Medicine and Health Sciences Commons^™

Diagnostic Accuracy Of Axillary Ultrasound In Predicting Nodal Metastasis Among Patients With Early Breast Cancer At Aga Khan University Hospital, Nairobi, David Mwaniki

Theses & Dissertations

With emerging evidence showing that the incidence of breast cancer in Kenya is increasing, there is renewed emphasis on screening, early detection, and management of breast cancer. Early breast cancer (EBC) has a better prognosis and is potentially curable. Axillary nodal metastasis is an important prognostic indicator in breast cancer. Axillary ultrasound is the best modality for assessing, and managing, the affected nodes. It is a readily available and versatile tool with several sonographic nodal characteristics suggestive of metastatic involvement having been described in previous studies. Axillary ultrasound (AUS) performance in predicting nodal metastasis has yielded variable results which are …

Efficacy Of Preoperative Manual Detorsion For Intravaginal Testicular Torsion: A Systematic Review, Ralph Ombati

Theses & Dissertations

Background: Preoperative manual detorsion for acute testicular torsion has been postulated to improve testicular salvage rates through reduction in testicular ischemia time. Manual detorsion however has several potential risks including worsening degree of torsion, incomplete detorsion and potentially missing the opportunity to perform definitive orchidopexy.

Objectives: To assess the efficacy of preoperative manual detorsion compared to immediate scrotal exploration in improving testicular salvage in acute intravaginal testicular torsion.

Methods: The MEDLINE, SCOPUS and AJOL databases along with the CENTRAL registry were searched for trials comparing preoperative manual detorsion to immediate scrotal exploration for acute intravaginal testicular torsion. Both randomized and …

Feasibiity And Acceptability Of Tele-Neurology Services At A Regional Tertiary Referral Centre: A Prospective Study., Fazal Yakub

Theses & Dissertations

Background: Neurological diseases are a leading cause of morbidity and mortality worldwide with a great burden lying in Sub-Saharan Africa. The paucity of neurologists in the region makes neurological care disproportionately inaccessible. Utility of tele-medicine is low cost, time efficient, convenient, reducing the carbon footprint and ultimately increasing health care access.

Objective: We identified whether the concept of tele-neurology was feasible within our setup for patients with stable neurological diseases while establishing the cost effectiveness, efficiency, convenience and the carbon footprint burden.

Methods: We conducted a prospective cross-sectional study. New patients were triaged by the neurologist based on guidelines from …

Hiv Among Cancer Patients: Prevalence And Cancer Description By Hiv Status, Diana Wambui Muturi

Theses & Dissertations

Background: Antiretroviral therapy (ART) has resulted in a higher life expectancy of persons living with Human Immunodeficiency Virus (PLHIV) leading to an aging population at risk for non-AIDS defining cancers (NADCs) rather than AIDS-defining cancers (ADCs). Identification of HIV-cancer comorbidity through diagnostic HIV testing of patients presenting for cancer care is not offered routinely. The HIV prevalence among cancer patients in Kenya is undefined. In addition, the spectrum of malignancies in PLHIV has not been well characterized outside of ADCs.

Objective: Our primary objective was to determine the prevalence of HIV among patients with cancer. Secondary objectives were to determine …

Determinants Of The Uptake Of Prenatal Aneuploidy Screening Among Pregnant Women At The Aga Khan University Hospital, Nairobi, Kenya, Duncan Ndegwa

Theses & Dissertations

INTRODUCTION: Aneuploidies present with an abnormal copy number of chromosomes. Majority are lethal with only a handful carrying on to term and beyond in pregnancy. Its currently recommended that all pregnant women be offered screening for aneuploidies. This is to facilitate pregnant women make informed choices regarding their pregnancies. At present the current uptake rate of aneuploidy screening in Kenya is unknown. The purpose of this study this study was to determine whether pregnant women are aware of aneuploidy screening, the uptake rate of screening and the determinants of screening at a tertiary private healthcare facility in Nairobi, Kenya.

