Medicine and Health Sciences Commons^™

Long-Term Bone Changes At Edentulous Sites, Teerarat Neal Phuatrakoon

Master's Theses (2009 -)

BACKGROUND: Tooth loss is a debilitating occurrence that may affect the patient’s emotional and mental well-being. Delays in necessary restorative treatment may occur dependent on the patient’s finances or other elaborate dental treatment plans. Prosthetically guided implants have become the standard of care regarding definitive treatment, however there is a lack of evidence discussing the stability of edentulous sites if deferment of treatment is required. OBJECTIVE: The aim of this study is to measure long-term changes of the edentulous alveolar ridge (height and width) and anatomical structures (e.g. sinus floor, inferior alveolar canal). METHODS: Charts of patients with at least …

Comparison Of Hand-Wrist And Cvms Methods For Craniofacial Growth Spurt Assessment, Ardita Ajvazi

Master's Theses (2009 -)

Objective: Hand-wrist (HW) radiographs are considered the most accurate method for assessing pubertal growth spurts in orthodontics but have declined in use due to added radiation exposure and the expertise required. Cervical vertebral maturation staging (CVMS) is now commonly used, given the routine availability of lateral cephalograms. However, the validity of CVMS remains uncertain. A recent study reported only 66% inter-observer reliability across time periods (Ingersoll, 2024). This follow-up study aims to evaluate CVMS as a predictor of growth to guide clinical decision-making. Methods: With protocol approval (MU HR-4695), this retrospective study followed a design modeled after a prior study …

Death Becomes Us: The Consumptive Body In Nineteenth-Century Gothic Literature, Jennifer Marie Mcmahon

All NMU Master's Theses

This thesis examines the impacts of nineteenth-century tuberculosis epidemics on gothic literature published between 1842 and 1872. In this period of time, tuberculosis was the leading cause of death in the United States and in Europe, killing an estimated one in seven people. Using theoretical lenses of psychoanalysis and material ecocriticism, this project considers borders between material bodies—specifically those between bacterial agents and humans—to be illusory and socially constructed. The first chapter focuses on the ways in which representations of tuberculosis, and its associated entanglement with the environment, appear in the work of two authors from the United States: Edgar …

Phytochemicals And Human Health, Erin Kelley Richards

Theses and Dissertations

This review explores the intricate relationship between phytochemical intake and human health. It first highlights the contrast between the phytochemical-poor Standard American Diet (SAD) and ancestral diets rich in diverse plant and animal foods. The classification, sources, and health benefits of various phytochemicals, including polyphenols, flavonoids, alkaloids, and terpenes are described and discussed. The bioavailability of these compounds and their interactions with the gut microbiome are elucidated, emphasizing on their potential in modulating multiple pathways associated with aging and chronic diseases. The 12 hallmarks of aging and how phytochemicals may influence these hallmarks are reviewed. While exploring the potential benefits …

It-Enabled Services In Online Healthcare Platforms, Anqi Zhao

Dissertations and Theses Collection (Open Access)

Despite the growing prevalence of IT-enabled applications and interventions, online healthcare platforms (OHPs) face notable challenges in addressing technological and informational barriers, maintaining patient and physician engagement, and ensuring quality of care. To address these challenges, this dissertation examines the impact of IT-enabled services in OHPs across key stages of the healthcare service process—preconsultation, consultation, and postconsultation.

In the preconsultation stage, we scrutinize the effects of online preconsultation from both physician and patient perspectives. The findings reveal that preconsultation, significantly increases the consultation physician’s response speed,support abundance, and informational support. However, because emotional support is the …

The Relationship Between Perceived Stress, Rumination, And Sleep Quality Among University Students, Aljazeeya Almansoori

