Medicine and Health Sciences Commons^™

At The Table Together: Exploring Child Perception Of Lunch Buddy Mentoring, Lauren K. Primm

Psychological Science Undergraduate Honors Theses

Research suggests school-based mentoring is a promising strategy for helping children who experience school bullying and peer victimization. Lunch Buddy Mentoring (LBM) is a school-based mentoring program that places mentors in the lunchroom and has them sit with the mentee and peers at the lunch table. Research shows that LBM is positively perceived by both parents and teachers, but there is little research on the perceptions of LBM held by children at the lunch table. Negative perceptions of LBM by children who sit with the mentor could reduce its success by further isolating or victimizing children it aims to support …

The Effects Of Starting Hormonal Contraceptive Use On Rumination, Abigail Brien

Psychological Science Undergraduate Honors Theses

Rumination, a cycle of repetitive dwelling on negative feelings and distress, is associated with mental health issues such as depression and anxiety. Although there is a substantial body of research on rumination and its association with depression and anxiety in women, there is a lack of studies specifically examining the role of hormonal fluctuation in this process. Changes in the menstrual cycle linked to estrogen and progesterone have been associated with mood regulation and susceptibility to depression, yet the impact of hormonal contraceptives (HCs) on rumination remains unexplored. The current study examined the role of HCs on rumination by comparing …

Culturally Concordant Dbt Steps-A Intervention In Orthodox Jewish Schools, Arielle Hershkovich-Elgavi

Theses, Dissertations and Culminating Projects

Existent research indicates that Dialectical Behavioral Therapy (DBT) is an efficacious treatment for mental health issues in many adult and adolescent populations, yet there is little research on the effect of DBT on culturally diverse, underserved populations (Mercado, & Hinojosa, 2017). Orthodox Jews are a culturally diverse, understudied, and underserved population (Schnall et al., 2014), that contends with strong stigmas against mental health treatment (Gearing et al., 2022). Orthodox Jewish community teachings are governed by religious values and precepts with a resistance to secular influence (Freund & Band-Winterstein, 2017). The social-emotional learning that is occasionally taught in some community schools …

Improving Brain Health: Exercise As A Tool For Enhancing Executive Function And Reducing Stress In Older African Americans, Destiny Ellise Ramos

Theses, Dissertations and Culminating Projects

Older African American (AA) adults face disproportionately higher risk of stress and Alzheimer's Disease and Related Dementias (ADRD) compared to other racial and ethnic groups, yet they remain underrepresented in intervention-based research. Previous research has suggested aerobic exercise may reduce stress and benefit executive functioning, which is among the first cognitive domains to be affected in ADRD; however, no studies to date have directly tested the impact of aerobic vs. non-aerobic exercise in older AAs at high risk for developing ADRD. The current study evaluated the effects of a group-based cardio dance fitness (CDF) exercise intervention versus a strength, flexibility, …

The Role Of Endogenous Estrogen In Effects Of Non-Invasive Brain Stimulation On Cognitive Performance, Samantha Walsh

Theses, Dissertations and Culminating Projects

High-definition transcranial direct current stimulation (HD-tDCS) directly modulates brain activity, allowing the study of brain-behavior relationships in cognitive processes. However, cognitive effects of tDCS vary widely, partly due to individual differences in baseline brain activity. Estrogen levels, which fluctuate during the menstrual cycle, are known to affect cortical excitability and impact neural response to tDCS, but no research to date has examined the potential moderating role of endogenous estrogen in tDCS effects on cognition. In this study, N = 16 healthy female adults completed four sessions of a working memory (WM) task while receiving tDCS (two active sessions, two sham) …

Advancing Drug-Drug Interaction Prediction Using Multi-Modal Feature Integration With Graph Neural Networks, Ernest C. Chianumba

Theses, Dissertations and Culminating Projects

Pharmaceutical treatments are essential for managing medical conditions, but drug-drug interactions (DDIs) pose significant risks to patient safety and healthcare outcomes. This research integrates Knowledge Graphs and Graph Neural Networks to predict DDIs by exploring complex drug relationships. We construct a comprehensive knowledge graph using DrugBank data (1,000 drugs, 155,774 interactions) enriched with molecular features from PubChem. Our methodology introduces a novel multi-modal approach by integrating transformer-based embeddings (ChemBERTa, SPECTER, and SBERT) to create 1152-dimensional feature vectors that capture structural, biomedical literature, and semantic properties of drugs. Formulating DDI prediction as a link prediction task, we compare three Graph Neural …

