Medicine and Health Sciences Commons^™

An Investigation Into The Possibility Of Transmission Of Tick-Borne Pathogens Via Blood Transfusion, P. M. Arguin, J. Singleton, L. D. Rotz, E. Marston, T. A. Treadwell, K. Slater, M. Chamberland, A. Schwartz, L. Tengelsen, J. G. Olson, J. E. Childs

United States Public Health Resources

BACKGROUND: Tick-borne illnesses were diagnosed in a group of National Guard members, including some who had donated blood a few days before the onset of symptoms. A voluntary recall of those blood components was issued and a multistate investigation was conducted to determine if transfusion-transmitted illness had occurred.

STUDY DESIGN AND METHODS: Donors and recipients were asked to complete questionnaires regarding symptoms and risk factors for infection and to provide blood samples for laboratory analysis.

RESULTS: Among National Guard personnel who donated blood, 12 individuals were found to have a confirmed or probable case of Rocky Mountain …

An Investigation Into The Possibility Of Transmission Of Tick-Borne Pathogens Via Blood Transfusion, P. M. Arguin, J. Singleton, L. D. Rotz, E. Marston, T. A. Treadwell, K. Slater, M. Chamberland, A. Schwartz, L. Tengelsen, J. G. Olson, J. E. Childs, Transfusion-Associated Tick-Borne Illness Task Force

United States Public Health Resources

BACKGROUND: Tick-borne illnesses were diagnosed in a group of National Guard members, including some who had donated blood a few days before the onset of symptoms. A voluntary recall of those blood components was issued and a multistate investigation was conducted to determine if transfusion-transmitted illness had occurred.
STUDY DESIGN AND METHODS: Donors and recipients were asked to complete questionnaires regarding symptoms and risk factors for infection and to provide blood samples for laboratory analysis.
RESULTS: Among National Guard personnel who donated blood, 12 individuals were found to have a confirmed or probable case of Rocky Mountain spotted fever or …

The Hidden Work Of The Farm Homemaker, Deborah B. Reed, Susan C. Westneat, Steven R. Browning, Lana Skarke

Preventive Medicine and Environmental Health Faculty Publications

Despite women’s involvement in agricultural production, the work role of women residing in farm households has not been thoroughly examined. Data collected in 1994-1995 as part of the NIOSH-sponsored Farm Family Health and Hazard Surveillance Project were used to address task issues and health status of farm women in Kentucky. In 1996, the farm woman component of the Kentucky study was replicated in five counties in west Texas, allowing an examination of farm women in two large agricultural states. The Kentucky study employed a two-stage cluster design;the Texas study was based on a systematic quota sample of farms. Both studies …

Bone And Renal Stone Disease In Patients Operated For Primary Hyperparathyroidism In Pakistan: Is The Pattern Of Disease Different From The West?, Syed Raziuddin Biyabani, Jamsheer J Talati

Section of Urology

Objective: To document the clinical presentation of primary hyperparathyroidism (PHPT) in a developing country and note differences from the West.
Setting: A tertiary care teaching hospital.
Method: The records of 37 patients operated for PHPT between January 1986 and December 1997 were reviewed. Symptoms, laboratory parameters and histopathology results were analyzed.
Results: Surgery for PHPT accounted for 0.055% of 67,566 operative procedures performed in the Department of Surgery during the 12 year period. The mean age of our patients was 38.4±13.2 years (range 17 to 73 years). Ninety percent of patients were less than 60 years old and 51% less …

Communication Characteristics Of Children With Developmental Apraxia Of Speech, Laura Jean Ball

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Speech-language pathology researchers have pursued a strategy to identify children with distinct DAS characteristics in an effort to study the characteristics, possible cause(s), and interventions for this disorder. Increasingly, reports indicate that children with suspected DAS experience a range of speech, language, social interaction, behavioral, and academic disabilities. Investigators in DAS continue to recommend intervention strategies that focus primarily on motor speech impairments, although it is clear that few children with a distinct version of DAS exist.

Evaluations of communication skills were obtained from 36 children identified with suspected DAS for this research project. Hierarchical cluster analysis was completed on …

Developing Policy For Hiv/Aids In Sport: Separating Fact From Fiction, Karin A. E. Volkwein, Gopal Sankaran, Dale R. Bonsall

Public Health Sciences Faculty Publications

In recent years, HIV-positive athletes have increasingly made the headlines, leading to questions and concerns regarding HIV transmission through sport. Based on limited understanding and irrational fear, athletes have been excluded from sport competitions or encouraged to retire prematurely. In other cases, they have been subjected to random, mandatory HIV testing prior to sport competition. Because HIV/AIDS is a medical and social problem, information from health-related sources is included in this analysis, including the modes of HIV transmission. This analysis focuses on further issues related to rights, obligations, risks, privacy, and policy. The growing dilemma for the sport professionals to …

La Qualité De L'Air Des Scieries Du Québec Et Son Impact Sur La Santé Des Travailleurs De Scierie : Influence Des Sites De Travail Et Des Essences De Bois Sur La Qualité De L'Environnement, Caroline Duchaine, Anne Mériaux, Gaétane Racine-Bédard, Serge Simard, Yvon Cormier

Rapports de recherche scientifique

No abstract provided.

