Medicine and Health Sciences Commons^™

Comparative Efficacy And Preference Of Estrogen Cream Or Gel Vs. Vaginal Ring Estrogen For Hormone Replacement Therapy In Menopausal Individuals, Clara Burkman

Physician Assistant Scholarly Project Papers

Menopause is a natural, nonpathological event that occurs due to decreasing estrogen levels that may be achieved naturally or through surgical means. One of the most commonly reported and often painful symptoms of menopause is urogenital atrophy, also known as vaginal atrophy. Symptoms include vaginal pruritus, dyspareunia, dryness, vaginal irritation, dysuria, and tightness associated with thinning and reduced elasticity of the vaginal mucosa. These symptoms can negatively impact the quality of life. Local estrogen therapy is the preferred treatment option due to its minimal systemic absorption, potential as a safe option for menopausal patients with hormone-sensitive conditions, and ease of …

Efficacy Of Glp-1 Receptor Agonists In Women With Polycystic Ovary Syndrome, Ellie Fischer

Physician Assistant Scholarly Project Papers

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women and is characterized by irregular menstrual cycles, hyperandrogenism, and obesity (Brady et al., 2023). The purpose of this literature review is to compare glucagon-like-peptide-1 receptor agonists (GLP-1 RAs) to the typical treatment, metformin, in improving outcomes such as weight loss, insulin resistance, hyperandrogenism, and menstrual regularity in obese women with PCOS. Electronic databases including PubMed, Embase, and ScienceDirect were searched from April to July 2024 using a variety of keywords and MeSH terms. This review included studies from 2014-2024, randomized control trials, pilot studies, and clinical …

Efficacy And Safety Of Angiopoietin-Like 3 Inhibitors In Decreasing Low-Density Lipoprotein Cholesterol, Paige Fritz

Physician Assistant Scholarly Project Papers

Hypercholesterolemia is estimated to effect 31.7% of the United States population according to the Center for Disease Control and Prevention. The mainstay of treatment for this condition is currently statin therapy. While these medications are often effective in decreasing low-density lipoprotein cholesterol (LDL-C) to patient’s goal range, there are populations in which they are not sufficient. These populations include those who have genetic predispositions, such as familial hypercholesterolemia, or those who experience refractory hypercholesterolemia to statin medications. To combat this issue, a class of medications named Angiopoietin-like 3 (ANGPTL3) inhibitors have been created to use as an adjunct to statin …

Impact Of Altering Gut Microbiota With Multinutrient Supplementation On Neuropsychiatric Symptoms In Attention Deficit/Hyperactivity Disorder, Benjamin Hinkle

Physician Assistant Scholarly Project Papers

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neuropsychiatric condition affecting children, often characterized by inattention, hyperactivity, and impulsivity. Recent evidence suggests a potential link between gut microbiota composition and neuropsychiatric disorders, including ADHD, through the gut-brain axis (GBA). A literature review of studies published between 2017 and 2024 explores the efficacy of multinutrient interventions on influencing gut microbiota to treat the core symptoms of ADHD in children ages 6-12 years old. Findings indicate that multinutrient supplementation may modulate gut microbiota and subsequently impact neuropsychiatric symptoms, offering a promising adjunctive treatment for ADHD. However, variability in study methodologies and small sample sizes …

Effectiveness Of Epinephrine In Cardiac Arrest On Survivability With A Favorable Neurologic Outcome, Nathan Young

Physician Assistant Scholarly Project Papers

Cardiac arrest represents a critical medical emergency characterized by the cessation of effective cardiac function resulting in loss of blood flow to vital organs. The management of cardiac arrest often involves pharmacological interventions, primarily the administration of epinephrine. Historically, epinephrine has been the first-line agent in resuscitation protocols due to its sympathomimetic properties that can enhance cardiac contractility and blood circulation. However, the efficacy of epinephrine in yielding favorable long-term survival outcomes with maintained neurological function remains in question. This literature review examines the effectiveness of epinephrine in adult cardiac arrest, comparing outcomes to scenarios of no drug use and …

Outcomes Of Blood Flow Restriction Training In Comparison To Traditional Strength Training In Patients Undergoing Acl Reconstruction, Alex Lange

Physician Assistant Scholarly Project Papers

ACL injuries are common in athletes and active individuals, with a significant impact on knee stability, function and strength. The ACL is crucial in activities involving jumping, cutting, and pivoting which places the ligament under increased stress, increasing the risk of rupture. ACLR surgery is often necessary, especially in younger, active individuals, to restore knee stability, function and strength. The purpose of this literature review is to explore the effectiveness of BFR-RT as an alternative or adjuvant to traditional rehabilitation techniques following ACLR surgery. The electronic databases PubMed and Embase were searched, and the seven studies included for this review …

