Medicine and Health Sciences Commons^™

Analysis Of Risk Factors For Fatal Rocky Mountain Spotted Fever: Evidence For Superiority Of Tetracyclines For Therapy, Robert C. Holman, Christopher D. Paddock, Aaron T. Curns, John W. Krebs, Jennifer H. Mcquiston, James E. Childs

Zoonotics and Wildlife Disease: Publications

Epidemiologic and clinical characteristics of fatal and nonfatal cases of Rocky Mountain spotted fever (RMSF) were compared to identify risk factors for death caused by this disease. Confirmed and probable RMSF cases reported through US national surveillance for 1981- 1998 were analyzed. Among 6388 RMSF patients, 213 died (annual case-fatality rate, 3M; range, 4.9 % in 1982 to 1.1 % in 1996). Use of tetracycline-class antibiotics for treatment of RMSF increased significantly in the 1990s, compared with use in the 1980s. Older patients, patients treated with chloramphenicol only, patients for whom tetracycline antibiotics were not the primary therapy, and patients …

Prp-C And Prp-Sc At The Fetal-Maternal Interface, Wenbin Tuo, Dongyue Zhuang, Donald P. Knowles, William P. Cheevers, Man-Sun Sy, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Scrapie is a naturally occurring prion (PrP) disease causing a fatal neurodegenerative disorder in sheep and goats. Previous studies suggest that scrapie is transmitted naturally through exposure to the scrapie agent in wasted placentas of infected ewes. This study determined the distribution and biochemical properties of PrP cellular (PrP-C) and the distribution of PrP scrapie (PrP-Sc) in reproductive, placental, and selected fetal tissues and fetal fluids in sheep. Glycosylated, N-terminally truncated, proteinase K-sensitive PrP-C with apparent molecular masses of 23–37 kDa was present in reproductive, placental, and fetal tissues and fetal fluids. PrP-C was low or undetectable in intercotyledonary chorioallantois, …

Immunohistochemical Detection Of Scrapie Prion Proteins In Clinically Normal Sheep In Pennsylvania, Hyun Kim, Katherine I. O'Rourke, Mark Walter, H. Graham Purchase, John Enck, Tae Kyun Shin

Zoonotics and Wildlife Disease: Publications

Following diagnosis of scrapie in a clinically suspect Suffolk sheep, 7 clinically normal flockmates were purchased by the Pennsylvania Department of Agriculture to determine their scrapie status using an immunohistochemical procedure. Two of the 7 euthanized healthy sheep had positive immunohistochemical staining of the prion protein of scrapie (PrP-Sc) in their brains, nictitating membranes, and tonsils. The PrP-Sc was localized in the areas of the brain where, histopathologically, there was neurodegeneration and astrocytosis. The PrP-Sc occurred within germinal centers of the affected nictitating membranes and tonsils and was located in the cytoplasm of the dendrite-like cells, lymphoid cells, and macrophages. …

Preliminary Findings On The Experimental Transmission Of Chronic Wasting Disease Agent Of Mule Deer To Cattle, Amir N. Hamir, Randall C. Cutlip, Janice M. Miller, Elizabeth S. Williams, Mick J. Stack, Michael W. Miller, Katherine I. O'Rourke, Melanie J. Chaplin

Zoonotics and Wildlife Disease: Publications

To determine the transmissibility of chronic wasting disease (CWD) to cattle and to provide information about clinical course, lesions, and suitability of currently used diagnostic procedures for detection of CWD in cattle, 13 calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Between 24 and 27 months postinoculation, 3 animals became recumbent and were euthanized. Gross necropsies revealed emaciation in 2 animals and a large pulmonary abscess in the third. Brains were examined for protease-resistant prion protein (PrP^res) by immunohistochemistry and Western blotting and for scrapie-associated fibrils (SAFs) by negative-stain electron microscopy. Microscopic …

Latino Access To Health Care: The Role Of Insurance, Managed Care, And Institutional Barriers, J. Emilio Carrillo, Fernando M. Trevino, Joseph R. Betancourt, Alberto Coustasse

Management Faculty Research

The health care system in the United States is the most expensive and yet arguably among the least cost effective in the developed world (Anderson, 1998). Despite the highest per person health care spending among the Organization for Economic Cooperation and Development (OECD) nations, the United States still ranks below many along a variety of health indicators (Woolhandler & Himmelstein, 1991). In a complicated health care system where the rules are many and economic forces drive both structure and function, the needs of vulnerable populations inevitably suffer. This chapter explores the consequences of these market forces on a vulnerable population--Latinos …

Tell Me My Fortune, Margaret M. Hansen Edd, Msn, Rn

Nursing and Health Professions Faculty Research and Publications

No abstract provided.

