Medicine and Health Sciences Commons^™

Isolation Of A New Subspecies, Bartonella Vinsonii Subsp. Arupensis, From A Cattle Rancher: Identity With Isolates Found In Conjunction With Borrelia Burgdorferi And Babesia Microti Among Naturally Infected Mice, David F. Welch, Karen C. Carroll, Erick K. Hofmeister, David H. Persing, Denise A. Robison, Arnold G. Steigerwalt, Don J. Brenner

Zoonotics and Wildlife Disease: Publications

Bacteremia with fever due to a novel subspecies of Bartonella vinsonii was found in a cattle rancher. The subspecies shared major characteristics of the genus Bartonella in terms of most biochemical features and cellular fatty acid profile, but it was distinguishable from other subspecies of B. vinsonii by good growth on heart infusion agar supplemented with X factor and by its pattern of enzymatic hydrolysis of peptide substrates. DNA relatedness studies verified that the isolate belonged to the genus Bartonella and that it was genotypically related to B. vinsonii. The highest level of relatedness was observed with recently characterized …

Oral Transmission And Early Lymphoid Tropism Of Chronic Wasting Disease PrpRes In Mule Deer Fawns (Odocoileus Hemionus), Christina J. Sigurdson, Elizabeth S. Williams, Michael W. Miller, Terry R. Spraker, Katherine I. O'Rourke, Edward A. Hoover

Zoonotics and Wildlife Disease: Publications

Mule deer fawns (Odocoileus hemionus) were inoculated orally with a brain homogenate prepared from mule deer with naturally occurring chronic wasting disease (CWD), a prion-induced transmissible spongiform encephalopathy. Fawns were necropsied and examined for PrP^res, the abnormal prion protein isoform, at 10, 42, 53, 77, 78 and 80 days post-inoculation (p.i.) using an immunohistochemistry assay modified to enhance sensitivity. PrP^res was detected in alimentarytract- associated lymphoid tissues (one or more of the following: retropharyngeal lymph node, tonsil, Peyer’s patch and ileocaecal lymph node) as early as 42 days p.i. and in all fawns examined thereafter …

Prp Genotypes Of Captive And Free-Ranging Rocky Mountain Elk (Cervus Elaphus Nelsoni) With Chronic Wasting Disease, Katherine I. O'Rourke, T. E. Besser, M. W. Miller, T. F. Cline, T. R. Spraker, A. L. Jenny, M. A. Wild, G. L. Zebarth

Zoonotics and Wildlife Disease: Publications

The PrP gene encodes the putative causative agent of the transmissible spongiform encephalopathies (TSEs), a heterogeneous group of fatal, neurodegenerative disorders including human Creutzfeldt–Jakob disease, bovine spongiform encephalopathy, ovine scrapie and chronic wasting disease (CWD) of North American deer and elk. Polymorphisms in the PrP gene are associated with variations in relative susceptibility, pathological lesion patterns, incubation times and clinical course of TSEs of humans, mice and sheep. Sequence analysis of the PrP gene from Rocky Mountain elk showed only one amino acid change (Met to Leu at cervid codon 132). Homozygosity for Met at the corresponding polymorphic site (Met …

Archaeal Aminoacyl-Trna Synthesis: Unique Determinants Of A Universal Genetic Code?, Michael Ibba, A. W. Curnow, J. Bono, P. A. Rosa, C. R. Woese, D. Söll

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

No abstract provided.

Customizable And Ontology-Enhanced Medical Information Retrieval Interfaces, Gondy Leroy, K.M. Tolle, Hsinchun Chen

CGU Faculty Publications and Research

This paper describes the development and testing of the Medical Concept Mapper as an aid to providing synonyms and semantically related concepts to improve searching. All terms are related to the userquery and fit into the query context. The system is unique because its five components combine humancreated and computer-generated elements. The Arizona Noun Phraser extracts phrases from natural language user queries. WordNet and the UMLS Metathesaurus provide synonyms. The Arizona Concept Space generates conceptually related terms. Semantic relationships between queries and concepts are established using the UMLS Semantic Net. Two user studies conducted to evaluate the system are described.

