Medicine and Health Sciences Commons^™

National Alliance Of Sickle Cell Centers Consensus Recommendations On Sickle Cell Disease Health Maintenance: A Consensus Statement, Seethal A Jacob, Sana Saif-Ur-Rehman, Et Al.

2020-Current year OA Pubs

IMPORTANCE: The most common inherited blood disorder in the world, sickle cell disease (SCD) is a known global health concern. While survival of children into adulthood has improved significantly over the last few decades in high-resource countries, substantial gaps in care standards and limited practice harmonization persist.

OBJECTIVE: To provide up-to-date recommendations for preventive care and treatment of all people living with SCD and its related comorbidities.

EVIDENCE REVIEW: As part of the National Alliance of Sickle Cell Centers (NASCC), 41 pediatric and adult sickle cell disease experts developed consensus standards and recommendations based on available evidence and expert consensus …

Trends In Hallucinogen-Related Emergency Department And Hospital Admissions, 2016 To 2023, Jacob T Steinle, Lisa Gong, Joanna L Buss, Suraj Shankar, Joshua S Siegel, Leopoldo J Cabassa, Ruth Ling, Regina Huang, Danielle R Adams, Patricia Cavazos-Rehg, Arpana Agrawal, Ginger E Nicol, Richard Grucza, R J Waken, Kevin Y Xu

2020-Current year OA Pubs

No abstract provided.

Availability Of Multidisciplinary Treatment Modalities And Outcomes Among Patients With Resected Early-Stage Non-Small Cell Lung Cancer, Brendan T Heiden, Su-Hsin Chang, Yan Yan, Ana A Baumann, Theodore S Thomas, Steven Tohmasi, Nikki Rossetti, Daniel Kreisel, Ruben G Nava, Bryan F Meyers, Benjamin D Kozower, Varun Puri, Et Al.

2020-Current year OA Pubs

BACKGROUND: Comprehensive, multidisciplinary care is crucial for managing early-stage non-small cell lung cancer (NSCLC), typically treated via lung resection or stereotactic body radiation therapy (SBRT). We evaluated how variable access to on-site SBRT may be associated with clinical outcomes for patients with stage I NSCLC receiving surgical resection within an integrated health-care system.

METHODS: We performed a retrospective cohort study of patients with stage I NSCLC treated with lung resection at Veterans Health Administration (VHA) facilities between 2006 and 2016. The VHA provides thoracic surgery at approximately 100 facilities, whereas lung SBRT is currently available at approximately 20 facilities. We …

Muscle Fatigue Arising Intrinsically From Sur2- But Not Kir6.1-Dependent Gain-Of-Function In Cantu Syndrome Mice, Rosa Scala, Maya Mukadam, Yuezhou Chen, Courtney Frazier, Nathaniel W York, Robert C Tryon, Gretchen A Meyer, Colin G Nichols

2020-Current year OA Pubs

Cantu syndrome (CS) is a rare disease caused by gain-of-function (GOF) mutations of Kir6.1 or SUR2 subunits of ATP-sensitive potassium (KATP) channels. CS patients with SUR2 and Kir6.1 variants display a similar constellation of symptoms, including muscle weakness and fatigue. The effects of CS mutations on skeletal muscle KATP channels, and any consequent direct effects on contractility, are currently unclear. Here, we used two knock-in mouse models of CS, respectively, carrying GOF mutations Kir6.1[V65M] or SUR2[A478V], to assess KATP channel properties and contractility in isolated fast-twitch extensor digitorum longus (EDL) and slow-twitch soleus (SOL) muscles. Electrophysiological recordings in isolated myofibers …

Pip2-Driven Cytoplasmic Domain Motions Are Coupled To Kir2 Channel Gating, Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G Nichols, Sun-Joo Lee

2020-Current year OA Pubs

Inwardly rectifying potassium (Kir) channel activity is important in the control of membrane potentials in both excitable and non-excitable cells and is regulated through various ligands, including specific membrane lipids. Phosphatidyl-4,5-bisphosphate (PIP2) is required for activity of all Kir channels, binding to the cytoplasmic domain in a compact conformation tightly tethered to the transmembrane domain. Most Kir2 channel structures determined in complex with PIP2 molecules are nevertheless in a closed state, requiring additional conformational changes for channel opening. We have carried out full atomistic MD simulations, which indicate PIP2-dependent conformational changes that are coupled to opening and closing of the …