The Effect Of Training With Nmes On Elbow Flexion Strength, Shante Hill

All Volumes (2001-2008)

Neuromuscular electrical stimulation (NMES) may be used to prevent atrophy and strength loss associated with postsurgical immobilization. A number of studies have tested the effectiveness of NMES using primarily knee extensors. The purpose of this investigation is to test the effectiveness NMES when training the elbow flexors by comparing NMES to voluntary training. Twenty-four university students were assigned with a counter-balanced design to one of three groups: NMES training, voluntary training, or a control group that did not train. Testing and training sessions were completed using a Biodex™ dynamometer. After a standard warm-up, subjects were positioned on the Biodex™ with …

The Effect Of Meal Composition And Body Fat On Sleep And Tiredness, Michael Malone

All Volumes (2001-2008)

The role of dietary carbohydrates, dietary fat, and body fat in the regulation of sleep and tiredness was determined by studying sleep and tiredness in nineteen female subjects of different body compositions. It was hypothesized that dietary fat and body fat interact to cause an increase in sleep and tiredness. Subjects were healthy college students between the ages of 18 and 25 years old. This study was dual-phased. Phase I involved a 21 day record of normal hours slept per day and self-reported tiredness. In Phase II, the subjects consumed both a high-fat and high-carbohydrate diet for five days (for …

Accuracy Of Predictive Formulas To Estimate Resting Energy Expenditure Of Thermally Injured Patients, Roland N. Dickerson, Jane M. Gervasio, Marti L. Riley, James E. Murrell, William L. Hickerson, Kenneth A. Kudsk, Rex O. Brown

Scholarship and Professional Work – COPHS

Abstract from the 25th Clinical Congress of the American Society for Parenteral and Enteral Nutrition, Chicago, IL, January 21-24, 2001.

Mdmx Binding To Arf Affects Mdm2 Protein Stability And P53 Transactivation, Mark W. Jackson, Mikael S. Lindström, Steven J. Berberich

Educator Preparation & Leadership Faculty Works

Regulation of p53 involves a complex network of protein interactions. The primary regulator of p53 protein stability is the Mdm2 protein. ARF and MdmX are two proteins that have recently been shown to inhibit Mdm2-mediated degradation of p53 via distinct associations with Mdm2. We demonstrate here that ARF is capable of interacting with MdmX and in a manner similar to its association with Mdm2, sequestering MdmX within the nucleolus. The sequestration of MdmX by ARF results in an increase in p53 transactivation. In addition, the redistribution of MdmX by ARF requires that a nucleolar localization signal be present …

Hiv Voluntary Counseling And Testing Among Youth Ages 14 To 21: Results From An Exploratory Study In Nairobi, Kenya, And Kampala And Masaka, Uganda, Horizons Program, Kenya Project Partners, Uganda Project Partners

HIV and AIDS

HIV voluntary counseling and testing (VCT) programs increase safe sexual behavior and use of care and support services among adults. By helping clients learn their HIV serostatus and creating a personalized HIV risk-reduction plan, VCT can provide the information and support necessary to change risky behaviors that could lead to HIV infection or transmission. Counseling and a risk-reduction plan are the key features distinguishing VCT from other HIV testing services. VCT has become a widely advocated HIV/AIDS prevention strategy among adults. Sixty percent of all new HIV infections in sub-Saharan Africa, however, occur among young people ages 10–24. Because few …

Community Involvement In The Prevention Of Mother-To-Child Transmission Of Hiv: Insights And Recommendations, Naomi Rutenberg, Mary Lyn Field-Nguer, Laura Nyblade

HIV and AIDS

Mother-to-child transmission is the primary route of HIV infection in children under 15 years of age. Since the beginning of the HIV epidemic, an estimated 5.1 million children worldwide have been infected with HIV. Clinical trials in several countries have shown that mother-to-child transmission of HIV can be greatly reduced through administering antiretroviral therapy to pregnant women. These trials culminated in a recommendation by UNAIDS and its partners in the Interagency Task Team for the Prevention of Mother-to-Child Transmission that prevention of perinatal transmission should be a part of the standard package of care for HIV-positive women and their children. …

