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Articles 1531 - 1560 of 159483
Full-Text Articles in Medicine and Health Sciences
The Perijunctional Zone Is A Molecularly Distinct Muscle Subdomain Altered In Duchenne Muscular Dystrophy, Seth G Haddix, Chuansheng Zhang, Yanhong Liu, Juan Oses-Prieto, Alma L Burlingame, Matthew N Rasband
The Perijunctional Zone Is A Molecularly Distinct Muscle Subdomain Altered In Duchenne Muscular Dystrophy, Seth G Haddix, Chuansheng Zhang, Yanhong Liu, Juan Oses-Prieto, Alma L Burlingame, Matthew N Rasband
Faculty, Staff and Students Publications
The neuromuscular junction (NMJ) is a well-established model for synapse development, structure, and function. Surrounding the NMJ is a narrow perijunctional zone (PJZ), enriched in muscle-specific voltage-gated sodium channels that prevent synaptic fatigue. Despite this role, the PJZ remains poorly characterized. To determine its molecular composition, we engineered mice to express the biotin ligase TurboID fused to the cell adhesion molecule neurofascin (Nfasc), and that localizes to the PJZ through ankyrin scaffolding proteins. Using proximity proteomics, we identify numerous PJZ-associated proteins, including Perilipin 4 (Plin4), that are highly enriched and clustered at the PJZ. We also perform proximity proteomics on …
When Qtc Shrinks After Rhythm Conversion, Mohammed Hussein Kamareddine, Alyssa Zakala, Farid Farkouh, Ibrahim Alameh, Gan-Xin Yan
When Qtc Shrinks After Rhythm Conversion, Mohammed Hussein Kamareddine, Alyssa Zakala, Farid Farkouh, Ibrahim Alameh, Gan-Xin Yan
Department of Medicine Faculty Papers
CASE SUMMARY: An 83-year-old man with a history of atrial fibrillation on amiodarone therapy was admitted for direct-current cardioversion because of recurrent atrial fibrillation with a ventricular rate of approximately 105 beats per minute. Cardioversion successfully restored sinus rhythm. Postcardioversion 12-lead electrocardiography revealed an unexpectedly short QTc of 344 ms despite chronic treatment with a QT-prolonging agent. This finding was attributed to QT hysteresis, reflecting delayed adaptation of ventricular repolarization to the abrupt reduction in heart rate after rhythm conversion.
TAKE-HOME MESSAGE: QT hysteresis can result in transient QTc shortening and has important implications for interpretation of QT intervals during …
Pr Interval Alternans And The Mystery Of Inverse Decremental Conduction, Alyssa Zakala, Mohammed Hussein Kamareddine, Farah Olleik, Ali Keramati, Gan-Xin Yan
Pr Interval Alternans And The Mystery Of Inverse Decremental Conduction, Alyssa Zakala, Mohammed Hussein Kamareddine, Farah Olleik, Ali Keramati, Gan-Xin Yan
Department of Medicine Faculty Papers
CASE SUMMARY: A 73-year-old man with severe aortic stenosis and preexisting right bundle branch block (RBBB) underwent transcatheter aortic valve replacement. Postprocedural day 4 mobile cardiac outpatient telemetry revealed intermittent atrioventricular block. A 12-lead electrocardiogram obtained in the emergency department revealed PR interval alternans with RBBB, with longer PR following longer preceding RP intervals, and shorter PR following shorter RP intervals. He suddenly experienced cardiac arrest due to proximal atrioventricular block, requiring cardiopulmonary resuscitation.
