Medicine and Health Sciences Commons^™

Extended-Phase Anticoagulation For Pediatric Venous Thromboembolism After Einstein Jr, Nathan Wilken, Jun Teruya

Faculty, Staff and Students Publications

No abstract provided.

Fgfr3::Tacc3 Fusion And Notch1 Loss-Of-Function In A Case Of Hpv-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge And Implications For Targeted Therapy, Xu Cao, Hong Yu, Reham Hamdy Abdulazim Soliman, Pei Ying, Songlin Zhang, Li Liang

Faculty, Staff and Students Publications

Sinonasal squamous cell carcinoma (SNSCC) comprises a heterogeneous group of tumors with emerging molecular subtypes. Human papillomavirus (HPV)-associated SNSCC is a distinct entity, although actionable genomic alterations beyond HPV-driven pathways remain underexplored. Distinguishing HPV-associated SNSCC from carcinoma ex inverted papilloma can be particularly challenging in limited biopsy specimens, as these lesions may appear morphologically similar. We report a case of HPV-associated SNSCC with concurrent FGFR3::TACC3 fusion and NOTCH1 p.C1416 stop-gain mutation.

Promoting The Hpv Vaccine Across The League Of Arab States: A Scoping Review Of Interventions, Basil H. Aboul-Enein, Patricia J. Kelly, Fatmah Almoayad, Teresa Keller

College of Nursing Faculty Papers & Presentations

INTRODUCTION: This scoping review examined existing interventions designed to promote and educate about HPV vaccination in the league of Arab states (LAS).

METHODS: Following PRISMA-ScR guidelines and using a PICOS-informed approach, a comprehensive search was conducted across 16 databases to identify peer-reviewed intervention studies published between 2010 and August 2025.

RESULTS: Twenty-two studies met the inclusion criteria. Most interventions originated from Egypt and Saudi Arabia and were delivered in academic or clinical settings using short, didactic, one-group pre-post designs. Only a few studies incorporated behavioral theories, digital modalities, or multi-component strategies. Nearly all studies reported short-term improvements in HPV-related knowledge …

Forecasting Covid-19 New Cases Using Nbeats Deep Learning And Mobility Data, Amril Nazir, Mohammad Shorfuzzaman, Muhammad Lujaini Lotfi, Firuz Kamalov, Sufian Badawi, Maen Takruri, Abdul Halim Jallad

All Works

COVID-19 is a highly contagious disease transmitted primarily through human contact. Therefore, understanding population mobility is essential for predicting COVID-19 case trends. In this paper, we propose a novel deep learning approach for forecasting new COVID-19 cases using a neural architecture called Neural Basis Expansion Analysis for Interpretable Time Series (N-BEATS). The N-BEATS model effectively handles long input sequences and large output horizons without information loss or increased computational complexity. We compare the performance of N-BEATS with a state-of-the-art benchmark model, LSTM-Markov, across four major countries: the United States, the United Kingdom, Russia, and Brazil. Three distinct COVID-19 datasets from …

Dnp Final Report: Enhancing Radiation Oncology Training For Advanced Practice Providers, Katherine A. Bukolt

DNP Final Reports

Background: Rising cancer incidence and improved survivorship are straining the oncology workforce, increasing reliance on Advanced Practice Providers (APPs). However, there is a lack of standardized educational resources for APP radiation oncology training across practice settings. Most APPs receive variable, resource-dependent, and on-the-job training. Evidence shows that the lack of standardized training leads to gaps in foundational knowledge, reduced confidence in toxicity management, inconsistent role development, and variable satisfaction with training and transition into practice.

Purpose: This quality improvement project evaluated the feasibility of implementing an 18-module Advanced Practice Radiation Oncology (APRO) asynchronous online curriculum to standardize APP radiation oncology …

Application Of Toast Criteria, Comorbidities And Outcomes In Patients With Ischemic Stroke: Multicenter Collaboration In The Dominican Republic, Ryna Then, Maria Muñoz, Cristina Ramos, Marcos Mota, Priscilla Sepulveda, Lisa José, Luis Suazo, Francisco Mendez, Yahaira Franco, Cosme González Villamán, Acela Gonell, Violiza Inoa, Gillian Gordon Perue, Manuel Colomé-Hidalgo, Nadja García

Einstein Health Papers

INTRODUCTION: Stroke is a leading cause of neurological-related death in the Caribbean. The Dominican Republic has among the highest stroke-related mortality rates in the Americas. We aimed to determine ischemic stroke etiologies, characterize comorbidities, and describe outcomes in the Dominican Republic using the TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification.