Theses

Sleep is a crucial physiological function that underpins human health and wellbeing, profoundly affecting cognitive abilities, emotional stability, and the overall quality of life. Disruptions in sleep quality and quantity are commonly associated with increased perceived stress and rumination. This study aimed to investigate the correlations among perceived stress, rumination, and sleep quality in university students in the UAE, while also considering demographic factors such as age, gender, marital status, and educational level. It was hypothesized that higher levels of perceived stress and rumination would be associated with lower sleep quality. The study employed a cross-sectional design, involving a sample …

The Cellular Trafficking And Targeting Of Angiotensin-Converting-Enzyme-2 (Ace2) And Neutral-Amino-Acid-Transporter (B0at1) Variants: Implications For The Pathogenesis Of Associated Diseases And Therapy, Nesreen Fayyad Alkhofash

Dissertations

Angiotensin-converting enzyme 2 (ACE2) and the neutral amino acid transporter B0AT1, encoded by SLC6A19, are membrane proteins with pivotal roles in human physiology. ACE2 is involved in regulating blood pressure and serves as the cellular entry receptor for SARS-CoV-2, while B0AT1 facilitates amino acid absorption in the intestine. The interplay between ACE2 and B0AT1, particularly their physical interaction and co-expression in the intestine, underscores their relevance in both normal physiology and disease. Dysregulation of these proteins has been implicated in conditions such as hypertension, and Hartnup disease and they have been usurped by SARS-CoV-2 to cause COVID-19. Despite their …

The Epidemiology Of Major Congenital Anomalies In The United Arab Emirates: The Mutaba'ah Study, Hiba Mahdi Adam

Dissertations

Major Congenital Anomalies (MCAs) are significant contributors to perinatal morbidity and mortality. The absence of clear baseline prevalence data for MCAs hinders the development of targeted interventions to mitigate their burden. Furthermore, studies on adverse obstetric and birth outcomes in pregnancies complicated by MCAs are scarce, emphasizing the need for research to enhance management strategies. This dissertation aimed to: (1) estimate the live birth prevalence of perinatally diagnosed MCAs and describe study population characteristics by MCA status, (2) investigate the impact of MCAs on fetal presentation and delivery mode, and (3) investigate the impact of MCAs on preterm and low …

Food Allergies On The College Campus: Increasing Awareness, Kelly Wagner

DNP Projects

Project Title: Food Allergies on the College Campus: Increasing Awareness

Background and Rationale: The prevalence of food allergies in the United States is high and continues to increase, affecting approximately 32 million people (10.8% of the population). Food allergies are a chronic disease, and students transitioning to college are in the age group that experiences the highest rate of lethal anaphylactic reactions related to food allergies. Current best practice guidelines recommend that colleges should have a comprehensive, campus-wide approach to food allergy awareness, management, and emergency protocol. At a midsize southeastern university, there was no campus-wide approach to addressing the …

The Association Between Maternal Nutrition, Perinatal Mental Health, And Birth Outcomes In Socioeconomically Disadvantaged Women, Kimberly Terrisa Ieasha Dudley

Walden Dissertations and Doctoral Studies

According to recent studies, disparities in the United States indicated a prevalence of adverse outcomes associated with maternal nutrition and perinatal mental health among women facing socioeconomic challenges. The purpose of this quantitative cross-sectional study was to investigate the association between maternal nutrition, perinatal mental health, and birth outcomes with a focus on women facing socioeconomic challenges. The theoretical framework that guided this study was the socioecological model. The research design involved using secondary data from the Pregnancy Risk Assessment Monitoring System and employing multiple regression analysis. Key findings revealed significant associations between maternal nutrition, perinatal mental health, and birth …

Understanding The Factors Influencing Movement Behaviors Among Dog Owners, Katherine Eileen Devivo

Theses and Dissertations

This dissertation investigates two key objectives: 1) to understand influences of physical activity among dog owners, and 2) to determine if there were differences in objectively measured physical activity levels and/or affect at times when dog owners are with their dogs compared to times when they are not with their dogs. To address the first objective, a qualitative study was conducted with 20 dog owners using semi-structured interviews, constant comparative methodology, grounded theory, and open coding. The findings revealed several key barriers to physical activity and dog walking such as physical health, seasons/weather, time/schedules, and dog specific limitations. Key facilitators …

