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Articles 151321 - 151350 of 160158

Full-Text Articles in Medicine and Health Sciences

Auto-Inhibition Of Ets-1 Is Counteracted By Dna Binding Cooperativity With Core-Binding Factor Α2, Tamara L. Goetz, Ting-Lei Gu, Nancy A. Speck, Barbara J. Graves Jan 2000

Auto-Inhibition Of Ets-1 Is Counteracted By Dna Binding Cooperativity With Core-Binding Factor Α2, Tamara L. Goetz, Ting-Lei Gu, Nancy A. Speck, Barbara J. Graves

Dartmouth Scholarship

Auto-inhibition is a common transcriptional control mechanism that is well characterized in the regulatory transcription factor Ets-1. Autoinhibition of Ets-1 DNA binding works through an inhibitory module that exists in two conformations. DNA binding requires a change in the inhibitory module from the packed to disrupted conformation. This structural switch provides a mechanism to tightly regulate Ets-1 DNA binding. We report that the Ets-1 partner protein core-binding factor α2 (CBFα2; also known as AML1 or PEBP2) stimulates Ets-1 DNA binding and counteracts auto-inhibition. Support for this conclusion came from three observations. First, the level of cooperative DNA binding (10-fold) was …

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The Use Of Intra Aortic Baloon Pump In Patients Undergoing Coronary Artery Bypass Grafting At The Aga Khan University Hospital, Karachi, Aamir M. Jafarey, Muneer Amanullah, Sajid A. Khan, Sulaiman B. Hasan Jan 2000

The Use Of Intra Aortic Baloon Pump In Patients Undergoing Coronary Artery Bypass Grafting At The Aga Khan University Hospital, Karachi, Aamir M. Jafarey, Muneer Amanullah, Sajid A. Khan, Sulaiman B. Hasan

Department of Surgery Docs

Objective: To review the experience in the use of Intra Aortic Balloon Pump (IABP) in patietits undergoing Coronary Artery Bypass Grafting (CABG) at a tertiary care hospital with a new Open Heart surgery program. Design: Retrospective study. Setting: The Aga Khan University Hospital, Karachi.
Patients: Medical records of all patients undergoing CABG between November 1994 and July 1997 were reviewed and those in whom IABP device was used, were included in this study.
Results: A total of 15 patients had IABP suppOrt during the study period. Four surgeries were done urgently while two were emergencies. There were three mortalities. Ejection …

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Lineage-Restricted Function Of Nuclear Factor Kappab-Inducing Kinase (Nik) In Transducing Signals Via Cd40., Norman Garceau, Yoko Kosaka, Sally Masters, John Hambor, Reiko Shinkura, Tasuko Honjo, Randolph J. Noelle Jan 2000

Lineage-Restricted Function Of Nuclear Factor Kappab-Inducing Kinase (Nik) In Transducing Signals Via Cd40., Norman Garceau, Yoko Kosaka, Sally Masters, John Hambor, Reiko Shinkura, Tasuko Honjo, Randolph J. Noelle

Dartmouth Scholarship

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40.

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Risk Of Imported Filariasis In Pakistan, M A. Beg Jan 2000

Risk Of Imported Filariasis In Pakistan, M A. Beg

Department of Pathology and Laboratory Medicine

No abstract provided.

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He’S The Top Sports Marketer In 1,000 Years, Rick Burton Dec 1999

He’S The Top Sports Marketer In 1,000 Years, Rick Burton

Sport Management - All Scholarship

No abstract provided.

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Implantable Controlled Release Device To Deliver Drugs Directly To An Internal Portion Of The Body, Paul Ashton, Paul A. Pearson Dec 1999

Implantable Controlled Release Device To Deliver Drugs Directly To An Internal Portion Of The Body, Paul Ashton, Paul A. Pearson

Ophthalmology and Visual Science Faculty Patents

A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed.