Exploring The Role Of The Id2 And Rab11fip3 Pathway In X-Linked Chronic Granulomatous Disease (Xcgd) Through Comparative Gene Expression Analysis, Kaili Coenen

Honors Theses

X-linked chronic granulomatous disease (XCGD) is a debilitating immunodeficiency disorder primarily affecting men. The disease results from mutations in the CYBB gene on the X chromosome, which encodes the GP91^PHOX protein responsible for electron transfer from NADPH to molecular oxygen. Despite the identification of the CYBB mutation, the pathological mechanism underlying the reduction in reactive oxygen species (ROS) generation in XCGD remains unclear. We hypothesized that comparative gene expression analysis, combined with pathway analysis, could identify genes and signaling pathways contributing to reduced reactive oxygen species (ROS) levels in XCGD. In this study, we analyzed gene expression data from four …

The Impact Of Early Ambulation In Coronary Artery Bypass Graft Patients At The Oklahoma Heart Hospital, Kennedy G. Berger

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background

Coronary artery bypass graft (CABG) procedures are conducted across the United States to patients that have blocked arteries resulting in the heart not receiving enough profusion to adequately function. This is an invasive, lifesaving surgery that also welcomes complications post-surgery. 1 in 8 patients will check back into the hospital at least 30 days after their CABG procedures. Readmission can be related to arrhythmias and congestive heart failure; however, most patients see respiratory complications or infection (Shawon, et al., 2021).

Purpose

The purpose of this externship was to learn if early ambulation had a positive impact on patients who …

What's In It For Me? The Benefits Of Breastfeeding For The Mother, Emily H. Mcmennamy

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The purpose of this systematic review was to investigate both the short- and long-term benefits that breastfeeding has on maternal physical and mental health. The PICOT question was: In postpartum mothers, how does breastfeeding compared to formula and mixed feeding affect maternal physical and mental health, including outcomes in cardiovascular health, BMI, bleeding risk, and mental health both short term and long term? For this research, EBSCOhost and the National Library of Medicine databases were searched to find relevant studies and systematic reviews. Terms such as “breastfeeding and maternal health benefits,” “breastfeeding and postpartum health,” and “breastfeeding and weight loss” …

Standardizing Patient Education For Living Kidney Donors, Diana Thompson

Doctoral Scholarly Projects & Capstones

Living kidney donation occurs when a person voluntarily donates a functioning kidney to another individual in need. The kidney donation process is lengthy, complex, and can be overwhelming for many potential donors. A gap was identified in the patient education process at the project site as evidenced by frequent postoperative questions and concerns expressed by living donors and their caregivers. A literature review suggested this was a national problem, yet a standardized education process for living kidney donors has yet to be developed. The purpose of this scholarly project was to develop a standardized process for living kidney donor education …

Bridging The Nature Gap: Understanding Barriers And Promoting Outdoor Engagement Among African Americans In Chattanooga, Kennie Almonor

Honors Theses

This paper outlines my process of writing a physical guidebook for outdoor engagement in Chattanooga. It explores the historical context of Black exclusion from outdoor spaces and examines the health disparities that disproportionately affect Black communities. The physical connection between outdoor activity and overall well-being will also be explained. Additionally, this paper details my methodology for conducting focus groups to better understand barriers to outdoor engagement and how participant insights could inform the guidebook’s development. This paper also outlines my research on best practices for structuring an effective guide, writing process, challenges faced, and considerations for extending this project in …

Role Of Evolutionarily Conserved G4 Structures In Enhancer-Promotor Interactions, Shahem Alqudah

Honors Theses

Gene regulation is governed by complex networks of interactions between enhancers and promoters, regions of the genome that are typically distant from one another yet functionally linked through chromatin looping. Recent research has revealed the significant role of Gquadruplexes (G4s) in facilitating these interactions. This thesis explores the role of long Gquadruplex regions (LG4s) in enhancer–promoter communication, proposing that these regions mediate physical interactions between enhancers and their target promoters through direct G4:G4 interactions. Using a chromatin conformation capture (EQuIP-seq), electrophoretic mobility shift assays (EMSA), and luciferase reporter assays, the study demonstrates that LG4s may drive gene expression by promoting …

