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Articles 5731 - 5760 of 159981
Full-Text Articles in Medicine and Health Sciences
Effects Of Exercise Interventions On Motor Coordination In Children With Developmental Coordination Disorder (Dcd): A Systematic Review And Meta-Analysis, Changhui Peng, Jinrong He, Kai Xu, Xueping Wu, Dandan Wang, Lei Zhang
Effects Of Exercise Interventions On Motor Coordination In Children With Developmental Coordination Disorder (Dcd): A Systematic Review And Meta-Analysis, Changhui Peng, Jinrong He, Kai Xu, Xueping Wu, Dandan Wang, Lei Zhang
Research outputs 2022 to 2026
Background Exercise interventions are recognized as an established therapeutic approach for children with DCD. This review aims to quantify the effectiveness of exercise interventions and examine the influence of potential moderating factors on outcomes. Methods We systematically searched PubMed, Web of Science, Embase, the Cochrane Library, and EBSCO from inception to November 1, 2025. All studies were rigorously screened based on predefined eligibility criteria. Risk of bias was assessed using ROB 2 and ROBINS-I. Effect sizes were calculated as Hedges’ g (g) and pooled under a random-effects model, and potential moderators were examined through subgroup and regression analyses. Results A …
Emergency Clinicians’ Knowledge And Practice Of Pain Assessment For Older Adults With Cognitive Impairment: A Cross-Sectional Study, Carrie Janerka, Kaoru Nosaka, Aaron Lapuz Alejandro, Jeffery Hughes, Natasya Raja Azlan, Amineh Rashidi, Wenhong Zhao, Rosemary Saunders
Emergency Clinicians’ Knowledge And Practice Of Pain Assessment For Older Adults With Cognitive Impairment: A Cross-Sectional Study, Carrie Janerka, Kaoru Nosaka, Aaron Lapuz Alejandro, Jeffery Hughes, Natasya Raja Azlan, Amineh Rashidi, Wenhong Zhao, Rosemary Saunders
Research outputs 2022 to 2026
Background Older adults with cognitive impairment frequently present to emergency departments and often experience poor pain management. Patients’ impaired self-reporting, limited clinician training, inconsistent use of behavioural tools, and environmental pressures have been reported challenges. This study examined emergency clinicians’ knowledge and practices in assessing pain for this population. Methods A descriptive cross-sectional survey was conducted across two emergency departments in Australia. An 86-item survey collected clinicians’ pain assessment knowledge and practices. Quantitative data were analysed using descriptive statistics, and qualitative responses were thematically analysed. Results 148 clinicians (110 nurses, 21 doctors, 17 allied health staff) responded to the survey …
Facilitators To The Implementation Of Exercise Into Cancer Care: A Systematic Review, Georgia L. White, Mary A. Kennedy, Brent J. Cunningham, Riley Dunn, Jason Martin, Meegan Walker, Craig T. Wallington-Gates, Hattie Wright, Bryan Chan, Grace L. Rose
Facilitators To The Implementation Of Exercise Into Cancer Care: A Systematic Review, Georgia L. White, Mary A. Kennedy, Brent J. Cunningham, Riley Dunn, Jason Martin, Meegan Walker, Craig T. Wallington-Gates, Hattie Wright, Bryan Chan, Grace L. Rose
Research outputs 2022 to 2026
Purpose: Although governing bodies urge the importance of integrating exercise into routine cancer care, facilitators to implementation have not been systematically identified and collated. This review aimed to summarise facilitators to implement exercise services within real-world settings. Methods: A systematic review of qualitative, quantitative, and mixed-method studies was conducted (three databases, 13th September 2024). Reports were included if they documented the implementation of co-located exercise services (delivered onsite within cancer centres) or referral pathways to external exercise services from cancer centres. The updated Consolidated Framework for Implementation Research (CFIR 2.0) was used to code and synthesise facilitators. Results: Of 8544 …
Priorities For Multimorbidity Management And Research In Cancer: A Delphi Study Of Australian Cancer Survivors, Clinicians, And Researchers, Rebecca L. Venchiarutti, Haryana Dhillon, Carolyn Ee, Nicolas H. Hart, Michael Jefford, Bogda Koczwara
Priorities For Multimorbidity Management And Research In Cancer: A Delphi Study Of Australian Cancer Survivors, Clinicians, And Researchers, Rebecca L. Venchiarutti, Haryana Dhillon, Carolyn Ee, Nicolas H. Hart, Michael Jefford, Bogda Koczwara
Research outputs 2022 to 2026
