Medicine and Health Sciences Commons^™

A Cbfa1-Dependent Genetic Pathway Controls Bone Formation Beyond Embryonic Development, P Ducy, M Starbuck, M Priemel, J Shen, G Pinero, V Geoffroy, M Amling, G Karsenty

Faculty, Staff and Student Publications

The molecular mechanisms controlling bone extracellular matrix (ECM) deposition by differentiated osteoblasts in postnatal life, called hereafter bone formation, are unknown. This contrasts with the growing knowledge about the genetic control of osteoblast differentiation during embryonic development. Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in differentiated osteoblasts postnatally. The perinatal lethality occurring in Cbfa1-deficient mice has prevented so far the study of its function after birth. To determine if Cbfa1 plays a role during bone formation we generated transgenic mice overexpressing Cbfa1 DNA-binding domain (DeltaCbfa1) in differentiated osteoblasts only postnatally. DeltaCbfa1 has a higher …

Interaction Of Cationic Liposomes And Their Dna Complexes With Monocytic Leukemia Cells, Pedro Pires, Sérgio Simões, Shlomo Nir, Rogério Gaspar, Nejat Düzgüneş, Maria C. Pedroso De Lima

All Dugoni School of Dentistry Faculty Articles

Cationic liposomes complexed with DNA have been used extensively as non-viral vectors for the intracellular delivery of reporter or therapeutic genes in culture and in vivo. We examined the relationship between the characteristics of the lipoplexes, their mode of interaction with monocytic THP-1 cells and their ability to transfect these cells. We determined the size and ζ potential of cationic liposomes (composed of 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP) and its mixtures with neutral lipids), and lipoplexes at different (+/-) charge ratios. As the (+/-) charge ratio of the lipoplexes decreased to (1/1), a significant reduction in ζ potential and an increase in …

Adolescent Victims And Intergenerational Issues In Sexual Abuse, Debra B. Hecht, David J. Hansen

Department of Psychology: Faculty Publications

The transitional period of adolescence is characterized by a number of changes and challenges that occur both within and outside the individual. Many developmental events occur during adolescence that have a significant impact on an adolescent’s functioning, including a variety of physical, cognitive, emotional, behavioral, and social changes. In addition, adolescents may experience a variety of other important events, such as peer group changes, school moves, changes in family structure or functioning, and alterations in societal and community expectations (Hansen, Giacoletti, & Nangle, 1995; Peterson & Hamburg, 1986). Unfortunately, many adolescents are further challenged by being a victim of sexual …

Child Physical Abuse And Neglect, Jody E. Warner-Rogers, David J. Hansen, Debra B. Hecht

Department of Psychology: Faculty Publications

Children ideally develop and learn about their world from the safe and stimulating environment of their home. Therefore, it is quite disturbing when violence occurs within the supposedly protective domains of the home and the parent-child relationship, although such acts have been committed throughout history (Zigler & Hall, 1989). Even though acts of child maltreatment have a long history, the concept that society should be responsible for the protection of children, including identification, reporting, and treatment of both the victims and perpetrators of maltreatment, is a relatively recent development.

This chapter addresses the physical abuse and neglect of children by …

Hipaa As A Regulatory Model: Early Experiences And Future Prospects, Karl Polzer

National Health Policy Forum

In the context of the debate over bolstering consumer protection in health care without imposing excessive costs or onerous regulatory requirements, this paper examines the Health Insurance Portability and Accountability Act of 1996 (HIPAA) as a regulatory model. The paper reviews the provisions of the legislation, examines the roles of the Department of Labor and the Health Care Financing Administration in implementing HIPAA, raises issues surrounding implementation and enforcement, and examines the usefulness of the HIPAA model as a vehicle for applying consumer protection measures.

Ada News - 04/05/1999, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Homeless And Working Street Youth In Latin America: A Developmental Review, Marcela Raffaelli

Department of Psychology: Faculty Publications

In most Latin American countries, a substantial proportion of children grow up in circumstances of extreme deprivation and early independence. These include "street youth", youngsters who work and sometimes live on city streets in developing countries. Most street youth research has been conducted from an applied perspective and emphasizes service and policy needs. Little developmental research has been conducted with street youth, and the long-term impact of street life is largely unknown. This review synthesizes empirical findings on the developmentally-relevant experiences of sub-groups of street youth in Latin America. It includes research in four areas: social networks, daily survival, health …

Mid-Atlantic Ethics Committee Newsletter, Spring 1999

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Stress And Burnout In Female High School Athletic Directors, Jeffrey J. Martin, Betty Kelley, Candice Dias

