Medicine and Health Sciences Commons^™

Molecular Mechanism Of Congenital Cataract Caused By G91 Deletion In Cryβa1, Akosua Konadu Boateng

All ETDs from UAB

The Deletion of Glycine 91 is a mutational hotspot in the CRYβA1 gene (mutant named βA3ΔG91), which causes autosomal dominant congenital nuclear cataracts in several ethnically diverse populations worldwide. Previous in-vitro studies of recombinant βA3ΔG91 protein revealed that this mutation results in defective protein folding, reduced solubility, and oligomerization with other crystallins. While βA3/A1-crystallin is primarily known as a structural protein in the lens, it also plays a role in autophagy regulation in the retinal pigment epithelium (RPE) by controlling endolysosomal acidification through the V-ATPase proton pump. This study employs a novel βA3ΔG91 knock-in mouse model to investigate the pathogenic …

Neural Mechanisms Of Proactive And Reactive Cognitive Control In Humans, Anas Khan

All ETDs from UAB

Cognitive control enables flexible, goal-directed behavior by dynamically adjusting our actions in response to changing task demands. This dissertation investigates the neural mechanisms underlying proactive and reactive cognitive control, particularly focusing on the dorsolateral prefrontal cortex (dlPFC) and the dorsal anterior cingulate cortex (dACC) during tasks that require response inhibition and conflict processing. Using intracranial electroencephalography (iEEG) recordings from human participants, this research examines the distinct roles of oscillatory activity in these regions in both short-term reactive adjustments and long-term proactive control strategies. Chapter 2 explores the role of low-frequency oscillations in the mid-rostral dlPFC during motor inhibition, revealing that …

The Dopaminergic Cell-Intrinsic Clock And Bidirectional Relationships Of Circadian Disruption And Synucleinopathy, Ananya Swaroop

All ETDs from UAB

Circadian rhythms are crucial endogenous cycles with period of ~24 hours that evolved to adapt to light – dark driven changes in environmental conditions. At a molecular level, circadian rhythms are generated by the actions of clock genes that form a transcriptional- translational feedback loop and regulate the rhythmic expression of downstream clock-controlled genes. Cumulatively, the actions of these molecular clocks regulate rhythmicity of physiological and behavioral processes and are extensively characterized within the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Like SCN neurons, dopaminergic neurons of the SN are intrinsically pacemaking, though it is unknown if this intrinsic firing …

Parental Monitoring, Peer Connectedness, And Potential Exposure To Stis In Adolescents Using The Youth And Risk Behavior Survey (Yrbs) Of 2021, Allyson L. Pullen

All ETDs from UAB

Background: Adolescents are significantly affected by sexually transmitted infections (STIs), a public health challenge linked to high-risk sexual behaviors, including early sexual initiation, unprotected intercourse, multiple partners, and substance use. Protective factors such as parental monitoring and peer connectedness have demonstrated the potential to reduce adolescent risky behaviors. This study aims to examine the relationship between parental monitoring, peer connectedness, and potential exposure to STIs in high school students. Methods: This study analyzed data from the 2021 Youth Risk Behavior Survey (YRBS), focusing on potential STI exposure, parental monitoring, and peer connectedness among U.S. high school students. Potential STI exposure …

Association Of Hospitals’ Organizational Characteristics And Market Factors Offering Integrative Medicine Services To Adult Cancer Patients, Sanober Ajani

All ETDs from UAB

Integrative medicine (IM) plays an important role in cancer symptom management by providing patients with a range of non-pharmacological options to help manage the physical and emotional symptoms associated with cancer and its treatment. More patients are seeking IM services due in part to a more holistic or patient-centered approach to cancer care, alleviating side effects from cancer treatments, improving quality of life, and enhancing cancer treatment effectiveness. Although the demand for IM services is increasing, there is a gap in our knowledge regarding which cancer hospitals are providing IM programs and what services are offered within these programs. Therefore, …

Elucidating The Impact Of Ribosome Biogenesis On Breast Cancer, Amr Rafat Elhamamsy

All ETDs from UAB

Ribosome biogenesis, a complex and multi-step process that occurs predominantly in the nucleolus, plays a critical role in cellular function by mediating protein synthesis through the assembly of ribosomal RNAs (rRNAs) and ribosomal proteins into functional ribosomes. In cancer, dysregulation of this process is linked to the development of specialized ribosomes (onco-ribosomes) that support oncogenic translation programs, enhancing tumor progression and therapeutic resistance. This dissertation explores the interplay between ribosome biogenesis and cancer, focusing particularly on the role of RNA Polymerase I (RNA Pol I) activity under hypoxic conditions and rRNA modifications in breast cancer. My first study elucidates the …