Overexpression Of The Signaling Coordinator Gab2 Can Play An Important Role In Acute Myeloid Leukemia Progression, Michael H. Kramer, Stephanie N. Richardson, Yang Li, Tiankai Yin, Nichole M. Helton, Daniel R. George, Michelle Cai, Sai Mukund Ramakrishnan, Casey Ds Katerndahl, Christopher A. Miller, Timothy J. Ley

2020-Current year OA Pubs

Mutations that initiate acute myeloid leukemia (AML) can cause clonal expansion without transformation (clonal hematopoiesis). Cooperating mutations, usually in signaling genes, are needed to cause overt disease, but these may require a specific fitness state to be tolerated. Here, we show that nearly all AMLs arising in a mouse model expressing 2 common AML-initiating mutations (Dnmt3aR878H and Npm1cA) acquired a single copy amplification of chromosome 7 (chr7), followed by activating mutations in signaling genes. We show that overexpression of a single gene on chr7 (Gab2, which coordinates signaling pathways) was tolerated in the presence of the Npm1cA mutation, could accelerate …

Diffusely Metastatic Glioblastoma With Fgfr3::Tacc3 Fusion: Cell-Free Dna Fragmentation Analyses And Molecular Characterization Of Matched Primary And Metastatic Tumor Sites, Miguel A Hernandez-Rovira, Alicia Vagnozzi, Tyler Bales, Keerthana N Prabhu, Noushin Niknafs, Milan Chheda, Jiayi Huang, Albert H Kim, Michelle Miller-Thomas, Omar Butt, Katie D Vo, Bhargavi S Sovani, Ashwin Singh Parihar, Suzanne Crumley, Sonika Dahiya, Dimitrios Mathios

2020-Current year OA Pubs

Extracranial metastasis of IDH-wildtype glioblastoma is very rare and poorly understood at the molecular level. We report a case of FGFR3::TACC3 fusion IDH-wildtype glioblastoma in a 61-year-old male, whose preoperative blood sample showed highly aberrant cfDNA fragmentation patterns, which could be suggestive of early systemic dissemination, undetected by standard-of-care imaging of his body. Eleven months post-resection and adjuvant therapy, he developed widespread extracranial metastases. Comprehensive molecular profiling of matched primary and metastatic tumors revealed broadly conserved genomic, transcriptomic, and copy number landscapes, with the metastasis harboring an additional ERCC6 deletion and enriched expression of receptor tyrosine kinase signaling genes. These …

Availability, Healthiness And Sodium Content Of Packaged And Unpackaged Foods And Beverages In Nigeria: A Cross-Sectional Study, Adedayo E Ojo, Erica L Jamro, Iyer Guhan, Mark D Huffman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Nigeria is experiencing a growing burden of diet-related non-communicable diseases, particularly hypertension and cardiovascular disease, largely driven by high sodium intake and poor diet quality. Unhealthy dietary patterns characterized by excessive sodium, sugars, and unhealthy fats, and low intake of essential nutrients contribute to approximately 31% of global deaths annually. However, there is limited data on the sodium content and nutritional quality of foods in Nigerian markets. This study assessed and compared the availability, healthiness, and sodium content of packaged and unpackaged foods in Nigerian markets.

METHODS: From August 2022 to December 2022, we collected and compared nutrition data …

Music As A Strategy To Improve Hypertension And Stroke Management: Evidence From A Crowdsourcing Open Call And Designathon In Nigeria, Chidi Okafor, Shravya Allena, Olufunto A Olusanya, Titilola Gbaja-Biamila, Temitope Ojo, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: In Nigeria, cardiovascular diseases, especially hypertension, are on the rise. This increase in hypertension correlates with more strokes, significantly impacting mortality. Since hypertension often persists into adulthood, early interventions are crucial to prevent its complications. Non-invasive methods, such as music and creative activities, can effectively improve blood pressure and reduce stroke risk. This study aims to improve intergenerational awareness of hypertension and promote sustainable preventive practices by involving youth and caregivers within families and communities.