Kinesiology, Health and Sport Studies

In the current study we examined the relationships between stress predictors, stress, and burnout in female high school athletic directors (N = 52). Significant negative correlations between stress and hardiness and between stress and number of social support providers were found. Significant positive correlations between stress and time concerns, personnel concerns, and program success (e.g., winning) subscales of the athletic directing issues scale were also found. Subjects high in hardiness and with adequate social support networks, who also reported few athletic directing issues, were likely to report minimal stress. Significant positive correlations also indicated that stress was related to …

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the April, 1999 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

• Dietary Mutagens and Breast Cancer: Potent Carcinogens In Cooked Food
• College of medicine received AALAC Accreditation
• BASS appointed chair of internal medicine
• Congratulations...
• Deputy Director appointed to Alabama AHEC program
• Health Science Fellowship Granted
• MARCIA GROVE recognized by National Cancer research group
• Infertility specialist team successful
• BENNETT named Vice-Dean for student affairs and medical education
• College of Medicine chairs of Pathology and Physiology recognized by Disciplines
• New Electronic products available from Biomedical Library
• 1999 Residency selection

Ua61/1 Wku Nursing Class 1999, Wku Nursing

WKU Administration Documents

Members of the 1999 nursing class: Kelly Anderson, Shawn Arnett, Gretchen Baugh-Carneal, Kelly Beckner, Megan Brown, Sonia Carter, Laura Claycomb, Mary Conley, Melissa Dunn, Jayme Forbis, Diana Glass, Linda Hampton, Melissa Henderson, Jennifer Houchin, Tammy Jackson, Lori Jaggers, Brandi Mattingly, Sherry May, Kristina Natcher, Karen Randolph, Samantha Scott, Cheryl Smith and Christina Winn.

Observations And Possible Function Of The Striking Anterior Coloration Pattern Of Galathea Intermedia (Crustacea: Decapoda: Anomura), J. M. Hall-Spencer, P. G. Moore, L. U. Sneddon

Veterinary Science and Medicine Collection

Galathea intermedia is common, but cryptic, on Clyde maerl deposits where it lives in small groups of mixed sex and age, sharing shelters (typically dead Dosinia shells) to avoid predation. Its appearance is marked by six iridescent blue spots which may play an important role in intra- or interspecific interactions.

Center For Psychology Studies Newsletter - Spring 1999, Nova Southeastern University

Center for Psychological Studies Newsletter

No abstract provided.

Breaking The Rules: A Rebuttal Of Normal-Tension Glaucoma, David Brey

Mahurin Honors College Capstone Experience/Thesis Projects

Glaucoma is a disease of the eyes generally characterized by high intraocular pressure, optic nerve death, and visual loss. Open-angle glaucoma and angle-closure glaucoma are the two main forms of the disease However, there is one form of open angle glaucoma that cannot be described by the above abnormalities. This form is known as normal-tension glaucoma, and while it is characterized by optic nerve death and visual loss, it does not display an abnormally high intraocular pressure. Indeed, as this thesis argues, normal-tension glaucoma should not be labeled as a glaucoma disease at all.

Nsu Achievements - Spring 1999, Nova Southeastern University

NSU Achievements

No abstract provided.

Wellness Center Healthletter - April 1999, Nova Southeastern University

Wellness Center Healthletter

No abstract provided.

Perceptual-Mnemonic Functions Of The Perirhinal Cortex., Murray, Bussey

Brain and Mind Institute Researchers' Publications

It is widely acknowledged that the perirhinal cortex, located in the ventromedial aspect of the temporal lobe, is essential for certain types of memory in macaque monkeys. For example, removal of the perirhinal cortex yields severe impairments on tests of stimulus recognition and stimulus-stimulus association. There is considerable disagreement, however, about the most accurate way to characterize the function of the perirhinal cortex; some views emphasize a role in perception whereas others posit a role exclusively in declarative memory. In this article, we review recent findings from anatomical, physiological and ablation studies in monkeys, and discuss related findings obtained in …

From Housing To Homes: A Review Of The Literature On Housing Approaches For Psychiatric Consumers/Survivors, Shannon Parkinson, Geoffrey Nelson, Salinda Horgan

Psychology Faculty Publications

In this paper, we review the literature on housing for psychiatric consumer/survivors since the publication of the Nelson and Smith Fowler (1987) review more than a decade ago. First, we review research and propose a definition to contrast key features of three approaches to housing: (a) custodial, (b) supportive, and (c) supported. Second, we examine studies of the relationships between the characteristics of housing and adaptational outcomes for residents (e.g., personal empowerment). Third, we review studies which have examined out-comes for residents for these three different housing approaches. We conclude by critically reflecting on the values and research of the …