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Transcriptional Silencing Elements And Their Binding Factors, Joseph Chappell, Jeffrey D. Newman, Shaohui Yin Dec 1999

Transcriptional Silencing Elements And Their Binding Factors, Joseph Chappell, Jeffrey D. Newman, Shaohui Yin

Pharmaceutical Sciences Faculty Patents

The invention features an isolated gene silencing regulatory element that includes 5' TACNNTAC 3'. Vectors, transgenic plants and seeds thereof that include such a gene silencing regulatory element are also disclosed. The invention further provides methods of decreasing the transcription of a DNA sequence in a transgenic plant using the isolated gene silencing regulatory element.

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Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd Dec 1999

Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide, (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone, (POBN), and (TEMPO) spin-trapping derivatives thereof. …

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Ada News - 12/13/1999, American Dental Association, Publishing Division Dec 1999

Ada News - 12/13/1999, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

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Sterilization In The United States: Prevalence And Controversies, Carey Brown Dec 1999

Sterilization In The United States: Prevalence And Controversies, Carey Brown

Masters Theses & Specialist Projects

There have been many breakthroughs in birth control technologies, many of which have been beneficial for women. However, many feminists who advocate reproductive freedom also warn that freedom for some might lead to further oppression for others. The case in point is the practice of tubal ligation in the United States. Conflict theory indicates that the field of medicine is a social structure that is based upon capitalistic ideology and serves to perpetuate inequality. Feminist theory argues that medicine systematically disempowers women and that notions of family are very narrowly defined. This study examined the prevalence of tubal ligation among …

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Social Identity And Substance Abuse In The Lesbian Community, Molly Kerby Dec 1999

Social Identity And Substance Abuse In The Lesbian Community, Molly Kerby

Masters Theses & Specialist Projects

The purpose of this study was to determine the degree of substance use (alcohol, tobacco, and other drugs) among members of the lesbian community. Additionally, the investigator attempted to determine if there was a relationship between negative social identity and low selfesteem that is reflected in higher rates of substance abuse. The data collection method employed in this study was a type of nonprobability sampling procedure referred to as a purposive sample. The questionnaire was derived from instruments used by other researchers and validated by an expert panel. In order to select respondents from the lesbian population to be included …

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Increased Severity Of Murine Infection With Toxioplasma Gondii Following Vitaman E And Selenium Supplementatoin, Susan Mccarthy Dec 1999

Increased Severity Of Murine Infection With Toxioplasma Gondii Following Vitaman E And Selenium Supplementatoin, Susan Mccarthy

Masters Theses & Specialist Projects

At present, toxoplasmosis is one of the most common opportunistic infections in immunocompromised patients. The need for a reliable experimental model is crucial not only for achieving a better understanding of the pathophysiology of this infection but also for developing a better method to evaluate new therapeutic regimens. This study was organized to determine if the antioxidants vitamin E and selenium would provide a beneficial effect in mice chronically infected with Toxoplasma gondii. In the first phase of the study, 35 female Swiss Webster mice were infected with oocysts of the Me49 strain of Toxoplasma gondii while receiving diets supplemented …

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Wellness Center Healthletter - December 1999, Nova Southeastern University Dec 1999

Wellness Center Healthletter - December 1999, Nova Southeastern University

Wellness Center Healthletter

No abstract provided.

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Fungal Diseases (Field Manual Of Wildlife Diseases), Milton Friend Dec 1999

Fungal Diseases (Field Manual Of Wildlife Diseases), Milton Friend

Zoonotics and Wildlife Disease: Publications

Fungi are important causes of disease in wild birds and other species. Three basic types of disease are caused by these agents: mycosis, or the direct invasion of tissues by fungal cells, such as aspergillosis; allergic disease involving the development of a hypersensitivity of the host to fungal antigens; and mycotoxicosis, which results from ingestion of toxic fungal metabolites. Mycosis and allergic disease may occur together, especially when the lung is infected. This section will address only mycosis. Mycotoxicosis is addressed in Section 6, Biotoxins. Allergic disease is not well studied in wild birds and it is beyond the scope …

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Parasites And Parisitic Diseases (Field Manual Of Wildlife Diseases), Rebecca A. Cole, Milton Friend Dec 1999