Gateways, Barriers, And Facilitators To Opioid Use Treatment For Low-Income Pregnant And Postpartum Women In The State Of Alabama, Lindsey Allison Rice Bender

All ETDs from UAB

Low income, pregnant and postpartum women who misuse opioids in the state of Alabama face potentially life-threatening challenges when seeking substance misuse treatment and recovery support services. Our study used an explanatory sequential mixed-methods approach to explore gateways, barriers, and facilitators to opioid use disorder (OUD) treatment for pregnant and postpartum women in the state of Alabama. Surveys from 32 pregnant and postpartum individuals and in-depth interviews with 15 pregnant and postpartum individuals (four pregnant, four 0-6 months postpartum, four 7-12 months postpartum and three 13-18 months postpartum) were used to identify gateways, barriers, and facilitators to OUD treatment. Our …

Predictors Of Antidepressant Use In Stroke Survivors And Evaluating The Role Of Time-Varying Depressive Symptoms On The Association Between Antidepressant Use And Stroke, Hely Divyanshu Nanavati

All ETDs from UAB

Depression is a mental health crisis affecting 21 million Americans. Consequently, antidepressants are one of the most prescribed classes of medications in the American population. Depression is also a common adverse outcome after stroke with one in three patients having depressive symptoms within the first year of their stroke recovery phase. Antidepressants are effective in the treatment and prevention of depressive symptoms in stroke patients. However, the overall antidepressant use in the acute post-stroke phase and the patient characteristics influencing the prevalence of receiving antidepressant prescriptions during acute stroke hospitalization are not known. Depression is also associated with higher risk …

Shear Bond Strength Of A Composite Resin To 3d-Printed Resins With Various Designed Surface Texture: An In-Vitro Study, Venkata Sruthi Surabathula

All ETDs from UAB

Background: Three-dimensional (3D) printing has revolutionized dentistry by enabling the fabrication of interim restorations that protect prepared teeth and maintain aesthetics and function during prosthesis creation. These interim shells often require relining with composite resins for precise fitting and enhanced durability, relying on achieving a strong shear bond strength (SBS) between the 3D-printed shell and the composite resin. Surface roughness and texture are critical factors that create micro-mechanical retention sites, enhancing SBS by increasing surface area and improving adhesive properties through techniques like air-abrasion. Research into novel surface textures mimicking natural dentinal tubules aims to further boost bond strength, comparing …

Social Dominance And Cortical Neuronal Synchrony In Male Mecp2 Knockout Mice, Cesar Andres Acevedo Triana

All ETDs from UAB

Social behaviors are critical for the survival of individuals, and their dysfunction is common in several neuropsychiatric and neurodevelopmental disorders including autism, where impaired sociability is one of the core diagnostic symptoms and compromises the interpretation of social cues, with an apparent lack of interest in others. Among the neurodevel opmental disorders associated with autism, Rett syndrome (RTT) is a disorder predominantly affecting females and caused by spontaneous loss-of-function mutations in the X-linked MECP2 gene, which encodes the transcriptional regulator MeCP2 that regulates many critical genes. RTT individuals have impaired motor, cognitive, and social abilities most of which are recapitulated …

The Relationship Between Molten Iron Chemistry Of A Cupola Furnace And Airborne Contaminants, Darkeya D. Rowe

All ETDs from UAB

The purpose of this research was to understand the potential relationship between the molten iron chemistry of a cupola furnace and airborne contaminants. Three-day air sampling was performed for the emissions of a cupola furnace using 37 mm mixed cellulose ester (MCE) filter cassettes at an iron foundry. The samples were analyzed for 21 elements and compounds by a commercial laboratory using the modified National Institude for Occupational Safety and Health (NIOSH) Method 7303, most of which were metals. The concentrations of 13 out of 21 elements and compounds were compared to the corresponding elements in molten metal/iron stream analyzed …

The Postpartum Wellness Survey: Exploring The Role Of Social Determinants In The Diet–Depression Link, Ashley G. Brown