Purpose: Multimorbidity is common in people with cancer and associated with increased complexity of care, symptoms, mortality, and costs. This study aimed to identify priorities for care and research for cancer survivors with multimorbidity. Methods: A Delphi consensus process was conducted. Elements of care and research were based on Australia’s National Strategic Framework for Chronic Conditions, a literature review, and expert input. In Round 1, health professionals, cancer survivors, and researchers rated the importance of 18 principles, 9 enablers, and 4 objectives. In Round 2, new elements were rated and all elements were ranked. Results: In Round 1, all elements …
Co-Design Of An Online Mindfulness Program For Informal Carers Of People Living With Dementia: A Qualitative Study Of Co-Designers’ Experience, Charunya A.K.R. Abeysinghe Mudiyanselage, Seng Giap Marcus Ang, Aisling Smyth, Joanne M. Dickson, Beverley Ewens
Co-Design Of An Online Mindfulness Program For Informal Carers Of People Living With Dementia: A Qualitative Study Of Co-Designers’ Experience, Charunya A.K.R. Abeysinghe Mudiyanselage, Seng Giap Marcus Ang, Aisling Smyth, Joanne M. Dickson, Beverley Ewens
Research outputs 2022 to 2026
Introduction: Informal carers face significant challenges related to care provision for people living with dementia. Participating in a mindfulness-based stress reduction program could improve the wellbeing of informal carers. However, engaging in these programs can be difficult for informal carers due to the needs of their care recipients. Purpose: This study aimed to co-design an online mindfulness program in collaboration with a range of stakeholders and those with lived experience as carers. Methods: This co-design study adopted an interpretive descriptive qualitative approach to the development of the program. The stakeholders (co-designers) included people with lived experience as informal carers and …
Fall Prevention Interventions In Community-Dwelling Older People With Cognitive Impairment: A Systematic Review, Sumattana Glangkarn, Pelden Chejor, Rujira Nonsa-Ard, Kasama Wongprachum, Sirapat Khodseewong, Chaiwut Bourneow, Davina Porock
Fall Prevention Interventions In Community-Dwelling Older People With Cognitive Impairment: A Systematic Review, Sumattana Glangkarn, Pelden Chejor, Rujira Nonsa-Ard, Kasama Wongprachum, Sirapat Khodseewong, Chaiwut Bourneow, Davina Porock
Research outputs 2022 to 2026
Introduction: Falls are a major health concern for older adults, particularly those with cognitive impairment. Many factors contribute to the risk of falls, making it a complex issue to manage. Aim: This systematic review aimed to identify and describe the implementation strategies used for fall prevention in community-dwelling older people with cognitive impairment. Eligibility criteria: The review included studies on fall prevention interventions for community-dwelling adults aged > 50 years with cognitive impairment. Eligible studies were primary research, including experimental, quasi-experimental, qualitative, and mixed methods designs, with detailed implementation strategies. Systematic reviews, protocols, editorials, opinions, commentaries, and conference papers were excluded. …
National Consensus On The Capabilities That Inform The Role Of Advanced Practice Paramedics: A Delphi Study, Alessia Restiglian, Lorna Martin, David Long, Louise Reynolds, Tony Walker, Ben Meadley, Ashleigh Finn, Alan Batt, Alecka Miles, Tania Johnston, Brendan Shannon
National Consensus On The Capabilities That Inform The Role Of Advanced Practice Paramedics: A Delphi Study, Alessia Restiglian, Lorna Martin, David Long, Louise Reynolds, Tony Walker, Ben Meadley, Ashleigh Finn, Alan Batt, Alecka Miles, Tania Johnston, Brendan Shannon
Research outputs 2022 to 2026
Advanced Practice Paramedics (APPs) are highly skilled paramedics who operate in diverse clinical settings both within and outside traditional ambulance services. International evidence demonstrates that APPs enhance patient outcomes in areas such as critical and primary care. In Australia, the expansion of APP roles and responsibilities has gained momentum; however, no nationally recognised framework exists to define their expected capabilities. This gap leads to inconsistencies in education, practice and role clarity. A standardised capability framework is therefore vital to guide the development, implementation and integration of APP roles within the Australian healthcare system. The primary aim of this study was …
Superior Effects Of High-Intensity Interval Eccentric Cycling Training On Neuromuscular Adaptations With Similar Aerobic Adaptations To Concentric Cycling, Marcin Lipski, Joanne Trezise, Chris R. Abbiss, Kazunori Nosaka
Superior Effects Of High-Intensity Interval Eccentric Cycling Training On Neuromuscular Adaptations With Similar Aerobic Adaptations To Concentric Cycling, Marcin Lipski, Joanne Trezise, Chris R. Abbiss, Kazunori Nosaka
Research outputs 2022 to 2026