METHODS: …

Randomized Controlled Trial Comparing Post Operative Pain Outcome Between Suture And Tissue Glue Wound Apposition Post-Circumcision In The Pediatric Age Group, Happiness Obare

Theses & Dissertations

Introduction: Circumcision is one of the oldest and most common surgical procedures in the male population. Of the various circumcision techniques, sutures and tissue glue are utilized for wound closure in the free-hand techniques. Locally, sutures are routinely used for wound closure in the free-hand techniques. Whilst there are studies comparing the two wound apposition techniques using various outcomes, pain as a primary outcome comparing the two has been poorly researched. One hypothesis is that local ischemia at the suture site contributes to post-circumcision pain. It is against this background that we sought to explore differences in pain between these …

Diagnostic Utility Of Red Cell Indices In Relation To Serum Iron Indices For Evaluation Of Iron Deficiency In Heart Failure, Larry Wangai Mburu

Theses & Dissertations

Background: Iron deficiency (ID) in heart failure (HF) causes poorer outcomes, and evaluation using ferritin and transferrin saturation (TSAT) in our setting is hampered by cost and availability. Though the red cell indices (RCIs), routinely used for assessment of ID anaemia, have shown utility in predicting outcomes in HF, they have not been evaluated in this population for prediction of ID relative to the iron indices. A combination of the RCIs, the combined cell index (CCI), may be more accurate. Validating the diagnostic accuracy of the RCIs would improve evaluation of ID in low-resource settings and improve uptake of iron …

Dysglycemia In Patients Presenting With Stroke And Acute Coronary Syndrome At Aga Khan University Hospital, Nairobi, Beverly Yongo Owino

Theses & Dissertations

Background: Dysglycemia is often diagnosed late in sub-Saharan Africa with a significant number of patients presenting with complications. Data is needed to expand knowledge on the impact diabetes has on major adverse cardiovascular outcomes.

Objective: We aimed to determine the prevalence of dysglycemia in patients with stroke and Acute Coronary Syndrome (ACS) and define characteristics of the patients with dysglycemia.

Methods: A prospective cross-sectional study was conducted at Aga Khan University Hospital, Nairobi which is a tertiary facility. Consenting adults above 18 years (n=211) with stroke and acute coronary syndrome were recruited in the study in the period of April …

Renal Angina Index As A Predictor Of Acute Kidney Injury In Critically Ill Children, Athul Shelly Kooliyath

Theses & Dissertations

Background: Acute kidney injury is associated with increased morbidity and mortality in hospitalized children. In the critically ill,DR WILLIAM M MACHARIA acute kidney injury (AKI) is prevalent and difficult to diagnose. Using conventional methods, AKI is often missed thus delaying the diagnosis up to 48 hours after initial injury. Though some biomarkers that identify AKI early have been identified, they may still be insufficient due to prohibitive costs. Renal angina index is used to identify ongoing renal injury. It is a product of the clinical state and the estimated glomerular filtration rate (eGFR) of a patient during admission to a …

Optimal Fasting Duration To Effectively Suppress Physiological 18f- Fluorodeoxyglucose (Fdg) Myocardial Uptake On A Positron Emission Tomography Scan., Fatima Abdullahi Ali

Theses & Dissertations

Background: Positron emission tomography (PET) with 18F fluorodeoxyglucose (FDG) is used in evaluation of inflammatory disorders, including the heart such as cardiac sarcoidosis and myocarditis. However, the normal uptake of the myocardium is a challenge as it can obscure pathological uptake in these conditions. The primary objective of this study is to determine the optimal fasting duration to suppress physiological myocardial uptake and thereafter establish an imaging protocol.

Methods: Patients who had whole body FDG PET CT examination for oncological evaluation at the Aga Khan University Hospital between January 2019 and December 2020 were retrospectively reviewed. Patients were divided into …

Association Between Third Trimester Cerebro-Placental Ratio And Adverse Outcomes In Appropriate For Gestational Age Foetuses, Morris Wabacha Kimani