College Of Pharmacy Student Handbook 2001-2002, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Anorexia Nervosa : A Psychological Perspective Of Etiology And Current Treatment Procedures, Arlene Lagary

Graduate Research Papers

Anorexia nervosa is a chronic and sometimes fatal illness characterized by physical and psychological complications. Although no etiology for this illness has been determined, this paper presents a psychological etiology based on a synthesis of both traditional and current literature. The influence of culture, the therapeutic alliance, and client resistance are also considered. Relapse is common and the illness may last for many years. The health care community has addressed the complexity and chronicity of this illness by using a multi-component approach that includes psychoeducation, cognitive-behavioral therapy, psychodynamic interventions, family therapy, and psychopharmacology.

Is Extended Volume Of External Beam Irradiation Beneficial In Post-Esophagectomy High Risk Patients Receiving Combined Chemoradiation Therapy?, E. Yu, A. R. Dar, R. Ash, G. Videtic, P. Truong, L. Stitt, A. Tomiak, M. Vincent, R. Malthaner, I. Craig, E. Brecevic, W. Kocha, R. Inculet, M. Lefcoe

Oncology Presentations

OBJECTIVE: To assess the value of extended volume irradiation with anastomotic coverage in high risk resected esophageal cancer patients.

METHOD: A retrospective study was undertaken at LRCC from 1989-1999 for high risk resected esophageal cancer patients. Adjuvant treatments consisted of 4 cycles of chemotherapy (epirubicin/fluorouracil/cisplatin or cisplatin/fluorouracil), and local regional irradiation with or without coverage of the anastomotic site. Radiation dose ranged from 45-60Gy at 1.8-2.0 Gy/fraction given with initial anterior-posterior/posterior-anterior arrangement with either extended (with anastomotic coverage) or small (without anastomotic coverage) field followed by oblique fields for boost.

RESULT: One hundred eighty-eight charts were reviewed. Seventy-two patients were …

Globalization, Diet, And Health: An Example From Tonga, Mike Evans, Robert C. Sinclair, Caroline Fusimalohi, Viliami Liava’A

Aboriginal Policy Research Consortium International (APRCi)

The increased flow of goods, people, and ideas associated with globalization have contributed to an

increase in noncommunicable diseases in much of the world. One response has been to encourage lifestyle changes with educational programmes, thus controlling the lifestyle-related disease. Key assumptions with this approach are that people’s food preferences are linked to their consumption patterns, and that consumption patterns can be transformed through educational initiatives. To investigate these assumptions, and policies that derive from it, we undertook a broad-based survey of food-related issues in the Kingdom of Tonga using a questionnaire. Data on the relationships between food preferences, perception …

Inhalant Use By Canadian Aboriginal Youth, Heather Coleman, Grant Charles, Jennifer Collins

Aboriginal Policy Research Consortium International (APRCi)

While inhalant abuse is a significant problem among Canada’s Aboriginal (indigenous) people, it is poorly understood. This study was conducted in response to these issues. The authors followed 78 Aboriginal young people who received treatment for inhalant abuse in a program established by the federal government. Data were based on a secondary analysis of case files as well as follow-up information from community workers.

Seventy-four percent of the 78 young people tracked during follow- up relapsed after discharge from treatment. Many of the young people came from backgrounds marked by isolation, poverty, family violence and substance abuse. The average age …

Eye Position Sense Contributes To The Judgement Of Slant., F M James, S Whitehead, G K Humphrey, M S Banks, T Vilis

Brain and Mind Institute Researchers' Publications

We measured monocular judgements of the slant of a cube face while varying eye position in the absence of stereoscopic and external lighting cues. Errors were found to be small, only 10% on average of the cube's eccentricity. Two factors appear to have contributed approximately equally to this error: an underestimate of cube slant as seen by the eye and an underestimate of eye position. When prism adaptation altered the sensed eye position, the pattern of slant judgements changed to reflect the altered sense of eye position.

Lack Of Effect Of Induction Of Hypothermia After Acute Brain Injury, Guy L. Clifton, Emmy R. Miller, Sung C. Choi, Harvey S. Levin, Stephen Mccauley, Kenneth R. Smith, J. Paul Muizerlaar, Franklin C. Wagner, Donald W. Marion, Thomas G. Luerssen, Randall M. Chesnut, Michael Schwartz

Biostatistics Publications

Background

Induction of hypothermia in patients with brain injury was shown to improve outcomes in small clinical studies, but the results were not definitive. To study this issue, we conducted a multicenter trial comparing the effects of hypothermia with those of normothermia in patients with acute brain injury.