Purpose: We compared the effects of high-intensity interval eccentric (EC) versus concentric cycling (CC) training on aerobic capacity, muscle function and morphology. Methods: Healthy men (19–56 y) performed EC (n = 9) or CC (n = 8) training twice a week for 8 weeks. The training progressed from 5 × 2-min intervals with 1-min rest to 7 × 2-min intervals with 30-s rest. EC and CC were matched for perceived effort, and progressed from 30 to 36% of concentric peak power output (PPO10s) for CC and from 45 to 70% PPO10s for EC. Changes in peak oxygen consumption (VO2peak), incremental …
Determining The Mental Wellbeing Of Family Day Care Educators In Australia, Theresa Rayfield, Ruth Wallace, Karen Lombardi, Eben Afrifa-Yamoah, Brennen Mills
Determining The Mental Wellbeing Of Family Day Care Educators In Australia, Theresa Rayfield, Ruth Wallace, Karen Lombardi, Eben Afrifa-Yamoah, Brennen Mills
Research outputs 2022 to 2026
Family Day Care (FDC) is an essential service supporting Australian families requiring convenient, versatile, and quality education and care for their children. FDC educators’ mental wellbeing (MWB), often overlooked, is vital to ensure optimal education and care. This study aimed to gauge Australian FDC educators’ MWB and identify factors positively or negatively affecting MWB. A cross-sectional questionnaire measuring MWB, and eight predictor variables influencing MWB, was completed by Australian FDC educators. Structural equation modelling was utilised to ascertain relationships of the predictor variables on MWB. This study established MWB was lower than population norms (N = 292) and provided a …
The Nurse's Role In Curative-To-Palliative Transitions In Advanced Cancer: A Theory Synthesis Using Turner's Method, Geya George, Deborah Kirk, Davina Porock
The Nurse's Role In Curative-To-Palliative Transitions In Advanced Cancer: A Theory Synthesis Using Turner's Method, Geya George, Deborah Kirk, Davina Porock
Research outputs 2022 to 2026
Aim: This paper aims to explain the process of formulating a robust theory that comprehensively explains the nurse's role during the transition from curative to the palliative phase in advanced cancer care. Design: A qualitative theory synthesis approach was applied, utilising Turner's 9-step theory synthesis method to integrate five grounded theories and 10 qualitative studies. The Walker and Avant method of concept development and analysis further ensured rigour. Methods: Turner's theory synthesis was used to formulate a more comprehensive, testable theory from five existing grounded theories and 10 other qualitative studies that explain the nurse's role in supporting and facilitating …
Gwas Meta-Analysis Provides New Insights Into Uveal Melanoma Risk, Matthew D’Mellow, Huanwei Wang, Jane M. Palmer, Kari Hemminki, Colleen M. Cebulla, Aaron B. Beasley, Nikolaos E. Bechrakis, Antonia L. Pritchard, Karin W. Wadt, Peter A. Johansson, Lenha Mobuchon, Samantha Barlow, Kelly Brooks, Timothy Beckman, Catherine M. Olsen, Sunil K. Warrier, Lindsey Byrne, Helen Kalirai, Colette Mustard, Nathan Ingold, Asta Försti, Timothy Isaacs
Gwas Meta-Analysis Provides New Insights Into Uveal Melanoma Risk, Matthew D’Mellow, Huanwei Wang, Jane M. Palmer, Kari Hemminki, Colleen M. Cebulla, Aaron B. Beasley, Nikolaos E. Bechrakis, Antonia L. Pritchard, Karin W. Wadt, Peter A. Johansson, Lenha Mobuchon, Samantha Barlow, Kelly Brooks, Timothy Beckman, Catherine M. Olsen, Sunil K. Warrier, Lindsey Byrne, Helen Kalirai, Colette Mustard, Nathan Ingold, Asta Försti, Timothy Isaacs
Research outputs 2022 to 2026
Objective: The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. Methods: Five novel UM genome-wide association studies (GWAS) were performed and included for meta-analysis with four previously published UM GWAS. A fixed-effects inverse-variance weighted (IVW) meta-analysis was performed by combining data from these nine UM case-control cohorts. A follow-up transcriptome-wide association study (TWAS) was conducted to identify candidate target genes at UM risk loci. Genetic correlations with melanoma-related phenotypes were measured to elucidate UM’s genetic architecture. …
Implementation Of Risk Prediction And Stratification Approaches For Ageing Populations In Australian Healthcare: A Systematic Review, Leanne Greene, Jacob Brain, Belinda Brown, Claire V. Burley, Elissa Burton, Zhongyang Guan, Bronwyn Myers, Katherine Ride, Serena Sabatini, Mario Siervo, Abay Woday Tadesse, Eugene Yee Hing Tang, Blossom C.L. Stephan, Jennifer Dunne
Implementation Of Risk Prediction And Stratification Approaches For Ageing Populations In Australian Healthcare: A Systematic Review, Leanne Greene, Jacob Brain, Belinda Brown, Claire V. Burley, Elissa Burton, Zhongyang Guan, Bronwyn Myers, Katherine Ride, Serena Sabatini, Mario Siervo, Abay Woday Tadesse, Eugene Yee Hing Tang, Blossom C.L. Stephan, Jennifer Dunne