Department of Nutrition Student Projects

Postpartum mental health is a critical, yet both clinically and socially underrecognized, component of maternal care. Postpartum depression (PPD) affects up to 1 in 7 mothers and significantly impacts both maternal and family well-being. The Postpartum Wellness Survey (PWS) was developed to assess the interconnected relationships among dietary quality and nutrition knowledge, postpartum mood and emotional health, and social determinants of health (SDOH). Twenty-four participants within 12 months of delivery completed the survey, which integrated validated psychological and dietary assessment tools to capture community-level patterns in postpartum wellness. Composite scores across three PWS domains – Postpartum Mood and Emotional Health, …

The Role Of Maternal Position During The Second Stage Of Labor On Reducing Perineal Injury: An Integrative Review, Ericka L. Dalton, Tabatha Ruth Erlandson

All Electronic Theses and Dissertations

Introduction: Perineal lacerations remain a common occurrence amongst vaginal deliveries. While there are some recommendations for supportive techniques throughout the literature, position is typically not included in these. Perineal trauma can have a lasting effect on the individual and increase health care costs. The purpose of this review is to identify what birthing positions are most effective at preventing perineal injury.

Methods: A formalized search of the literature was conducted via PubMed, CINAHL, Google Scholar, and SCOPUS databases. Of the 344 articles identified, 22 original studies met the inclusion and exclusion criteria for this review. A literature matrix and quality …

Facilitators And Barriers To Interprofessional Collaboration Between Physicians And Midwives: An Integrative Review, Kathy D. Lambright, Anesha E. Martin

All Electronic Theses and Dissertations

Introduction: Early models of interprofessional collaborative care suggest that when there is a collaboration between midwives and physicians, the outcomes for mothers and babies are improved. The purpose of this integrative review of the relevant literature is to identify the facilitators and barriers to collaborative relationships between physicians and midwives.

Methods: A keyword search was done using the Science Direct, PubMed, and CINAHL databases. Inclusion criteria were that they must be original research, identify facilitators and barriers in interprofessional collaborative relationships, and include healthcare professionals involved in maternity care. The database search yielded a total of 348 articles, which were …

Freestanding Birth Centers-Safety And Efficacy Related To Maternal And Neonatal Outcomes: An Integrative Review, Nicole Lynn Muzik, Casey Renee Workman

All Electronic Theses and Dissertations

Introduction: The goal of this literature review is to determine the safety of community birth by evaluating if low-risk pregnant women at term, who deliver in the community setting, specifically at freestanding birth centers, have comparable or lower maternal and neonatal morbidity and mortality outcomes, than low-risk women who deliver at an in-hospital birthing facility.

Methods: The authors of this integrative review retrieved original research articles from computerized databases (Nursing and Allied Health, PubMed, and CINAHL), as well as online journal hand searching, followed by cited reference searching. A total of 48 articles underwent a full-text review, and a total …

The Health Impact Of Clinical Training On Nursing Students In Cambodia, Felicia Kim Yee, Kimberly Aguilar Mondragon

Nursing | Senior Theses

Background: Clinical training presents significant challenges for nursing students worldwide, particularly evident in developing countries like Cambodia, where these difficulties are intensified by a lack of training, resources, and health issues like stress and fatigue. Many students struggle without adequate guidance, forcing them to navigate complex clinical environments independently. These factors not only impact students’ confidence and academic performance, but also their health and well-being. Through this study, we can gain insight into nursing in a developing country that hasn’t been widely studied, contributing to global nursing research. Purpose: The purpose of this study is to explore the health impact …

Psychological Impact Of Ulcerative Colitis On Pregnancy And Postpartum Period, Stephanie C. Carver

Nursing | Senior Theses

Background

Ulcerative colitis (UC) poses significant challenges during pregnancy, affecting both physical and mental health. While the physiological effects of UC during pregnancy are well documented, less is known about its impact on maternal mental health. This study aims to investigate the psychological effects of UC on pregnant women, focusing on stress levels, postpartum depression (PPD) incidence, and the role of multidisciplinary care in improving mental health outcomes.