Theses & Dissertations

Background: Small for gestational age (SGA) fetuses are at increased risk of adverse outcomes and appropriate vigilance is put in place in terms of antenatal and intrapartum surveillance. Appropriate for gestational age (AGA) fetuses have a lower incidence of adverse outcomes, although majority of these outcomes occur in this cohort. AGA fetuses can fail to reach their genetic growth potential due to placental insufficiency and 25 % have actually been found to have placental histological features of chronic hypoxia. Therefore, there is need to use other methods of screening for adverse perinatal outcomes apart from estimated fetal weight (EFW), with …

Validation Of The Kiswahili Version Of The Migraine Disability Assessment Scale In Dar Es Salaam, Tanzania, Aliasger Nagri

Theses & Dissertations

Background: Migraine is a chronic paroxysmal neurological disorder characterized by multiphase attacks of head pain and many neurological symptoms. The MIDAS is a five (5) question-based questionnaire used in clinical practices to identify the disability caused by migraine at work, school, household or social life; with a score indicating little or no disability (0-5), mild disability (6-10), moderate disability (11-20), and severe disability (21+). Translated versions of the MIDAS scale in a number of languages has been validated. Translating and validating the Kiswahili version of the MIDAS questionnaire is essential and needed to ensure its comparability to the original English …

Radiological Comparison Of Tumour Burden Of Lymphoma In Hiv Positive And Hiv Negative Patients, Poonamjeet Kaur Loyal

Theses & Dissertations

Introduction: Patients with Human Immunodeficiency Virus (HIV) are known to exhibit atypical pattern of lymphoma on imaging. There is paucity of literature on differences in tumour volume or burden of disease amongst HIV positive patients compared with HIV negative patients and how this correlates with clinicopathological parameters of aggressiveness and effects on prognosis.

Objective: The purpose of this study was to evaluate the tumour burden of non-Hodgkin’s lymphoma in HIV positive patients compared with HIV negative and how this correlates with the clinicopathological parameters of aggressiveness and the overall clinical outcome.

Methods: This was a retrospective analytical cross-sectional study. All …

What Motivates The Choice Of Specialty Among Medical Doctors In Tanzania, Thabit Ramadhani

Theses & Dissertations

Background: Studies have shown there is a low specialist workforce, coupled with wide range of disparity among different specialities in the country to cater for the needs of more than 54 million Tanzanians. The theories of motivation and development have shown many theories influencing choices made by people in life.

Objectives: This study aims to assess the motivation for choice of specialty among medical doctors (including registrars, residents, and specialists) in Dar es Salaam, Tanzania.

Methods: A descriptive cross-sectional study was conducted at Muhimbili University of Health and Allied Sciences, Muhimbili National hospital, and the Aga Khan University Hospital Dar …

Adequacy Of Pain Management Among Advanced Cancer Patients With Solid Tumors Attending Palliative Care Centers In Dar Es Salaam, Judith Mwijage

Theses & Dissertations

Background: Cancer pain is a universal undesirable symptom among cancer patients that if not addressed causes suffering and impedes quality of life of both the patients and their family. Observational studies available have shown increase in palliative care programs in Tanzania but there is dearth of information regarding the adequacy of pain control among patients with cancer after the initiation of these programs and improvement of the available interventions.

Objectives: This study aimed to determine adequacy of pain management among advanced cancer patients with solid tumors as well as factors affecting adequate Cancer Related Pain management.

Methods: We conducted a …

Burden In Family Caregivers Of Patients With Chronic Mental Illness In Aga Khan University Hospital And Mathari National Referral Hospital, Nairobi, Kenya., Norah Atieno Obungu

Theses & Dissertations

Introduction: In Africa, about 60% of patients with chronic mental health disorders live with their relatives. Family caregivers bear the responsibility of managing relatives with mental illness in the home environment, and this may result in psychopathology in the caregivers. Although extensively studied in the Western world, not much is known about the caregiver burden in Kenya.

