Medicine and Health Sciences Commons^™

Malignant Hyperthermia, Christina Bensley

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia

Christina Bensley

Department of Nursing, Otterbein University

NURS 6810: Advanced Pathophysiology for the Advanced Practice Nurse

Dr. Batross and Dr. Bhatnagar

August 5th, 2022

Abstract

Malignant Hyperthermia (MH) is a rare genetic mutation of the skeletal muscle that induces a hypermetabolic response when patients are exposed to volatile inhaled anesthetics or depolarizing neuromuscular blockers (Weant & Gregory, 2021). The first case of MH was identified in 1960, with an estimated mortality rate of 70-80% without appropriate treatment (Hopkins et al., 2021). Perioperative care providers must be able to identify triggering agents, recognize presenting signs and symptoms, and know …

Perioperative Malignant Hyperthermia, Mitchell Mccorkle

Nursing Student Class Projects (Formerly MSN)

Abstract

Malignant Hyperthermia (MH) is a rare inherited disorder in which exposure to triggering agents such as volatile anesthetics or depolarizing neuromuscular blockers causes a hypermetabolic reaction leading to patient fatality. MH susceptible patients have a genetic mutation on the ryanodine one receptor (RYR1) in skeletal muscle, allowing uninhibited calcium release (Smith, Tranovich, & Ebraheim, 2018). Increases in free calcium result in an uncontrollable sustained muscle contraction through the excitation-contraction coupling of myosin and actin. Sustained muscle contraction rapidly consumes adenosine triphosphate stores and stimulates conversion to lactate producing anaerobic metabolism (Smith et al., 2018). Immediate recognition and treatment of …

Malignant Hyperthermia, Brennon Pinion

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia is a rare but potentially fatal disorder that is triggered by the use of certain anesthetic medications. It is caused by a mutation in specific proteins in skeletal muscle that causes prolonged contraction, leading to a hypermetabolic state. This condition can have deadly effects like kidney failure, hemodynamic instability, and cardiac arrest. It is normally discovered during surgery and must be treated right away. The discovery of the treatment of Malignant Hyperthermia has dramatically decreased the fatality of the disorder, but treatment must be given immediately. For patients who develop Malignant Hyperthermia to have the highest chance of …

Malignant Hyperthermia, Emmanuel Mensah

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia is a rare but fatal disorder usually triggered using succinylcholine, a depolarizing muscle blocker, or other volatile anesthetics (Yang et al., 2020). MH is characterized by signs and symptoms including Hyperthermia, acidosis, tachycardia, hypercarbia, acidosis, etc. (Yang et al., 2020). When the signs and symptoms of MH are recognized, the provider should stop what he or she is doing and call for immediate help. When additional assistance arrives, the patient must receive Dantrolene. Dantrolene is a muscle relaxant that prevents the sarcoplasmic reticulum from releasing calcium. Additional interventions include cooling the patient using ice packs, treating electrolyte abnormalities, …

Malignant Hyperthermia, Courtney Morris

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia as defined by the International Classification of Diseases is a rare but progressive, and life-threatening hyperthermic reaction in response to a triggering agent such as general anesthetic gases or the depolarizing neuromuscular blocking agent Succinylcholine (Hopkins et. al., 2020). MalignantHyperthymia is a genetic disorder of the skeletal muscle, that leads to continuous muscle contraction and the inability to relax skeletal muscle (Haili and Weant, 2021). Signs and symptoms can vary from patient to patient and can be masked by anesthesia, but the classical signs include an increase in end-tidal CO2, increased heart rate, and a rapid increase in …

Malignant Hyperthermia, Nicholas Colangelo

Nursing Student Class Projects (Formerly MSN)

Malignant hyperthermia is a rare manifestation of a genetic mutation involving the ryanodine receptors. This mutation causes a sustained intracellular calcium release that is triggered by certain anesthetics such as depolarizing neuromuscular blockers and volatile gases. The extended release of calcium functions as a dangerous catalyst for hyper-metabolism that will lead to rapid death if unrecognized and untreated. Current treatment involves the drug dantrolene in tandem with symptomatic management in the intensive care setting. Symptomatic treatment may likely involve rapid cooling, fluid resuscitation, electrolyte management, and mechanical ventilation until symptoms resolve. A literature review of malignant hyperthermia is of vital …

Malignant Hyperthermia For The Nurse Anesthetist, Victor Clark

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia (MH) is a rare, autosomal dominant skeletal muscle disorder that can have an insidious onset in susceptible patients exposed to the triggering agents succinylcholine, halothane, desflurane, sevoflurane, and isoflurane. MH can occur in patients who have received anesthesia with these agents in the past (Nagelhout & Plaus, 2018, p 775). Patients with a family history of MH or associated skeletal muscle disorder must be treated as MH-susceptible until proven otherwise. Failure to detect an MH crisis can lead to kidney failure, profound acidosis, coagulopathies, rhabdomyolysis, cardiac dysrhythmias, cardiovascular collapse, and death (Seifert et al., 2015). It is the …