Improving Fertility In Women With Endometriosis, Todd Marchant

Physician Assistant Scholarly Project Papers

Endometriosis is a common condition in women and has a strong association with infertility. The purpose of this literature review is to determine the efficacy of hormonal therapy as compared to surgical therapy before assisted reproductive therapy (ART) on endometriosis-related infertility. The electronic databases PubMed and Embase were searched from June 23, 2024, to January 4, 2025. Keywords used were associated with fertility, IVF, and endometriosis. Article selection was limited to research published after the year 2000 with a preference for randomized control trials (RCTs), although one pilot study and one clinical cohort study were also included. The search yielded …

The Utility Of Pharmacogenetic-Guided Opioid Therapy In Pain Reduction, Jacqueline Mattson

Physician Assistant Scholarly Project Papers

Chronic pain is one of the most common reasons patients seek care from primary care providers. Individualized responses to pain medications make pain difficult to treat effectively. The purpose of this literature review is to examine the utility of pharmacogenetic-guided opioid therapy across chronic, postoperative, and cancer-related pain. A structured search of PubMed and Embase yielded 151 articles, of which nine met the inclusion criteria. Findings suggest that pharmacogenetic-guided therapy may reduce opioid dosages and enhance pain control, particularly in chronic pain settings. Evidence for postoperative pain outcomes was mixed, and studies on cancer-related pain emphasized the role of genetic …

Comparing The Efficacy And Safety Of Glp-1 Receptor Agonists Versus Gastric Bypass Surgery In The Treatment Of Obesity And Type 2 Diabetes, Abir Oliver

Physician Assistant Scholarly Project Papers

Obesity and type 2 diabetes are interconnected global health challenges, contributing significantly to morbidity, mortality, and healthcare costs. This literature review compares the efficacy, safety, and applicability of glucagon-like peptide-1 (GLP-1) receptor agonists and bariatric surgery as treatment options. A literature search with defined inclusion and exclusion criteria was conducted using PubMed and EBSCOhost from May to July 2024, resulting in 14 randomized controlled trials for evaluation. This literature review supports the efficacy of both GLP-1 receptor agonists, particularly semaglutide, and bariatric surgery as effective interventions for weight loss and glycemic control in patients with obesity and type 2 diabetes. …

D-Mannose Efficacy In Preventing Recurrent Urinary Tract Infections In Women, Miah Lee

Physician Assistant Scholarly Project Papers

Recurrent urinary tract infections (rUTIs) are a significant health concern for women, affecting their quality of life and requiring effective and safe prophylactic and therapeutic interventions. This literature review evaluates the efficacy, safety, and mechanisms of D-mannose, a natural sugar, in preventing and treating UTIs. This review is based on a structured search and selection of randomized controlled trials and pilot studies identified through databases such as PubMed, Embase, and Google Scholar. Evidence from assorted studies, including randomized controlled trials and pilot research, indicates that D-mannose may reduce UTI recurrence rates and alleviate acute symptoms with comparable efficacy to standard …

Telehealth And Medical Consumerism In The Digital Age, Yibing Hu

Finance Undergraduate Honors Theses

This paper discusses the role of telehealth in medical consumerism. As a cheap and convenient model of healthcare, telehealth enables patients to access healthcare regardless of location, as long as they have the necessary technology.

In the current healthcare landscape, insurance policies and high costs push patients to act as consumers of medical services. With the rise of telehealth as another healthcare option, the medical sector further becomes consumer-oriented. This ultimately changes the way patients interact with healthcare.

Relationship Between Nutritional Knowledge And Eating Disorder Risk Levels, Valeria Fernandez

Human Nutrition and Hospitality Management Undergraduate Honors Theses

The prevalence of disordered eating is a critical public health concern that often progresses towards the development of a diagnosable eating disorder (ED). This, in turn, has detrimental physical and psychological consequences for individuals. Organizations such as the American Society of Parenteral and Enteral Nutrition (ASPEN) and the Academy of Nutrition and Dietetics (AND) have recognized nutrition education as a crucial component of prevention and recovery. Determining the extent to which nutrition knowledge is related to risk factors for EDs is worth investigating due to its implications for healthcare approaches – especially among adolescent and young adult populations. The goal …