One-Year Prospective Prediction Of Violence Perpetration Among High Risk Youth From Personal And Social-Environmental Variables, Alan W. Stacy, Steve Sussman, Thomas R. Simon, Clyde W. Dent, Jill M. Steinberg

CGU Faculty Publications and Research

Objective: Measures of drug use, law-abidance beliefs, sensation seeking, fear of victimization, high-risk group identification, self- protection needs and behaviors, and demographics were investigated as longitudinal predictors of violence perpetration among 870 high-risk adolescents. Method: Self-reports from the same youth were obtained 1-year apart. Results: In addition to baseline violence perpetration, marijuana use, relatively youn1 age, male sex, high-risk group self-identification, low perceived efficacy of the police department, and nonavoidance of dangerous places predicted later perpetrated violence. Conclusion: Personal and social factors beyond baseline violent behavior predict risk for future violent behavior.

Physical Therapy Program 1999, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

College Of Medical Sciences Student Handbook, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Measured Energy Expenditure Of Tube-Fed Patients With Severe Neurodevelopment Disabilities, Roland N. Dickerson, Rex O. Brown, Jane M. Gervasio, Emily B. Hak, Lawrence J. Hak, John E. Williams

Scholarship and Professional Work – COPHS

Objective: To determine measured resting energy expenditure (REE) of nonambulatory tube-fed patients with severe neurological neurodevelopmental disabilities.

Methods: Twenty patients were prospectively studied. Only steady state indirect calorimetry measurements were taken. All measurements were conducted using a canopy system. Nutritional needs were met entirely by enteral feedings via a permanent ostomy.

Results: REE was widely distributed from 16 kcals/kg/day to 39 kcals/kg/day. The mean REE (888 ±176 kcals/day) of the patients was significantly (p < 0.01) lower than predicted as estimated by the Harris-Benedict equations (1081 ± 155 kcals/day) and World Health Organization equations (1194 ± 167 kcals/day). Fat-free mass (FFM) was the best parameter for predicting REE. Two predictive equations were developed that are not significantly biased and more precise (≤ 15% error) than conventional predictive formulas.

Conclusion: Conventional formulas for estimating energy expenditure are inaccurate and generally overestimate measured energy expenditure of nonambulatory patients with severe developmental …

Cooperative Binding Of Heat Shock Factor To The Yeast Hsp82 Promoter In Vivo And In Vitro, Alexander M. Erkine, Serena F. Magrogan, Edward A. Sekinger, David S. Gross

Scholarship and Professional Work – COPHS

revious work has shown that heat shock factor (HSF) plays a central role in remodeling the chromatin structure of the yeastHSP82 promoter via constitutive interactions with its high-affinity binding site, heat shock element 1 (HSE1). The HSF-HSE1 interaction is also critical for stimulating both basal (noninduced) and induced transcription. By contrast, the function of the adjacent, inducibly occupied HSE2 and -3 is unknown. In this study, we examined the consequences of mutations in HSE1, HSE2, and HSE3 on HSF binding and transactivation. We provide evidence that in vivo, HSF binds to these three sites cooperatively. This cooperativity is seen …

Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley

Departmental Papers (Biology)

No abstract provided.

The Red Road Approach To Healing As Used In Native American Adolescent Addiction Treatment, Colleen M. Husak

Graduate Research Papers

Traditional treatment programs have not worked with Native Americans. Instead, programs designed to be culturally sensitive are needed (Burn, 1992). In this paper, the author will explore the specific theory of the Red Road approach as used in Native American adolescent substance abuse treatment facilities. The Red Road approach is practical in its psychological application at the same time that it incorporates and encourages the spiritual beliefs which are a major part of the philosophy of most Native Americans (Black Elk & Lyon, 1991). As Black Elk and Lyons (1991) noted, even Native Americans who no longer practice their ancestral …

Women's Basketball Media Guide 1999-2000, Indiana State University

Intercollegiate Athletics

No abstract provided.