Associations Between Cardiovascular Disease And Utilization Of Dental Preventive And Periodontic Services, Amirhossein Fakhre Yaseri

Theses and Dissertations

Cardiovascular disease (CVD), including coronary artery disease, heart failure, myocardial infarction, and stroke, remains a leading cause of global mortality, with approximately 20.5 million deaths in 2021. Despite advancements in medical science, CVD prevalence continues to rise, underscoring the need for preventive approaches and increased awareness. CVD is closely associated with oral diseases, and poor oral health is linked to worse cardiovascular outcomes. This study investigates the association between CVD and the utilization of dental preventive and periodontal services using data from the Dental Experience and Research Exchange (DERE) database, which aggregates clinical data from dental practices across the U.S. …

Estimating Proximity To Failure Using Repetitions In Reserve In Adults Treated For Cancer, Kylah Elizabeth Jackson

Theses and Dissertations

BACKGROUND: There is a consensus from governing bodies that more evidence is needed in understanding how to properly prescribe, monitor and progress resistance training (RT) in oncology populations. Repetitions in reserve (RIR) has been demonstrated as a quick/easy tool to monitor proximity to failure and interventions using RIR have shown promise in improving muscle strength and mass in older adults and apparently healthy populations. However, the validity of RIR in RT in oncology has yet to be examined. Therefore, the purpose of this study was to assess the accuracy of RIR predications in individuals treated for cancer in a pragmatic …

The Contribution Of Individual Movements To The Learning Of A Movement Sequence, Hannah K. Ammons

Senior Theses

This thesis explores how the overall learning of a motor sequence through repeated practice is impacted by the individual movement’s components. Changes seen in the response time, peak velocity, and the hand path distance were examined whilst considering the Fitts’s ID and inertial demands of the individual movements. During data collection, twenty-four right-handed participants completed a series of repeated and random reaching movements that varied in direction and distance in a 3D virtual environment. When considering only the repeated sequences, the results indicated significant improvement in both the hand path distance and response time across all target combos, specifically Target …

Shifting Healthcare In Rural South Carolina: A Study Of Media Coverage Of The Effects Of Hospital Closures, Morgan Harper

Senior Theses

Rural hospital closures have become an increasingly urgent issue in healthcare across the United States. These closures have impacted access to healthcare, the job market, and general community health. Most hospitals have been forced to close due to low patient volumes, financial struggles, and corporate ownership. Immediate implications of closures include the displacement of healthcare workers, community concern about lacking a central healthcare facility, and increased travel times to access care.

This thesis examines South Carolina’s healthcare landscape in areas with hospital closures since 2012 and explores the effects of and responses to these closures as discussed in newspapers and …

The Benefits Of Blood Flow Restriction Training Combined With Low-Load Resistance Training In Arthritis Treatment: A Scoping Review, Maya L. Butcher, Dr. Christine Pellegrini, Kailyn Horn

Senior Theses

Background: Arthritis is a condition affecting millions worldwide, with osteoarthritis (OA) and rheumatoid arthritis (RA) being the most common forms. Resistance training is a widely accepted intervention to strengthen muscles and support joint function, however, high-load resistance training may exacerbate joint pain. Blood Flow Restriction (BFR) training, which involves applying controlled vascular occlusion during low-intensity resistance exercises, has gained attention as a potential alternative to promote muscle growth and strength with minimal joint stress. Objective: This scoping review aims to explore the benefits of BFR techniques in conjunction with low-intensity resistance training for the treatment of arthritis. Methods …

From Pregnancy To Postpartum: A Longitudinal Analysis Of Maternal Depressive Symptoms And Hemoglobin Concentration In Uttar Pradesh, India, Abdullah Nurus Salam Khan