Methods

The study subjects were 392 patients 16 to 65 years of age with coma after sustaining closed head injuries who were randomly assigned to be treated with hypothermia (body temperature, 33°C), which was initiated within 6 hours after injury and maintained for 48 hours by means of surface cooling, or normothermia. …

Template: History And Physical Examination, Vivian Mcalister

Data and Test Instruments

This simple template contains the headings for a classic history and physical examination report. Clerks and residents on our surgical team are encouraged to use it or a similar system. It is vital to the learning process that you reach a conclusion about a patient's illness and formulate a plan independently. You should verify your findings and care with somebody senior to you on the team.

The Motivational Quality Of Global Attributions In Hypothetical And Experienced Situations Of Gender Discrimination, Mindi D. Foster

Psychology Faculty Publications

Traditionally, global attributions have been thought to reduce instrumental behavior aimed at resolving negative events. However, the present research shows global attributions for gender discrimination are related to taking action against unfair treatment. In Study 1, women ( N = 157) completed a questionnaire assessing attributions for hypothetical scenarios of discrimination and collective responses to discrimination. In Study 2, women ( N = 79) were placed into a laboratory situation of discrimination and asked to indicate their attributions for and responses to their unfair treatment. In both studies, hierarchical regression analyses showed that global attributions were related to both individual …

Describing Individual Incidents Of Sexual Abuse: A Review Of Research On The Effects Of Multiple Sources Of Information On Children’S Reports, Kim P. Roberts, Martine B. Powell

Psychology Faculty Publications

Objective. For successful prosecution of child sexual abuse, children are often required to provide reports about individual, alleged incidents. Although verbally or mentally rehearsing memory of an incident can strengthen memories, children’s report of individual incidents can also be contaminated when they experience other events related to the individual incidents (e.g., informal interviews, dreams of the incident) and/or when they have similar, repeated experiences of an incident as in cases of multiple abuse.

Method. Research is reviewed on the positive and negative effects of these related experiences on the length, accuracy, and structure of children’s reports of a particular incident. …

Differential Diagnosis Of Orofacial Pain I: Associated With Intracranial And Extracranial Structures And Psychogenic Disorders, Rodolfo Acosta-Ortiz

HPD Articles

Orofacial Pain (OFP) is a common problem among the general population and represents a condition that is potentially debilitating and deteriorating. The correct diagnosis is the principal base for an adequate management; in patients with DOF this may be a simple task or a very complex and frustrating experience for both, clinician, and patient. However, the clinician's knowledge of all possible pain condition that can affect the orofacial region can facilitate the diagnostic process. It is important to emphasize that is very difficult to diagnose something unknown for the clinician and even though "common things occur commonly", it is not …

Beer Before Liquor, Or Liquor Before Beer : A Research Review Of Binge Drinking Escalation In Greek-Letter Societies On College Campuses Today, Thomas M. O'Shea

Graduate Research Papers

In 1990 college presidents rated college student alcohol abuse as the problem that gave them the greatest concern (Boyer, 1990). However, one specific college campus population that seems to be more likely to binge drink is those students affiliated with the National Fraternities and Sororities.

The purpose of this paper is: • To focus on and define the concept of binge drinking • To establish specific data that show that binge drinking is a problem with fraternity and sorority members • To research and suggest possible solutions that college administrators may use to combat the binge drinking problem on their …

Arbovirus Infection Increases With Group Size, Charles R. Brown, Nicholas Komar, Sunita B. Quick, Rajni A. Sethi, Nicholas A. Panella, Mary Bromberger Brown, Martin Pfeffer

Zoonotics and Wildlife Disease: Publications

Buggy Creek (BCR) virus is an arthropod-borne alphavirus that is naturally transmitted to its vertebrate host the cliff swallow (Petrochelidon pyrrhonota) by an invertebrate vector, namely the cimicid swallow bug (Oeciacus vicarius). We examined how the prevalence of the virus varied with the group size of both its vector and host. The study was conducted in southwestern Nebraska where cliff swallows breed in colonies ranging from one to 3700 nests and the bug populations at a site vary directly with the cliff swallow colony size. The percentage of cliff swallow nests containing bugs infected with BCR …