Objective

The primary objective of this research proposal is to evaluate the psychological impact of UC during pregnancy and determine whether disease activity increases the risk of PPD and stress. A secondary …

Improving Maternal Mental Health: The Role Of Specialized Support For Queer Women With Postpartum Depression, Dan-Tam Pham

Nursing | Senior Theses

Queer women face disproportionately high rates of postpartum depression compared to heterosexual and cisgender individuals. Studies showed that queer women face heightened mental health challenges, including higher rates of depression and anxiety due to factors like discrimination, limited support systems, and negative healthcare experiences. There is a need for culturally competent, LGBTQ+-affirming interventions to improve maternal mental health outcomes; despite the health disparities faced by this population, research on specialized postpartum interventions is limited, revealing gaps in effective mental health care for queer mothers. The key search terms for the articles used in the study included: postpartum depression, queer women, …

In Vivo Evaluation Of Novel Nanoparticles And Repurposed Pharmaceuticals To Combat Antimicrobial Resistance, Sarah E. Evans

Theses, Dissertations and Capstones

In a 2019 report by the Centers for Disease Control and Prevention (CDC), infections resistant to antibiotic treatment amount to about three million infections and 48,000 deaths. Antimicrobial resistance is an escalating global threat as existing antibiotics lose efficacy over time. The project described is focused on partnering with pharmaceutical researchers and producers to test new nanoparticle-based or repurposed compounds. The central hypothesis of this thesis is that pharmaceutical formulations such as nanoparticles may provide a cost-effective means of combating the emerging antimicrobial resistance. The nanoparticle compounds allowed for a wide range of customization for the pharmaceutical design, since the …

Effects Of Push-In Occupational Therapy Services In Kindergarten On Writing Foundations, Heather A. Hyndman

Occupational Therapy Doctorate Capstone Projects

Background: According to the Compensation & Workforce Survey, 24.89% of occupational therapy practitioners (OTPs) work in schools (AOTA, 2023). This researcher has worked in a public-school setting for over 20 years, and her caseload continues to grow each year, doubling in the past 10 years. Handwriting difficulties account for most referrals for this researcher.

Purpose: The purpose of this research was to determine if an occupational therapy (OT) led fine motor intervention small group along with push-in occupational therapy services during literacy instruction would improve kindergarten students’ handwriting.

Theoretical Framework: Motor learning theory is applicable to teaching handwriting. This …

The Head, The Heart, And The Human: A Developmental Cascade Perspective Of Adults With Dextro-Transposition Of The Great Arteries, Alexandra Brooke Roseman

Selected Full-Text Dissertations 2020-

As survival rates for individuals with complex congenital heart disease (CHD), such as dextro-Transposition of the Great Arteries (d-TGA), increase, there is a growing need to examine neurocognitive and psychosocial challenges from a lifespan perspective. However, research often overlooks the integration of these factors, despite evidence from other chronic illness populations suggesting their interplay influences psychosocial functioning in adulthood. This study assessed psychosocial maturity in emerging adults with d-TGA and explored its relationship with executive functioning (EF) and social cognition (SC) longitudinally. Data were drawn from the Boston Circulatory Arrest Study (BCAS) cohort at age 16 (n = 80) and …

Suicide Exposure In The Army National Guard: A Three Manuscript Dissertation, Rebecca Willis-Nichols

Theses and Dissertations--Social Work

Between 2000-2022, the U.S. suicide rate increased 36% with one death now occurring every 11 minutes (CDC, 2024). Despite the Department of Defense making a concerted effort to curb the suicide increases in their ranks, the rates have continued to rise. Active-duty component rates have slowly increased since 2011 while reserve and guard components have held steady (U.S. Department of Defense, 2023). After adjusting for age, the suicide rate in the veteran population was 57% greater than the civilian population in 2020 (CDC, 2024). There is a need for a better understanding of the impact of these deaths and the …

Alteplase Vs. Tenecteplase: Comparing Health Outcomes Following Thrombolytic Administration In Acute Ischemic Stroke, Brittany Taubman

The PA Department Journal of Medical Science

Introduction: Acute ischemic stroke (AIS) results in death of brain tissue necessitating prompt intervention to restore blood flow and minimize neurological damage. Tissue plasminogen activator (tPA), specifically alteplase, has long been the standard treatment for AIS. However, recent research explores the potential advantages of tenecteplase, an alternative thrombolytic agent.

Methods: PubMed was searched, utilizing free text, randomized control trials, systematic reviews, and meta-analyses from 2019-2024. The literature search yielded four relevant results to include in this review comparing tenecteplase and alteplase, focusing on efficacy, safety, and overall clinical outcomes.

Results: All four articles reviewed were systematic reviews and meta-analyses focusing …

Prophylactic Aspirin For The Prevention Of Pre-Eclampsia In High-Risk Pregnant Women, Nia Walker

The PA Department Journal of Medical Science

Introduction: Pre-eclampsia is a leading cause of maternal mortality worldwide. The purpose of this clinical review is to analyze the efficacy of aspirin vs placebo in the prevention of pre- eclampsia in high-risk pregnant women.