METHODS: We employed a participatory, observational design, incorporating a five-month crowdsourcing open call followed by a designathon event. Participatory social and health innovations were …

Mobile Health (Mhealth) Access In A Dc Population With Fall Diagnosis: Background Research To Inform Equitable Access To Mhealth Platforms As Part Of An Emergency Medicine Department-Initiated Digital Fall Prevention Program, Leah Steckler, Krystl Haerian, Nasima Mannan, Addison Gwinner, Colton Hood, Michael Williams

Emergency Medicine Faculty Posters and Presentations

Background: Falls are the leading cause of injury-related death in adults over age 65 (CDC, 2024). Traditional exercise-based interventions may have an impact on fall prevention (US Preventive Services Task Force et al., 2024). Providing these programs is resource-intensive, however mHealth applications may expand comprehensive fall prevention. We seek to know if there are differences in the interactions with mHealth in adults ages 65-89 in the Medical Faculty Associates (MFA) population and if these differences are related to social determinants of health (SDOH).

Methods: IRB waiver was obtained for human subjects research. We accessed data from years 2019-2024 in Epic …

Moderators Of Peer Influence Effects For Adolescents’ Smoking And Vaping Norms And Outcomes In High And Middle-Income Settings, Jennifer M. Murray, Sharon C. Sánchez-Franco, Olga L. Sarmiento, Erik O. Kimbrough, Christopher Tate, Shannon C. Montgomery, Rajnish Kumar, Laura Dunne, Abhijit Ramalingam, Erin L. Krupka, Felipe Montes, Huiyu Zhou, Laurence Moore, Linda Bauld, Blanca Llorente, Frank Kee, Ruth F. Hunter

Economics Faculty Articles and Research

Background: Peer influence is central to adolescent smoking initiation, yet its impact varies depending on individual and contextual factors. Understanding which moderators (personality, contextual, cultural, and environmental traits) shape these processes can inform more effective prevention strategies. We investigated hypothesized moderators of peer influence for adolescent smoking/vaping norms and other smoking-related outcomes in high and low-middle-income countries (LMICs): Northern Ireland and Bogotá.

Methods: Across 12 schools (n = 1,344, age 12–13 years), participants completed novel behavioral economics experiments measuring social norms, and self-report surveys, before and after school-based prevention interventions (ASSIST and Dead Cool). We examined how peer influence …

Ready Or Not? Merits Of An End-Of-Fourth-Year Summative Osce, Shruti Chandra, Md, Mehp, Deborah Ziring, Md, Katherine Berg, Md, Mph, Stefani Russo, Md

JeffMD Academic Affairs

Purpose

To develop a summative OSCE for fourth-year medical students to assess core clinical skills for internship readiness and remediate low performers.

Program directors report gaps between expectations and interns’ skills.

End of clerkship OSCEs, End of third-year summative OSCE

• Different competencies assessed
• Not reflective of graduation skills

An end-of-fourth-year summative OSCE was developed to

• Assess advanced reasoning and communication
• Assure residency readiness
• Identify and remediate clinical skills deficiencies

Characterization Of Androctonus Mauritanicus Venom And In Vitro Screening Of Sars-Cov-2 Entry Inhibitors Candidates, Reda Chahir, Jacob Galan, Hicham Hboub, Ahmed Salim Lahlou, Salma Chakir, Hinde Aassila, Reda Ben Mrid, Najat Bouchmaa, Reto Stöcklin, Rachid El Fatimy, Naoual Oukkache

Human Genetics Publications

Animal venom, known for its complex biochemical composition, presents a valuable source of therapeutic molecules, particularly for antiviral applications. Despite this potential, the industrial use of venom remains limited, with fewer than a dozen venom-derived compounds reaching commercial markets. This study underscores the significance of exploring venom’s natural diversity as a reservoir for novel bioactive compounds that could drive innovative drug development. We investigated the venom of the Moroccan black scorpion Androctonus mauritanicus (Am), applying solid-phase extraction (SPE) and high-performance reversed-phase liquid chromatography (RP-HPLC) to fractionate the venom into 80 distinct samples. These fractions were subjected to detailed analysis …

Proteomic Perspectives On Kras-Driven Cancers And Emerging Therapeutic Approaches, Ramesh Karki, Ru Chen, Sheng Pan

