Medicine and Health Sciences Commons^™

Overview Of Inference About Roc Curve In Medical Diagnosis, Jingjing Yin

Biostatistics Faculty Publications

Medical diagnosis aims to identify diseased individuals through the evaluation of the measurements of some biomarkers by performing a diagnostic test based on some biomarker measurements. Biomarkers are measured on either discrete or continuous scale and continuous biomarkers are utilized more often in medical practice. This article introduces the most popular tool for evaluating continuous biomarkers: the Receiver Operating Characteristic (ROC) curve.

The Interrelationships Among A Concussion-Related Biomarker, Head Hits, And Impact Test In Collegiate Football Players, Lucas Bianco

UNLV Theses, Dissertations, Professional Papers, and Capstones

Head injuries are prevalent in collegiate athletics with concussions being common among contact sports, such as football. Concussion assessment and diagnosis is complicated by the lack of objective and assessment techniques. The purpose of the study was to determine if there is a relationship between the level of a concussion-related biomarker, self-report (subjective) head hits, video-analyzed head hits, and ImPACT test scores in college football athletes before and after a football practice session.

After being recruited and consented to participate, 29 Division I college football athletes provided a blood sample via finger stick two days before a 2014 spring football …

Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes

Master's Theses

The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual examination of suspicious regions …

Passive Smoking As A Stress Factor In Diabetic Children, Maha A. Tawfik, Maha A. El Bassuoni, Rabab A. Elsabagh, Soheir S. El-Ella

Menoufia Medical Journal

Objective This study aimed to measure urinary cotinine level and urinary cotinine/creatinine ratio as a biomarker of passive smoking in diabetic children. DNA damage was estimated in peripheral leukocytes by a DNA fragmentation assay in diabetic children. Background Exposure to passive smoking is associated with a number of health hazards such as prenatal damage to the fetus, poor growth, respiratory illness, atopy and asthma, coronary heart disease, and sudden infant death syndrome. Patients and methods This study was carried out on 54 diabetic children attending the Genetic and Endocrine Unit of the Pediatric Department, Faculty of Medicine, Menoufia University. The …

Circulating Tumor Cells In Metastatic Breast Cancer: A Prognostic And Predictive Marker, Sayyed Farshid Moussavi-Harami, Kari B. Wisinski, David J. Beebe

Journal of Patient-Centered Research and Reviews

The role of circulating tumor cells (CTCs) as a marker for disease progression in metastatic cancer is controversial. The current review will serve to summarize the evidence on CTCs as a marker of disease progression in patients with metastatic breast cancer. The immunohistochemistry (IHC)-based CellSearch^® is the only FDA-approved isolation technique for quantifying CTCs in patients with metastatic breast cancer. We searched PubMed and Web of Knowledge for clinical studies that assessed the prognostic and predictive value of CTCs using IHC-based isolation.

The patient outcomes reported include median and Cox-proportional hazard ratios for overall survival (OS) and progression-free survival …

Urinary Cotinine Level In Passive Smoker Nondiabetic Children Of Diabetic Families, Maha A. Tawfik, Maha A. El Bassuoni, Mohamed I. Yahia, Soheir S. Abou El-Ella

Menoufia Medical Journal

Objective The aim of the study was to measure urinary cotinine level as a biomarker of passive smoking in children. Background Children«SQ»s exposure to passive smoking is associated with a number of health hazards such as prenatal damage to the fetus, poor growth, respiratory illness, atopy and asthma, coronary heart disease, and sudden infant death syndrome. Materials and methods This study was conducted on 54 nondiabetic children from attendance of Genetic and Endocrine Units of Pediatric Department, Menofiya Faculty of Medicine. They were divided into two groups: group A (34 children exposed to passive smoking) and group B (20 children …

Investigation Of Dna And Rna Markers By Novel Technologies Demonstrates Dna Content Intratumoral Heterogeneity And Long Non-Coding Rna Aberrations In Breast Tumors, Zhouwei Zhang

Graduate College Dissertations and Theses

BACKGROUND:

Breast cancer is the most commonly diagnosed cancer and second leading cancer death cause among females in the U.S.A. About 1 in 8 women in U.S will develop invasive breast cancer over the course of her lifetime. In 2013, 234,580 new invasive breast cancer cases are expected to occur in women within the US and approximately 64,640 non-invasive carcinomas in situ were diagnosed in 2013, most of which were ductal carcinoma in situ (DCIS). Along with technological advances, a wide variety of candidate biomarkers have been proposed for cancer diagnosis and prognosis, including DNA content and non-coding RNA. Current …

Quantitative Mass Spectrometric Investigations Of Protein Biomarkers: Serum Thymidine Kinase 1 And Human Osteopontin, Morse Faria

Theses and Dissertations

Mass spectrometry is being increasingly used in biomarker research mainly due to its ability to achieve high selectivity coupled with high sensitivity. This dissertation focuses on quantitative mass spectrometric investigations of two protein biomarkers i.e. serum thymidine kinase 1 (TK1) and human osteopontin (OPN).

First part of this research was focused on developing a liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method for measuring the activity of TK1 in serum by monitoring the conversion of a TK1 specific exogenous substrate, 3’-deoxy-3’-fluorothymidine (FLT), to its mono-phosphorylated form 3’-deoxy-3’-fluorothymidine monophosphate (FLT-MP). A method to quantify FLT-MP on LC-MS/MS was developed and …