Medicine and Health Sciences Commons^™

The Interrelationships Among A Concussion-Related Biomarker, Head Hits, And Impact Test In Collegiate Football Players, Lucas Bianco

UNLV Theses, Dissertations, Professional Papers, and Capstones

Head injuries are prevalent in collegiate athletics with concussions being common among contact sports, such as football. Concussion assessment and diagnosis is complicated by the lack of objective and assessment techniques. The purpose of the study was to determine if there is a relationship between the level of a concussion-related biomarker, self-report (subjective) head hits, video-analyzed head hits, and ImPACT test scores in college football athletes before and after a football practice session.

After being recruited and consented to participate, 29 Division I college football athletes provided a blood sample via finger stick two days before a 2014 spring football …

Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes

Master's Theses

The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual examination of suspicious regions …

Investigation Of Dna And Rna Markers By Novel Technologies Demonstrates Dna Content Intratumoral Heterogeneity And Long Non-Coding Rna Aberrations In Breast Tumors, Zhouwei Zhang

Graduate College Dissertations and Theses

BACKGROUND:

Breast cancer is the most commonly diagnosed cancer and second leading cancer death cause among females in the U.S.A. About 1 in 8 women in U.S will develop invasive breast cancer over the course of her lifetime. In 2013, 234,580 new invasive breast cancer cases are expected to occur in women within the US and approximately 64,640 non-invasive carcinomas in situ were diagnosed in 2013, most of which were ductal carcinoma in situ (DCIS). Along with technological advances, a wide variety of candidate biomarkers have been proposed for cancer diagnosis and prognosis, including DNA content and non-coding RNA. Current …

Quantitative Mass Spectrometric Investigations Of Protein Biomarkers: Serum Thymidine Kinase 1 And Human Osteopontin, Morse Faria

Theses and Dissertations

Mass spectrometry is being increasingly used in biomarker research mainly due to its ability to achieve high selectivity coupled with high sensitivity. This dissertation focuses on quantitative mass spectrometric investigations of two protein biomarkers i.e. serum thymidine kinase 1 (TK1) and human osteopontin (OPN).

First part of this research was focused on developing a liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method for measuring the activity of TK1 in serum by monitoring the conversion of a TK1 specific exogenous substrate, 3’-deoxy-3’-fluorothymidine (FLT), to its mono-phosphorylated form 3’-deoxy-3’-fluorothymidine monophosphate (FLT-MP). A method to quantify FLT-MP on LC-MS/MS was developed and …