Medicine and Health Sciences Commons^™

The Comparison Of Once Daily Insulin And Once Weekly Insulin In Patients With Diabetes Mellitus, Carly Gilbertson

Physician Assistant Scholarly Project Papers

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or a combination of both. The purpose of this literature review is to determine if patients with diabetes mellitus taking once weekly insulin injections compared to once daily insulin injections offer the same, or better, effectiveness at lowering their HbA1c. This is critical in the management and progression of the disease. The electronic databases PubMed, Clinical Key and Embase were searched and there were 92 articles found. Inclusion criteria included articles published within the past 5 years, randomized clinical trials and meta-analysis. …

Monoclonal Antibody Therapy Versus Oral Immunotherapy In Food Allergies, Kendra Bohm

Physician Assistant Scholarly Project Papers

Food allergies are classified as an immune hyperreaction that leads to various symptoms that can range from mild to severe and even result in death. Often, management of food allergies includes avoidance of triggering substances or rescue treatment after exposure has occurred. This literature review aims to examine preventative management options for food allergies, including oral immunotherapy, and recent medications, including monoclonal antibodies. The databases searched for this literature review include PubMed, Embase, and Google Scholar. Additional references were also selected from reference lists in those studies as they pertained. This review explores the success in reaching desensitization following treatment …

Analysis Of Pre-Procedural Intranasal Anxiolytic Use In The Emergency Treatment Of Pediatric Laceration Repair, Mackenzie Weis

Physician Assistant Scholarly Project Papers

Pediatric laceration repair is a common, yet anxiety-inducing procedure for patients who must undergo them, with limited research analyzing the different types of pre-procedural anxiolytic medications. The purpose of this research and literature review was to analyze two different, but commonly used intranasal anxiolytics, dexmedetomidine and midazolam, and to compare the efficacy, adverse effects, and overall pediatric anxiety and parental satisfaction. Only articles including clinical trials and pediatric participants were included. A combination of keywords and MeSH phrases included, but were not limited to “pediatric”, “laceration repair”, “anxiolytic”, “administration intranasal”, “intranasal midazolam”, “intranasal dexmedetomidine”, and “parent satisfaction” were used to …

Safety And Efficacy Of Combined Glucosamine And Chondroitin Supplementation In Osteoarthritis, Klayton Johnson

Physician Assistant Scholarly Project Papers

According to the CDC, over 30 million adults in the United States have osteoarthritis, many of whom experience pain, stiffness, and swelling that hinder daily activities. Typical treatment consists of nonsteroidal anti-inflammatory drugs, which are associated with gastrointestinal, renal, and cardiovascular risks. This literature review examines key research on glucosamine and chondroitin supplementation to provide a comprehensive understanding of its impact on adults with osteoarthritis. A literature search was conducted using the electronic databases PubMed, Embase, and Google Scholar. Keywords and MeSH terms were used to identify studies discussing the combination of glucosamine and chondroitin as a potential alternative, effective, …

Disparities In Guideline-Directed Medical Therapies In Rural And Underserved Heart Failure Patients, Shawn Mcclaughry

Physician Assistant Scholarly Project Papers

Heart failure with reduced ejection fraction (HFrEF) continues to be a substantial public health challenge, thus optimal management through guideline-directed medical therapy (GDMT) continues to be vital. Evolving GDMT has established four pillars of first-line optimal treatment with expeditious and maximized titration of established target dosing of pillar medications. GDMT has been shown to decrease mortality among HF patients. Although continuing advancements in treatment efficacy prevail, studies demonstrate that vulnerable populations, particularly rural, Black and Hispanic individuals, exhibit significantly lower rates of GDMT optimization, leading to increased hospitalization and mortality. This literature review evaluates disparities in GDMT implementation among urban, …

Efficacy Of Stem Cell Therapy Versus Standard Drug Therapy In Adults With Heart Failure, Evie Reynolds

Physician Assistant Scholarly Project Papers

Myocardial infarction (MI) or other damage to the heart tissue may result in ischemia, and because cardiomyocytes have limited regenerative capacity, this often leads to the development of heart failure (HF). Typical symptoms of HF include dyspnea, edema, cough, fatigue, and chest pain, which arises from fluid overload and congestion. Current medical treatments focus on alleviating these symptoms through loop diuretics, which reduce fluid accumulation but do not treat the underlying ischemic damage. Recent studies have shifted focus towards stem cell therapy, which have shown potential to differentiate into cardiomyocytes and regenerate ischemic heart tissue. A comprehensive search of databases …