Examination Of Language Sample Analysis In Children Who Are D/Hh Using Clan, Caroline G. Stewart

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Hearing is the building block of developing receptive and expressive oral language skills used to effectively communicate. Children who experience hearing loss typically experience delays in phonological, morphological, semantic, and even pragmatic development. Understanding the specific language challenges faced by deaf and hard of hearing (D/hh) young preschool-age children is crucial for developing targeted intervention strategies aimed at optimizing their language development. This research aims to analyze the nuanced aspects of phonological, morphological, semantic, and pragmatic language development among D/hh children, shedding light on areas that may require specialized support. The preliminary research will inform best practices in language assessment …

Assessing Language Skills Of Children Within The Head Start Program Using Language Sampling Analysis, Lynley Bowen

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Fluency disorders, including stuttering and cluttering, disrupt one’s natural rate of speech and can cause implications for one’s emotional well-being. This study explores the relationship between language factors and stuttered events in preschool-age children by analyzing a spontaneous language sample using two transcription software programs, CLAN and SALT. A language sample was collected from a child enrolled in a local Head Start program and was transcribed and analyzed using the software programs. Results from CLAN’s KIDEVAL and FLUCALC features offered analysis of the child’s language profile, as well as SALT’s standards measure report feature. This study highlights the importance of …

A Comparative Analysis Of Salt And Clan In The Context Of Analyzing Disfluencies In Preschool-Age Children Who Stutter, Addilin G. Brown

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

This case study compares two widely used language sample analysis (LSA) programs including the Systematic Analysis of Language Transcripts (SALT) software and the Child Language Analysis (CLAN) software. The comparison aims to evaluate their effectiveness in analyzing the conversation-based language sample of a preschool-aged child who was reported at-risk for stuttering. A conversational language sample was collected from a four-year-old male at a local head-start program. The sample was transcribed and analyzed using both SALT and CLAN. SALT provided a user-friendly interface with clear results and a comparison to normative data. Some of these results included a maze and word …

Over-Imitation In Adolescents With Autism Compared With Typically Developing Peers: An Expanded Literature Review, Elizabeth Floeck

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Abstract

Background:

Over-imitation, the act of imitating both relevant and irrelevant actions, is a behavior commonly found in human learning and social development. It is often observed in typically developing (TD) children and is believed to play a role in both social and learning development. While the exact motivations behind over-imitation remain a mystery, over-imitation appears to be a socially motivated behavior. Children may over-imitate when they know certain actions are unnecessary, suggesting this behavior stems from social acceptance and norms. In individuals with autism spectrum disorder (ASD), social and communicative behaviors are drastically different from TD individuals. In individuals …

Empowering Through Technology: An Internship Report On Augmentative And Alternative Communication Devices, Olivia G. Macdonald

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Augmentative and Alternative Communication (AAC) devices play a crucial role in supporting individuals with communication challenges, particularly children with developmental disabilities such as Autism Spectrum Disorder (ASD). This paper provides a comprehensive review of the literature on AAC and offers a detailed report of an internship experience at the University of Arkansas WE CARE Summer Camp. During the internship, firsthand experiences provided valuable insights into how AAC technologies can be applied to enhance communication, foster social connections, and support behavioral regulation.

The literature review explores the different types of AAC systems, including both aided and unaided options, and discusses the …

Over-Imitation Skills In Children With Autism Spectrum Disorder Compared To Typically Developing Peers: An Expanded Literature Review, Josephine M. Stadler

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Abstract

Background:

Imitation, a foundational social and cognitive development mechanism, enables individuals to acquire cultural norms, communication skills, and problem-solving strategies. Over-imitation— the replication of both relevant and irrelevant actions demonstrated by others—plays a critical role in social learning. While typically developing children often engage in over-imitation to promote social bonding and affiliation, the role and underlying motivations for over-imitation in children with ASD remain less clearly understood.

Purpose:

Through a critical synthesis of professional and scholarly literature, this review aims to evaluate the history and development of research on imitation and over-imitation, assess empirical findings regarding typically developing children …

Identifying Predictors Of Student Success During Occupational Therapy Level Ii Fieldwork, Melissa R. Foster

Graduate Theses and Dissertations

The training paradigm for new occupational therapy (OT) practitioners includes both didactic classroom learning and clinical fieldwork experiences in order for them to establish clinical competency. However, many students struggle with the theory-to-practice gap of translating classroom knowledge to clinical experiences. When students struggle in this manner, it causes stress for all stakeholders involved, including the fieldwork educator, clinic managers, OT program faculty, as well as the student.