TAKE-HOME MESSAGES: Inverse decremental conduction, known as Yan conduction, demonstrates an inverse relationship between conduction time and frequency of upstream stimulation. Inverse decremental conduction within the …
Bridging The Vaccine Gap: Multilingual Vaccine Education For Families In Transitional Housing, Isaac Olaes, Alexia Sandoval, Kassandra Solano, Rachael Termure, Sydney Webber, Jordan West, Maya Parman
Bridging The Vaccine Gap: Multilingual Vaccine Education For Families In Transitional Housing, Isaac Olaes, Alexia Sandoval, Kassandra Solano, Rachael Termure, Sydney Webber, Jordan West, Maya Parman
Nursing Leadership in Community Engagement Projects
As part of a health promotion initiative in the community, our leadership team of seven nursing students is partnering with an agency that supports families experiencing housing instability by providing transitional housing. According to agency staff, some families have limited health literacy regarding vaccinations. Common concerns include illness following a vaccination, perceived risks of autism, and attention deficit hyperactivity disorder. To address these concerns, we have developed a vaccine education binder containing materials in handout form. To accommodate language accessibility, we provided handouts in the four most spoken languages including English, French, Amharic, and Tigrinya. Through this initiative, we aim …
Exceptional Response Of Radiotherapy-Naïve Cranial Meningiomas To Dual Immune Checkpoint Blockade In Bap1 Tumor Predisposition Syndrome, Gary Gallia, Christine Hann, Calixto-Hope Lucas, Licia Pacheco Luna, David Kamson, Takami Sato
Exceptional Response Of Radiotherapy-Naïve Cranial Meningiomas To Dual Immune Checkpoint Blockade In Bap1 Tumor Predisposition Syndrome, Gary Gallia, Christine Hann, Calixto-Hope Lucas, Licia Pacheco Luna, David Kamson, Takami Sato
Department of Medical Oncology Faculty Papers
Meningiomas are the most common primary central nervous system tumors, and while most are benign, atypical and anaplastic variants frequently recur and have limited effective treatment options. Recent trials of PD-1 blockade in unselected meningioma cohorts have demonstrated modest activity, with low objective response rates. These findings highlight the need to identify molecular biomarkers that may predict immunotherapy sensitivity in this disease. BRCA1-associated protein 1 (BAP1) is a tumor suppressor critical for chromatin regulation and DNA repair, and germline pathogenic variants cause BAP1 tumor predisposition syndrome (BAP1-TPDS), a hereditary cancer syndrome characterized by uveal melanoma, mesothelioma, renal cell carcinoma, meningioma, …
Mitochondrial Ca2+ Uniporter (Mcu) Variants Form Plasma-Membrane Channels, Iuliia Polina, Jyotsna Mishra, Michael Cypress, Maria Landherr, Nedyalka Valkov, Isabel Chaput, Bridget Nieto, Brian Rhee, Ameneh Ahrari, Nathan Demichaelis, Kye-Im Jeon, Ulrike Mende, Peng Zhang, Bong Sook Jhun, Jin O-Uchi
Mitochondrial Ca2+ Uniporter (Mcu) Variants Form Plasma-Membrane Channels, Iuliia Polina, Jyotsna Mishra, Michael Cypress, Maria Landherr, Nedyalka Valkov, Isabel Chaput, Bridget Nieto, Brian Rhee, Ameneh Ahrari, Nathan Demichaelis, Kye-Im Jeon, Ulrike Mende, Peng Zhang, Bong Sook Jhun, Jin O-Uchi
Center for Translational Medicine Faculty Papers
MCU, originally known as CCDC109A, is widely recognized as the gene responsible for encoding a pore-forming subunit of a Ca2+-selective channel, mitochondrial Ca2+ uniporter complex (mtCUC). While MCU expression is typically highly mitochondrial-specific, we report here a protein variant derived from the MCU gene, termed MCU-S, which lacks the mitochondria-targeting sequence (MTS) and forms a Ca2+-permeable channel outside of mitochondria. The mRNA of MCU-S was ubiquitously expressed in all cell types/tissues tested, with particularly high expression in human platelets. MCU-S protein formed Ca2+ channels at the plasma membrane, which exhibited similar channel properties to those observed in mtCUC. MCU-S channels …
Symmetrical Drug-Related Intertriginous And Flexural Exanthema Associated With Tirzepatide, William Goodman, Karan Pandher, Mahaa Ayub
Symmetrical Drug-Related Intertriginous And Flexural Exanthema Associated With Tirzepatide, William Goodman, Karan Pandher, Mahaa Ayub
Department of Dermatology and Cutaneous Biology Faculty Papers
No abstract provided.