METHODS: We analyzed a multicenter quality registry between January 2022 and October 2024. Statistical analyses included Mann–Whitney U and Kruskal–Wallis tests with Bonferroni correction, chi-square tests, and Spearman correlation.

RESULTS: The most common stroke subtype was undetermined etiology (54.8%), followed by large artery atherosclerosis (17.2%) and cardioembolism …

Association Of Cerebrovascular Center Volume With Patient Outcomes, Stacey Quintero Wolfe, Justin R. Mascitelli, Kyle Fargen, Peter Kan, Ketan Bulsara, Christopher P. Kellner, Brian M. Howard, Michael R. Levitt, Rocco Armonda, Joshua Osbun, Clemens Schirmer, Mark Bain, William J. Mack, Stavropoula Tjoumakaris, Adam Arthur

Department of Neurosurgery Faculty Papers

Current guidelines acknowledge the importance of both microsurgical and neuroendovascular expertise in the treatment of cerebrovascular disease. To achieve optimal care for these patients, it is becoming increasingly evident that procedural volumes impact patient outcomes. This is demonstrated across various cerebrovascular diseases.In this literature review, we demonstrate the association of volume with patient outcomes across multiple cerebrovascular disease states and interventions. Microsurgical aneurysm clipping remains essential even with the rise of endovascular therapy and mortality and patient-safety indicator events are clearly lower at high-volume centers for both ruptured and unruptured aneurysms. Likewise, patients undergoing surgery for cerebrovascular malformations and carotid …

Cervical Insufficiency Revisited: A Proposal For A New Treatment-Aligned Definition, Vincenzo Berghella, Ilaria Paladino, Moti Gulersen, Rupsa Boelig, Amanda Roman

Department of Obstetrics and Gynecology Faculty Papers

Cervical insufficiency [CI] has traditionally been defined as painless cervical dilation resulting in recurrent second-trimester pregnancy loss in the absence of labor or placental pathology. Definitions from the American College of Obstetricians and Gynecologists and the Royal College of Obstetricians and Gynecologists emphasize historical clinical presentation. However, contemporary obstetrics relies increasingly on ultrasound-based cervical length surveillance and evidence-based cerclage indications rather than retrospective diagnosis. The objective of the review was to propose a definition of cervical insufficiency aligned with current evidence-based indications for mechanical prevention of preterm birth, i.e. cervical cerclage. In modern obstetric practice, the operational diagnosis of clinically …

Maternal Mental Health: What Utahns Need To Know, Brie Sparks, Susan R. Madsen

Marketing and Strategy Faculty Publications

Pregnancy and the transition to motherhood are often portrayed as joyful and fulfilling experiences, yet many women face significant emotional and psychological challenges. Maternal mental health conditions, including depression and anxiety, are among the most common complications of pregnancy and the postpartum period. Despite growing awareness, stigma, screening gaps, and limited access to care persist. In Utah, where rates are similar to or higher than national averages, expanding screening and resources will create a clearer path to better support mothers and families.

Chemotherapeutic Induction Of Cytosolic Single-Stranded Dna Accumulation Sensitizes Triple-Negative Breast Cancer To Immunotherapy, Yong Du, Li Yang, Hui Dai, Jianli Zhou, Zhicheng Zhou, Ruoxi Yuan, Rui Ye, Anh Thai Quynh Nguyen, Kishor Bhatia, Shiaw-Yih Lin

Faculty, Staff and Students Publications

Background: Despite the widespread adoption of chemoimmunotherapy in triple-negative breast cancer (TNBC), the mechanisms by which cytotoxic chemotherapy engages antitumor immunity remain poorly defined. Identifying tumor-intrinsic immunogenic programs that predict and enhance responsiveness to immune checkpoint blockade (ICB) is therefore of critical clinical importance.