College Of Dental Medicine Student Handbook 1999-2000, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

College Of Optometry Student Handbook, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

College Of Pharmacy Student Handbook, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Igf Paracrine And Autocrine Interactions Between Conceptus And Oviduct., A J Watson, M E Westhusin, Q A Winger

Obstetrics & Gynaecology Publications

Development in vitro is influenced by embryo density, serum, somatic cell co-culture and the production of 'embryotrophic' paracrine and autocrine factors. Research in our laboratory has focussed principally on the insulin-like growth factor (IGF) family. We have demonstrated that pre-attachment bovine and ovine embryos express mRNAs encoding a number of growth factor ligand and receptor genes including all members of the IGF ligand and receptor family throughout this developmental interval. In addition, early embryos express mRNAs encoding IGF-binding proteins (IGFBPs) 2-5 from the one-cell to the blastocyst stage and IGFBP5 mRNA at the blastocyst stage. Cultured bovine blastocysts release up …

Functionally Dissociating Aspects Of Event Memory: The Effects Of Combined Perirhinal And Postrhinal Cortex Lesions On Object And Place Memory In The Rat., T J Bussey, J L Muir, J P Aggleton

Brain and Mind Institute Researchers' Publications

Reciprocal interactions between the hippocampus and the perirhinal and parahippocampal cortices form core components of a proposed temporal lobe memory system. For this reason, the involvement of the hippocampus in event memory is thought to depend on its connections with these cortical areas. Contrary to these predictions, we found that NMDA-induced lesions of the putative rat homologs of these cortical areas (perirhinal plus postrhinal cortices) did not impair performance on two allocentric spatial tasks highly sensitive to hippocampal dysfunction. Remarkably, for one of the tasks there was evidence of a facilitation of performance. The same cortical lesions did, however, disrupt …

Education In Schizophrenia Support For Families, Amresh Srivastava

Data and Test Instruments

No abstract provided.

Trudy Govier’S Dilemmas Of Trust, Carolyn Mcleod, S. Burns

Philosophy Publications

No abstract provided.

Perceiving And Responding To The Personal/Group Discrimination Discrepancy, Mindi D. Foster, Kimberley Matheson

Psychology Faculty Publications

To explain why minority group members recognize less personal than group discrimination, research has focused on cognitive processes. While within self-categorization theory it may be argued the discrepancy is a function of a salient social self that perceptually discounts the personal self, it can also be argued that depersonalization allows for the cognitive possibility of perceiving similar amounts of personal and group discrimination. The present study suggested that, consistent with group consciousness theories, the social self may serve to both discount as well as integrate the social self, depending on the way in which the social self is defined. Using …

Acting Out Against Gender Discrimination: The Effects Of Different Social Identities, Mindi D. Foster

Psychology Faculty Publications

Self-categorization theory suggests that when a social identity is salient, group- oriented behavior will ensue. Thus, women should be likely to act out against gender discrimination when their social identity as women is salient. However, self-categorization theory has typically defined a social identity along stereo- types, which may serve instead to maintain the status quo. Two studies therefore examined the effects of two different social identities on taking action against discrimination. Participants were female students (Anglo American (93%), African American (2%), Native American (2%), Hispanic (1%), Asian American (1%) and Other (1%)). Study 1 examined a structural model and Study …

1999 Transactions, American Dental Association

ADA Transactions

This item is part of the Transactions of the ADA, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT). It is from the Transactions section, one of three subtitles that make up the full publication. Generally, the ADA Transactions are published in multiple volumes throughout the year. Pages from the Annual Reports and the Transactions are numbered consecutively (e.g. Annual Reports volume ends pg. 500 and Transactions volume starts at pg. 501). NOTE: All three subtitles are collectively known as the Transactions of the ADA or, alternatively, the ADA Transactions. Transactions refers …

Developing Local Action Plans, The Kentucky Partnership For Farm Family Health And Safety

Nursing Faculty Publications

No abstract provided.

Mobilizing The Community To Form And Sustain A Grassroots Organization, The Kentucky Partnership For Farm Family Health And Safety

Nursing Faculty Publications

No abstract provided.