Research outputs 2022 to 2026
Despite widespread development of prognostic risk stratification tools, their implementation in Australian healthcare remains poorly characterised. This review identified tools implemented for adults aged ≥40 years and examined their real-world use. Following PRISMA and SWiM guidelines, MEDLINE, EMBASE, Web of Science, PsycINFO, and CINAHL Plus were searched from inception to 20th February 2026. Eligible studies reported implementation of a risk stratification tool in Australian healthcare and health, functional, or implementation outcomes. The Mixed Methods Appraisal Tool assessed study quality. Of 7115 records screened, 21 studies were included across primary care, hospitals, residential aged care, and community services. Interventions included electronic …
Is A Fear Of Death Keeping You Awake At Night? Death Anxiety Predicts Insomnia Through Nightmare Severity, Rachel E. Menzies, Jessie Brown, Mitchell Turner, David Cunnington, Malisa Burge, Ian C. Dunican, Hailey Meaklim
Is A Fear Of Death Keeping You Awake At Night? Death Anxiety Predicts Insomnia Through Nightmare Severity, Rachel E. Menzies, Jessie Brown, Mitchell Turner, David Cunnington, Malisa Burge, Ian C. Dunican, Hailey Meaklim
Research outputs 2022 to 2026
The fear of death (death anxiety) is a risk factor for various mental health conditions. Death anxiety has been theorized to elicit physiological arousal and worry and is empirically associated with attachment insecurity, each of which has been linked to disrupted sleep. However, limited research has explored the relationship between death anxiety, nightmares and insomnia. We examined the relationship between death anxiety and insomnia, as well as attachment style as a potential moderator, and nightmare severity as a possible mediator. Five hundred and fifteen adults completed an online survey; 70% were female, and 89% resided in Australia. Regression analyses revealed …
Maternal Prebiotic Supplementation Modifies Associations Between Intrapartum Antibiotics And Infant Allergy, Summer V.M. Walker, Thomas R. Sullivan, Rachelle A, Pretorius, Nina D'Vaz, Johnny Lo, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Claus T. Christophersen, Debra J. Palmer
Maternal Prebiotic Supplementation Modifies Associations Between Intrapartum Antibiotics And Infant Allergy, Summer V.M. Walker, Thomas R. Sullivan, Rachelle A, Pretorius, Nina D'Vaz, Johnny Lo, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Claus T. Christophersen, Debra J. Palmer
Research outputs 2022 to 2026
Background: Prebiotics promote growth of beneficial gut bacteria, whereas antibiotics can disrupt the microbial balance, reduce diversity, and potentially cause gut dysbiosis. This investigation aimed to determine whether antibiotic use before, during, or after birth altered the risk of infant allergic disease outcomes within a maternal prebiotic dietary supplementation trial. Methods: Maternal participants were allocated to consume daily prebiotics (galacto-oligosaccharides and fructo-oligosaccharides) or placebo (maltodextrin) powder from 18 to 20 weeks' gestation until 6 months postnatal. All infants had a family history of allergic disease. Maternal and infant antibiotic use was prospectively collected monthly throughout the trial intervention period, and …
Measuring Mental Health Promoting Behaviours: Development And Psychometric Properties Of A Danish Act Belong Commit-Mental Health Promoting Behaviours (Abc-Mhpb) Scale, Line Nielsen, Ziggi Ivan Santini, Malene Kubstrup Nelausen, Carsten Hinrichsen, Frederik Schou-Juul, Vibeke Jenny Koushede, Robert J. Donovan, Charlotte Bjerre Meilstrup
Measuring Mental Health Promoting Behaviours: Development And Psychometric Properties Of A Danish Act Belong Commit-Mental Health Promoting Behaviours (Abc-Mhpb) Scale, Line Nielsen, Ziggi Ivan Santini, Malene Kubstrup Nelausen, Carsten Hinrichsen, Frederik Schou-Juul, Vibeke Jenny Koushede, Robert J. Donovan, Charlotte Bjerre Meilstrup
Research outputs 2022 to 2026
Background: The Act Belong Commit-ABCs of Mental Health campaign is the world’s first comprehensive, population-wide, community-based initiative to promote mental health. In response to a growing demand for valid tools to monitor mental health promoting behaviours, this study presents the development and psychometric evaluation of the ABC-Mental Health Promoting Behaviours (ABC-MHPB) scale in a Danish population-based sample. Methods: A 10-item scale was developed, based on the ABC framework, to assess mental health promoting behaviours. A total of 119,221 randomly selected participants aged 18+ filled out an electronic survey, including the scale to measure the underlying construct of mental health promoting …