Persistance Des Fibres Minérales De Synthèse Dans Le Poumon : Pathologie Et Cinétique De Rétention Dans Le Lobe Trachéal Du Mouton, André Dufresne, Raymond Bégin, Serge Massé, Hiroshi Yamato, Guy Perrault

Rapports de recherche scientifique

No abstract provided.

Effects Of Plasma Hiv Rna, Cd4+ T Lymphocytes, And The Chemokine Receptors Ccr5 And Ccr2b On Hiv Disease Progression In Hemophiliacs, Eric S. Daar, Sharyne Donfield, Edward Gomperts, Margaret Hilgartner, Keith Hoots, David Chernoff, Cheryl Winkler, Stephen J. O'Brien, Hemophilia Growth And Development Study

Biology Faculty Articles

We have investigated the effects of plasma HIV RNA, CD4⁺ T lymphocytes and chemokine receptors CCR5 and CCR2b on HIV disease progression in hemophiliacs. We prospectively observed during follow-up 207 HIV-infected hemophiliacs in the Hemophilia Growth and Development Study. Plasma HIV RNA was measured on cryopreserved plasma from enrollment using the Chiron Corporation bDNA (version 2.0) assay. Genotype variants CCR2b-641 and CCR5-Δ32 were detected using standard molecular techniques. Those with the mutant allele for CCR2b, and to a lesser extent CCR5, had lower plasma HIV RNA, and higher CD4⁺ T lymphocytes than did those without these …

Association Of Low Back Pain With Self-Reported Risk Factors Among Patients Seeking Physical Therapy Services, Pamela Levangie

All PTHMS Faculty Publications

Background and Purpose. This study investigated the magnitude of association between low back pain (LBP) and self-reported factors thought to increase the risk of LBP. Subjects and Methods. Questionnaires were completed by 150 patients who were receiving physical therapy for LBP and by 138 patients who were being treated for other reasons. The solicited information was used to estimate odds ratios and 95% confidence intervals for the LBP-risk factor association. Results. Low back pain was positively associated with smoking status, pregnancy, industrial vibration exposure, and time spent in a car (odds ratios [is greater than or equal to] 2.21). Daily …

Genetic And Structural Analyses Of Cytoplasmic Filaments Of Wild-Type Treponema Phagedenis And A Flagellar Filament-Deficient Mutant, Jacques Izard, William A. Samsonoff, Mary Beth Kinoshita, Ronald J. Limberger

Department of Food Science and Technology: Faculty Publications

Unique cytoplasmic filaments are found in the treponeme genus of spirochete bacteria. Their function is unknown, but their location underneath the periplasmic flagellar filaments (PFF) suggests a role in motility and/or cell structure. To better understand these unique structures, the gene coding for the cytoplasmic filaments, cfpA, was identified in various treponemal species. Treponema phagedenis cfpA was 2,037 nucleotides long, and the encoded polypeptide showed 78 to 100% amino acid sequence identity with the partial sequence of CfpA from T. denticola, T. vincentii, and T. pallidum subsp. pertenue. Wild-type T. phagedenis and a …

Global Cns Gene Transfer For A Childhood Neurogenetic Enzyme Deficiency: Canavan Disease., Paola Leone, Christopher G Janson, Scott J Mcphee, Matthew J During

Department of Neurosurgery Faculty Papers

The neurogenetic prototypic disease on which we chose to test our gene therapy strategy is Canavan disease (CD). CD is an autosomal recessive leukodystrophy associated with spongiform degeneration of the brain. At present the disease is uniformly fatal in affected probands. CD is characterized by mutations in the aspartoacylase (ASPA) gene, resulting in loss of enzyme activity. In this review, recent evidence is summarized on the etiology and possible treatments for CD. In particular, we discuss two gene delivery systems representing recent advances in both viral and liposome technology: a novel cationic liposome-polymer-DNA (LPD) complex, DCChol/DOPE-protamine, as well as recombinant …

Facial Nerve Palsy Unusual Complication Of Percutaneous Angiography And Emoblization For Juvenile Angiofibroma, Mubasher Ikram, Kamaluddin Khan, Moazzam Murad, Tanveer Ui Haq

Section of Otolaryngology, Head & Neck Surgery

Juvenile angiofibrorna is a locally invasive, vascular and non-encapsulated neoplasm occurring almost exclusively in adolescent males. Although histologically benign, these tumors are highly aggressive and are associated with significant morbidity and occasional mortality. It has marked tendency to recur if not completely removed1 . As the tumor is highly vascular, surgely is frequently accompanied by significant intraoperative hemorrhage, which may contribute to incomplete removal and additional morbidity and mortality2 . Roberson (1972) was first to advocate pre-operative angiography and embolization of major feeding vessels as an adjunct therapeutic method in addition to surgery, to facilitate complete excision of the tumOr …

Telomere, Telomerase And Digestive Cancer, Javed Yakoob, Hu Guo-Ling, Fan Xue-Gong, Zhang Zheng

Section of Gastroenterology

No abstract provided.