Theses and Dissertations

Background: Perinatal depression and maternal anemia impact maternal health, pregnancy outcomes, and infant growth in low- and middle-income countries. This study examines the prevalence and risk factors of these conditions during pregnancy and postpartum in rural Uttar Pradesh, India. Methods: A prospective cohort study was conducted among 475 pregnant women recruited during early pregnancy (≤20 weeks gestation) and followed through late pregnancy (≥27 weeks) and postpartum (< 42 days of childbirth). The outcome variables were, i) depressive symptoms, assessed using the Edinburgh Postnatal Depression Scale (EPDS), and ii) hemoglobin concentrations, measured using HemoCue Hb 301 analyzer from capillary blood. Multivariable linear regression examined associations of the outcome variables with sociodemographic, obstetric, nutritional, interpersonal, and perinatal factors. Path analysis evaluated direct and indirect paths influencing postpartum hemoglobin. Results: Prevalence of probable depression (EPDS score≥13) peaked in early pregnancy (24%) and declined in late pregnancy (17%) and postpartum (4%). Mean hemoglobin declined from early (10.5 g/dL) to late pregnancy (9.7 g/dL), and partially recovering in postpartum (10.4 g/dL). Household food insecurity was associated with higher depressive symptoms during pregnancy and postpartum (early pregnancy:β=2.61, p=0.011; late pregnancy:β=2.84, p< 0.001; postpartum:β=1.40, p=0.023). Psychological intimate partner violence was associated with greater depressive symptoms in early pregnancy (β=3.19, p=0.001). Receiving more antenatal visits was associated with decrease in depressive symptoms in late pregnancy (β=-0.46, p=0.001) and hemoglobin at postpartum (β=-0.11, p=0.070). Consumption of more food groups was associated with increase in depressive symptoms (β=0.63, p=0.004) and hemoglobin in late pregnancy (β=0.10, p=0.026). Iron folic acid (IFA) consumption was associated with increase in hemoglobin in late pregnancy (β=0.01, p< 0.001) and postpartum (β=0.004, p=0.031). Experiencing postpartum health complications was associated with increase in depressive symptoms (β=0.41, p=0.013) and decrease in hemoglobin concentrations (β=-0.18, p=0.036). Antenatal hemoglobin concentrations mediated the associations of IFA supplementation and dietary diversity with postpartum concentrations. Conclusion: Perinatal depression was associated with socioeconomic vulnerabilities, food insecurity, and intimate partner violence, while hemoglobin concentrations were associated with maternal nutrition and perinatal care. Integrating mental health services and comprehensive nutrition interventions into antenatal and postpartum care can improve psychological and physical well-being of mothers during and after pregnancy.

The Role Of B Cells In Promoting Lipid Absorption By Promoting Lacteal Development, Kenny Johnson

Theses and Dissertations

The absorption of dietary lipids in the gut is necessary to maintain the metabolic tone of tissues. Inflammation in the gut can cause defects in lipid absorption, which can result in tissue wasting, otherwise known as cachexia. Cachexia is commonly observed in patients with inflammatory bowel disease and cancer patients. The underlying cause of cachexia is unknown, and there are currently no effective therapeutic options available to treat it. Lymphatic drainage in the small intestine (SI) is specialized to promote the transport of dietary lipids into circulation. Lacteals are blunt-ended lymphatic vessels localized to the central axes of villi in …

An Evaluation Of Exercise-Related Self-Efficacy Metrics Following A Resistance Training Program In Individuals Treated For Cancer, Kayla S. Adler

Senior Theses

As the number of cancer survivors grows, managing treatment side effects and promoting healthy behaviors like physical activity is crucial. Low exercise self-efficacy, an individual's belief in their capability to perform exercise, is a significant barrier to physical activity adherence. This study assessed if an 8-week supervised resistance training program could improve self-efficacy for exercise (SEE) and outcome expectations of exercise (OEE) in individuals treated for cancer. Participants (n=25) attended twice-weekly, one-hour sessions. SEE and OEE scales were administered pre- and post-intervention. Results indicated a significant increase in SEE scores (mean difference = 8.96 ± 19.87, p = 0.041), demonstrating …

Examining Racial Disparities In Cancer Incidence And Mortality Across South Carolina Regions, William Stokes, Swann Arp Adams, Kara M Montgomery

Senior Theses

Purpose: To provide updated cancer mortality-to-incidence ratio (MIR) data across South Carolina (SC).