Negotiating Relationships With Food, The Body, And Physical Activity: Who Is The Healthiest Of Them All?, Valeria Varea, Victoria Evans, Dawn Penney, Eibhlish O'Hara
Negotiating Relationships With Food, The Body, And Physical Activity: Who Is The Healthiest Of Them All?, Valeria Varea, Victoria Evans, Dawn Penney, Eibhlish O'Hara
Research outputs 2022 to 2026
Healthy eating and regular exercise are things that many people aspire to, mainly for health reasons. However, these practices can be complex given broader societal discourses. This paper aims to critically interrogate the social conditions and discursive formations that underpin everyday exercisers’ relationships with food, the body, and physical activity by using biopower and biopedagogies as a theoretical approach, and healthism as a set of discourses. Photo elicitation interviews with vignettes were conducted with nine participants who were regular exercisers. We constructed three different scenarios from the interview data and the theoretical approach: 1. Anna: A performance-driven, health compliant, private …
Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon
Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon
Research outputs 2022 to 2026
Epigenetic changes, in particular DNA methylation, accumulate with age across different tissues, but whether these changes follow consistent patterns across different organs remains poorly understood. Here we show, through a meta-analysis of more than 15,000 human methylation profiles spanning 17 tissues, that aging produces both conserved and tissue-specific epigenetic signatures. We identify systemic shifts in methylation levels, increases in methylation variability, and growing molecular disorder across tissues. Network analysis revealed tightly connected gene clusters that are not modified by beneficial interventions, alongside a more modifiable cluster linked to NAD+ metabolism, supporting NAD+ as a potential therapeutic target in …
Patients’ And Health Professionals’ Perspectives On Transforming The Burden Of Haemodialysis (Hd) Treatment To An Opportunity: An In-Depth Qualitative Investigation, Haseeba Shouket, Eyal Gringart, Deirdre Drake, Ulrich Steinwandel
Patients’ And Health Professionals’ Perspectives On Transforming The Burden Of Haemodialysis (Hd) Treatment To An Opportunity: An In-Depth Qualitative Investigation, Haseeba Shouket, Eyal Gringart, Deirdre Drake, Ulrich Steinwandel
Research outputs 2022 to 2026
Most patients with End Stage Kidney Failure (ESKF) in Pakistan must undergo maintenance haemodialysis (HD) to survive. Session duration and the often lifelong nature of this treatment, along with other factors associated with HD, make it difficult to tolerate. This study took a positive psychological perspective and considered that HD sessions’ duration, which has been a major challenge for HD patients, can be turned to an opportunity for patients’ meaningful engagement. Such meaningful engagement can positively transform Pakistani patients’ experience of HD and extend into their lives outside HD. Twenty-four HD patients and six healthcare professionals were interviewed to explore …
Protective Effect Of Lower Limb Strength On Lower Limb Injuries Within International Sixes Lacrosse Players: A Nine-Month Prospective Study, Nicholas Joel Ripley, Matthew Collier, Jack T. Fahey, Paul Comfort
Protective Effect Of Lower Limb Strength On Lower Limb Injuries Within International Sixes Lacrosse Players: A Nine-Month Prospective Study, Nicholas Joel Ripley, Matthew Collier, Jack T. Fahey, Paul Comfort
Research outputs 2022 to 2026
Abstract – Ripley, NJ, Collier, M, Fahey, JT, and Comfort, P. Protective effect of lower limb strength on lower limb injuries within international sixes lacrosse players: A nine-month prospective study. J Strength Cond Res XX(X): 000–000, 2026—The aim of this study was to prospectively determine whether lower limb strength, assessed through the isometric mid-thigh pull (IMTP), offers a protective effect to future lower limb injury in international men's sixes lacrosse players. Nineteen elite nonprofessional men's sixes lacrosse players from the British Men's Lacrosse team (25.4 ± 4.1 years, 1.8 ± 0.1 m, 88.9 ± 6.8 kg) performed 3 trials of …
Reduced Physical Activity During Submarine Deployment: Health And Performance Consequences And Feasible Countermeasures—A Narrative Review, Benjamin J.C. Kirk, Georgios Mavropalias, Anthony J. Blazevich, Jodie L. Cochrane Wilkie, Aus Molan, Kazunori Nosaka