Malignant Hyperthermia, Alec Smith

Nursing Student Class Projects (Formerly MSN)

Abstract: There are many issues that healthcare professionals face in the evolving world of medicine. One of these is the development of a disease process known as Malignant Hyperthermia (MH). This condition is precipitated by frequently used anesthetic agents such as volatile gases and depolarizing muscle relaxants. The onset of MH is sudden and can be life-threatening, therefore, diligent monitoring of patients is essential in early recognition and treatment of MH. The purpose of this poster is to provide in -depth knowledge about MH. This includes the pathophysiology of the disease, signs and symptoms, treatment options, and implications MH has …

Poster: Malignant Hyperthermia Preparedness For Labor And Delivery Nurses, Patricia Rabinowitz

Doctor of Nursing Practice Scholarly Projects

Malignant Hyperthermia (MH) is a rare, inherited disorder of skeletal muscle triggered by general anesthesia in susceptible individuals. Although MH can occur later in the anesthetic course as well as post-operatively, it most frequently occurs shortly after induction of general anesthesia.

Operating room (OR) nurses receive extensive training in MH crisis management. On labor and delivery (L&D) units, neuraxial (spinal and epidural) blocks are the safest and most commonly used anesthetics during pregnancy. General anesthesia is utilized only when the life of the mother or infant is in jeopardy or when a neuraxial block is not possible. Under these circumstances, …

Malignant Hyperthermia, Ashley Casimir Vasnaik

Nursing Student Class Projects (Formerly MSN)

The Certified Registered Nurse Anesthetist (CRNA), as well as other anesthesia providers and support staff interact with a variety of patients on a day to day basis. These patients come to the hospital to seek help for their medical and surgical ailments. As every patient is different, they can also have a variety of health-related issues, many of which can also impact their anesthetic plan. One of the most difficult issues and or emergent situations that can impact everyone in the operating room is an exacerbation of Malignant Hyperthermia (MH), whether it is anticipated or unanticipated. The task of preventing …

Malignant Hyperthermia, Ryan Vincent

Nursing Student Class Projects (Formerly MSN)

No abstract provided.

Malignant Hyperthermia, David Kanotz

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia (MH) is a life-threatening skeletal muscle disorder that presents as a hypermetabolic response to several inhaled anesthetics and to the depolarizing muscle relaxant succinylcholine. It is extremely important for certified registered nurse anesthetist (CRNA) to understand the pathophysiology, clinical symptoms, and treatment plan of MH due to their vital role in managing these patients in the operating room.

Malignant Hyperthermia, Aaron Roth

Nursing Student Class Projects (Formerly MSN)

Malignant hyperthermia is a rare disease trait and can take place in a variety of settings. If not treated in a timely manner, the consequences will be dire. It is recommended that nurses and other healthcare personnel be properly educated on MH crises. By detecting the signs and symptoms associated with the disease, providers can efficiently remedy the crisis and save patient lives (Seifert, 2014). Since the discovery of dantrolene in 1975 and the advancement of genetics regarding MH, death rates dropped from about 80% to about 5% (Schneiderbanger et al., 2014). Today there is a MH group called the …

Malignant Hyperthermia, Chase Contri

Nursing Student Class Projects (Formerly MSN)

Although very rare, occurring one out of every 100,000 anesthesia cases, malignant hyperthermia is a hypermetabolic disorder that anesthesia providers screen and interrogate patients prior to every case they are administering anesthesia. Many research studies about anesthesia induced malignant hyperthermia have explored new methods of testing for the genetic susceptibility for malignant hyperthermia and into hospital based protocols when a patient starts to show the signs and symptoms of the metabolic disorder. This new knowledge and understanding has decreased patient mortality of anesthesia induced malignant hyperthermia from eighty percent to five percent over the past three decades (Rosenberg et al, …

Malignant Hyperthermia, Devin Poncsak

Nursing Student Class Projects (Formerly MSN)

A crisis of malignant hyperthermia is a medical emergency, and must be treated immediately with a coordinated, multidisciplinary team response in order to give the patient the highest chance for a successful recovery (Dirksen, Van Wicklin, Mashman, Neiderer, & Merritt, 2013). Malignant hyperthermia is defined by Bandschapp & Girard (2012), as “a disturbance of the skeletal muscle calcium homeostasis, triggered by volatile anaesthetics and depolarizing muscle relaxants.” Once a vulnerable patient is exposed to one of these triggering agents, a pathologic hypermetabolic response ensues, and the patient has a rapid increase in oxygen consumption and expired carbon dioxide, hyperthermia, acidosis, …