Methods: State and national incidence and mortality data were collected from the South Carolina Central Cancer Registry (SCCCR) and the National Cancer Institute’s Surveillance Epidemiology and End Results Program (SEER). MIRs (mortality rate/incidence rate) were calculated for all cancer sites, cervical, colon, female breast, lung and bronchus, oral cancers, and prostate cancers from the years 2016-2021, excluding 2020.

Results: Major racial disparities in MIR were found in SC, with the largest discrepancies seen in cervical, colon, and prostate cancers. Of note, each SC region had white cervical …

The Effect Of Grape Seed Extract Against The Formation Of S.Aureus Biofilms In A Clinical Setting, Srestha Samaddar

Senior Theses

The rise of antibiotic-resistant bacterial infections, particularly those caused by Staphylococcus aureus, poses a serious threat to public health and clinical care. A major contributor to the persistence of these infections is the formation of bacterial biofilms, structured communities that protect S. aureus from antibiotics and immune responses, especially on surgical sites and medical devices. As conventional treatments become less effective, interest in alternative, natural antimicrobial agents has increased, due to public dissatisfaction with conventional medicine and a growing trust in complementary and alternative medicine. Grape seed extract (GSE), a polyphenol-rich byproduct of winemaking, has emerged as a promising candidate …

Addressing Gaps In Access: Examining Language Barrier Accommodations In Medicaid Member Handbooks, 2015-2019, Sanskruti Patel

Senior Theses

Objective: This study examines the linguistic accessibility of Medicaid Managed Care Organization (MCO) handbooks from 2015 to 2019 by analyzing the instructions provided to access interpreter and written translation services. Trends were compared over time, considering state and plan-level factors that impact equitable healthcare access for Limited English Proficiency (LEP) enrollees.

Methods: A systematic search using manual efforts and FOIA requests located all publicly available Medicaid handbooks from 2015-2019 (N=657) across 39 states with comprehensive MCO plans. These handbooks were coded by independent reviewers to assess the study outcome variables. Random mixed-effects logistic and linear regression models were conducted to …

Impacts On College-Aged Asian American Mental Health, Zahra Soherwardy

Senior Theses

This study explores the relationship between different forms of racial harassment and mental health issues in Asian American college students. Asian American mental health is a growing concern in the field of public health. Asian Americans have the lowest treatment rates and some of the highest stigma levels of any demographic. They are also impacted by the model minority myth and discrimination, further alienating them from getting help. The topics of subtle racism, blatant racism, and current racial discrimination were compared to depressive symptoms, anxiety, self-esteem, and four domains of aggression using survey data. Subtle racism was found to be …

Preeclampsia: Implementation Of The American College Of Obstetricians And Gynecologists Standardized Protocol, Sheila Ann Harwell

Electronic Theses and Dissertations

Preeclampsia is a significant medical condition that affects the perinatal population, posing risks to both the mother and fetus. Complications associated with preeclampsia include stroke, seizure, placental abruption (premature separation of the placenta from the uterus), fetal growth restriction (impaired growth due to reduced blood flow through the placenta), premature birth, and low-birth-weight infants with associated developmental issues. Because there is no cure for preeclampsia, the current management involves the timely administration of intravenous antihypertensives to reduce the risk of stroke and seizure. The gap in practice identified was the obstetrical department’s lacking a standardized protocol, compared to adopting the …

Adolescent Sleep Health, Mental Health, And Cardiovascular Disease Risk In Adulthood, Prince Nii Ossah Addo