This study aims to avoid this stress by identifying predictors of student success by analyzing data from recent graduates of the University of Arkansas/University of Arkansas for Medical Sciences OT program through …

Implementation Of Houdini Guidelines Nurse-Driven Protocol To Lower Catheter-Associated Urinary Tract Infections And Foley Utilization Days, Tammie N. Collins

Electronic Theses and Dissertations

Catheter-associated urinary tract infections are a common issue in healthcare settings. These issues contribute to hospital-acquired infections and can lead to complications and increased healthcare costs. The quality project evaluated the impact of the HOUDINI guidelines nursedriven protocol to reduce infection rates and Foley utilization days. A structured guideline for Foley catheter safe removal was implemented using a quantitative method. Catheter-associated urinary tract infection rates and Foley utilization days pre- and postintervention were tracked. Data were collected using the electronic health records, infection control data sheets, and the HOUDINI checklists. A baseline assessment of catheter-associated urinary tract infections rates was …

The Effects Of Loving-Kindness Meditation (Lkm) On Relationship Satisfaction In Couple Therapy, Ruimeng Gao

Electronic Theses and Dissertations

This thesis explores the integration of loving-kindness meditation (LKM) into couple therapy sessions and its impact on relationship satisfaction. Meditation, historically rooted in religious practices, has increasingly been adopted in Western therapeutic contexts due to its demonstrated benefits for mental health and interpersonal well-being. Although mindfulness-based interventions have gained popularity in psychotherapy, research specifically examining the use of LKM in couple therapy remains limited. This study investigates whether incorporating LKM into therapy sessions enhances relationship satisfaction compared to standard therapy alone. Couples were randomly assigned to either a control group, which received standard therapy, or an experimental group, which practiced …

Examining The Mediating Effects Of Symptoms Of Depression, Anxiety, And Perceived Stress On The Association Between Bereavement And Inflammation, Kylee Faith Behringer

Master's Theses

Bereavement is a stressor that impacts the psychological well-being of an individual and their physical health. This study aimed to develop a more nuanced understanding of the association between bereavement and its psychological and biological consequences, and the potential mediating role of symptoms of depression, anxiety, and stress within the relationship between bereavement and inflammation. Data was collected through Midlife in the United States (MIDUS) Refresher 1, a longitudinal study that examines social, psychological, and biological vulnerabilities associated with potential health outcomes (Weinstein et al., 2019). The study consisted of 863 participants (bereaved=373, non-bereaved=490) who completed an in-person study visit …

Authentic Self-Actualization: The Underlying Mechanisms Of The Self That Are Associated With Well-Being And Alcohol Outcomes Among At-Risk Drinkers, Rebeca Fierro Perez-Martinez

Open Access Theses & Dissertations

Research indicates that individuals who consume alcohol beyond recommended guidelines are at-risk for harmful health outcomes. Moreover, alcohol is often used as a coping strategy to alleviate negative emotions that stem from self-discrepancies, potentially reinforcing maladaptive drinking behavior and exacerbating alcohol-related problems. Although various motivational theories related to the self-concept have independently contributed to our understanding of drinking behavior, no framework has synthesized these perspectives. Grounded in self-discrepancy theory, self-determination theory, and self-actualization, the present study introduces Authentic Self-Actualization as a comprehensive theoretical framework to examine how motivational aspects of the self-concept influence well-being and alcohol-related outcomes. A total of …

Teaching Bilingual Features To A Young Augmentative And Alternative Communication User With Autism, Paola Gallegos

Open Access Theses & Dissertations

This study examines how a minimally verbal, young Spanish-English bilingual child with Autism Spectrum Disorder (ASD) uses translanguaging toggle features on an Augmentative and Alternative Communication (AAC) device to produce multi-word picture descriptions. The study employed a Rapidly Alternating Treatments Design (RATD) to analyze AAC performance under language-controlled Spanish-only and English-only conditions. A quantitative analysis examined the frequency and patterns of bilingual AAC feature use during aided modeling and instruction, while qualitative methods explored the related challenges and benefits. This study highlights the potential for bilingual AAC systems to enhance communication effectiveness and underscores the importance of incorporating user and …

Testing A Benign Multi-Modal Bilingual Intervention To Increase Self-Efficacy, Intentions, And Willingness To Administer A Covid-19 Antigen Rapid Test In A Predominately Hispanic Sample, Uchenna Gbugu