Methods: Transcriptomic signatures of TREX1 deficiency were generated from CRISPR-engineered TNBC models and applied to multiple independent TNBC cohorts treated with chemoimmunotherapy. Cytosolic single-stranded DNA (ssDNA) accumulation was quantified using a flow cytometry-based assay to functionally screen chemotherapeutic agents. Immune activation and therapeutic efficacy were evaluated using in vitro assays, syngeneic mouse tumor models, flow cytometry, …

Reply To: A Lethal Progressive Neuroinflammation Disguised As Mogad Revealing A Final Diagnosis Of Griscelli Syndrome: Regarding: Mogad Is The Most Common Cause Of Isolated Optic Neuritis In Children, Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Adeseye, Jonathan M Yarimi, Nikita Shukla, Timothy E Lotze, Kristen S Fisher, Alexander J Sandweiss

Faculty, Staff and Students Publications

No abstract provided.

Tusc3 Serves As A Rate-Limiting Gatekeeper Of A Glycan-Mediated Er Triage Checkpoint For Bmp4/Dpp, Antonio Galeone, Emilio Solazzo, Francesco Lavezzari, Seung Yeop Han, Gaia Consonni, Bruna My, Riccardo Rizzo, Giuseppe Gigli, Hamed Jafar-Nejad, Thomas Vaccari

Faculty, Staff and Students Publications

Trimming of the three glucose residues decorating nascent N-glycoproteins is a critical step for their entry into the endoplasmic reticulum quality control (ERQC) and recognition by ER chaperones. However, the functional relevance of the second glucose (G2) and the regulatory step upstream of its removal by glucosidase II (GCS2) remain poorly understood. Here, we report that TUSC3, a component of the oligosaccharyltransferase (OST) complex, regulates G2 to G1 trimming on N-glycosylated bone morphogenetic protein 4 (BMP4) and its Drosophila homolog Dpp to promote their ERQC entry. Loss- and gain-of-function genetic experiments and biochemical assays in mammalian cells and flies indicate …

Two Decades Of Progress In The Prevention And Treatment Of Colorectal Cancer: From Aspirin To Targeted Therapy, Lovyanne Vergel De Dios, Salique Hassan Shaham, Puneet Vij, Manish Kumar Tripathi

School of Medicine Publications

No abstract provided.

Unveiling Unwritten Curricula: Enhancing Junior Faculty Development In Academic Emergency Medicine, Abagayle Bierowski, Casey Morrone, Erin Hoag, Ridhima Ghei, Michael Pasirstein, Julie Blaszczak, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

INTRODUCTION: The transition from resident to junior faculty in academic emergency medicine (EM) may be shaped not only by formal training and institutional policies but also by the "unwritten curriculum," a set of norms and expectations embedded in institutional culture. However, the unwritten curriculum and its potential to impact junior faculty development remains largely unexplored. Little is known about how junior faculty perceive, experience, and navigate these informal expectations, or the formal and informal structures that influence this process. In this study we aimed to explore junior faculty members' experiences with the unwritten curriculum in academic EM, with a focus …

Letter To The Editor: Hemodynamic Role In Hepatic Encephalopathy Pathogenesis Following Transjugular Intrahepatic Portosystemic Shunt Placement, John Halphen, Yash S Dayal, Cameron Laurie, Mohadese Ahmadzade, David Wynne, Mohammad Ghasemi-Rad

Faculty, Staff and Students Publications

Hepatic encephalopathy (HE) is a common complication following transjugular intrahepatic portosystemic shunt (TIPS) placement and is thought to result from reduced hepatic detoxification of neurotoxins. However, Zhuang et al in the World Journal of Radiology demonstrate that this understanding may be incomplete through exploration of the pathophysiology from a hemodynamic perspective. They found significant changes in cerebral blood flow (CBF) and spontaneous brain activity following TIPS. Initially, CBF increased in specific areas within the first month, followed by a return to baseline at three months. These CBF changes coincided with increased spontaneous brain activity that persisted in some areas, suggesting …

Self-Management For Youth And Young Adults With Childhood-Onset Chronic Conditions: A Scoping Review Of Health Care Transition Planning Literature, Jennifer Emilie Mannino Ph.D., R.N., Cne, Cara C. Young, Monique M. Ridosh, Kristin Cleverley, Lin Li, Lynn Kysh, Catherine A. Harwood, Brooke Allemang, Linda Tirabassi-Mathis, Sharon Hudson, Stephanie M. Key, Benjamin C. Schwartzman, Jihye Lee, Manu Raam, Cecily L. Betz

Nursing: Faculty Publications

Objective: To determine the extent to which self-management has been investigated and reported in literature focused on the transition from pediatric to adult healthcare for youth and young adults with childhood-onset chronic conditions (CCCs).