Predictive Models Of Student Mental Health: The Correlation Between Academic Burnout And Depression In The Higher Education Environment, Hyejoon Song
Masters Theses
Importance: Over 80% of U.S. college students report significant emotional difficulties, and 58% endorse academic burnout as a persistent concern, yet institution-specific data at faith-integrated universities such as Liberty University remain scarce, limiting evidence-based programmatic response.
Objective: To examine the correlation between academic burnout and depressive symptomatology at Liberty University, identify the most predictive individual burnout item via Random Forest machine learning, and characterize distinct student risk profiles via KMeans clustering. Design, Setting, Participants: Cross-sectional survey (IRB-FY24-25-1491, Exempt) of 236 Liberty University students (mean age 36.9 ± 14.3 years; 84.0% female; 61.0% graduate-level), 2025–2026 academic year.
Main Outcome and Measures: …
Exploring The Role Of Self-Efficacy In Undergraduate Nursing Students: A Transcendental Phenomenological Study, Dorothy Elaine Rolling
Exploring The Role Of Self-Efficacy In Undergraduate Nursing Students: A Transcendental Phenomenological Study, Dorothy Elaine Rolling
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to explore the role of self-efficacy for nursing students whose primary language was not English and who were enrolled in higher education in the northeastern area of the United States. The theory guiding this study was Bandura’s theory on self-efficacy. The major tenets of the self-efficacy theory aligned with the metaparadigm of nursing (person, health, environment, nursing) and with the study’s focus, which was to explore how English as a second language (ESL) nursing students could successfully complete the registered nursing program at an institution of higher learning. The central research question was: …
Evaluation Of The Effectiveness Of The Guardian Protective Cap In Reducing The Incidence And Recovery Duration Of Concussions Among Division Ii Collegiate Football Players In The State Of West Virginia, Dave Mcentire
Doctoral Dissertations and Projects
This study focuses on a retrospective quasi-experimental design to evaluate the effectiveness of the Guardian protective cap in reducing the incidence and recovery duration of concussions among Division II football players in the state of West Virginia. The study will evaluate the medical records, obtained from the NCAA certified athletic trainers, of four seasons worth of data from two separate football teams. The study will examine two seasons worth of data of the teams prior to mandating the usage of the protective caps during practice, and two seasons of data following their implementation. The study will compare the overall incidence …
Barriers To Physical Activity Among Community College Students, Erica Keels
Barriers To Physical Activity Among Community College Students, Erica Keels
Doctoral Dissertations and Projects
The purpose of this qualitative study was to explore the perceived barriers, motivators, and student-identified strategies related to physical activity among students enrolled at a community college located in Northwest Florida. Guided by the Social Ecological Model (SEM), Self-Determination Theory (SDT), Health Belief Model (HBM), and Theory of Planned Behavior (TPB), this study employed a qualitative descriptive design to examine students’ lived experiences and perceptions that influence their physical activity behaviors. Data were collected through an online open-ended survey administered to students aged 18 years and older. A total of 134 students initially accessed the survey, and 126 eligible participants …
Beyond Crisis: Patient Access And Sustainability, Miguel A. Mendoza
Beyond Crisis: Patient Access And Sustainability, Miguel A. Mendoza
Doctoral Dissertations and Projects