Open Access Theses & Dissertations

Introduction. Testing is one of the most effective methods for reducing the spread of COVID-19. COVID-19 antigen tests can detect proteins from the COVID-19 virus called antigens and produce results within minutes, making them suitable for at-home use. Several factors have been identified as barriers to self-administering a COVID-19 antigen test, including the language of the testing instructions, the cost of testing, and access to tests. Interventions to reduce barriers to self-administering COVID-19 rapid tests are warranted to reduce the spread of COVID-19. The purpose of the present study is to test the impact of a benign multi-modal bilingual intervention …

Finding Strength In The Struggle: The Impact Of Resilience On Life Satisfaction Among Veterans With Mental Illness, Marissa Gonzalez

Open Access Theses & Dissertations

Background: Veterans living with mental illness often face challenges that impact their overall life satisfaction and adjustment to civilian life. While resilience is widely considered a protective factor, limited research has examined its role in conjunction with personality traits, psychosocial factors, and demographic characteristics. Purpose: This cross-sectional study examined the associations between resilience and life satisfaction among U.S. veterans with mental illnesses, while accounting for personality dimensions, demographic variables, and psychosocial factors. Methods: Secondary data from 156 veterans diagnosed with mental illness were analyzed. Hierarchical linear regression was used to assess the relationship between resilience and life satisfaction, controlling for …

Intratumoral Fibrin As A Novel Immunomodulatory Factor In Pancreatic Ductal Adenocarcinoma, Mazharul Karim

Open Access Theses & Dissertations

In-situ coagulation is a common clinical feature of pancreatic ductal adenocarcinoma (PDAC) that presents a highly thrombotic and crosslinked insoluble fibrin (x-fibrin)-laden tumor stroma (FibTS). However, the specific impact of FibTS on immune cells behavior remains largely unexplored in this poorly infiltrated tumor. We aimed to elucidate how FibTS in PDAC regulates immune cell infiltration, polarization, and crosstalk that favors immunosuppressive microenvironment and tumor growth. We characterized human PDAC tissues by multiplex immunostaining and checked the spatial distribution of immune cells based on the presence of x-fibrin. We investigated how FibTS influences the infiltration of tumor-associated macrophage (TAM) and T-cell …

Exploring Willingness To Seek Help And Well-Being In Rural Veterans With Health Conditions: A National Rural Health Study, Jimena Isabel Ortiz

Open Access Theses & Dissertations

The population of Veterans in the United States has increased significantly, with a substantial number residing in rural areas. This study aims to highlight and understand the correlation between military service members' physical and mental well-being and the quality/access to care they receive. This study also aims to explore mental health-seeking behaviors, health, and well-being in rural Veterans with health conditions. The study included 400 rural-dwelling Veterans with documented physical and mental health conditions. Data was collected through surveys distributed via various media channels, including social media platforms, and the results demonstrated that willingness to seek psychological help was positively …

Jak1 V658f Drives Oncogenic Transformation Via Transcriptional Reprogramming Independent Of Y598 Phosphorylation And Canonical Jak-Stat Signaling, Omar Javier Rodriguez Moncivais

Open Access Theses & Dissertations

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and complex malignancy that accounts for 15% of pediatric acute lymphoblastic leukemia (ALL) cases in the United States. Tyrosine kinases control critical cellular processes, including the development, survival, and activation of T cells, and are established drivers of leukemia.Tyrosine kinases involved in hematological disorders include receptor tyrosine kinases and non-receptor tyrosine kinases family members such as SRC, ABL, FAK, and Janus kinases (JAKs). This study primarily focused on JAK1 gain-of-function (GoF) mutations. These mutations are recognized as hyperactivating mutations, maintaining kinase activity of JAKs on and essentially keeping downstream signaling effectors, like …

The Relationships Between Behavioral And Sociocultural Constructs And Electronic Nicotine Delivery Systems (Ends) And Cannabis Patterns In Hispanic Young Adult University Students, Kevin Sandoval Medina

Open Access Theses & Dissertations

The proliferation of both electronic nicotine delivery systems (ENDS) and cannabis has contributed to a concerning trend of dual usage, posing a greater public health risk, particularly pronounced among at-risk populations of increased substance use, such as Hispanic young adult college students. This study utilized the socioecological framework and social cognitive theory to observe behavioral and sociocultural constructs associated with dual use and identify potential risk and protective factors. Four hundred and twenty-one Hispanic young adult university students completed a cross-sectional survey assessing sociodemographics, depression, anxiety, stress, familism, acculturation, self-efficacy, and past month dual use and dual use recency of …