Parasites And Parisitic Diseases (Field Manual Of Wildlife Diseases), Rebecca A. Cole, Milton Friend

Zoonotics and Wildlife Disease: Publications

Parasitism is an intimate relationship between two different species in which one (parasite) uses the other (host) as its environment from which it derives nourishment. Parasites are a highly diverse group of organisms that have evolved different strategies for infecting their hosts. Some, such as lice and ticks, are found on the external parts of the body (ectoparasites), but most are found internally (endoparasites). Some are microscopic, such as the blood protozoans that cause avian malaria; however, many are macroscopic. Life cycles differ greatly between major types of parasites and are generally classified as direct or indirect (Table 1). Direct …

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Biotoxins (Field Manual Of Wildlife Diseases), Tonie E. Rocke, Milton Friend Dec 1999

Biotoxins (Field Manual Of Wildlife Diseases), Tonie E. Rocke, Milton Friend

Zoonotics and Wildlife Disease: Publications

Biotoxins are usually defined as poisons that are produced by and derived from the cells or secretions of living organisms. These natural poisons include some of the most toxic agents known and they are found within a wide variety of life forms. Organisms that produce such toxins are generally classified as being venomous or poisonous. The classification of venomous is usually associated with animal life forms such as poisonous reptiles and insects that have highly developed cellular mechanisms for toxin production and that deliver their toxins during a biting (rattlesnake) or stinging (black widow spider) act. Poisonous organisms are generally …

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Chemical Toxins (Field Manual Of Wildlife Diseases), Milton Friend Dec 1999

Chemical Toxins (Field Manual Of Wildlife Diseases), Milton Friend

Zoonotics and Wildlife Disease: Publications

Many kinds of potentially harmful chemicals are found in environments used by wildlife. Some chemicals, such as pesticides and polychlorinated biphenyls (PCBs), are synthetic compounds that may become environmental contaminants through their use and application. Other materials, such as selenium and salt, are natural components of some environments, but contaminants of others. Natural and synthetic materials may cause direct poisoning and death, but they also may have adverse effects on wildlife that impair certain biological systems, such as the reproductive and immune systems. This section provides information about some of the environmental contaminants and natural chemicals that commonly cause avian …

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Field Manual Of Wildlife Diseases: General Field Procedures And Diseases Of Birds, Milton Friend, J. Christian Franson Dec 1999

Field Manual Of Wildlife Diseases: General Field Procedures And Diseases Of Birds, Milton Friend, J. Christian Franson

Zoonotics and Wildlife Disease: Publications

The “Field Manual of Wildlife Diseases: General Field Procedures and Diseases of Birds” presents practical, current information and insights about wild bird illnesses and the procedures to follow when ill birds are found or epidemics occur. Section 1 of the Manual provides information about general field procedures. Sections 2 through 5 describe various bird diseases. Sections 6 and 7 provide information about toxins that affect birds, and Section 8 describes miscellaneous diseases and hazards that affect birds. Manual lists institutions and laboratories that offer diagnostic services; sources of supplies for collecting, preserving, and shipping specimens; and it contains color illustrations …

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Screening For Mutants In The Output Pathway Of The Circadian Clock In Chlamydomonas Reinhardtii, Wei Yuan Dec 1999

Screening For Mutants In The Output Pathway Of The Circadian Clock In Chlamydomonas Reinhardtii, Wei Yuan

Masters Theses & Specialist Projects

The circadian clock is a basic component of biological systems and has been found in many organisms. It is composed by three major components: the input pathway, the oscillator and the output pathway. The purpose of this research is to study the output pathway of the circadian clock in Chlamydomonas reinhardtii strain Carnil by screening mutants, which were generated by insertional mutagenesis via glass bead transformation. The plasmid pSP124S containing the ble marker was used to introduce mutations. The CABII-1 gene has been reported to show a circadian rhythm in expression. The reporter gene ARS2 that was transcriptionally fused to …

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Introduction To General Field Procedures (Field Manual Of Wildlife Diseases), J. Christian Franson, Milton Friend, Dale E. Toweill, Robert L. Brownell Jr., Victor F. Nettles, Donald S. Davis, William J. Foreyt Dec 1999