Faculty, Staff and Student Publications

KRAS mutations are implicated in approximately 23% of all human malignancies, with particularly high prevalence in pancreatic ductal adenocarcinoma (PDAC) (~92%), colorectal cancer (CRC) (~49%), and non-small cell lung cancer (NSCLC) (~35%). The recent approval of the KRASG12C-specific inhibitors for NSCLC represents a pivotal advancement in KRAS-targeted therapy. Nevertheless, the emergence of intrinsic and acquired resistance to KRAS-targeted therapies poses a significant clinical obstacle to targeting KRAS, which necessitates a deeper understanding of the resistance mechanisms. Recent progress in proteomic studies has enabled comprehensive profiling of the proteomic alterations driven by KRAS mutations, offering valuable insights into the disrupted KRAS …

Impact And Effectiveness Of Phq-9 Training For School Counselors On Mental Health Referrals For High School Students, Sherikee Dorice Grim Bsn, Rn, Ja’Quay Brister Dnp, Pmhnp-Bc, Margaret Harvey Phd, Aprn, Acnp, Chfn, Fhrs

Doctor of Nursing Practice Projects

Purpose/Background

Adolescents' mental health has worsened and become a public health issue, with depression being a primary concern. There is an urgent need for early screening, school-based referral pathways, and interventions to address common problems in high schools. Patient Health Questionnaire-9 (PHQ-9) is a validated, evidence-based tool for detecting depression; however, its systematic use in school-based counseling settings through organized training has not been studied for implementation in high schools. This review assesses the current literature on the impact and effectiveness of PHQ-9 training for school counselors on mental health referrals among high school students, with a focus on early …

Understanding Ai Literacy: Implications For Practice​, Devon Olson, Janet Anderson, Sara Westall

Librarian Publications

Presentation from the 2025 Mountain Plains Library Association Tri-Conference, held in Grand Forks, ND. This presentation provides an overview of basic AI concepts and frameworks for AI literacy, discussing the impact of different patron and learner demographics on learner needs, competencies, and instructional strategies.

Insecticide Resistance Profile In Nashville Culex Spp. Mosquito Populations, Ellie Sebaugh, Zachary Bement, Abelardo Moncayo, Darlene Panvini

Science University Research Symposium (SURS)

Mosquitoes may develop resistance to insecticides used by control programs, potentially increasing population density and the risk of mosquito-borne diseases. Culex spp. mosquitos are the primary vector of West Nile Virus (WNV), the leading cause of mosquito-borne disease in the United States and a reportable disease in Tennessee. Resistance profiles were constructed for two insecticides, permethrin and malathion, in a Culex spp. population from Nashville, Tennessee. Adult female mosquitoes were live-captured using gravid traps and tested using the Centers of Disease Control and Prevention (CDC) bioassay protocol to assess resistance or susceptibility. Three inhibitors were also included to identify metabolic …

Imaging In Sports Medicine: Frequency Of Abnormal Findings And The Value Of Point-Of-Care Ultrasound, James Wilcox,, Haia Ramzi Qanadilo,

Family Medicine Collaborative Works

Many musculoskeletal imaging modalities are considered the cornerstone of sports medicine, though the diagnostic yield is different across each modality. Radiographs often detect abnormalities in fewer than half of cases, with the MURA dataset reporting only 39% of abnormal extremity films (Rajpurkar et al., 2018). In contrast, musculoskeletal ultrasound has been shown to identify pathology in up to 83% of examinations (Chiavaras et al., 2008). Point-of-care ultrasound (POCUS) further enhances rapid bedside diagnosis, with emergency department studies showing pathology in approximately 79% of cases (Situ-LaCasse et al., 2018). This review aimed to describe the frequency of abnormal findings across imaging …

Policy Analytic Approach To Overcoming Barriers In Transitional Support For Autistic Racial And Ethnic Minority Youth, Rosaline Owusu Dnp, Mph, Fnp-Bc, Crnp

Department of Family Medicine

No abstract provided.

