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Full-Text Articles in Medicine and Health Sciences
Freezing Of Gait: Mechanisms, Mechanics, And Management, Peter S. Myers
Freezing Of Gait: Mechanisms, Mechanics, And Management, Peter S. Myers
Arts & Sciences Electronic Theses and Dissertations
Parkinson disease (PD) is a neurodegenerative disease with multiple motor and non-motor symptoms, including postural instability, gait impairments, and cognitive deficits. More than 50% of individuals with PD experience a symptom called freezing of gait (FOG), described as a transient inability to take another step forward. Individuals with PD who experience FOG (freezers) have further postural, gait, and cognitive impairments compared to individuals with PD without FOG (non-freezers). While degeneration of the dopaminergic neurons in the substantia nigra is accepted as the primary etiology of the disease, research shows that the disease has a global impact on the brain, accounting …
Effects Of Resistance Exercise On Postprandial Metabolism In Obese Men With Prediabetes, Adam Bittel
Effects Of Resistance Exercise On Postprandial Metabolism In Obese Men With Prediabetes, Adam Bittel
Arts & Sciences Electronic Theses and Dissertations
Prediabetes is a metabolic condition defined by elevated fasting (impaired fasting glucose (IFG)) and/or postprandial (impaired glucose tolerance (IGT)) glucose. Prediabetes affects nearly 86 million adults in the United States, with most (up to 70%) progressing to type 2 diabetes within as little as one year. Recent studies have indicated that elevated post-prandial glycemia and hypertriglyceridemia are early indicators of prediabetes, and are major risk factors for complications of prediabetes, including cardiovascular disease (CVD), stroke, elevated blood pressure, and obesity. Resistance exercise is a central component of exercise recommendations for individuals with type 2 diabetes and prediabetes, but the effect …
Functional And Skeletal Muscle Impairments In Progressive Diabetic Ckd, Daniel Bittel
Functional And Skeletal Muscle Impairments In Progressive Diabetic Ckd, Daniel Bittel
Arts & Sciences Electronic Theses and Dissertations
1-in-3 persons with type 2 diabetes (T2DM) develop chronic kidney disease (CKD), which is characterized by progressive renal dysfunction leading to end-stage renal disease. In response to elevated blood glucose and systemic inflammation of diabetes, a process of active thickening of the renal glomerular basement membrane ensues with concomitant damage to the structural supports (podocytes) of the kidneyճ filtration barrier. This results in impaired renal filtration. The metabolic sequelea of T2DM and CKD also, synergistically, alter skeletal muscleճ degradative pathways, satellite cell function (muscle reparative cells), and mitochondrial health (muscle energetic machinery) -- resulting in muscle breakdown, poor muscle quality, …