Implementation Of The American College Of Cardiology And American Diabetes Association Clinical Practice Guidelines For Statin Therapy In Reducing Cardiovascular Risk Among Patients With Type 2 Diabetes, Edward Eloy Iruegas

Doctor of Nursing Practice

The incidence of type 2 diabetes has significantly increased over the past decade, making it a risk factor for cardiovascular disease (Banach et al., 2022). Individuals with type 2 diabetes are four times more likely to develop atherosclerotic cardiovascular disease, accounting for up to a 75% mortality rate. Despite this, the risk for atherosclerotic cardiovascular disease remains underestimated and undertreated in this population (Banach et al., 2022). The purpose of this project was to enhance adherence to the American College of Cardiology 2019 and the American Diabetes Association 2023 clinical practice guidelines regarding statin therapy for patients with type …

The Impact Of Quality Of Life And Recovery Capital On Inhibitory Control In Patients On Medication For Opioid Use Disorder, Caroline K. Jeffries

All Theses

The opioid crisis persists as a global health challenge, necessitating a comprehensive understanding of the complex interplay between psychological factors and neurocognitive responses among individuals with opioid use disorder (OUD). Two such psychological factors include recovery capital, an individual's internal and external resources to supporting recovery, and quality of life. Past work suggests that positive levels of recovery capital and quality of life may enhance individuals’ ability to regulate emotions and manage cravings. However, it is unclear how these variables are affected when buprenorphine is taken. This study investigates the influence of recovery capital and quality of life on inhibitory …

Healthy Dietary Patterns’ Impact On Depressive Symptoms: A Meta-Analysis Of Randomized Controlled Trials, Angela Encardone

All Theses

As the search for innovative mental health treatments expands, dietary interventions have emerged as a promising approach for alleviating depressive symptoms. This thesis presents a meta-analysis of randomized controlled trials (RCTs) examining the efficacy of whole-of-diet nutritional interventions in reducing depression symptoms among adults. Grounded in Bronfenbrenner’s Bioecological Model and Engel’s Biopsychosocial Model, this study explores the intersection of biological, psychological, and social factors that influence mental health outcomes. A systematic review identified six eligible RCTs assessing the impact of healthy dietary patterns, including the Mediterranean diet and other plant-based interventions, on depression symptoms. A random-effects meta-analysis revealed a significant …

Antiproliferative Effects Of Salvia On Breast Cancers., Allison C. Portaro

College of Arts & Sciences Senior Theses

Breast cancer is the most common cancer diagnosed in female adults, with 2.3 million new cases worldwide in 2020. Plants have been used in traditional medicine and are a potential source of pharmaceuticals. One example is the large Lamiaceae (mint) family. The Salvia genus, commonly known as the sages, is the largest genus in Lamiaceae with almost 900 known species. Salvia lyrata (lyre-leaved sage) has a history of Native American medicinal use to treat cancers and other ailments resulting in this plant being referred to as ‘cancer weed.’ Extracts were produced from the leaves of S. lyrata, S. lyrata …

Small But Mighty: Strengthening The Value Of Local Pocket Parks, Makana Sm Higa

Capstone Projects and Master's Theses

In Monterey County, youth obesity rates are climbing at an alarming rate. Ventana Wildlife Society, and Wellness Through Nature program seek to help lower these rates. Ventana looks to achieve this through outdoor education and family trips with migrant farm working families in the cities of Soledad and Salinas. These trips attempt to increase environmental stewardship and improve community health. The project aims to evaluate the effectiveness and community engagement in regards to pocket parks. The parks visited were Bataan Memorial Park, Harden Neighborhood Park, Cesar Chavez Park, Joe Ledesma Park and San Antonio Park. The research seeks to increase …

Gender And Ethnic Differences In Mental Health Outcomes In Sexual And Gender Minority (Sgm) Youth And Young Adults In Texas And California, 2022-2024, Michelle Gil

Open Access Theses & Dissertations

Background: Depression and anxiety affect populations differently, particularly LGBTQ+, ethnic minorities, and youth with limited access to competent care. Risk factors include harassment, victimization, and discrimination. Purpose: To examine gender identity and ethnic differences in depression and anxiety among SGM youth in Texas and California. It is hypothesized that both Latinx and gender minority youth will report higher rates of depression and anxiety compared to non-Latinx and cisgender youth. Methods: Secondary analysis used data from the Family, Housing, and Me (FHAM) Project, following 83 LGBTQ+ youth from South Texas and California's Inland Empire over 25 months. Data includes sociodemographic characteristics, …