Economic Evaluation Of Screening, Treatment, And Prevention Interventions For Perinatal Mood And Anxiety Disorders: A Systematic Review, Sabrina Alam, Brian Christman, Emma Mcneill, Man Tang, Rong Rong, Qing Li, William Hillegass, Janice Hall, Laura Wright, Chisa Lanier, Xu Xiong, Lizheng Shi, Abigail Gamble

Preventive Medicine Publications

Objective

Methods

Characterization Of Colorectal Cancer Cell Responses Using A Wound-Healing Scratch Assay Model On Wild-Type (P53 +/+) And Knockout (P53 -/-), Mehrael Faragalla, Karen Barsoum, Erick Spears

Science University Research Symposium (SURS)

Colorectal cancer progression is driven in part by dysregulated signaling pathways that alter cell growth and migration. One key pathway is the Wnt signaling pathway, a key regulator in colorectal tumorigenesis, which promotes MYC overexpression, leading to uncontrolled proliferation. Interestingly, in the absence of p53, MYC has been found to induce expression of the tumor suppressor gene EGR1, shifting the cellular response toward apoptosis rather than growth. This study investigates the MYC–EGR1 pathway in HCT116 colorectal cancer cells with either wild-type (p53+/+) or knockout of the TP53 gene (p53−/−). Early findings indicate that p53+/+ cells exhibit faster initial growth compared …

Multinational Transfusion Practices And Outcomes In Haematology Patients Admitted To The Intensive Care Unit, Caroline Schaap, Laurens Oomen, Senta Raasveld, Jimmy Schenk, Sanne De Bruin, Merijn Reuland, Claudia Oord, Jan Bakker, Maurizio Cecconi, Marcus Lance

Anaesthesiology, East Africa

Background and Objectives The number of critically ill patients with haematological conditions is increasing, yet transfusion practices in this population remain poorly defined. This study aimed to compare transfusion strategies in critically ill patients with versus without haematological conditions.

Study Design and Methods This international, prospective observational substudy of the International Point Prevalence Study of Intensive Care Unit [ICU] Transfusion Practices (InPUT) evaluated transfusion use in ICU patients with and without haematological conditions, including benign or malignant diseases or a history of stem cell transplantation. Outcomes included use of red blood cells (RBCs), platelets, plasma, haemostatic interventions, transfusion indications and …

Gut Bacterial Dysbiosis In Pediatric Severe Malaria Associates With Post-Discharge Mortality, Olivia Bednarski, Sawyer Lehman, David Mzinza, Caroline Kazinga, Ruth Namazzi, Robert Opoka, Jie Ren, Tuan Tran, Terrie Taylor, Karl Seydel

Paediatrics and Child Health, East Africa

Gut microbiota have been implicated in severe malaria in murine models, but their contribution to the pathogenesis of severe malaria in children is unknown. Here we show through analysis of gut bacteria in stool samples from two separate African studies enrolling children with severe malaria, and children from local communities, that children with severe malaria have gut bacteria dysbiosis. Among children with severe malaria, there is increased abundance of Enterobacteriaceae that associates with multiple clinical complications of severe malaria. Moreover, increased abundance of Escherichia coli was a predictor of post-discharge mortality. Metagenome analysis identify elevated metabolic pathways and genes supporting …

Neonatal Unit Human Resources: Coverage For Six Cadres And Trends For Staff-To-Baby Ratios In 65 Neonatal Units Implementing With Nest360 In Kenya, Malawi, Nigeria, And Tanzania, Rebecca Penzias, Eric Ohuma, Opeyemi Odedere, Olabisi Dosunmu, George Okello, Hannah Mwaniki, Robert Tillya, Josephine Shabani, Vincent Ochieng, Ekran Rashid, William Macharia

Paediatrics and Child Health, East Africa

Background: Implementing small and sick newborn care (SSNC) requires skilled health workers; however, there is a shortage, adversely impacting patient outcomes and health worker wellbeing. There are limited data and no cur‑ rent World Health Organization (WHO) standards for staftobaby ratios in neonatal units in low and middleincome countries (LMICs) to inform policy, planning, and investment.

Methods: In 65 neonatal units (36 in Malawi, 13 in Kenya, 7 in Tanzania, and 9 in Nigeria), a health facility assessment (HFA) for SSNC and governmentled quality improvement (QI) processes were implemented. Stafng data were col‑ lated from baseline HFA (Sept 2019–March 2021) …

The Importance Of Medication Reconciliation In A Patient With Parkinson's Disease, Charlie Wright Pharmd, Bcps, Sarah Steely Wright Pharmd, Bcps

Faculty Research ​and Publications

In this case, a 67-year-old male experienced a progression of his Parkinson’s disease symptoms following an inpatient hospitalization for pneumonia. He presents to the neurology clinic for follow-up, where the neurology ambulatory care pharmacist was consulted to assist with his case. The pharmacist identified a medication reconciliation discrepancy that resulted in an unintentional change in the dosing frequency of his carbidopa/levodopa. This, combined with the initiation of metoclopramide, a dopamine-receptor antagonist, led to a worsening of his Parkinson’s symptoms. His carbidopa/levodopa dose was titrated back to the previous regimen, metoclopramide was discontinued, and his symptoms significantly improved. This case highlights …

Empowering Nursing Teams To Prevent Delirium, Caroline "Candy" Smead Dnp, Rn, Scrn

Nursing Publications, Posters, & Presentations

Project Aim: To empower nursing teams to reduce delirium by using an embedded evidence-based delirium prevention bundle.