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Summer, 1999 edition of the ALHeLa newsletter - Synapse.

Contents include:

• President's Column
• ALHeLA 1999 Annual Conference
• ALHeLA Member wins national award
• ALHeLA Directory Update
• Summary of ALHeLA/NAAL teaching project
• Letter from SC/MLA governmental relations committee
• Electronic and Internet-based resources survey
• Alabama Health Libraries Association - 1999 Executive Committee
• Alabama Health Libraries Association - Executive Committee Meeting - Minutes

Effects Of Community Structure On The Seagrass Thalassia Testudinum, Craig D. Rose, Clinton J. Dawes

Integrative Biology Faculty and Staff Publications

The influence of community structure on the seagrass Thalassia testudinum was studied in 3 distinct communities: low and high density monocultures, and patches intermixed with Halodule wrightii, in Cockroach Bay, Tampa, Florida. T. testudinum shoot-specific leaf mass and growth were significantly higher in low density monocultures, and both variables were negatively correlated with short-shoot density. Intraspecific, competition-density effects in high-density seagrass beds may be responsible for the relatively lower shoot-specific leaf mass and growth rates, possibly due to the reduction of available light from dense leaf canopies. These observations are supported by significantly higher T. testudinum leaf C:N and …

Mental Health Coverage Parity: Separating Wheat From Chaff, Karl Polzer

National Health Policy Forum

This paper examines the issue of mandating parity in coverage of mental health services in the context of the growing use by private-sector employers of managed behavioral health care providers. Existing parity laws are reviewed, along with estimates of the costs of parity. The tools used by behavioral health care firms to manage care and costs are also discussed.

Protein Adducts Of Iso[4]Levuglandin E2, A Product Of The Isoprostane Pathway, In Oxidized Low Density Lipoprotein, Robert G. Salomon, Wei Sha, Cynthia Brame, Kamaljit Kaur, Ganesamoorthy Subbanagounder, June O'Neil, Henry F. Hoff, L. Jackson Roberts Ii

Pharmacy Faculty Articles and Research

Levuglandin (LG) E₂, a cytotoxic seco prostanoic acid co-generated with prostaglandins by nonenzymatic rearrangements of the cyclooxygenase-derived endoperoxide, prostaglandin H₂, avidly binds to proteins. That LGE₂-protein adducts can also be generated nonenzymatically is demonstrated by their production during free radical-induced oxidation of low density lipoprotein (LDL). Like oxidized LDL, LGE₂-LDL, but not native LDL, undergoes receptor-mediated uptake and impaired processing by macrophage cells. Since radical-induced lipid oxidation produces isomers of prostaglandins, isoprostanes (isoPs), via endoperoxide intermediates, we postulated previously that a similar family of LG isomers, isoLGs, is cogenerated with isoPs. Now …

Quality Of Care In Investor-Owned Vs Not-For-Profit Hmos, David U. Himmelstein, Steffie Woolhandler, Ida Hellander, Sidney M. Wolfe

Publications and Research

Context The proportion of health maintenance organization (HMO) members enrolled in investor-owned plans has increased sharply, yet little is known about the quality of these plans compared with not-for-profit HMOs.

Objective To compare quality-of-care measures for investor-owned and not-for-profit HMOs.

Design, Setting, and Participants Analysis of the Health Plan Employer Data and Information Set (HEDIS) Version 3.0 from the National Committee for Quality Assurance's Quality Compass 1997, which included 1996 quality-of-care data for 329 HMO plans (248 investor-owned and 81 not-for-profit), representing 56% of the total HMO enrollment in the United States.

