Medicine and Health Sciences Commons^™

Jefferson Alumni Bulletin – Volume 50, Number 2, March 2001

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 50, Number 2, March 2001 Tom Nasca’75 in appointed Dean, page 4 Hospital for neuroscience is created in wills building, page 5 Key molecular pathway in apoptosis, page 8 Swallowing a gene to treat or prevent Cancer? Page 9 “He served Jefferson during difficult times”, page 10 Gardner, Keeley, Slogoff are nominees for trustee, page 21

Flow Cytometric Analysis Of Childhood Leukemias, R. Z. Yusuf, Shahid Pervez, S. A. Aziz, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Objective: To collect demographic data for childhood (less than 15 years) leukemias in Karachi, describe the accuracy of the cell surface markers routinely used in the flow cytometric analysis of leukemic cells and arrive at an ideal panel of antibodies for analyzing leukemic samiples.

Materials and Methods: Data from 62 consecutive cases of childhood leukemias referred to the Department of Pathology, Aga Khan University Hospital. (AKUH) between January 1995 and December 1998 was analyzed using Epi Info Version 6. Flow cytometry on all samples was performed using standard protocols.

Results: The mean age of patients was 8.2 years and 49 …

Optimal Designs For Evaluating A Series Of Treatments, Denis H. Y. Leung, You Gan Wang

Research Collection School Of Economics

Several articles in this journal have studied optimal designs for testing a series of treatments to identify promising ones for further study. These designs formulate testing as an ongoing process until a promising treatment is identified. This formulation is considered to be more realistic but substantially increases the computational complexity. In this article, we show that these new designs, which control the error rates for a series of treatments, can be reformulated as conventional designs that control the error rates for each individual treatment. This reformulation leads to a more meaningful interpretation of the error rates and hence easier specification …

Comparison Of Spontaneous With Controlled Mode Of Ventilation In Tonsillectomy, F A. Khan, G A. Memon

Department of Anaesthesia

Methods: This randomized study compares spontaneous versus controlled ventilation in 60 ASA I and II patients undergoing tonsillectomy as regards haemodynamic stability, recovery characteristics, intra- and immediate postoperative complications and surgical impressions.Results: The patients in the balanced anaesthesia (B) group showed less haemodynamic variability compared to baseline after tracheal intubation, mouth gag application and removal and incision. Two patients had dysrhythmias in the B group compared to six in the spontaneous breathing (S) group. Six patients in the S group had a rise in endtidal carbon dioxide concentration above 7.8 kPa (60 mmHg). Recovery scores were higher in the B …

Arsenic Alters The Function Of The Glucocorticoid Receptor As A Transcription Factor, Ronald C. Kaltreider, Alisa M. Davis, Jean P. Lariviere, Joshua W. Hamilton

Dartmouth Scholarship

Chronic human exposure to nonovertly toxic doses of arsenic is associated with an increased risk of cancer. Although its carcinogenic mechanism is still unknown, arsenic does not directly cause DNA damage or mutations and is therefore thought to act principally as a co-mutagen, co-carcinogen, and/or tumor promoter. Previous studies in our laboratory demonstrated that effects of low-dose arsenic (III) (arsenite) on expression of the hormone-regulated phosphoenolpyruvate carboxykinase (PEPCK) gene were strongly associated with the glucocorticoid receptor (GR)-mediated regulatory pathway. We therefore examined specifically the effects of arsenite on the biochemical function of GR in hormone-responsive H4IIE rat hepatoma cells. Completely …

Nurse-Midwives’ Knowledge And Promotion Of Lactational Amenorrhea And Other Natural Family-Planning Methods For Child Spacing, Richard J. Fehring, Lisa Hanson, Joseph B. Stanford

College of Nursing Faculty Research and Publications

The purpose of this study was to describe and assess certified nurse-midwives’ (CNMs) knowledge and promotion of two modalities for child spacing, natural family-planning (NFP) and the lactational amenorrhea method (LAM). One thousand two hundred CNMs were randomly selected from a national membership list and mailed a 24-item questionnaire on NFP and LAM. Of the 514 respondents (42.8% return rate), 450 (87.5%) were currently practicing as CNMs. Respondents had an average age of 46 years, with an average of 10 years of practice. CNMs ranked NFP as the ninth most used and the eighth most effective family-planning method in their …

Dietary Intake And Energy Expenditure Of Female Collegiate Swimmers During Decreased Training Prior To Competition, Laura Ousley-Pahnke, David R. Black, Randall J. Gretebeck

College of Nursing Faculty Research and Publications

Swimmers, like all athletes, require a well-balanced diet with adequate energy intake for normal daily activities and the demands of training and competition. Investigators have typically studied nutritional status of athletes during heavy or peak training (1), (2). These studies generally show low levels of energy intake relative to expenditure, and carbohydrate intake also well below recommendations. However, several studies of the effects of exercise on energy intake have shown that as exercise energy expenditure increases or decreases, dietary intake tends to remain the same (3), (4), (5). Because training volume varies with the competitive season, it is important to …

Walker-Assisted Gait In Rehabilitation: A Study Of Biomechanics And Instrumentation, Rebecca Ann Bachschmidt, Gerald F. Harris, Guy G. Simoneau