Reduced Physical Activity During Submarine Deployment: Health And Performance Consequences And Feasible Countermeasures—A Narrative Review, Benjamin J.C. Kirk, Georgios Mavropalias, Anthony J. Blazevich, Jodie L. Cochrane Wilkie, Aus Molan, Kazunori Nosaka
Research outputs 2022 to 2026
Objectives: Submarine environments pose unique challenges to maintaining physical activity due to space constraints, operational demands, and prolonged confinement. This review aims to synthesize existing literature on the health and performance consequences of reduced physical activity in submarine personnel and to examine feasible strategies to mitigate these effects during deployment. Methods: A narrative overview methodology was adopted, with peer-reviewed studies identified from PubMed, Scopus, and Google Scholar. Articles examining physical activity patterns, health outcomes, and exercise or movement-based interventions in submarine environments and comparable confined operational settings were included. Results: Submarine deployments are consistently associated with reduced physical activity, low …
The Basis For Recommending The Selection Of Samplers In Determining Occupational Exposures To Aerosols, Martin Harper, Pieter Bertier, Marcus Cattani, Karen Galea, Darrah Sleeth, Steven Verpaele
The Basis For Recommending The Selection Of Samplers In Determining Occupational Exposures To Aerosols, Martin Harper, Pieter Bertier, Marcus Cattani, Karen Galea, Darrah Sleeth, Steven Verpaele
Research outputs 2022 to 2026
Measurements are considered to be the basis of exposure assessments used to determine risks to workers. Inhalation exposure poses the greatest risk for most airborne chemicals, and measurements are based on collecting (sampling) and analyzing air samples. Samplers have been developed for more than 120 years. Each new design has been intended to address flaws perceived in earlier designs. Users are faced with a varied array of samplers from which to choose. Comparisons are difficult to make because tests of sampler performance were not standardized until recently and have not been applied consistently. The existing large body of work does …
The Impact Of A Vancomycin Intervention On Vancomycin-Associated Nephrotoxicity In Children: A Quality Improvement Initiative, Megan R. Nettleton, Hwi Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell
The Impact Of A Vancomycin Intervention On Vancomycin-Associated Nephrotoxicity In Children: A Quality Improvement Initiative, Megan R. Nettleton, Hwi Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell
Research outputs 2022 to 2026
Background: Vancomycin is first-line treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections. However, despite guideline recommendations, there is no evidence that targeting vancomycin trough concentrations of ≥15 mg/L in children confers clinical benefit and is associated with vancomycin-associated nephrotoxicity (VAN). Aim: This study aimed to evaluate the impact of a vancomycin safety bundle on VAN and vancomycin utilisation in hospitalised paediatric inpatients. Method: A pre–post-intervention study was conducted in a tertiary paediatric hospital comparing January–December 2018 (pre-intervention) to May 2019–April 2020 (post-intervention). Hospitalised children, aged 30 days to <18 years, that received intravenous vancomycin with at least one trough concentration were included. The intervention bundle comprised: (1) lowered empiric vancomycin trough targets (5–15 mg/L), (2) enhanced creatinine monitoring (concomitant serum creatinine with vancomycin trough), (3) guideline modification (reduced pre-authorised indications for empiric vancomycin use), and (4) prescriber education initiatives. Ethical approval was granted by the WA Child and Adolescent Health Service Research Ethics Committee, Governance Evidence Knowledge Outcomes Program (Reference no: 41830) and the study conforms with the National Health and Medical Research Council's Ethical considerations in quality assistance and evaluation activities. Results: A total of 314 vancomycin prescriptions were analysed (n = 204 pre-intervention; n = 110 post-intervention). Post-intervention, VAN incidence decreased almost twofold from 0.46 to 0.25 episodes per 1000 patient bed days (p ≤ 0.01), and vancomycin prescription days decreased by 19%. Total hospital drug costs for vancomycin decreased by AUD $16 033. Overall, and for paediatric invasive MRSA, no significant difference in clinical outcomes or 30-day mortality was observed between study periods. Conclusion: This study demonstrated the implementation of a vancomycin safety bundle significantly reduced paediatric VAN and vancomycin utilisation without compromising clinical outcomes. These data support antimicrobial stewardship interventions to improve medication safety for children.