Introduction: An estimated 1.2 million youth with CCCs are expected to enter adulthood annually in the United States. As these youth transition from pediatric to adult health systems, they are at risk for experiencing critical gaps in care continuity and adverse health outcomes. Health care transition models have emerged to address these gaps, with self-management recognized as a critical component of successful transition.

Inclusion criteria: The …

Long-Term Functional Synaptic Integration Of Genome-Edited Retinal Organoids In A Primate Model Of Macular Degeneration, Atsuta Ozaki, Akihiro Kawai, Ryutaro Akiba, Satoko Okayama, Nobuhiko Ohno, Keisuke Kajita, Tomohiro Masuda, Satoshi Yokota, Shin-Ichiro Ito, Du Peiyan, Kenta Onoue, Shigenobu Yonemura, Mineo Kondo, Yasuo Kurimoto, Yingbin Fu, Michiko Mandai

Faculty, Staff and Students Publications

Retinal organoids represent a promising regenerative strategy for restoring vision in retinal degenerative diseases, but the capacity of host cone bipolar cells in the primate macula to rewire with transplanted photoreceptors has not been established. In this study, we transplanted genome-edited ISL1-/- human retinal organoids lacking ON-bipolar cells into an acute laser-induced macular photoreceptor ablation non-human primate model. Using immunohistochemistry, ultrastructural imaging, and focal macular electroretinography, we demonstrate that host rod and cone bipolar cells actively extend dendrites toward grafted photoreceptors and form synaptic contacts, with evidence of functional signal transmission in a subset of transplanted eyes. Longitudinal, per-eye analyses …

The Effect Of The Covid-19 Pandemic On Diagnostic Testing Time Completion For African American End Stage Renal Disease (Esrd) Patients Being Evaluated For Kidney Transplantation, Kesha Levesque, Martina Mueller, Julie Anderson, Jennifer Gander, Gayenell Magwood Phd, Rn, Faha, Faan, Ahmed I. Kamal, Michael Jin Casey, Susan Newman Phd, Rn, Crrn, Faan

Publications

PURPOSE: The COVID-19 pandemic was directly associated with fewer additions to the kidney transplant waiting list and likely contributed to delays in transplant rates, particularly for African Americans. It remains unclear if the pandemic specifically had an impact on diagnostic testing time completion for African Americans being evaluated for kidney transplant waitlisting. AIMS: To examine the impact of the COVID-19 pandemic on kidney transplant diagnostic test completion time and assess racial disparities between African American and White patients. DESIGN: This retrospective study analyzed data on patients approved for kidney transplantation at a southeastern academic medical center between January 2018 and …

The Effect Of The Covid-19 Pandemic On Diagnostic Testing Time Completion For African American End Stage Renal Disease (Esrd) Patients Being Evaluated For Kidney Transplantation, Kesha Levesque, Martina Mueller, Julie Anderson, Jennifer Gander, Gayenell Magwood Phd, Rn, Faha, Faan, Ahmed I. Kamal, Michael Jin Casey, Susan Newman Phd, Rn, Crrn, Faan

Publications

PURPOSE:

The COVID-19 pandemic was directly associated with fewer additions to the kidney transplant waiting list and likely contributed to delays in transplant rates, particularly for African Americans. It remains unclear if the pandemic specifically had an impact on diagnostic testing time completion for African Americans being evaluated for kidney transplant waitlisting.

AIMS:

To examine the impact of the COVID-19 pandemic on kidney transplant diagnostic test completion time and assess racial disparities between African American and White patients.