Introduction To General Field Procedures (Field Manual Of Wildlife Diseases), J. Christian Franson, Milton Friend, Dale E. Toweill, Robert L. Brownell Jr., Victor F. Nettles, Donald S. Davis, William J. Foreyt

Zoonotics and Wildlife Disease: Publications

Section 1 of the Manual provides basic information regarding general field procedures for responding to wildlife disease events. Field biologists provide a critical linkage in disease diagnostic work and greatly affect the outcome of the laboratory efforts by the quality of the materials and information that they provide. The chapters in this section are oriented towards providing guidance that will assist field biologists in gathering the quality of information and specimens that are needed. Readers will find information regarding what to record and how; guidance for specimen collection, preservation, and shipment; and how to apply euthanasia when such actions are …

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Bacterial Diseases (Field Manual Of Wildlife Diseases), Milton Friend Dec 1999

Bacterial Diseases (Field Manual Of Wildlife Diseases), Milton Friend

Zoonotics and Wildlife Disease: Publications

Diseases caused by bacteria are a more common cause of mortality in wild birds than are those caused by viruses. In addition to infection, some bacteria cause disease as a result of potent toxins that they produce. Bacteria of the genus Clostridium are responsible for more wild bird deaths than are other disease agents. Clostridium botulinum, which causes avian botulism, is primarily a form of food poisoning and it is included within the section on biotoxins (see Chapter 38). Other Clostridium sp. that colonize intestinal tissues produce toxins that cause severe hemorrhaging of the intestine, thus leading to tissue …

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Viral Diseases (Field Manual Of Wildlife Diseases), Douglas E. Docherty Dec 1999

Viral Diseases (Field Manual Of Wildlife Diseases), Douglas E. Docherty

Zoonotics and Wildlife Disease: Publications

Historically, viral diseases have not been recognized as major causes of illness and death in North American wild birds. Until relatively recently, this may have been due to inadequate technology to culture and identify these organisms. Unlike bacteria, viruses are too small to be seen under the light microscope and they cannot be grown on artificial media. Nevertheless, studies of infectious diseases caused by viruses have often predated discovery of the causative agents by many years as evidenced by smallpox immunizations being used centuries before that virus was identified. The isolations of a tobacco mosaic virus in 1892 and foot …

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Miscellaneous Diseases (Field Manual Of Wildlife Diseases), Milton Friend, Nancy J. Thomas Dec 1999

Miscellaneous Diseases (Field Manual Of Wildlife Diseases), Milton Friend, Nancy J. Thomas

Zoonotics and Wildlife Disease: Publications

The fact that “Nature is far from benign” is clearly evident from the preceding chapters of this Manual. The diseases and other conditions described are the proverbial “tip of the iceberg” relative to the number of specific causes of ill health and death for free-ranging wild birds, but the wild bird health problems described account for most major wild bird disease conditions seen within the United States. However, the full toll from disease involves many other causes of illness and death that individually may cause substantial die-offs. Two examples of these other causes of die-offs are the deaths of Canada …

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Introduction, Foreword, Table Of Contents (Field Manual Of Wildlife Diseases) Dec 1999

Introduction, Foreword, Table Of Contents (Field Manual Of Wildlife Diseases)

Zoonotics and Wildlife Disease: Publications

Cover
credits
Title page
Foreword by Thomas M. Yuill
Introduction by Milton Friend
Table of Contents

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Appendices, Glossary, And Index (Field Manual Of Wildlife Diseases) Dec 1999

Appendices, Glossary, And Index (Field Manual Of Wildlife Diseases)

Zoonotics and Wildlife Disease: Publications

A. Sample specimen history form
B. Sources of wildlife diagnostic assistance in the United States
C. Sources of supplies used for collecting, preserving, and shipping specimens
D. Normal brain cholinesterase activity values
E. Common and scientific names of birds in text
F. Common and scientific names other than birds
G. Chemical names
H. Conversion table