Critical systems underwent drastic workflow adaptations during the COVID-19 pandemic. Many of these operational alterations persist today, while others have been reduced or eliminated. This is a qualitative study on the operational, technological, and human-centered challenges experienced by healthcare organizations providing primary care services in Southwest Ohio during and immediately after the pandemic. This flexible research design implements in-depth, semi-structured interviews with healthcare professionals leading primary care operations to capture a longitudinal perspective on pandemic-era service delivery, and the legacy systems still in place today. Thematic analysis revealed seven themes that determine the effectiveness of care delivery models. Social Determinants …
Psychological Impact Of Career Roles On African American Women: A Qualitative Study On The Long-Term Effects On Behavioral Health Providers' Field, Yolanda Seals-Stewart
Psychological Impact Of Career Roles On African American Women: A Qualitative Study On The Long-Term Effects On Behavioral Health Providers' Field, Yolanda Seals-Stewart
Doctoral Dissertations and Projects
There is an untold narrative regarding the levels of stress, anxiety, and depression. This leaves a gap in researchers understanding systemic, cultural, and social factors that shape mental health outcomes in a unique way. There is also a deeper need for exploration of resiliency and coping skills strategies utilized by African American women in the behavioral health field, as well as how behaviors such as discrimination, workplace dynamics, and microaggression impact the overall psyche. By addressing these gaps, a more thorough understanding of the long-term psychological effect can be addressed, and these women can receive support mechanisms and interventions that …
The Association Between Diet Quality, Nutritional Knowledge, Low Energy Availability, And Eating Disorder Risk In Collegiate Student-Athletes, Laurel Koontz Awald
The Association Between Diet Quality, Nutritional Knowledge, Low Energy Availability, And Eating Disorder Risk In Collegiate Student-Athletes, Laurel Koontz Awald
Doctoral Dissertations and Projects
This study aimed to investigate the association between diet quality, nutritional knowledge, low energy availability, and eating disorder risk in a sample of collegiate student-athletes across several sporting disciplines. The quantitative cross-sectional survey was developed using validated questionnaires to investigate diet quality (The Athlete Diet Index), nutritional knowledge (The Platform for Evaluating Athlete Knowledge in Sports – Nutrition Questionnaire), low energy availability (The Low Energy Availability in Females Questionnaire and Low Energy Availability in Males Questionnaire), and eating disorder risk (DESA – 6). College athletes were recruited from Division I and III universities: (N = 31) from the track and …
From Perception To Performance: The Acute Impact Of Virtual Reality On Hitting Metrics In Collegiate Baseball And Softball Hitters, Darrianne Kylie Hale
From Perception To Performance: The Acute Impact Of Virtual Reality On Hitting Metrics In Collegiate Baseball And Softball Hitters, Darrianne Kylie Hale
Doctoral Dissertations and Projects
The purpose of this study was to examine the acute effects of the four warm-up conditions of virtual reality (VR), heavy bat, light bat, and game bat on hitting metrics in collegiate baseball and softball players. Specifically, this research investigated whether a perceptual-cognitive warm-up using virtual reality produced performance outcomes comparable to traditional physical warm-ups in key physical hitting metrics, including bat speed, time to contact, launch angle, and exit velocity. Each participant experienced all four warm-up conditions in a within-subjects, repeated measures design. Performance was measured using Blast Motion and HitTrax technologies, and statistical analysis was conducted using a …
The Relationship Between Mentorship And Career Longevity For New Clinicians In Emergency Medical Services, Katherine Elizabeth Contreras
The Relationship Between Mentorship And Career Longevity For New Clinicians In Emergency Medical Services, Katherine Elizabeth Contreras
Doctoral Dissertations and Projects