Efficacy Of Prediabetes Management Options For Lowering Cardiovascular Risk, Cassidy Mindeman

Physician Assistant Scholarly Project Papers

Around 86 million people in the United States are diagnosed with prediabetes, a metabolic syndrome characterized by insulin resistance and inflammation. The inflammatory nature of the disease increases a patient's cardiovascular risk. Common treatment options include metformin and lifestyle intervention – primarily exercise and diet plans. However, there is no standard medical recommendation for lowering cardiovascular risk. The purpose of this literature review is to determine which treatment options, including the combination of lifestyle and intervention, best lower cardiovascular risk and better detail the effect of prediabetes on cardiovascular risk. Electronic databases PubMed and Embase were utilized and 12 studies …

Creating A Multi-Sensory Room At The University Of Arkansas, Alexandra R. Smith

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Autism Spectrum Disorder, or autism, is a genetic neurological condition that can affect all aspects of an individual’s life, depending on their symptoms. Autistic people tend to struggle most significantly with social and emotional issues, which often results in declining academic success. With such a multifaceted disability, autistic students can struggle to perform at the same standards as their non-autistic peers, mostly due to the complications from their disability paired with limited accommodations. The consequences of these issues can manifest as lower admission rates, higher dropout rates, and higher stress levels for autistic students. This creative and service-learning honors thesis …

Functional Characterization Of The C-Terminal Cholinesterase-Like (Chel) Domain Of The Thyroid Hormone Precursor Protein, Berenice Morales-Rodriguez

Pharmaceutical Sciences (MS) Theses

Vertebrate life is unsustainable without thyroid hormones. The only known precursor for thyroid hormone synthesis is thyroglobulin (Tg), composed of upstream regions I-II-III and a C-terminal cholinesterase-like (ChEL) domain, which bears 47% similarity to acetylcholinesterase (AChE). Mutations in Tg cause congenital hypothyroidism, the most common congenital endocrinopathy affecting 1 in 2,000-4,000 newborns, with a varying degree of phenotypic manifestations. Tg protein, regulated by TSH, is secreted to the lumen of thyroid follicles, where thyroxine (T₄) is formed primarily at the N-terminus, and triiodothyronine (T₃) is formed primarily in the ChEL domain. Previous in vitro studies indicated …

Implementation Guidelines For Total Hip And Total Knee Arthroplasty To Reduce The Incidence Of Deep Vein Thrombosis And Subsequent Pulmonary Embolism, Mitchell Mccorkle

Doctor of Nursing Practice Scholarly Projects

With patients living longer, the orthopedic sector has given rise to joint prostheses as a treatment for those experiencing osteoarthritis (OA). With the increase of these procedures, there is also an increased risk of deep vein thrombosis (DVT) and subsequent pulmonary embolus (PE) following these surgical procedures. The orthopedic medical community and anesthesia providers aim to decrease DVT and PE risk through multiple modalities. The anesthesia focuses on reducing DVT, and PE involves a multimodal approach to each anesthetic. Modalities used for the multimodal approach involve peripheral nerve blocks (PNB), neuraxial spinal anesthesia, early mobilization, postoperative nausea and vomiting (PONV) …

The Impact Of Structured Feedback And Evaluation Systems On Clinical Preceptor Performance And Student Satisfaction In Medical Laboratory Science Programs, Kyleen Newman, Mary Coleman, Heather Langerud

Medical Laboratory Science Independent Study Projects

Medical Laboratory Science (MLS) students' education heavily relies on clinical practicum experiences to bridge the gap between theory and practice. Knowledgeable clinical preceptors are vital for engaging and inspiring learning and enabling students to interact within authentic clinical environments involving laboratory peers, patients, and healthcare providers. This literature review explores the impact of implementing a structured feedback and evaluation system for clinical preceptors in medical laboratory science (MLS) programs, highlighting its influence on student satisfaction and preceptor performance. The databases utilized for this literature review include PubMed and CINAHL. Due to a profound lack of published literature available additional healthcare …

Benefits Of Succession Planning In Medical Laboratories, Christina Jones, Samantha Peterson, Robert Porter

Medical Laboratory Science Independent Study Projects

This discussion examines the potential impact of implementing a succession plan in the laboratory to reduce survey deficiencies. It highlights the importance of understanding the determinants of quality in the lab, addressing staffing shortages and turnover, and the role of succession plans in improving workplace quality. Quality encompasses various aspects from quality control to quality management. Accreditation and inspection processes, such as those required by the Clinical Laboratory Improvement Amendments of 1988 (CLIA ‘88), play a crucial role in ensuring quality laboratories.