Aluminum And Phosphorus Separation: Application To Preparation Of Target From Brain Tissue For 26Al Determination By Accelerator Mass Spectrometry, Russell D. Brauer, J. David Robertson, Pankaj Sharma, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Acid digested brain containing 4 mg added ²⁷Al was ashed at 1000°C to prepare an Al₂O₃ target for accelerator mass spectrometry (AMS) analysis of ²⁶Al. A glass-like material usually resulted which was thought to be aluminum (Al) oxyphosphate. The separation of Al and phosphate was investigated. Al, but not phosphate, was bound by a cation exchange resin (AG 50-X8). Hydrofluoric acid eluted the Al from the resin. Removal of phosphate from acid digested brain by this method produced an amorphous material after ashing that was easier to recover from the porcelain crucible and had a …

Radiculopathy And Myelopathy At Segments Adjacent To The Site Of A Previous Anterior Cervical Arthrodesis., Alan S. Hilibrand, Gregory D. Carlson, M A Palumbo, P K Jones, H H Bohlman

Rothman Institute Papers

BACKGROUND: We studied the incidence, prevalence, and radiographic progression of symptomatic adjacent-segment disease, which we defined as the development of new radiculopathy or myelopathy referable to a motion segment adjacent to the site of a previous anterior arthrodesis of the cervical spine.

METHODS: A consecutive series of 374 patients who had a total of 409 anterior cervical arthrodeses for the treatment of cervical spondylosis with radiculopathy or myelopathy, or both, were followed for a maximum of twenty-one years after the operation. The annual incidence of symptomatic adjacent-segment disease was defined as the percentage of patients who had been disease-free at …

The Comparative Importance Of Books: Clinical Psychology In The Health Sciences Library, Jeffrey M. Wehmeyer, Susan Wehmeyer

University Libraries' Staff Publications

Clinical psychology has received little attention as a subject in health sciences library collections. This study seeks to demonstrate the relative importance of the monographic literature to clinical psychology through the examination of citations in graduate student theses and dissertations at the Fordham Health Sciences Library, Wright State University. Dissertations and theses were sampled randomly; citations were classified by format, counted, and subjected to statistical analysis. Books and book chapters together account for 35% of the citations in clinical psychology dissertations, 25% in nursing theses, and 8% in biomedical sciences theses and dissertations. Analysis of variance indicates that the citations …

Developing A Hospital Web Site As A Marketing Tool: A Case Study, Thomas G. Widmer, C. David Shepherd

Faculty Articles

This article presents a case study which described the efforts of Siskin Hospital to develop a Web site as its marketing tool in 1999. Several years ago. Siskin Hospital, a rehabilitation facility in the southeastern U.S., began the process of developing a hospital Web site. It was agreed that a multidisciplinary team was needed. Then, the next step was to determine target audiences for the site based on the objectives. Fourteen distinct targets were identified. The type of information each would require was brainstormed and detailed. The information types were then prioritized using a matrix developed by the team.

A Comparison Of The Use Of Tympanic, Axillary, And Rectal Thermometers In Infants, Russell Wilshaw, Renea L. Beckstrand, Dawn Waid, Bruce Schaallje

Faculty Publications

This study examined the relationship between three instruments used in measuring tympanic, axillary, and rectal temperatures in infants less than 1 year of age. Temperatures were measured by Oto-temp Pedi Q tympanic thermometers, Becton Dickinson axillary thermometer, and rectal thermometers. A convience sample of 5 infants less than 90 day and 54 greater than 90 days with fever, as well as 34 infants less than 90 days and 27 infants greater than 90 days without fever were studied. Correlations of infants less than 90 days and greater 90 days of age, as well as differences between infant temperature with and …

Purification Of 10-5a9 Antigen In Alzheimer's Disease, Gary Isaacs

Senior Honors Theses

Alzheimer's Disease (AD) is a neurodegenerative disorder that results in memory loss and reduced cognitive function. Characteristic lesions include senile plaques and neurofibrillary tangles. Evidence for a previously unknown component, cockroach 10-5A9 antigen, within these lesions has recently been discovered. It is the purpose of this study to purify to 10-5A9 antigen for further analysis. Immunohistochemistry was used to determine the antigen's presence in AD lesions and the Lewy bodies of Parkinson's disease. Although SDS-PAGE/Western blotting and immunoprecipitation techniques proved ineffective, the former indicated antigen presence in the particulate matter of AD brain homogenates. Negative results from ammonium sulfate experiments …

Insulinlike Growth Factor 1- And 2-Augmented Collagen Gel Repair Of Facial Osseous Defects, James S. Toung, Roy C. Ogle, Raymond F. Morgan, William H. Lindsey

School of Medical Diagnostics & Translational Sciences Publications

BACKGROUND: Defects of the facial bone structure are common problems for the facial plastic surgeon. Native type 1 collagen gels (T1CGs) have been shown to mediate repair of facial critical-size defects in rat models.