DESIGN:

This retrospective study analyzed data on patients approved for kidney transplantation at a southeastern academic medical center between January 2018 and …

Folr1-Targeted Actinium-225-Based Alpha-Particle Therapy Eliminates Ovarian Cancer, Neetu Singh, Esther Need, Ayden Berndt, Matthew Goff, Lydia J. Wilson, Firas Mourtada, Feng Guo, Tara Mastren, Taslim Al-Hilal, Anil K. Sood, Amit Maity, Scott C. Miller, Satoshi Minoshima, Shreya Goel, Sixiang Shi

Department of Radiation Oncology Faculty Papers

Despite the advancement in therapies, ovarian cancer treatment is challenging because of poor prognosis and high relapse associated with acquired resistance. Emerging targeted alpha particles, particularly actinium-225 (225Ac), for treating refractory cancers have opened avenues for improved therapeutic options. Here, we describe a successful example of folate receptor 1 (FOLR1)–targeted 225Ac alpha-particle therapy for treatment of ovarian cancer. Longitudinal positron emission tomography imaging demonstrated high tumor-specific uptake of αFOLR1 (anti-FOLR1 antibody) in SKOV3 xenografts. FOLR1-targeted 225Ac demonstrated high therapeutic efficacy, achieving marked tumor regression, 80% survival, and 40% complete tumor elimination. The therapy resulted in tumor-specific double-stranded DNA damage, and …

Online Rights Defense Among Chinese Americans Against Racial Aggression In The U.S. During The Covid-19, Fangzhu Lu, Wenshan Jia

Communication Faculty Articles and Research

Purpose

This study investigates how Chinese American communities responded to heightened racial discrimination during the COVID-19 pandemic by utilizing social media platforms to safeguard their civil rights, articulate collective concerns, and mobilize resistance against racial aggression.

Methodology

Through qualitative case study analysis, the research examines the social media activities of six advocacy organizations, including three X accounts (WashTheHate, Chinese for Affirmative Action, Asian Americans Advancing Justice) and three Instagram accounts (Stop AAPI Hate, Stop Asian Hate, Advancing Justice: AAJC). The analysis focuses on the content strategies and communication mechanisms employed to counteract racial hostility.

Findings

The selected organizations used social …

Early-Stage Corticostriatal Hyperactivity Impairs Cognitive Flexibility Alongside Striatal Cholinergic Dysfunction In An Alzheimer's Disease Model, Yufei Huang, Xueyi Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn Souza, Julia Hunter, Xin Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang

Faculty, Staff and Students Publications

Cognitive flexibility declines early in Alzheimer's disease, yet the underlying circuit mechanisms remain unknown. Here, we report that young 5xFAD mice exhibit deficits in instrumental reversal learning prior to spatial memory impairment. This behavioral inflexibility is associated with abnormal neuronal reactivation in the medial prefrontal cortex and dorsomedial striatum. Electrophysiological recordings reveal that medial prefrontal cortex neurons are hyperexcitable and receive increased excitatory input. Furthermore, glutamatergic transmission from the medial prefrontal cortex to striatal direct-pathway medium spiny neurons is enhanced and coincides with strengthened inhibitory transmission onto striatal cholinergic interneurons, reduced spontaneous firing, and diminished striatal acetylcholine release. Critically, sustained …

Human Milk Small Extracellular Vesicles Elicit Changes In Inflammatory Response In Infant Human Intestinal Enteroids, Kacie D Waiters, Anthony S Peidl, Hailey A Mcandrew, Ashfia F Khan, Grace Adeniyi-Ipadeola, Hephzibah Nwanosike, Sana Sharif, M Funmi Babajide, Micah Castillo, Preethi H Gunaratne, Samaneh Karami, Hoa Nguyen-Phuc, Xinli Liu, Sasirekha Ramani, Tasneem Bawa-Khalfe

Faculty, Staff and Students Publications

Human milk (HM) is the key nutritional source for infants and the most effective preventative approach against serious gastrointestinal inflammatory diseases like necrotizing enterocolitis (NEC) in preterm infants. Numerous studies in animal models indicate HM-derived small extracellular vesicles (HMEV) reduce severity of inflammation; however, data on human-specific models are limited. Isolated HMEV were characterized from early-HM (colostrum and transitional), mature-HM, and a combined, pasteurized donor bank-like HM sample (pool-); pool-HMEV retains a profile aligned with HMEV from both early- and mature-HM samples. Exposure to pool-HMEV initiates unique gene signatures associated with reduction of inflammation including NFkB-driven TNFα signaling in human …