However, frequent turnover, including leadership changes, poses challenges to maintaining quality. The laboratory workforce faces high turnover rates …

Targeting Student Outcomes Through Implementation Of Laboratory Experiences In A First Year Medical Neuroanatomy Course, Grant Boxey

Anatomical Education Dissertations

The pillars of anatomical sciences, including neuroanatomy, have undergone massive shifts in their teaching methodologies in recent years. With the increased enrollment in graduate medical education, as well as the introduction of new technologies, the anatomical sciences have reformed the ways in which future healthcare practitioners learn. Among the challenges to neuroanatomical education have been reliable access to donor specimens, and a decrease in laboratory-based hours. This study evaluated the introduction of voluntary laboratory-based experiences within a first-year medical neuroanatomy course. The first research question evaluated the effect of hands-on laboratory experiences on examination performance between participants and non-participants. There …

Designing For Autonomy: Enhancing The Autonomy Of Young Women With Postural Orthostatic Tachycardia Syndrome (Pots) Through Interactive Narrative, Jessica Gobble

Graduate Theses and Dissertations

Postural Orthostatic Tachycardia Syndrome (POTS) is an autonomic nervous system disorder with multisystem impacts. Classified as a chronic illness and oftentimes triggered by viral infections, incidents of POTS have become increasingly common following the outbreak of COVID-19. Primarily affecting young women ages 18 to 30, POTS disrupts an individual's health during their transition to adulthood. This issue is further complicated by medical gender bias, latent care, and misdiagnosis, which leave this demographic vulnerable within traditional healthcare systems (Shaw et al., 2019). As traditional healthcare systems primarily address acute rather than chronic conditions, interactions with these systems are intermittent. Consequently, individuals …

Education For Healthcare Providers: Psilocybin-Assisted Psychotherapy, Chelsi Carlson

Theses and Graduate Projects

Psilocybin-assisted psychotherapy is emerging as a promising therapeutic modality for addressing psychological distress in psychiatric and palliative care settings. This scholarly project explores the current literature on psilocybin-assisted therapy, providing an educational framework for healthcare providers regarding its clinical applications, potential benefits, and safety considerations. With the rise in treatment-resistant mental health disorders, there is an increasing need for innovative and holistic approaches to care. This project evaluates healthcare providers’ existing knowledge and attitudes toward psilocybin therapy and delivers an educational intervention aimed at reducing stigma and fostering informed clinical perspectives. Grounded in Margaret Newman’s Theory of Health as Expanding …

Analysis Of The Mechanical, Microstructural, And Biocompatibility Properties Of Novel Magnesium-Based Hybrid Nanocomposite Materials For Orthopedic Applications, Thomas H. Mcgehee

Biomedical Engineering Undergraduate Honors Theses

Bone fractures and complete joint replacements are becoming more common, primarily because of accidents and age-related issues. Conventional solutions to treat these orthopedic injuries involve inert metal alloys to correct bone fractures until the healing process is complete, where a secondary revision surgery is then required to remove the implant. Issues regularly associated with these solutions include stress shielding, bone resorption, infection, inflammation, and implant loosening. Magnesium (Mg)-based nanocomposites offer promising potential as an alternative to commonly used metal alloys because of their favorable mechanical properties and biocompatibility. A particularly advantageous property of Mg is its natural biodegradation in vivo, …

Promotion Of Women’S Preventative Health Behaviors For Breast And Cervical Cancer, Shelby Lopez

Doctor of Nursing Practice Scholarly Project

Women’s health prevention is typically not a significant topic for discussion. Health prevention measures are often discussed after a new diagnosis, rather than being a proactive approach toward improving women’s health. Breast and cervical cancer continue to be prevalent today and, to decrease the number of women diagnosed with late-stage cancer, this scholarly project will focus on improving the participation in prevention behaviors among women 18-45 years of age, but also acknowledge the role self-efficacy and perception of health behaviors has on the participation in prevention measures. Pender’s Health Promotion Model will help acknowledge how social-behavioral factors affect prevention behaviors. …

Promoting Increased Consumption Of Fruits And Vegetables In Older Adults Through Self-Efficacy And Social Cohesion, Ashley Lynn Nelson

Doctor of Nursing Practice Scholarly Project

The purpose of this scholarly project was to design and offer a nutrition education program on fruit and vegetable consumption to a group of rural adults aged 65 and older. It was hypothesized that the nutrition program would directly motivate older adults to increase dietary consumption of fruits and vegetables. The project utilized the Health Promotion Model as the theoretical framework. To incorporate this project into a quantitative design, the methodological design that was applied is a non-experimental or observational design. This project included a four-week educational program in the Spring of 2023 that provided information on the importance of …