Pilot Study To Compare A Therapeutic Exercise Protocol And Neuromuscular Taping On Improving Plantar Foot Pressure Among Type 2 Diabetes Patients, Sandra Rivera

Open Access Theses & Dissertations

Background: Diabetes has become one of the most prevalent non-communicable diseases worldwide. Diabetic foot ulcers (DFU) are a common complication of diabetes as it causes peripheral neuropathy. It is estimated that up to 50% of peripheral neuropathy in patients with diabetes may be asymptomatic. Justification: The purpose of this study was to determine if the therapeutic exercise protocol and/or Neuromuscular taping can delay changes in the plantar pressure of the foot in patients with Diabetes. Methods: A two-group quasi-experimental design was used in this study; data was collected at two different points in time; pre- and post-intervention. Baropodometric was used …

Machine Learning And Protein Engineering Approaches To Understanding Kinesin-5 Activity, Jason Eden Sanchez

Open Access Theses & Dissertations

Cancer is a term describing a collection of diseases that result in uncontrolled cell growth. Cancer has manifold etiologies and underlying cancers are rouge biochemical pathways involving many different proteins. In the current work, two approaches are used to enhance knowledge of kinesin-5, a potential cancer target involved in cell division. Kinesin-5 promotes cell division by cross-linking and separating microtubules in dividing cells. The first approach uses machine learning (ML) to identify small molecule inhibitors for kinesin-5. Though decades of research have uncovered classes of small-molecules which inhibit kinesin-5 in vitro and in vivo, no candidates have reached phase III …

Measuring The Strategies To Cope With Shift Work Among Healthcare Workers, Khushi Mehta, Lindsay Ham

Psychological Science Undergraduate Honors Theses

It is known that lack of sleep, no matter what career a person is in, is detrimental to the overall longevity and health of an individual. Balance of sleep can be easy to attain, especially if one’s work life is able to facilitate it. Healthcare workers, however, often do not have that luxury. Healthcare professionals work a variety of shifts ranging from night shifts, 12-16-hour shifts, regular daytime hours, and being on call during the night. These irregular working schedules can have a detrimental effect on their sleep quality and quantity. If healthcare workers don’t get enough sleep, it can …

Heterotopias Of Confinement: Zoo Architecture And The Loss Of Elephant Agency, Clayton Gill Beasley

Electronic Theses and Dissertations

Zoos functions as a site where human-animal relationships are structured through built environments that mediate control and representation. This study examines zoos as heterotopias—spaces where power and surveillance are negotiated between human observers and captive nonhuman animals. While zoos are often framed as spaces of conservation and education, their architectural design reinforces hierarchies of observation and confinement, shaping both human perceptions of nature and the lived experiences of nonhuman animals. This research focuses on Asian elephants as a critical species within this framework, exploring how their captivity illuminates tensions between human-imposed structures and nonhuman autonomy. Drawing from theories of heterotopia, …

Evaluation Of Fecal Egg Counts (Fec) As A Viable Means To Estimate Ascaridia Galli, Heterakis Gallinarum And Capillaria Obsignata Burdens In Laying Hens, Alexander H. Moss

Animal Science Undergraduate Honors Theses

The control of gastrointestinal helminths, specifically Ascaridia galli, Heterakis gallinarum, and Capillaria obsignata, is a critical component of poultry health management, particularly in free-range and organic farming systems. Methods of estimating parasite burdens, such as post-mortem examinations, are not feasible for large-scale commercial operations due to their invasiveness and time requirements. This study aimed to evaluate the use of fecal egg counts (FEC) as a non-invasive and efficient method for estimating the worm burdens of these parasites in laying hens. A flock of 12 brown egg laying, spent, hens were individually penned on concrete. Fecal samples (both cecal and intestinal) …

The Use Of Biomarker-Based Models In Clinical Settings To Support Early Detection Of And Treatment For Alzheimer's Disease., Steven A. Gonzales

College of Arts & Sciences Senior Theses

Traditional detection of and treatment methods for Alzheimer’s disease (AD) undermine the critical period of preclinical AD, a pathogenic process that appears decades before clinical symptoms arise. In the preclinical stage, biomarkers stipulate the advent of pathogenic processes, providing a crucial framework to integrate early detection and intervention well before clinical symptoms become evident. I hypothesize that the presence of biomarkers is a crucial early indicator of changes in memory function in the preclinical stage of AD. To test this hypothesis, a systematic literature review will be applied to gauge biomarker detection in order to consider it as a potential …