The purpose of this qualitative descriptive phenomenological study was to understand how mentorship assisted a new Emergency Medical Services (EMS) clinician in navigating the challenges of the first year at an EMS agency in Central Texas. Guiding the study was Lev Vygotsky’s theory of social constructivism, which focuses on knowledge gained through human activities, social interactions, and behavior modeling. Twelve study participants completed one-on-one interviews, two participants completed a single focus group interview, and the researcher conducted naturalistic observations, during which the participants shared personal, firsthand experiences that answered the study’s central research question: How does mentorship help new EMS …
Examining The Link Between Adenomas And Early-Onset Colorectal Cancer In Adults Aged 20–44, Ijeoma F. Erondu
Examining The Link Between Adenomas And Early-Onset Colorectal Cancer In Adults Aged 20–44, Ijeoma F. Erondu
Doctoral Dissertations and Projects
Early-onset colorectal cancer (EOCRC) has increased among adults younger than 50 years, raising concerns regarding risk identification and screening practices in younger populations. This study examined the association between colorectal adenomas and EOCRC among adults aged 20–44 years in the United States and evaluated whether this relationship was influenced by selected demographic and behavioral factors. A cross-sectional analytic design was used to examine medical claims data from the Optum Partner Health database. The study population included 186,790 individuals aged 20–44 years who underwent colonoscopy procedures. Demographic variables included age group, sex, race/ethnicity, and body mass index (BMI). Smoking status was …
Repurposing Semaglutide As An Adjunctive Treatment For Cocaine Use Disorder: Protocol For A Randomised Controlled Trial, Luba Yammine, Francesco Versace, Charles E Green, Heather E Webber, Jin Ho Yoon, Absalon D Gutierrez, Samuel J Leonard, Michael F Weaver, Joy Schmitz
Repurposing Semaglutide As An Adjunctive Treatment For Cocaine Use Disorder: Protocol For A Randomised Controlled Trial, Luba Yammine, Francesco Versace, Charles E Green, Heather E Webber, Jin Ho Yoon, Absalon D Gutierrez, Samuel J Leonard, Michael F Weaver, Joy Schmitz
Faculty, Staff and Student Publications
Introduction: Cocaine use disorder (CUD) is a significant public health concern in the USA, with considerable prevalence and mortality and no Food and Drug Administration (FDA)-approved pharmacotherapies. Recent advances in addiction science emphasise the need for novel, mechanism-based treatments. Glucagon-like peptide-1 receptor agonists, such as semaglutide, have shown promise in modulating reward-related behaviours and may offer therapeutic benefits for CUD. We present a study protocol evaluating semaglutide, as an adjunct to cognitive behavioural therapy (CBT), as a novel approach for treating CUD.
Methods and analysis: This is a randomised, double-blind, placebo-controlled trial enrolling 75 treatment-seeking adults with CUD. Participants will …
Brain-Wide Structural Markers Of Familial And Clinical Risk For Bipolar Disorder In Youth, Danella M Hafeman, Jamie Feldman, John Merranko, Mary L Phillips, Boris Birmaher, Si Gao, Yizhou Ma, Peter Kochunov
Brain-Wide Structural Markers Of Familial And Clinical Risk For Bipolar Disorder In Youth, Danella M Hafeman, Jamie Feldman, John Merranko, Mary L Phillips, Boris Birmaher, Si Gao, Yizhou Ma, Peter Kochunov
Faculty, Staff and Student Publications
Background: Bipolar Disorder (BD) is a severe mental illness, often emerging during adolescence, that is associated with significant psychosocial impairment. BD risk is elevated in offspring of affected parents, particularly those with antecedent symptoms (e.g., mood lability, subthreshold manic symptoms). However, robust, replicable brain-based markers of risk in this population are lacking. We assessed the degree to which the Regional Vulnerability Index for BD (RVI-BD), quantified as an individual's brain-wide similarity to BD patterns derived from meta-analytic studies, is elevated in youth at familial risk and correlates with symptom predictors of BD.