Multiparametric Flow Cytometry Immune Profiling Of Pulmonary And Extra-Pulmonary Tuberculosis Reveals Distinct Blood-Based Biomarker Signatures, Kalaiarasan Ellappan, Prakash Babu Narasimhan, Harriet N. Garlant, Seshadri Vasan, Komal Jain, Saka Vinod Kumar, Vishnukanth Govindaraj, Vir Singh Negi, Karen E. Kempsell
Multiparametric Flow Cytometry Immune Profiling Of Pulmonary And Extra-Pulmonary Tuberculosis Reveals Distinct Blood-Based Biomarker Signatures, Kalaiarasan Ellappan, Prakash Babu Narasimhan, Harriet N. Garlant, Seshadri Vasan, Komal Jain, Saka Vinod Kumar, Vishnukanth Govindaraj, Vir Singh Negi, Karen E. Kempsell
Research outputs 2022 to 2026
This study investigated immune cell distributions, cell-specific immune markers, and selected biomarker targets in pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) using multiparametric flow cytometry (MFC). Whole blood was collected from 45 individuals, including healthy controls (HC), EPTB, and PTB patients (n = 15/group). Peripheral blood leukocytes were analysed by MFC to characterize CD4+ and CD8+ T cells, natural killer (NK), invariant NKT (iNKT) and NKT cells, classical (CM), intermediate (IM) and non-classical monocytes (NCM), and activated monocytes (AM). Expression of GBP1, CALCOCO2, IFIT3, SNX10, ARG1, PD-1, and PD-L1 was assessed across these immune subsets. Increased frequencies of NK, NKT, …
A Multidimensional Evaluation Of Various Isometric Posterior Chain Strength Assessments: Comparative Force Production Characteristics, Administrative Feasibility, And Athlete-Reported Experience, Adam E. Sundh, Nicholas J. Ripley, Aj J. Lamb, Devin S. Vervoort, Paul Comfort
A Multidimensional Evaluation Of Various Isometric Posterior Chain Strength Assessments: Comparative Force Production Characteristics, Administrative Feasibility, And Athlete-Reported Experience, Adam E. Sundh, Nicholas J. Ripley, Aj J. Lamb, Devin S. Vervoort, Paul Comfort
Research outputs 2022 to 2026
Isometric posterior chain strength assessments are increasingly employed in high-performance sports for benchmarking and fatigue monitoring, yet little is known about how practical implementation factors influence protocol selection. The aim of this study was to examine the feasibility, practicality, participant perceptions, and reliability of four commonly used isometric posterior chain assessments, the long-lever bridge (LLB), standing 90:20, supine 90:90, and supine 30:30. Thirty-seven NCAA division II athletes (19 females: age = 20.1 ± 0.9 years, height = 166.7 ± 5.2 cm, body mass = 67.0 ± 12.1 kg; and 18 males: 19.7 ± 1.2 years, height = 178.9 ± 6.6 …
Associations Between Modifiable Lifestyle Risk Factors And Abdominal Aortic Calcification In The Uk Biobank Imaging Study, Nicola P. Bondonno, Abadi K. Gebre, Benjamin H. Parmenter, Jonathan Hodgson, Lauren C. Blekkenhorst, Catherine P. Bondonno, Richard Woodman, John P. Kemp, James Webster, Carl Schultz, Cassandra Smith, Afsah Saleem, Syed Zulqarnain Gilani, Emma L. Duncan, Joseph Hung, Wai H. Lim, Parminder Raina, John T. Schousboe, Nicholas C. Harvey, Marc Sim, Joshua R. Lewis
Associations Between Modifiable Lifestyle Risk Factors And Abdominal Aortic Calcification In The Uk Biobank Imaging Study, Nicola P. Bondonno, Abadi K. Gebre, Benjamin H. Parmenter, Jonathan Hodgson, Lauren C. Blekkenhorst, Catherine P. Bondonno, Richard Woodman, John P. Kemp, James Webster, Carl Schultz, Cassandra Smith, Afsah Saleem, Syed Zulqarnain Gilani, Emma L. Duncan, Joseph Hung, Wai H. Lim, Parminder Raina, John T. Schousboe, Nicholas C. Harvey, Marc Sim, Joshua R. Lewis
Research outputs 2022 to 2026
Background and aims: Abdominal aortic calcification (AAC) reflects subclinical atherosclerotic cardiovascular disease (ASCVD), but its lifestyle determinants remain uncertain. We investigated how a Healthy Lifestyle Score (HLS) relates to AAC and whether AAC mediates the HLS-ASCVD association. Methods and results: Participants from the UK Biobank Imaging study were assessed for AAC from DXA images. A Healthy Lifestyle Score (HLS), based on smoking, physical activity, diet quality, alcohol consumption, sleep, and BMI was developed, and categorised as low, moderate and high. Cross-sectional associations with (i) any AAC (AAC≥1) and (ii) high AAC (AAC≥6) were analysed using multivariable-adjusted logistic regression models. The …
Attitudes And Expectations Towards Acupuncture For Primary Dysmenorrhoea: Findings From A Cross-Sectional Survey In Australia, Weiting Liu, Amanda Towell-Barnard, Khui Hung Lee, Timothy Leen Kang
Attitudes And Expectations Towards Acupuncture For Primary Dysmenorrhoea: Findings From A Cross-Sectional Survey In Australia, Weiting Liu, Amanda Towell-Barnard, Khui Hung Lee, Timothy Leen Kang
Research outputs 2022 to 2026