OBJECTIVE: To evaluate the efficacy of T1CG augmented with insulinlike growth factor (IGF) 1, IGF-2, and a combination of IGF-1 and IGF-2 on the repair of facial critical-size defects in a rodent model.

METHODS: Twenty-four retired male breeder Sprague-Dawley rats were divided into 4 groups of 6 animals. Facial critical-size defects were created by removing the nasalis bones with a bone-cutting drill. Defects were treated with …

Arkansas Animal Science Department Report 1998, Stacey Gunter

Arkansas Agricultural Experiment Station Research Series

No abstract provided.

Carotid Doppler Ultrasonography In Young Stroke Patients, A A. Razzaq, B A. Khan, C K. Jadoon, S M. Baig

Section of Neurology

Background: The present study focuses on the role of carotid doppler ultrasonography (CDUS) in the diagnosis and management of carotid stenosis in young stroke patients.

Methods: The findings of carotid doppler in 45 ischemic stroke patients between 15-45 years of age were reviewed retrospectively. The variables of interest for this study included risk factors for atherosclerotic disease, primary abnormality detected on carotid doppler ultrasonography (ulceration vs. stenosis), degree of stenosis and the type of plaque (soft vs. calcified).

Results: The prevalence of hypertension and diabetes was 50% and 35% respectively. The rate of carotid stenosis in the …

Role Of Gamma Interferon In Cellular Immune Response Against Murine Encephalitozoon Cuniculi Infection, Imtiaz A. Khan, Magali Moretto

Dartmouth Scholarship

Microsporidia are obligate intracellular protozoan parasites that cause a wide variety of opportunistic infection in patients with AIDS. Because it is able to grow in vitro, Encephalitozoon cuniculi is currently the best-studied microsporidian. T cells mediate protective immunity against this parasite. Splenocytes obtained from infected mice proliferate in vitro in response to irradiated parasites. A transient state of hyporesponsiveness to parasite antigen and mitogen was observed at day 17 postinfection. This downregulatory response could be partially reversed by addition of nitric oxide (NO) antagonist to the culture. Mice infected withE. cuniculi secrete significant levels of gamma interferon (IFN-γ). Treatment …

Pregnant Rat Uterus Expresses High Levels Of The Type 3 Iodothyronine Deiodinase, Valerie Anne Galton, Elena Martinez, Arturo Hernandez, Emily A. St. Germain, Joanne M. Bates, Donald L. St. Germain

Dartmouth Scholarship

Although thyroid hormones are critically important for the coordination of morphogenic processes in the fetus and neonate, premature exposure of the embryo to levels of the hormones present in the adult is detrimental and can result in growth retardation, malformations, and even death. We report here that the pregnant rat uterus expresses extremely high levels of the type 3 iodothyronine deiodinase (D3), which inactivates thyroxine and 3,3′,5-triiodothyronine by 5-deiodination. Both D3 mRNA and activity were present at the implantation site as early as gestational day 9 (E9), when expression was localized using in situ hybridization to uterine mesometrial and antimesometrial …

Immunohistochemical Evaluation Of Small Round Cell Tumors Of Childhood, Sajid H. Shah, Irshad N. Soomro, M. Shahid Siddiqui, Shahid Pervez, Sheema H. Hassan

Department of Pathology and Laboratory Medicine

Objective:

This study was done to evaluate the pediatric undifferentiated small round cell tumors with immunohistochemical staining.

Setting:

The present study included consecutive cases of small round cell tumors which were diagnosed in children (<15 years) in the section of Histopathology at the Aga Khan University Hospital, Karachi during the period of two years.

Methods:

The group of undifferentiated small round cell tumors were evaluated immunohistochemically by using a panel of antibodies on sections from routinely processed, formalin fixed, paraffin embedded tissue blocks.

Results:

The category of undifferentiated small round cell tumors included rhabdomyosarcoma (23.2%), primitive neuroectodermal tumor (17.9%), non-Hodgkin’s lymphoma (16.1%), neuroblastoma (14.2%), Ewing’s sarcoma (10.7%) in order of frequency. Osteosarcoma (Small cell variant), retinoblastoma and medulloblastoma comprised …