Family Cluster Of Rocky Mountain Spotted Fever, James E. Childs, Timothy F. Jones, Allen S. Craig, Christopher D. Paddock, Don B. Mckechnie, Sherif R. Zaki, William Schaffner

Zoonotics and Wildlife Disease: Publications

Soon after a patient from Tennessee died of Rocky Mountain spotted fever (RMSF), several family members developed symptoms suggestive of the disease and were treated presumptively for RMSF. Fifty-four persons visiting the index patient's home were interviewed; serum samples were collected from 35. Three additional cases of RMSF were confirmed, all of which occurred in firstdegree relatives. Time spent at the family home and going into the surrounding woods were significantly associated with developing antibodies to Rickettsia rickettsii. Ticks were collected and examined for rickettsiae by polymerase chain reaction analysis. Because hyperendemic foci and family clusters of RMSF can …

Molecular Cloning And Characterization Of The Ehrlichia Chaffeensis Variable-Length Pcr Target: An Antigen-Expressing Gene That Exhibits Interstrain Variation, John W. Sumner, James E. Childs, Christopher D. Paddock

Zoonotics and Wildlife Disease: Publications

A clone expressing an immunoreactive protein with an apparent molecular mass of 44 kDa was selected from an Ehrlichia chaffeensis Arkansas genomic library by probing with anti-E. chaffeensis hyperimmune mouse ascitic fluid. Nucleotide sequencing revealed an open reading frame (ORF) capable of encoding a 198-aminoacid polypeptide. The ORF contained four imperfect, direct, tandem 90-bp repeats. The nucleotide and deduced amino acid sequences did not show close homologies to entries in the molecular databases. PCR with primers whose sequences matched the sequences flanking the ORF was performed with DNA samples extracted from cell cultures infected with nine different isolates of E. …

Serologic Testing For Human Granulocytic Ehrlichiosis At A National Referral Center, James A. Comer, William L. Nicholson, James G. Olson, James E. Childs

Zoonotics and Wildlife Disease: Publications

An indirect immunofluorescence assay (IFA) was used to identify patients with antibodies reactive to the human granulocytic ehrlichiosis (HGE) agent. Serum samples collected from clinically ill individuals were submitted to the Centers for Disease Control and Prevention by physicians via state health departments from throughout the United States and tested against a panel of ehrlichial and rickettsial pathogens. Antibodies reactive to the HGE agent were detected in 142 (8.9%) of 1,602 individuals tested. There were 19 confirmed and 59 probable (n = 78) cases of HGE as defined by seroconversion or a fourfold or higher titer to the HGE agent …

Bacterial Toxins: Friends Or Foes?, Clare K. Schmitt, Karen C. Meysick, Alison D. O'Brien

Uniformed Services University of the Health Sciences

Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes. These toxins, which affect eukaryotic cells by a variety of means, include Staphylococcus aureus α-toxin, Shiga toxin, cytotoxic necrotizing factor type 1, Escherichia coli heat-stable toxin, botulinum and tetanus neurotoxins, and S. aureus toxic-shock syndrome toxin. For each, we discuss the information available on its synthesis and structure, mode of action, and contribution to virulence. We also review the role certain toxins have played in unraveling signal pathways in eukaryotic cells and summarize …

Gender Differences In The Relationships Among Ses, Family History Of Alcohol Disorders And Alcohol Dependence, Geoffrey M. Curran, Scott F. Stoltenberg, Elizabeth M. Hill, Sharon A. Mudd, Frederic C. Blow, Robert A. Zucker

Department of Psychology: Faculty Publications

Objective: Potential moderator and mediator roles of several measures of socioeconomic status (SES) were investigated for the relationship between a family history of alcoholism( FH) and alcohol dependence symptoms in adulthood. Method: These analyses were performed with a sample of 931 men and 385 women participating in studies at the Alcohol Research Center, University of Michigan. Hierarchical multiple regression equations were used to assess whether SES mediated and moderated relationships between FH and alcohol dependence symptoms. Results: In general, measures of SES (education, occupation, personal and household income) were more important predictors of alcohol dependence symptoms among men, while FH …