Methods: PubMed, COCHRANE, and JAMA Network were searched with terms “pre- eclampsia” AND “prevention” AND “aspirin." Operators and filters were added to find RCTs, reviews, and meta-analyses within the last five years. One article was found using article reference searching. Four articles were chosen for review.

Results: One article was a randomized controlled trial comparing low dose aspirin against placebo in women identified as high …

Patellar Vs Hamstring Grafts For Acl Reconstruction, Taylor Jernigan

The PA Department Journal of Medical Science

Abstract

Introduction: The anterior cruciate ligament (ACL) is one of the most common injuries in orthopedic medicine, resulting in 400,000 reconstructions every year in the United States. Bone-Patellar Tendon-Bone (BPTB) and Hamstring Tendon (HT) grafts are the most common graft types used. The objective of this review is to compare HT grafts and BPTB grafts when it comes to return to sport, returning to pre-injury level, and overall long-term functional outcomes.

Methods: A complete search was conducted using Pub Med to look for randomized controlled trials (RCTs), systematic reviews, and meta-analyses on HT vs BPTB grafts. The variables studied were …

Transcatheter Mitral Valve Repair And Heart Failure: A Clinical Review, Caroline Robbins

The PA Department Journal of Medical Science

Introduction: Secondary Mitral Regurgitation due to heart failure is a major cause of morbidity and mortality. There is debate about surgical versus medical treatment options. This paper aims to evaluate the efficacy of adding transcatheter mitral valve repair (TMVR) with standard treatments for heart failure.

Methods: Using Pubmed, the search terms “transcatheter mitral valve repair” AND “heart failure” resulted in 835 articles that were then filtered to <5 >years, English language, and type of article. This produced 22 articles that matched the search criteria. In total, 6 articles were used to analyze all-cause mortality and rehospitalization of heart failure patients receiving …

Covid-19 Taking Aim At The Heart Of Public Education, Jeremy James Pyle

Theses, Dissertations and Capstones

The COVID-19 pandemic, distinguished by both its duration and widespread impact, stands apart from other crises typically faced by schools, such as natural disasters, school violence, or isolated traumatic incidents. Unlike these shorter-term events, the pandemic fundamentally altered the educational landscape, reshaping both school climate and instructional practices. This non-experimental, descriptive study employed a phenomenological research approach to examine the lived experiences of teachers during and after the pandemic. The central aim was to explore how pandemic-related stressors influenced teachers’ decisions to remain in or leave the profession, as well as to identify the supports educators perceived as necessary for …

The Impact Of Having A Native Spanish-Speaking Nurse In Labor And Delivery For Latina Mothers, Lesvia Muñoz Mazariegos

Nursing | Senior Theses

Labor and Delivery is the physiological process in which a pregnant woman gives birth to a baby. With an increase of the Hispanic/Latinx population, the need for Spanish-speaking nurses also increases. Specifically in labor and delivery, language barriers play a critical role for a Latina mother’s laboring experience. However, according to the research, there is limited data on the effects of language concordance/discordance for laboring Latina mothers. To investigate, primary research articles were reviewed focusing on patient experiences with language concordance and discordance, childbirth experiences across different races, and nurses' perceptions of patient experiences related to language barriers. This proposed …

Medical Aid In Dying Education For Hospice Nurses, Ian Woo

Nursing | Senior Theses

Background: Medical aid in dying (MAID) is an option surrounding end-of-life care for hospice patients. This process gives patients the autonomy to end their life during the time and location of their choosing. MAID is growing in legalization and practice across the US. However, many nurses feel uncomfortable or unprepared when providing care for patients contemplating it. Hospice nurses should have confidence in their ability to care for patients through the process of MAID. Objective: To evaluate the effectiveness of education in strengthening new hospice nurses’ ability to care for patients through the process of MAID. Method: The research will …

Caring For Native American Elders: Developing Cultural Knowledge And Comfort Levels Of Senior Nursing Students In Northern California, Ireland Odonnell

Nursing | Senior Theses

Providing appropriate care to patients in the healthcare setting includes being aware of their culture. Nurses play an important role in caring for patients and need to know how to be culturally sensitive toward their patients. Various research articles highlight the lack of knowledge and comfort that current nurses and nurse educators have when caring for culturally diverse patients. Research also shows that a lack of overall knowledge about how to be culturally competent, knowing how to care for patients from different backgrounds, and understanding the effect cultural beliefs have on modern-day medicine poses a challenge when trying to provide …