Investigating The Effects Of Prenatal E-Cigarette Exposure On Postnatal Liver Histology, Emma Mcclellan

College of Arts & Sciences Senior Theses

The electronic cigarette (e-cigarette) entered the American market in the mid-2000s and quickly became popular. This product poses a significant threat to youth with 1.63 million students reporting use in 2024. Adverse health effects to different organs are well known. The liver is less studied, and despite its role in detoxification of e-cigarette chemicals, is a target of injury. Unlike the known effects of cigarettes and nicotine on the liver from adult or prenatal exposure, effects of prenatal exposure to e-cigarettes on liver remain to be defined. The current study investigated the effects of prenatal exposure of e-cigarettes on liver …

Effects Of Cadmium And Diet On Metal Accumulation And Kidney Cell Death Pathways., Justin Xu

College of Arts & Sciences Senior Theses

Cadmium (Cd) is a non-biodegradable environmental toxin and accumulates in the body with an estimated half-life of 30-45 years. Humans can be exposed to Cd through diet, drinking water, tobacco smoking, and industrial pollution. Cd can especially accumulate in the kidney due to the release of Cd from protein-metal complexes when filtering blood in the tubules causing oxidative stress and inducing kidney injury. Obesity is another risk factor for kidney disease therefore we examined the dual effects of Cd and obesity on the accumulation of essential metals in mouse kidneys. Starting in utero and continuing until 24 weeks postweaning, male/female …

Investigation Of Anhedonia: A Literature Review, Austin G. Littlejohn

Honors Capstones

"Investigation of Anhedonia" serves as an independent study where a Literature Review was conducted to research different aspects and elements of the psychological phenomenon known as Anhedonia. With the support of psychology mentors and utilization of the library's resources, the research investigated what Anhedonia is and how it is connected to stress and trauma, the trajectory or progression of Anhedonia and its symptoms, the connection to more well known psychological disorders like Post-Traumatic Stress Disorder, PTSD, and Anhedonia's status of a stress response and whether or not it could be considered a separate disorder. The significance of the literature in …

Health Professional Perspectives On Sudden Unexpected Infant Death In Arkansas, Laura Hansen, Bart Hammig

Health, Human Performance and Recreation Undergraduate Honors Theses

Arkansas has one of the highest Sudden Unexpected Infant Death (SUID) rates in the nation, with 173.6 deaths for every 100,000 live births (CDC, 2024). This is much higher than the national rate, indicating a significant need for prevention education. Sudden Unexpected Infant Death is an umbrella term used to categorize Sudden Infant Death Syndrome (SIDS), unknown death causes, and accidental suffocation in bed. SUID rate reduction can be achieved by following infant-safe sleeping guidelines, which include crib use, flat and firm mattresses, no blankets, and putting babies on their backs. In this proposed study, health care professionals across Arkansas …

The Affordable Care Act: Analyzing Rates Of Healthcare Claim Denial, Lauren Sitter

Political Science Theses and Capstones

The United States healthcare industry is an integral aspect of every American’s life. The Affordable Care Act (ACA) in 2010 reformed the healthcare system by expanding coverage to millions of Americans and eliminating claim denials due to pre-existing conditions. It requires participating states to submit transparency data. Despite these reforms, coverage denials continue and vary by plan category, metal level, and among different states. I analyze data from The Kaiser Family Foundation (2023) and The CommonWealth Fund to test the correlation between claim denial and a variety of variables, including state political culture, plan type, metal level, and out-of-pocket costs. …

How Music Is Used To Facilitate Communication In Speech-Language And Music Therapy For Children With A Diagnosis Of Autism Spectrum Disorder, Anna Mcgreevy

Honors College Theses

The goal of this research was to determine how music is being used in speech and music therapy sessions for children with a diagnosis of autism spectrum disorder, to discover the most common targets of these therapy sessions, and to examine the anatomical and physiological constructs that support the inclusion of music. This study was a review of literature, and included research from a variety of articles, several written in the past 25 years. Overall, results showed that music-based speech interventions such as Melodic Based Communication Therapy and Developmental Speech and Language Training, as well as music therapy interventions, are …