Presented at the 6th Annual Parkview Nursing Research and Evidence-Based Practice Symposium. Theme: “From Paper to Practice: The Art of Implementation Science,” at the Parkview Mirro Center for Research and Innovation.

Oesophageal Cancer And Its Associated Factors Among Patients Attending Surgical And Oncology Clinics At Garissa County Referral Hospital, Kenya: A Case-Control Study, Abdi Bashir, Moses Ngari, Berrick Otieno, Makorani Y’Dhidha-A-Mjidho, Osman Abdullahi, Symon Kariuki

Institute for Human Development, East Africa

Background Oesophageal cancer (EC) is a common cause of cancer mortality. Evidence on the burden, risk factors and treatment outcomes is limited in low-income and middle-income countries. This study aimed to describe the features of EC cases and determine associated factors among patients attending surgical and oncology clinics in Garissa County Referral Hospital (GCRH).

Methods We conducted a case–control study in which cases were patients with EC and positive histological confirmation and controls were patients admitted to GCRH for other diseases. Data on exposures were extracted from patient files. Data on tobacco and alcohol use were based on current or …

Avasopasem Manganese Treatment For Severe Oral Mucositis From Chemoradiotherapy For Locally Advanced Head And Neck Cancer: Phase 3 Randomized Controlled Trial (Roman), Carryn Anderson, Christopher M. Lee, Joseph Randall Kelley, Gary V. Walker, Neal E. Dunlap, Voichita Bar-Ad, Douglas A. Miller, Vernon J. King, Abhinand V. Peddada, Douglas F. Ciuba, Francois Vincent, Brian C. Muzyka, Amanda Lynn Gillespie-Twardy, Stephen T. Sonis, Jon Holmlund, Robert A Beardsley, Eugene P Kennedy, Deborah Saunders

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: Of patients who receive standard concomitant chemoradiation (CRT; intensity-modulated radiation therapy [IMRT] plus cisplatin) for locally advanced head and neck cancer (HNC), approximately two-thirds will develop severe oral mucositis (SOM), limiting their ability to eat solids (WHO grade 3) or drink liquids (WHO grade 4). In a randomized, double-blind phase 2b trial, avasopasem manganese substantially reduced duration and incidence of SOM versus placebo. This phase 3 trial further assessed avasopasem's reduction of SOM due to CRT.

METHODS: In this double-blind, placebo-controlled trial (Clinicaltrials.gov: NCT03689712), patients receiving 60-72 Gy IMRT (>50 Gy to ≥2 oral mucosal sites) plus cisplatin …

Effects Of Tpa023b, An Α2/3/5gabaa Subtype-Selective Partial Allosteric Modulator, On Fentanyl-Induced Respiratory Depression In Male Rats: Comparison With The Non-Selective Benzodiazepine Midazolam, Loc M. Pham, Andria B. Nanney, Jordan Hasting, Daniela Rüedi-Bettschen, Kevin B. Freeman, James K. Rowlett

Psychiatry Publications

Rationale

Opioid-related overdose deaths involving benzodiazepines have increased in recent years, and prior studies have reported that clinically used benzodiazepines can enhance the respiratory-depressant effects of mu opioid receptor (MOR) agonists. TPA023B is an α1-sparing GABAA positive allosteric modulator developed as a potential anxiolytic with fewer benzodiazepine-typical side effects. However, it is unknown if and to what degree TPA023B can affect MOR-agonist induced respiratory depression.

Objectives

The current study compared the effects of either TPA023B or midazolam, alone and combined with fentanyl, on respiratory depression in rats, using whole-body plethysmography.

Methods

Male Sprague-Dawley rats were implanted with chronic indwelling intravenous …

Himmelfarb Headlines - November/December 2025, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

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