Plasma Gdf15 Affects Long-Term Dementia Risk And Alters Neuroimmune Signaling, Cassandra O Blew, Michael R Duggan, Dimitrios Tsitsipatis, Gabriela T Gomez, Zulema Rodriguez-Hernandez, Luke C Pilling, Jingsha Chen, Eva Jacobsen, Heather E Dark, Yifei Lu, Shannon M Drouin, Cassandra M Joynes, Minhao Yao, Murat Bilgel, Abhay Moghekar, Qu Tian, Julián Candia, Mary Kaileh, Aditi Gupta, Krystyna Mazan-Mamczarz, Myriam Gorospe, Alexey Lyashkov, Yevgeniya Lukyanenko, Mika Kivimaki, Philipp Frank, Lori L Jennings, Valborg Gudmundsdottir, Vilmundur Gudnason, Lenore J Launer, Naoto Kaneko, Shintaro Kato, Makio Furuichi, Masaki Shibayama, Masahisa Katsuno, Keita Hiraga, Yukiko Nishita, Rei Otsuka, James R Pike, Mary R Rooney, Pascal Schlosser, Yuhan Cui, Guray Erus, Christos Davatzikos, Rebecca F Gottesman, Iwao Waga, Priya Palta, Christie Ballantyne, Michael Griswold, Zhonghua Liu, Luigi Ferrucci, Allison B Herman, Keenan A Walker

Faculty, Staff and Students Publications

Growth/differentiation factor-15 (GDF15) is a secreted cytokine strongly associated with dementia risk. However, the extent to which GDF15 represents a biomarker and driver of dementia risk remains unclear. Across multiple cohorts, we demonstrated that plasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife, with stronger associations observed for vascular, compared to Alzheimer's disease (AD), dementia. Two-sample Mendelian randomization supported plasma GDF15's mechanistic role in AD and related dementias, while cohort studies linked it to cerebral small vessel disease, neurodegeneration, phosphorylated tau, and a cerebrospinal fluid proteomic signature indicative of neuroimmune activation. …

In Silico Screening And Molecular Analyses Identify Apigenin From Scutellaria Barbata As A Potent Akt1 Inhibitor In Breast Cancer, Md. Maruf Khan, Md. Arju Hossain, Fatematuz Zohora, Md. Sohel, Md. Faisal Amin, Fatematuz Zuhura Evamoni, M. Nazmul Hoque

School of Integrative Biological & Chemical Sciences Faculty Publications

Breast cancer (BC) remains a leading cause of cancer-related mortality in women worldwide. Scutellaria barbata, a traditional Chinese medicinal herb, possesses recognized anticancer properties, but its mechanistic role in BC is not fully elucidated. This study employed an integrated in silico approach to identify the key flavonoids, targets, and pathways through which S. barbata exerts its anti-BC effects. A multi-step computational methodology incorporating network pharmacology, molecular docking, and dynamics simulations was utilized to profile bioactive compounds from S. barbata. From an initial set of 34 phytocompounds, three flavonoids namely apigenin, 4’-hydroxywogonin, and hispidulin demonstrated favorable drug-likeness, high bioavailability, …

Harmonizing Intervention, Context, And Implementation Strategies With Context-Driven Co-Design (Cd2), Sarah A Birken, Emily R Haines, Cheyenne R Wagi, Bonny B Morris, Kathryn E Weaver, Kathleen M Lisborg, Sara J Landes, Geoffrey M Curran, Miriam Bender, Maria E Fernandez, Ashley Strahley, Kimberly Wiseman, Kristie L Foley

Faculty, Staff and Student Publications

Background: Extant approaches to close the gap between implementation evidence and practice have been unsuccessful due in part to overreliance on researcher engagement. In practice, change is often driven by mid-level managers. We developed Context-Driven Co-Design (CD2) to equip mid-level managers with a theory- and evidence-based approach to implementation planning.