Improving Breast Cancer Modifiable Risk Factor Knowledge Among Patients In A High Risk Breast Cancer Prevention Clinic In The Midwest, Bailee Torneden

Doctor of Nursing Practice Scholarly Project

Preventative health care is the best choice in moving forward to reduce disease incidence. In the case of breast cancer, prevention clinics have been set up for those who have been determined as a high risk status for developing breast cancer over the course of their lifetime. There are many risk factors for breast cancer that are out of the patient’s control, but there are lifestyle health behaviors that could be implemented to lower the patient’s risk. The potential impact of these can not only lower the incidence of breast cancer, but can be linked with reduction of other disease …

How Multidisciplinary Teams (Mdts) Shape The Occupational Therapy (Ot) Experience: Communication, Collaboration, And Challenges, Grace Schmidt

Theses/Capstones/Creative Projects

The goal of this study was to evaluate how occupational therapists (OTs) contribute to patient care within multidisciplinary teams (MDTs), with a focus on the challenges and benefits of collaboration. The research was conducted at Quality Living Inc. (QLI), a rehabilitation center specializing in neurological recovery. Four healthcare professionals (two occupational therapists, one physical therapist, and one exercise assistant) participated in interviews, either in person or over Zoom during the spring 2025 semester. A brief survey was used to collect demographic data, and nineteen open-endemd interview questions guided the data collection process. Responses were analyzed thematically and categorized into three …

Computationally Assessing The Specificity Of Receptor Tyrosine Kinase Inhibitors, Htoo Say

Theses/Capstones/Creative Projects

Receptor tyrosine kinases (RTKs) are vital to cell signaling processes such as growth, survival, and differentiation. Dysregulation through mutation or overexpression often contributes to cancer, making RTKs key therapeutic targets for tyrosine kinase inhibitors (TKIs). However, the low specificity of many TKIs leads to off-target effects. This project uses molecular docking to evaluate the binding affinities and selectivity of FDA-approved TKIs across 18 RTK subtypes. The dockings conducted revealed significant variability in binding affinities, with Sorafenib exhibiting strong specificity for EphB2 (-7.6 kcal/mol) and poor compatibility with EphA7 and ErbB4 (-3.0 kcal/mol). These findings underscore the role of specific molecular …

Justification For The Biological Foundation Of Methane On Mars: Methanogens’ Capacity To Metabolize On Montmorillonite Clay And Basalt, Ashley Ezeldin

Biological Sciences Undergraduate Honors Theses

The possibility of extraterrestrial life, particularly on Mars, remains a compelling question in astrobiology. Mars' harsh atmospheric conditions, dominated by carbon dioxide and extreme cold, prevent the survival of aerobic species. However, it still leaves the possibility of methanogens, an anaerobic species that can survive in extreme conditions, to inhabit this planet. Due to the discovery of methane on Mars, it is possible that methanogens may live and grow in the subsurface of this planet.

For this experiment, basalt and montmorillonite clay were chosen as substrates because they are believed to be found in the composition of Mars's subsurface. Methane, …

Understanding The Impact Of Language Barriers And Visit Duration On Caregiver Satisfaction In Pediatric Primary Care, Gavin Miller

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Children from households that speak languages other than English (LOE) face barriers in accessing healthcare, leading to poorer health outcomes. Language barriers contribute to these disparities, often resulting in diminished communication between providers and families. Visit duration may play a key role in facilitating effective communication and improving patient satisfaction.

Purpose: This study examines how language barriers affect caregiver satisfaction in pediatric primary care, and whether visit duration mediates this relationship. We hypothesized that caregivers from LOE households would have comparable visit durations to English-preferring caregivers but report lower satisfaction due to receiving less information within that time. …

The Inclusion Of Goal Setting In Promoting Exercise Adherence In Adolescent Athletes Who Sustained A Concussion: A Critically Appraised Topic, Caitlin Culhane

All Student Scholarship

Introduction/clinical scenario: Almost 2 million youth in the US sustain a concussion every year with several of them experiencing persistent post concussive symptoms. Past intervention has suggested that rest until symptom free is the best approach, while current findings suggest this approach is outdated and early exercise can help with a faster recovery. Several studies have researched the effects of goal setting strategies in different populations however there is a need for study in adolescent athletes. Focused clinical question: Is goal setting beneficial in promoting exercise adherence for adolescent athletes who sustained a sports related concussion? Summary of key findings: …