Glossary
Index

REPORT DOCUMENTATION PAGE

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The Utilization Of Outpatient Laboratory Resources At Ireland Army Community Hospital After Implementation Of Tricare, Susan Seeley Dec 1999

The Utilization Of Outpatient Laboratory Resources At Ireland Army Community Hospital After Implementation Of Tricare, Susan Seeley

Masters Theses & Specialist Projects

The purpose of this study was to compare out patient laboratory utilization patterns of active duty and retired military personnel and their dependents before and after the implementation of TRICARE. A stratified random sample was taken of patient test results over a two year period resulting in a sample size of 104 observations. The Complete Blood Count (CBC) results were used as indicators for the study. Data was gathered on the patient's rank, active duty/retiree status, age, dependent status, and gender. Additionally, the total number of tests were recorded for the year prior to the introduction of TRICARE and after …

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Prognostic Indicators Of Childhood Acute Viral Encephalitis, E Bhutto, M Naim, M Ehtesham, M Rehman, M A. Siddique, I Jehan Dec 1999

Prognostic Indicators Of Childhood Acute Viral Encephalitis, E Bhutto, M Naim, M Ehtesham, M Rehman, M A. Siddique, I Jehan

Community Health Sciences

Objective: To devise a set of clinical signs and laboratory parameters that would help clinicians assess prognosis in patients and plan appropriate management.Methods: Medical records of 147 paediatric cases (with a discharge diagnosis of acute viral encephalitis) admitted over a ten year period from 1987 to 1997 were reviewed and relevant information collected on a data extraction form.Results: Of 147 patients, 24 (16.3%) died and 48 (32.7%) were left with severe neurological deficits. A GCS (Glasgow Coma Scale) score between 6-10 had an association with poor outcome (OR = 2.62, Chi-square = 5.57, p-value = 0.018) and that a GCS …

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Voice Onset Times And Burst Frequencies Of Four Velar Stop Consonants In Gujarati, Manish Rami, Joseph Kalinowski, Andrew Stuart, Michael P. Rastatter Dec 1999

Voice Onset Times And Burst Frequencies Of Four Velar Stop Consonants In Gujarati, Manish Rami, Joseph Kalinowski, Andrew Stuart, Michael P. Rastatter

Communication Sciences & Disorders Faculty Publications

Voice onset times (VOT) and burst frequencies of two aspirated (i.e., /kh /, /gh/)  and two unaspirated (i.e., /k/, /g/) Gujarati velar stop consonants were investigated in an effort to provide characteristic acoustic information. Stop consonants in a monosyllabic vowel–consonant–vowel (VCV) production were obtained from eight native speakers of Gujarati. Differences in mean VOT and burst frequency as a function of voicing and aspiration were examined. A significant voicing by aspiration effect was found for VOT (p = 50.026). The two voiced stops, while not significantly different from each other had significantly shorter VOTs than voiceless …

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Conception D'Un Étançonnement Adapté Aux Excavations En Milieu Urbain : Phase 2, André Lan, Jean Arteau, Martin Tremblay, Serge Gamelin, Denis Leboeuf, Omar Chaallal, Jean-Marc Dugré Dec 1999

Conception D'Un Étançonnement Adapté Aux Excavations En Milieu Urbain : Phase 2, André Lan, Jean Arteau, Martin Tremblay, Serge Gamelin, Denis Leboeuf, Omar Chaallal, Jean-Marc Dugré

Rapports de recherche scientifique

No abstract provided.

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La Santé Et La Sécurité Du Travail Dans Les Supermarchés : Résumé, Lina Forcier, Sylvie Beaugrand, Claire Lapointe, Monique Lortie, Jacques Lemaire, Ilkka Kuorinka, Peter Buckle, Jean-Guy Richard Dec 1999

La Santé Et La Sécurité Du Travail Dans Les Supermarchés : Résumé, Lina Forcier, Sylvie Beaugrand, Claire Lapointe, Monique Lortie, Jacques Lemaire, Ilkka Kuorinka, Peter Buckle, Jean-Guy Richard

Rapports de recherche scientifique

No abstract provided.

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