Methods: We recruited n=82 adolescents (10-15 years old), …
Exploring The Impact Of Cultural Beliefs On Death Anxiety: A Qualitative Study To Inform Healthcare Education And Practices, Sharon Sonnilal
Exploring The Impact Of Cultural Beliefs On Death Anxiety: A Qualitative Study To Inform Healthcare Education And Practices, Sharon Sonnilal
Doctoral Dissertations and Projects
A hermeneutic phenomenological approach framed this qualitative study, examining how cultural beliefs, spiritual traditions, and relational contexts shape death anxiety and meaning-making among adults from diverse backgrounds. Terror Management Theory and Culturally Sensitive Grief Treatment guided the conceptualization of death anxiety as a culturally mediated and relational phenomenon rather than an isolated psychological response. A purposive sample of 13 adults aged 18 and older represented diverse cultural, racial, gender, and spiritual identities. Recruitment occurred via Instagram, and participants completed an open-ended demographic and narrative survey. Participants who provided rich survey narratives received invitations to complete semi-structured Zoom interviews to deepen …
Perceptions Of The Effects Of Launch Control Center Environmental Exposures And Alert Schedules Among Missile Operations Officers: A Mixed Methods Phenomenological Study, Dawnie Rae Ramie
Doctoral Dissertations and Projects
This mixed methods hermeneutic phenomenological study focused on an investigation of the perceptions of missile operations alert duty and the effects on health and sleep hygiene among Air Force missile operations officers. Questionnaires, interviews, and surveys were all used to gather data on subjects’ experiences and perspectives, including methods to mitigate the effects of poor sleep. Driving questions of research included how missile alert schedules affect sleep habits, as well as how missileers perceived alert duties may impact their health. Data was collected through a web-based Qualtrics Likert questionnaire (N=139), open-ended interviews with purposively selected subjects (N=17), and web-based Qualtrics …
Inadequate Access To Healthcare In Low-Income Hispanic Communities In Brooklyn, Joanna Marie Garcia
Inadequate Access To Healthcare In Low-Income Hispanic Communities In Brooklyn, Joanna Marie Garcia
Doctoral Dissertations and Projects
The purpose of this qualitative research was to understand healthcare disparities using the Solar and Irwin conceptual framework and to shed light on healthcare disparities as the reason low-income Hispanic patients, male and female, from the ages of 20-90 in Brooklyn, New York, received inadequate access to healthcare. Healthcare disparities represented a critical issue in providing adequate patient care for adult Hispanic patients within the United States healthcare system. Research into healthcare disparities has been conducted; however, detailed information about the causes of the disparities was lacking, especially concerning inadequate access to healthcare in low-income Hispanic communities. This qualitative research …
Factors Associated With Vaping Frequency Among University Students, Oluwatosin Marylyn Oduneye
Factors Associated With Vaping Frequency Among University Students, Oluwatosin Marylyn Oduneye
Masters Theses
Electronic cigarette use among university students is a growing public health concern, with approximately 20-25% reporting current use. Despite extensive research on vaping initiation, factors associated with vaping frequency among established users remain understudied. This study examined stress-coping mechanisms, peer influence, and health risk perceptions as predictors of vaping frequency, guided by Bandura's Social Cognitive Theory (SCT). A quantitative cross-sectional survey was administered via Microsoft Forms to 399 university students aged 21-25 with recent vaping experience, recruited nationally through campus flyers and online platforms. Multiple linear regression was conducted in SAS OnDemand for Academics, with stress-coping, peer influence, and health …
Phkg2 Confers Resistance Of Escc To Cisplatin And Enhances Cxcl8-Dependent Immunosuppression To Exacerbate Tumorigenesis, Jiayan Wu, Chengrui Zhong, Haosheng Zheng, Fei Qin, Xianyu Qin, Yuzhen Zheng, Junguo Chen, Gengfeng Wang, Bozhu Jian, Zui Liu, Xingping Yang, Chao Cheng, Guolin Li, Hongying Liao
Phkg2 Confers Resistance Of Escc To Cisplatin And Enhances Cxcl8-Dependent Immunosuppression To Exacerbate Tumorigenesis, Jiayan Wu, Chengrui Zhong, Haosheng Zheng, Fei Qin, Xianyu Qin, Yuzhen Zheng, Junguo Chen, Gengfeng Wang, Bozhu Jian, Zui Liu, Xingping Yang, Chao Cheng, Guolin Li, Hongying Liao