Methods: We used a two-pronged design. First, we engaged six established implementation researchers in a modified Delphi process, involving two hour-long meetings and asynchronous feedback to develop and refine a CD2 prototype. Second, we piloted an in-person CD2 training and conducted an hour-long focus group to solicit feedback from mid-level …

Real-World Outcomes Of Dedicated Leaflet Modification For Bioprosthetic Valve-In-Valve Tavr: A 150-Patient Commercial Experience., Raj R Makkar, Aakriti Gupta, Ignacio Inglessis, Curtiss T Stinis, Pradeep K Yadav, Vinod H Thourani, Stanley J Chetcuti, Matthew Summers, Vivek Patel, Bassem M Chehab, Apurva Patel, Gilbert H L Tang, Sahil Khera, Michael Rinaldi, Trevor Simard, Jeffrey Southard, Benjamin R Stripe, Brian Whisenant, Keith Allen, Yoseph Rozenman, Danny Dvir, Carlos E Sanchez, Jeffrey Popma, Martin B Leon, Philippe Généreux

Heart and Vascular Articles

BACKGROUND: Coronary obstruction during valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) is infrequent but catastrophic. Mechanical splitting of bioprosthetic leaflets may mitigate this risk, but real-world experience remains limited.

OBJECTIVES: The aim of this is to evaluate procedural performance and in-hospital outcomes of a dedicated mechanical leaflet-splitting device in ViV TAVR.

METHODS: Consecutive postapproval cases were performed at 28 centers from February to November 2025. Patients were selected for elevated risk based on preprocedural computed tomography criteria, including virtual valve-to-coronary distance ≤4 mm and/or virtual valve-to-sinotubular junction distance ≤3 mm. Procedural outcomes were assessed among patients in whom splitting was …

Effectiveness Of Lay Workers Delivering Behavioural Activation For People With Depression: Systematic Review And Meta-Analysis, Shwikar Othman, Lauren Blekkenhorst, Asangaedem Akpan, Irene Ngune, Nilufeur Mckay, Alison Kennedy, Elizabeth Armstrong, Michael Hunter, Kevin Murray, Mathew Coleman, Richard Gray, Emma Jones, Christopher Lee, Martin Jones

Research outputs 2022 to 2026

Background Behavioural activation is effective for depression, but its effectiveness in treating adults with depression when delivered by lay workers remains unclear. Aims To examine the effectiveness of behavioural activation delivered by lay workers, compared with any control group, in reducing depressive symptoms in adults. Method This systematic review searched six databases from inception to January 2025, for randomised controlled trials (RCTs) comparing behavioural activation and any control conditions for individuals with depression when delivered by lay workers. Additional searches were conducted in the international trial registries and reference lists (PROSPERO registration CRD42024625620). Risk of bias was assessed using the …

Adaptation Of The Transition Readiness Assessment Questionnaire For Pediatric-Onset Multiple Sclerosis: Protocol For A User-Centered Design Approach, Claudia Gambrah-Lyles, Aaron W Abrams, Sara Loud, Hollie Schmidt, Emily Blosberg, Melissa Wright, Kelsey E Poisson, Kristen S Fisher, Kimberly A O'Neill, Akash Virupakshaiah, John W Rose

Faculty, Staff and Students Publications

Background: Pediatric-onset multiple sclerosis (POMS) is a chronic, progressive neurologic condition requiring lifelong management and coordinated transition from pediatric to adult care. Evidence-based guidelines identify transition readiness assessment as a core component of successful transition; however, most POMS clinics do not formally assess readiness, and existing tools do not address POMS-specific challenges, such as fluctuating disability, complex treatment regimens, and cognitive impairment. This gap underscores the need for a transition readiness measure tailored to POMS.

Objective: This paper aims to describe a stakeholder-engaged, implementation science-guided protocol for adapting the Transition Readiness Assessment Questionnaire (TRAQ) version 6.0 to reflect the unique …

Continuing Medical Education As A Workforce Learning System For Artificial Intelligence In Clinical Practice, Tim Murphy, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Artificial intelligence (AI) is increasingly embedded in clinical decision support, documentation, imaging, predictive analytics, and workflow management. However, the educational systems responsible for preparing practicing physicians to use AI have not fully addressed the interpretive, ethical, and organizational demands of AI-supported care. This qualitative case study examined how continuing medical education (CME) shapes physicians’ readiness to integrate AI into clinical practice. Guided by the Unified Theory of Acceptance and Use of Technology (UTAUT) and human resource development (HRD), the study analyzed semi-structured interviews with 14 physicians from diverse specialties within a large academic health system. Organizational artifacts, including CME announcements, …