH access for racial and ethnic minority college students, explore how cultural, social, and institutional factors influence service utilization, and assess interventions proven effective in …

The Association Between Pain Sensitivity And Low Energy Availability, Sleep, Mental Health, And Stress In Female Endurance Athletes, Taylor R. Moler

Honors Undergraduate Theses

The disruption of certain physiological functions due to low energy availability (LEA) in female endurance athletes is a prominent concern. This condition resulting from LEA has been described as Relative Energy Deficiency in Sport (RED-S), which can include alterations in metabolism, menstrual function, bone deposition and resorption, mental well-being, and more. The goal of this study was to determine whether pain sensitivity was associated with LEA, sleep, mental health, and stress in female endurance athletes. Participants completed a demographic survey, the Low Energy Availability in Females Questionnaire (LEAF-Q), the Pittsburgh Sleep Quality Index (PSQI), the Patient Health Questionnaire (PHQ-4), and …

Evaluation Of The Dnazyme Gr5 For The Determination Of Lead Speciation In Natural Waters, Gaganprit Gill

Theses and Dissertations (Comprehensive)

This thesis explores the development and application of a DNAzyme-based biosensor designed to detect labile metal species in environmental samples. Real time and on-site monitoring of labile metal fractions would make a valuable contribution to environmental management, as these fractions are the most bioavailable and pose significant toxicity risks to aquatic organisms. Conventional methods for detecting labile metals, while effective, are often burdened by high costs, complexity, and lengthy processing times, making them less ideal for rapid and widespread environmental assessments.

The first manuscript of this thesis (chapter 2) establishes the fundamental capabilities of the Pb²⁺-specific DNAzyme GR5 …

Limiting H1n1 Replication Via The Dsrnai Pathway Using Sequence-Specific Ldsrna, Shawn Marie Sharon Carr, Stephanie Dewitte-Orr

Theses and Dissertations (Comprehensive)

The seasonal influenza virus causes a common respiratory illness that can be life threatening to the immunocompromised, the very young, and the elderly. The current strategies for avoiding a serious influenza virus infection are good hygiene practices and the annual influenza vaccine. Unfortunately, last year’s influenza virus vaccine effectiveness ranged between 32-60% for children and adolescents and 46-54% for adults. These low efficacy rates are due to the vaccine often targeting hemagglutinin, a highly variable surface protein. This thesis seeks to create a prophylactic treatment via the RNA interference (RNAi) response that targets the virus’s conserved genes that are integral …