Faculty, Staff and Students Publications
Cisplatin (DDP)-based chemotherapy serves as a foundational cornerstone in the clinical management of esophageal squamous cell carcinoma (ESCC). However, intrinsic or acquired resistance to DDP persists as a significant clinical challenge, severely undermining therapeutic efficacy and contributing to unfavorable patient prognoses. Through functional screening with a CRISPR/Cas9 knockout library, transcriptomic profiling of cisplatin-resistant cell lines and clinical specimens, and in vitro/in vivo validation assays, we identified PHKG2 as a key mediator of cisplatin resistance in ESCC. Mechanistically, PHKG2-mediated cisplatin resistance is driven by the phosphorylation of IGF2BP3 at residues T225 and T306. This post-translational modification enhances IGF2BP3 phase separation, thereby …
Movement-Stabilized Three-Dimensional Optical Recordings Of Membrane Potential Changes And Calcium Dynamics In Hippocampal Ca1 Dendrites, Kevin C Gonzalez, Satoshi Terada, Asako Noguchi, George N Zakka, Cliodhna O'Toole, Giuliana Bilbao, Luke Reynolds, Anna Jász, Borbála Kertész, Zoltán Szadai, Alissa Shen, François St-Pierre, Franck Polleux, Attila Losonczy, Balázs Rózsa
Movement-Stabilized Three-Dimensional Optical Recordings Of Membrane Potential Changes And Calcium Dynamics In Hippocampal Ca1 Dendrites, Kevin C Gonzalez, Satoshi Terada, Asako Noguchi, George N Zakka, Cliodhna O'Toole, Giuliana Bilbao, Luke Reynolds, Anna Jász, Borbála Kertész, Zoltán Szadai, Alissa Shen, François St-Pierre, Franck Polleux, Attila Losonczy, Balázs Rózsa
Faculty, Staff and Students Publications
Local dendritic computations are thought to critically influence neuronal signaling and plasticity yet remain largely unexplored in vivo due to challenges in stably imaging small structures at ultrafast timescales. We developed a 3D real-time motion correction platform for movement-stabilized, ultrafast two-photon voltage imaging. By co-labeling CA1 pyramidal neurons with voltage and calcium indicators, we simultaneously measured somato-dendritic and electro-calcium coupling at multiple dendritic sites. We characterized isolated dendritic spikes and distance-dependent backpropagation of naturally occurring and photostimulation-evoked bursts and single spikes. We found that bursts backpropagated more reliably than single spikes, validated that somato-dendritic coupling decreases with distance from soma, …
A Review Of Robotic Vnotes Surgery: Current Applications, Advantages, And Future Directions, Daniel Y Lovell, Qiannan Yang, Xiaoming Guan
A Review Of Robotic Vnotes Surgery: Current Applications, Advantages, And Future Directions, Daniel Y Lovell, Qiannan Yang, Xiaoming Guan
Faculty, Staff and Students Publications
Over the past 500 years, the convergence of three distinct paths - vaginal surgery, laparoscopy, and robotic technologies - has enabled the development of robot-assisted vaginal natural orifice transluminal endoscopic surgery (RA-vNOTES). The ongoing evolution of vaginal surgery has led to contemporary procedures such as hysterectomy, myomectomy, sacrocolpopexy, adnexal interventions, and oncologic operations, applicable to a wide range of diagnoses and pathologies. This approach offers patients significant benefits, including superior cosmetic outcomes, less pain, lower infection rates, and faster recovery of baseline quality of life. Surgeons benefit from improved ergonomics, better visualization, the ability to use multiple instruments, and enhanced …
Objective Oculomotor, Vestibular, Reaction Time, And Cognitive Signatures Of Vestibular Migraine, Claire E. J. Ceriani, Alexandr Braverman, Alexander Kiderman
Objective Oculomotor, Vestibular, Reaction Time, And Cognitive Signatures Of Vestibular Migraine, Claire E. J. Ceriani, Alexandr Braverman, Alexander Kiderman
Department of Neurology Faculty Papers
OBJECTIVE: To evaluate oculomotor, vestibular, reaction time, and cognitive (OVRT-C) function in patients with vestibular migraine (VM) using objective eye-tracking-based metrics and to identify patterns of dysfunction relative to healthy controls.
BACKGROUND: Vestibular migraine is a common yet underdiagnosed cause of vertigo. Diagnosis remains primarily clinical, because objective neurologic and vestibular findings are often absent or inconsistent. Quantitative methods capable of capturing the multisystem manifestations of VM may improve objective characterization of the disorder.