Objective: To describe attitudes towards acupuncture and expectations regarding potential treatment outcomes among women with self-reported primary dysmenorrhoea (PD) residing in Australia. Methods: A cross-sectional, descriptive online survey was conducted to assess attitudes and treatment expectancy using an adapted version of previously published complementary and alternative medicine (CAM) attitude scale and a validated acupuncture expectancy scale (AES). Data were analysed descriptively, with exploratory analysis conducted to support the interpretation of response patterns. Ethical approval was obtained from the Edith Cowan University Human Research Ethics Committee (2023-04471-LIU) and participants provided electronic informed consent. Results: A total of 247 responses were received. …
Barriers And Facilitators To Providing Women Postpartum Care By Health Care Providers In The First 12 Months After Childbirth: A Systematic Qualitative Meta-Aggregation Review, Maryam Rouhi, Silvana Bettiol, Sarah Prior, Narges Rouhi, Theodora Dedo Azu, Christine Stirling, Lynne Staff, Linda Jones, Antigoni Leftherioti, Patricia Nicholson
Barriers And Facilitators To Providing Women Postpartum Care By Health Care Providers In The First 12 Months After Childbirth: A Systematic Qualitative Meta-Aggregation Review, Maryam Rouhi, Silvana Bettiol, Sarah Prior, Narges Rouhi, Theodora Dedo Azu, Christine Stirling, Lynne Staff, Linda Jones, Antigoni Leftherioti, Patricia Nicholson
Research outputs 2022 to 2026
Introduction: Postpartum care is crucial for maternal and infant health but remains inconsistently administered. This systematic qualitative review aimed to synthesize health care providers’ perspectives by exploring the barriers and facilitators experienced by health care providers in administering optimal maternal care during the first 12 months after childbirth. Methods: A systematic qualitative meta-aggregation review was conducted using the Joanna Briggs Institute methodology. Peer-reviewed qualitative studies from January 2010 to April 2024 were retrieved from MEDLINE, CINAHL, Embase, and Web of Science. Findings were mapped onto the Behavioral Model of Health Services Use. Results: Twenty-three studies were included. Four key themes …
Blue Poppy Study: Frequency Of Ptsd In The West Australian Police Force, Daniel Talbot, Peter Drummond, Christopher Lee
Blue Poppy Study: Frequency Of Ptsd In The West Australian Police Force, Daniel Talbot, Peter Drummond, Christopher Lee
Research outputs 2022 to 2026
Objective: As exposure of police officers to traumatic incidents has increased in recent years, the aim was to determine the prevalence of post-traumatic stress disorder (PTSD) and associated distress in the West Australian (WA) Police Force. Method: Participants were 1,278 sworn officers from the Western Australia (WA) Police Force, recruited via advertisements placed in the WA Police Union newsletter. This sample represented approximately 18.5% of the WA Police workforce. PTSD symptoms were assessed using the PTSD Checklist for DSM-5 (PCL-5), administered through an online survey platform. This study employed a cross-sectional correlational design. Factors related to PTSD were assessed using …
Cardiovascular–Kidney–Metabolic Syndrome Through The Lens Of Gut‑Derived Uremic Toxins, Chudan Xu, Matthew Snelson, Francine Z. Marques
Cardiovascular–Kidney–Metabolic Syndrome Through The Lens Of Gut‑Derived Uremic Toxins, Chudan Xu, Matthew Snelson, Francine Z. Marques
Research outputs 2022 to 2026
Cardiovascular–Kidney–Metabolic (CKM) syndrome represents a complex, interconnected cluster of cardiovascular disease, chronic kidney disease, and metabolic disorders such as obesity and type 2 diabetes. These conditions share overlapping metabolic, inflammatory, and vascular pathways, with the gut microbiome increasingly recognised as a key contributor and common underlying risk factor. Uremic toxins, traditionally considered waste products of host and microbial metabolism, are now recognised as active mediators of tissue damage across the CKM spectrum, particularly in the context of impaired renal function. Their production and accumulation are amplified by disrupted intestinal barrier integrity, chronic inflammation, and reduced renal clearance, collectively driving systemic …
Dose–Response Association Between Systemic And Dermatologic Glucocorticoid Use And Type 2 Diabetes Mellitus: A Nationwide Case–Control Study, David Vadsholt, Annika V. Kvist, Chano Sandiramoorthy, Joshua R. Lewis, Peter Vestergaard, Johan Røikjer, Nicklas H. Rasmussen
Dose–Response Association Between Systemic And Dermatologic Glucocorticoid Use And Type 2 Diabetes Mellitus: A Nationwide Case–Control Study, David Vadsholt, Annika V. Kvist, Chano Sandiramoorthy, Joshua R. Lewis, Peter Vestergaard, Johan Røikjer, Nicklas H. Rasmussen
Research outputs 2022 to 2026
Aims: To investigate the association and dose–response between systemic and topical glucocorticoids and odds of Type 2 diabetes mellitus. Materials and Methods: We conducted a nationwide case–control study using Danish registry data from 2013 to 2021. People aged 40 years or older with incident type 2 diabetes mellitus (n = 149 113) were matched 1:3 with controls (n = 447 339) by age, sex and weighted Charlson Comorbidity Index. Glucocorticoid exposure was defined as ≥ 1 prescription within 1 year before the date of diagnosis and ≥ 2 within 3 years and classified as systemic or topical. Conditional logistic regression …