Theses and Dissertations

Background: Insufficient sleep and poor sleep quality are major public health issues among adolescents in the United States (U.S.). Mental health and substance use challenges are also common among adolescents, particularly those with sleep problems. Although exposures in adolescence have been evidenced to significantly impact future health, little is known about how adolescent sleep health, mental health, and substance use influence future cardiovascular disease (CVD) risk. We, therefore, examined the association between sleep health in adolescence and CVD risk in adulthood and assessed whether the association is mediated by depressive symptoms and substance use in adolescents. Further, we explored the …

Activation Of Basal Forebrain Afferents Following Systemic Inflammation, Alexis Morgan Blas

Theses and Dissertations

Sepsis is a large-scale immune response typically due to an imbalance of pro- and anti-inflammatory responses due to some type of infection or insult. Around 1.7 million adults in the United States will develop it each year, making it the leading cause of increased morbidity and mortality in hospitals. Sepsis can lead to many different symptoms, one of which is delirium. Delirium is a mental state of confusion and disorientation and involves delusions, hallucinations, memory issues, and most commonly inattention. Delirium is more prevalent in older individuals which leads to further complications and a higher likelihood of development of long-term …

Targeting Malaria Using Rts,S/As01 Liposome Based Therapy In Combination With Cryptolepis Sanguinolenta, Michelle Villacorta Del Castillo

Selected Honors Theses

Malaria has shown to be a threatening disease to half of the population of the world, with currently 241 million cases reported. Malaria treatments have yet to be completely effective due to their ability and resistance to antimalarial drugs Plasmodium falciparum has developed, making it challenging to help treat this disease. RTS, S/AS01 has been shown to act on the pre-erythrocytic stage of malaria, targeting the circumsporozoite protein of Plasmodium falciparum expressed by the malaria parasite during this stage. At the same time, Cryptolepsis Sanguinolenta has been shown to have 90% inhibition of Plasmodium falciparum K1 growth. They have both …

Supporting College Students’ Mental Health Through Occupational Therapy, Mallory R. Watts

Selected Honors Theses

The mental health of college students has emerged as a significant concern, particularly because of the pressures of academic, social, and personal demands intensify. This study investigates the role of Occupational Therapy (OT) in supporting the mental health of college students, exploring the potential need for integrating OT services into campus programs. By assessing the current mental health resources available to students and evaluating their effectiveness, this research aims to identify gaps in support and determine whether OT could serve as a valuable addition to existing services. Through a combination of surveys, interviews, and literature reviews, the study examines students' …

Advancing Pandemic Response: Integrated Strategies For Testing, Prediction, And Bias Mitigation, Tianshu Gu

Theses and Dissertations (ETD)

The COVID-19 pandemic, along with prior outbreaks such as SARS and Ebola, has revealed critical gaps in global pandemic preparedness, emphasizing the need for integrated approaches to infectious disease management. This dissertation addresses three key areas of pandemic response: developing scalable screening strategies, constructing reliable predictive models, and mitigating demographic biases in artificial intelligence (AI) models used for healthcare decision-making.

The first study introduces a global screening strategy designed to optimize resource use and increase testing capacity, particularly in low- and middle-income countries (LMICs) where resources are limited. This study leverages pooled testing methods, where multiple samples are combined into …

The Impact Of Hyperglycemia On Post-Reperfusion Outcomes In Patients With Hyperacute Ischemic Stroke, Nicole Schumacher

Theses and Dissertations (ETD)

Stroke is a major contributor to disability in the United States, with ischemic stroke accounting for approximately 87% of all cases. The use of approved reperfusion therapies, including intravenous thrombolysis with tissue plasminogen activator (tPA) and mechanical thrombectomy, has significantly improved functional outcomes for ischemic stroke patients. However, hyperglycemia at the time of hospital arrival is associated with worse outcomes, including increased infarct growth, higher rates of disability, and elevated mortality. Despite this, current stroke guidelines neither exclude hyperglycemic patients from receiving reperfusion therapy nor recommend glucose management during the hyperacute phase of care. While recent studies suggest that mild …