METHODS: Participants with a clinical diagnosis of vestibular migraine were recruited from a tertiary headache center and assessed using a battery of OVRT-C tests administered with …
Temporomandibular Joint Ganglion Cyst Causing Dynamic External Auditory Canal Obstruction And Position-Dependent Hearing Loss: A Case Report And Literature Review, Ali Akbar, Abdulrahman Meerza, Craig Pearl
Temporomandibular Joint Ganglion Cyst Causing Dynamic External Auditory Canal Obstruction And Position-Dependent Hearing Loss: A Case Report And Literature Review, Ali Akbar, Abdulrahman Meerza, Craig Pearl
Faculty, Staff and Student Publications
Purpose: Ganglion cysts of the temporomandibular joint (TMJ) are uncommon periarticular lesions and may be diagnostically challenging because symptoms are often nonspecific. When these lesions arise posterior to the joint, they can produce otologic complaints through dynamic narrowing of the external auditory canal (EAC). Herein, we report on a histologically confirmed TMJ ganglion cyst causing position-dependent hearing loss and review the relevant literature.
Case description: A 72-year-old woman presented with a 3-year history of bilateral preauricular pain, left-sided tinnitus, left aural fullness, and near-complete hearing loss in the left ear when the mandible was closed in occlusion. Clinical examination showed …
Sex-Biased Intratumoral Microbiome Influences Tumor Molecular And Immune Landscape And Disease Outcomes, Yuting Shan, Yingbo Huang, Adam Lee, Radwa M. Elmorsi, Tuyen Phan, Indrajit Chaudhury, Tom Corbiere, Lindsey B. Collins, Elizabeth B. Hirsch, Benjamin A. Weinberg, Jennifer M. Johnson, Emmanuel S. Antonarakis, Emil Lou, R. Stephanie Huang
Sex-Biased Intratumoral Microbiome Influences Tumor Molecular And Immune Landscape And Disease Outcomes, Yuting Shan, Yingbo Huang, Adam Lee, Radwa M. Elmorsi, Tuyen Phan, Indrajit Chaudhury, Tom Corbiere, Lindsey B. Collins, Elizabeth B. Hirsch, Benjamin A. Weinberg, Jennifer M. Johnson, Emmanuel S. Antonarakis, Emil Lou, R. Stephanie Huang
Department of Otolaryngology - Head and Neck Surgery Faculty Papers
The intratumoral microbiome is increasingly recognized as a regulator of cancer biology, yet sex-specific patterns and their relevance to cancer disparities remain poorly understood. We perform a multi-kingdom analysis of more than 5,000 tumors from seven datasets to identify sex-differential microbial taxa across aerodigestive and gastrointestinal cancers. We identify and validate 22 taxa with consistent sex-biased abundance, including in real-world cohort. These microbes show cancer-type- and microbe-specific associations with tumor transcriptomes, oncogenic pathways, and immune cell infiltration. Female-enriched microbes are linked to increased estrogen signaling and interferon responses, whereas male-enriched taxa show opposing patterns. In gastric cancer, intratumoral Epstein-Barr virus …
Cultura, Collaborations, And Chisme: The Latinx Caucus’ Oral History Project, Adela Justice, Brandon Kennedy, Jessica Diaz, Manuel Pasos, Saily Marrero, Sandra Desjardins
Cultura, Collaborations, And Chisme: The Latinx Caucus’ Oral History Project, Adela Justice, Brandon Kennedy, Jessica Diaz, Manuel Pasos, Saily Marrero, Sandra Desjardins
Library Staff Publications
The MLA Latinx Caucus began an oral history project featuring its members. Using a collaborative, community-based approach, the project brings together medical library professionals to share their experiences and reflect on cultural identity, professional growth, and collective advocacy. This poster describes the development of this significant project. Background: In Fall 2025 one of the caucus leaders shared that they had a robust oral history project at their library organization, and had learned oral history processes and standards. This began the idea of forming an oral history project at the MLA caucus level. Lessons learned from the MLA AAMLA Caucus showed …