Main Outcome Measures Rates for 14 HEDIS quality-of-care …

Laser Skin Graft Harvesting Apparatus And Related Method, David S. Kirn

Surgery Faculty Patents

A laser dermatome is disclosed for harvesting and meshing grafts of skin. A roller driven by a motor lifts the leading edge of a portion of skin for cutting by a beam of light generated by a laser. Adhesive tape attached to the roller aids in lifting the portion of skin and is further utilized to secure the severed portion of skin to the roller. A stage mounted atop an axle supports the laser or a beam director. The movement of the stage is controlled by second and third motors which drive the stage along or rotate it about the …

Access To Home Health Services Under Medicare's Interim Payment System, Nora Super

National Health Policy Forum

This issue brief explores the impact of the interim payment system (IPS) for home health agencies established under the Balanced Budget Act of 1997 (BBA). IPS was intended to constrain program outlays by imposing limits on spending per beneficiary and spending per visit in the existing cost-based reimbursement system. This issue brief examines the impact of the IPS on access to home health care, including home health agencies' responses to the payment system and its impact on provider availability and, ultimately, access to care for the sickest or most expensive populations

Methods Of Treating Eye Conditions With Human Leukocyte Elastase (Hle) Inhibitory Agents, George A. Digenis, Charles Khouri

Pharmaceutical Sciences Faculty Patents

A method of reducing corneal scarring or fibroblast proliferation comprises applying to an area of a subject's eye afflicted with the condition a corneal scar-fibroblast proliferation-reducing amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. A method of reducing neovascularization of corneal scar tissue comprises applying to an area of a subject's eye afflicted with the condition a neovascularization-inhibitory amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect.

Ada News - 07/12/1999, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Implementing The Bba: The Challenge Of Moving Medicare Post-Acute Services To Pps, Karen Matherlee

National Health Policy Forum

This issue brief examines the challenge of putting skilled nursing facilities (SNFs), medical rehabilitation units, and home health under prospective payment, requiring the development of classification systems for each. It looks at the three-year phase-in of SNF resource utilization groups (RUGs) that began July 1, 1998 and the debate over classification systems for medical rehabilitation facilities and home health. The paper goes beyond issues of classification to consider coordination problems in placing these post-acute services under Medicare PPS.

Intracellular Reactive Oxygen Species Mediate The Linkage Of Na+/K+-Atpase To Hypertrophy And Its Marker Genes In Cardiac Myocytes, Joseph I. Shapiro, Amir Askari, Zijian Xie, Peter Kometiani, Jie Li, Jiang Liu

Pharmaceutical Science and Research

We showed before that in cardiac myocytes partial inhibition of Na⁺/K⁺-ATPase by nontoxic concentrations of ouabain causes hypertrophy and transcriptional regulations of growth-related marker genes through multiple Ca²⁺-dependent signal pathways many of which involve Ras and p42/44 mitogen-activated protein kinases. The aim of this work was to explore the roles of intracellular reactive oxygen species (ROS) in these ouabain-initiated pathways. Ouabain caused a rapid generation of ROS within the myocytes that was prevented by preexposure of cells to N-acetylcysteine (NAC) or vitamin E. These antioxidants also blocked or attenuated the following actions of …

A Model Of Stress And Burnout In Male High School Athletic Directors, Jeffrey J. Martin, Betty Kelley, Robert C. Eklund

Kinesiology, Health and Sport Studies

No abstract provided.

Mid-Atlantic Ethics Committee Newsletter, Summer 1999

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the July, 1999 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

• Remodeling The Mammary Gland At The Termination of Breast Feeding: Role Of A New Regulator Protein BRP39
• New PH.D. graduates in Basic Medical Sciences
• University of South Alabama College Of Medicine Class Of 1999 Residency Appointments
• Honors convocation awards
• New tool in heart disease fight
• BARIK RECEIVES BURROUGHS WELLCOME MALARIA RESEARCH AWARD
• Community awareness meeting
• How University Get Licenses For Human Experiments

K-Cl Cotransport: Membrane Immunofluorescence Localization By Confocal Microscopy Of The Kcc1 Protein, Before And After Truncation Of The Cooh-Terminal Domain, In Human Embryonic Kidney (Hek293) Cells, Peter K. Lauf, Kenneth B.E. Gagnon, Jin Zhang, Eric Delpire, Robert E.W. Fyffe, Norma C. Adragna

Pharmacology and Toxicology Faculty Publications

No abstract provided.

Transfer Of Lacz Marker Gene To The Meniscus, Hideyuki Goto Md, Franklin D. Shuler Md, Phd, Chanin Lamsam Md, Hans D. Moller Md, Christopher Niyibizi Phd, Freddie H. Fu Md, Paul D. Robbins Phd, Christopher H. Evans Phd

Orthopaedics

Background: Lesions in the avascular two-thirds of the meniscus do not heal well and are of concern clinically. Various growth factors promote the synthesis of matrix by meniscal cells and thus have the potential to augment healing. However, their clinical application is severely hindered by problems with delivery. An attractive approach to overcoming such problems is to transfer genes that encode the growth factors in question to the site of the injury. As a prelude to this, we evaluated methods for delivering genes to the meniscus.

Methods: Gene transfer was evaluated in vitro and in vivo with a lacZ marker …