Public Beliefs About The Preventability Of Unintentional Injury Deaths, Deborah C. Girasek

Uniformed Services University of the Health Sciences

This report is based upon the results of a national random digit dialed telephone survey in which 943 adults were queried. Subjects reported the proportion of deaths due to motor vehicle crashes, falls, fires/burns, drowning and poisoning that they felt were preventable. On average, respondents believed that 56% of ‘fatal accidents’ were preventable; as were 62% of motor vehicle crash deaths, 53% of fall deaths, 67% of drownings, 62% of fire/burn fatalities and 70% of accidental poisonings. Logistic regression models predicting preventability beliefs differed according to the type of injury event in question, but socio-economic status and perceived alcohol involvement …

Predictors Of Patient Satisfaction, Jeffrey L. Jackson, Judith Chamberlin, Kurt Kroenke

Uniformed Services University of the Health Sciences

Correlates of patient satisfaction at varying points in time were assessed using a survey with 2-week and 3-month follow-up in a general medicine walk-in clinic, in USA. Five hundred adults presenting with a physical symptom, seen by one of 38 participating clinicians were surveyed and the following measurements were taken into account: patient symptom characteristics, symptom-related expectations, functional status (Medical Outcomes Study Short-Form Health Survey [SF-6]), mental disorders (PRIME-MD), symptom resolution, unmet expectations, satisfaction (RAND 9-item survey), visit costs and health utilization. Physician perception of difficulty (Difficult Doctor-Patient Relationship Questionnaire), and Physician Belief Scale. Immediately after the visit, 260 (52%) …

Tsc13p Is Required For Fatty Acid Elongation And Localizes To A Novel Structure At The Nuclear-Vacuolar Interface In Saccharomyces Cerevisiae, Sepp D. Kohlwein, Sandra Eder, Chan-Seok Oh, Charles E. Martin, Ken Gable, Dagmar Bacikova, Teresa Dunn

Uniformed Services University of the Health Sciences

The TSC13/YDL015c gene was identified in a screen for suppressors of the calcium sensitivity of csg2Δ mutants that are defective in sphingolipid synthesis. The fatty acid moiety of sphingolipids in Saccharomyces cerevisiae is a very long chain fatty acid (VLCFA) that is synthesized by a microsomal enzyme system that lengthens the palmitate produced by cytosolic fatty acid synthase by two carbon units in each cycle of elongation. The TSC13 gene encodes a protein required for elongation, possibly the enoyl reductase that catalyzes the last step in each cycle of elongation. The tsc13 mutant accumulates high levels of long-chain bases …

Absence Of All Components Of The Flagellar Export And Synthesis Machinery Differentially Alters Virulence Of Salmonella Enterica Serovar Typhimurium In Models Of Typhoid Fever, Survival In Macrophages, Tissue Culture Invasiveness, And Calf Enterocolitis, Clare K. Schmitt, Jack S. Ikeda, Stephen C. Darnell, Patricia R. Watson, Jennifer Bispham, Timothy S. Wallis, Debra L. Weinstein, Eleanor S. Metcalf, Alison D. O'Brien

Uniformed Services University of the Health Sciences

In this study, we constructed an flhD (the master flagellar regulator gene) mutant of Salmonella enterica serovar Typhimurium and compared the virulence of the strain to that of the wild-type strain in a series of assays that included the mouse model of typhoid fever, the mouse macrophage survival assay, an intestinal epithelial cell adherence and invasion assay, and the calf model of enterocolitis. We found that the flhD mutant was more virulent than its parent in the mouse and displayed slightly faster net growth between 4 and 24 h of infection in mouse macrophages. Conversely, the flhD mutant exhibited diminished …

Introduction: Fear And Loathing Of Evolutionary Psychology In The Social Sciences, Daniel Leger, Alan Kamil, Jeffrey A. French

Department of Psychology: Faculty Publications

When one looks at the intellectual landscape of the modern university, at the scholarly and scientific interests of its faculty, the panorama is seamless. There are no discontinuities. The interests of physicists transmogrify into those of chemists, those of chemists into those of biologists, and so on. The lines, the divisions, between departments have been created out of administrative, not intellectual, necessity.
For example, consider the divide between chemistry and biology. There is a set of chemical processes that are characteristic of living systems. Is the study of these processes chemistry or biology? This is a meaningless question. To be …