Advancing Research On Retinitis Pigmentosa: An Investigation Of Natural History, Visual System Plasticity, And Mutation-Independent Treatment., Cecilia A. Attaway

Electronic Theses and Dissertations

Retinitis Pigmentosa (RP) is an inherited retinal disease characterized by rod and then cone photoreceptor degeneration. ~25% of cases are caused by a genetic mutation that results in autosomal dominant RP (adRP). There has been a lack of exploration of the progression of degeneration in adRP models. In Chapter Two, I examined visual acuity (VA) changes, retinal structure, and function from early to late-stage disease in a murine P23H Rho ‘knock-in’ mouse model (Rho^P23H/+), the most common form of adRP in North America. To establish a natural history, I evaluated behavioral VA, using the visual water task, …

The Dynamic Role Of Hyaluronan In Acute Cardiac Wound Healing., Danielle T. Little

Electronic Theses and Dissertations

During acute myocardial infarction (MI), the composition of the extracellular matrix (ECM) undergoes significant changes. While collagen accumulation is one of the most well-documented ECM alterations, hyaluronan (HA) is equally abundant. However, the cellular sources, enzymatic regulation, and functional significance of HA accumulation remain largely unexplored. Here, we hypothesized that activated cardiac fibroblasts produce HA via hyaluronan synthase 2 (HAS2), facilitating scar formation and stability. Our findings demonstrate that HA accumulates post-MI and persists for at least four weeks. Through HA sizing techniques, we determined the molecular weight of this persistent HA. Additionally, RNA sequencing analysis of failing human hearts …

New Bayesian Methods For Longitudinal Data Analysis With Complex Dependence Structures., Anish Mukherjee

Electronic Theses and Dissertations

Longitudinal data in real-world settings are frequently found to be heterogeneous and exhibit intricate spatio-temporal dependence structures. Analyzing such complex data to obtain reliable estimation while quantifying uncertainty necessitates using sophisticated Bayesian methodology. In this work, we present novel Bayesian methods developed to address these challenges. We often observe heterogeneity in longitudinal data, where the mean and variance for certain profiles meaningfully differs from the rest. Some profiles may also exhibit outliers at a limited number of measurements. Using a standard mixed effects model, which assumes homogeneity, can lead to overestimating the residual variance and inefficient estimation. In this work, …

The Role Of Tgfβ-Activated Kinase 1 In Fibroblast Differentiation And Cardiac Remodeling After Injury., Daniel Chien Nguyen

Electronic Theses and Dissertations

Immediately following myocardial injury, a robust reparative response is orchestrated through intercellular communication. While various cell populations play critical roles in this process, cardiac fibroblasts have long been recognized as essential mediators of collagen synthesis and scar maturation; however, recent investigations have uncovered significant heterogeneity within the cardiac fibroblast population, revealing distinct subpopulations with roles that extend beyond their traditional functions. Notably, after tissue injury, fibroblasts exposed to damage signals can transition to an inflammatory phenotype, utilizing paracrine and autocrine signaling to coordinate immune cell recruitment and activation. Yet, the mechanisms underlying inflammatory cardiac fibroblast differentiation and their influence on …

Racial Disparity And Environmental Influences On Perinatal Health In Jefferson County, Kentucky., Felicia A Pugh

Electronic Theses and Dissertations

Background: Severe maternal morbidity (SMM) risk has tripled over the past 30 years. Adverse infant birth outcomes in the U.S. have also increased with substantial Black-White disparities. Objectives: This work compares the frequency of adverse maternal and infant birth outcomes by maternal race (Black vs White) and examines associations between maternal ambient heavy metal exposures and birth outcomes in Jefferson County, Kentucky, 2017-2022. Methods: Jefferson County inpatient hospital delivery and birth certificate records of self-identified Black or White birthing parents were used. Incidence of SMM, stillbirth, preterm birth (PTB), and small for gestational age (SGA) with 95% confidence intervals (CI) …

Advancing Speech Intelligibility Assessment: Comparing School-Based Speech-Language Pathologists, Laypersons, And Speech Recognition Software., Hannah Stewart

Electronic Theses and Dissertations

This non-experimental study utilized a convenience sample (N = 86) to investigate the comparability of school-based speech-language pathologists (SLPs), laypersons, and speech recognition software in the assessment of speech intelligibility for children with phonological disorders. Eighty-nine percent of participants were female, and 92% were white. All participants completed a survey comprised of 25 audio recordings of single-word utterances from an AI-generated voice of a four-year-old male with a phonological disorder and were asked to select what word they believed was heard from a pool of 12 options. The survey also included a passage read by the same AI-generated voice, and …