Objectives: The primary objective of the study was to find out the prevalence of caregiver burden among family caregivers of patients with chronic mental illness attending two psychiatric care facilities in Nairobi. The secondary objective was to determine the socio-demographic characteristics and correlates …

Facilitators And Barriers To Implementing A Community Rotation To The Internship Training In Kenya, Peter Mwanza Kioko

Theses & Dissertations

Background: Primary care is increasingly being prioritized all over the world more so in developing countries in an effort geared towards achieving health equity. The availability of skilled human resources at the community level has been shown to improve health outcomes. However, doctor numbers remain low in sub-Saharan countries. Kenya’s policy on universal health coverage aims to enable access to essential health services by all its citizens by 2022. The introduction of community placements among undergraduate medical students has proven beneficial in understanding community health problems, the role of primary care in health as well as increasing the likelihood of …

Knowledge, Attitude And Beliefs Towards Polypharmacy Amongst Older People Attending Family Medicine Clinic (Fmc) At The Aga Khan University Hospital, Nairobi, Kenya (Akuhn)., Maureen Wanjiru Kamau

Theses & Dissertations

Introduction: Life expectancy has increased over the last century amongst older individuals, and in particular, those 60 years and over. The World Health Organization estimates that the world's population of persons over 60 years will rise to 22 per cent by the year 2050. Ageing is associated with increasing disability, multiple chronic conditions, and an increase in the use of health services. Multiple chronic conditions associated with ageing are managed with different medications (polypharmacy) amongst the older population. Polypharmacy has numerous adverse effects including non-adherence, an increased risk of drug interactions with the various medications, reduced appetite, and risk of …

Comparison Of Maldi-Tof Ms And 16s Rrna Sequencing For Identification Of A Collection Of Clinical Isolates Of Nonntuberculous Mycobacteria In Kenya And Describing Their Antimicrobial Susceptibilities, David Enoch Kawalya

Theses & Dissertations

Study background: non-tuberculous mycobacteria (NTM) are members of the genus Mycobacteria that are ubiquitous in the environment. They are increasingly documented to cause multi-drug resistant human and animal infections in immunocompromised as well as immunocompetent hosts and thus, they are a huge burden on public health resources. Diagnosis and treatment of these infections is particularly challenging due to their variable clinical presentation and the lack of easily accessible identification methods. MALDI-TOF MS is a proteomic method that has gained traction in the identification of microbial organisms in clinical practice due to its fast turn-around time, high resolution, and cost-effectiveness but …

The Lived Experience Of Older Adults With Visual Impairments And Their Integration Into Social And Recreational Activities In The Long-Term Care Setting: A Phenomenological Study, Julie Ann Conboy Russo

Theses & Dissertations

The prevalence of vision loss in the elderly is high. Visual impairment in long-term care (LTC) settings may be a barrier to fully interacting in therapeutic recreational and social activities. Living with visual barriers may hamper safety (i.e., fear of falling and navigating in unfamiliar settings); cognitive ability; and participation in activities leading to isolation, depression, and loss of self-esteem. Decreased stimulation may affect one’s overall happiness and quality of life. A qualitative phenomenological design was followed to capture the lived experience of older adults with visual impairments living in LTC settings and their integration into social and recreational activities …

Descriptive, Comparative, And Correlational Study Related To End-Of-Life Care Prior To The Covid-19 Pandemic Outbreak (Time 1) And 12 Months Following Lockdown (Time2), Elizabeth Infante

Theses & Dissertations

Background

Palliative care has grown in its acceptance nationally and formed the base of a growing number of programs to provide care in a way that recognizes the importance of supporting people with chronic, debilitating, and life-limiting illnesses by focusing on “care” rather than “cure.” This special care warrants an understanding by all nurses and requires education across specialties and disciplines. Despite the increase of palliative care services in hospitals and other settings, long-term care and home care agencies continue to struggle with the education of staff and delivery of care to clients that incorporate the central tenets of what …

Urinary Incontinence In The Pre-Menopausal Woman And Impact On Quality Of Life, Jacqueline Skene Kirk

Theses & Dissertations

Background

Urinary incontinence (UI) is a medical condition that plagues millions of women worldwide, negatively affecting their quality of life. UI is the involuntary release of urine or what women refer to as having “accidents.” Women suffering from UI often feel embarrassed and become socially isolated. The majority of studies in the literature focus on UI in postmenopausal women. However, very few studies explore the lived experience of living with UI as a premenopausal woman, who are at a time in their lives when they are involved in their careers, having intimate relationships with their partners, and are raising their …