Physical Therapy Faculty Research and Publications

While walkers are commonly prescribed to improve patient stability and ambulatory ability, quantitative study of the biomechanical and functional requirements for effective walker use is limited. To date no one has addressed the changes in upper extremity kinetics that occur with the use of a standard walker, which was the objective of this study. A strain gauge-based walker instrumentation system was developed for the six degree-of-freedom measurement of resultant subject hand loads. The walker dynamometer was integrated with an upper extremity biomechanical model. Preliminary system data were collected for seven healthy, right-handed young adults following informed consent. Bilateral upper extremity …

Enhanced Expression Of Human Platelet-Derived Growth Factor In Pichia Pastoris, David M. Kaetzel

Pharmacology and Nutritional Sciences Faculty Patents

Enhanced yields of the platelet-derived growth factor (PDGF) B-chain are obtained using the Pichia pastoris yeast system. Yields of both wild-type and mutant human proteins are enhanced when the yeast is transformed with a vector containing the yeast mating factor promoter fused to a sequence encoding the mature protein. The secreted wild-type protein is indistinguishable from mature 29-32 kDa protein isolated from human and Chinese hamster ovary (CHO) cells. An RKK→EEE mutant exhibited reduced association with the cell surface and accumulated in the culture medium as 29-32 kDa forms. Stable transfection of U87 astrocytoma cells with RKK→EEE mutants of either …

Fueling Fan Passion Is Never Out Of Fashion, Rick Burton

Sport Management - All Scholarship

No abstract provided.

Ada News - 02/19/2001, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

A Closer Look At The Nature Of Intimate Partner Violence Reported By Women With A History Of Child Sexual Abuse, David Dilillo, Dawn Giuffre, George C. Tremblay, Lizette Peterson

Department of Psychology: Faculty Publications

This study provides an examination of violence occurring in the couple relationships of female survivors of childhood sexual abuse (CSA). Participants were 240 low-income women, 113 of whom (47%) reported some history of CSA. Compared with non–sexually abused women, those who had experienced CSA reported that their couple relationships were more likely to have involved several severe forms of violence, including hitting, kicking, and beating. Comparisons of the directional patterns of partner violence revealed that a greater proportion of CSA survivors’ relationships had involved at least one incident of both man-to-woman and woman-to-man aggression. An unexpected finding was that a …

Ada News - 02/05/2001, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

How Can Health Serve As A Bridge For Peace? Certi Crisis And Transition Tool Kit, Rosalia Rodriguez-Garcia, James Macinko, F. Xavier Solorzano, Marita Schlesser, George Washington University School Of Public Health And Health Services

Global Health Faculty Publications

No abstract provided.

Morality And God, John Hare

Center for the Study of Ethics in Society Papers

Paper presented at the Center for the Study of Ethics in Society at Western Michigan University, January 18,2001 with the title, "Does Morality Need God?"

Étude De Cas D'Amélioration Ergonomique Des Outils Présentant Des Risques D'Atteintes Musculo-Squelettiques, Georges Toulouse, Yves Beauchamp

Rapports de recherche scientifique

No abstract provided.

Financing And Payment Issues In Rural Long-Term Care Integration [Policy Brief], Paul Saucier Ma, Julie T. Fralich Mba

Disability & Aging

Federal and state policy makers, consumers, health plans, providers, and other stakeholders are interested in the benefits and disadvantages of integrating acute and long term care financing in rural areas. To date, experience with integrated financing is limited and is based largely in urban areas. This paper reviews current research and experience and identifies key policy and program considerations for integrated financing in rural areas.

Vestibular Schwannomas: Clinical Presentation, Management And Outcome, M S. Awan, H U. Qureshi, A A. Sheikh, M M. Ali

Section of Neurosurgery

Objective: To review the demographic trends clinical spectrum, diagnosis, management and outcome of patients with vestibular Schwannoma and to identify areas where improvements are needed.
Methods: All patients with vestibular schwannoma admitted to the Aga Khan University Hospital over the past 11 years were reviewed retrospectively.
Results: The age range of majority of 22 patients analyzed, was 41-50 years (23%). Hearing loss was the most common presenting symptom (96%). Other clinical features included cranial nerve palsies (59%) and headache (55%). Fifty percent had signs of raised intracranial pressure. Neuroimaging revealed "Stage IV b" (tumor distorting the brainstem and compressing the …

Comparison Of Two Azithromycin Distribution Strategies For Controlling Trachoma In Nepal, Susan Osaki Holm, Hem C. Jha, Ramesh C. Bhatta, J.S. P. Chaudhary, B. B. Thapa, Dale Davis, Ram Prasad Pokhrel, Miao Yinghui, Michael Zegans, Julius Schachter, Kevin D. Frick, Lisa Tapert, Thomas M. Leitman

Dartmouth Scholarship

OBJECTIVE:

The study compares the effectiveness of two strategies for distributing azithromycin in an area with mild-to-moderate active trachoma in Nepal.

METHODS:

The two strategies investigated were the use of azithromycin for 1) mass treatment of all children, or 2) targeted treatment of only those children who were found to be clinically active, as well as all members of their household.

FINDINGS:

Mass treatment of children was slightly more effective in terms of decreasing the prevalence of clinically active trachoma (estimated by clinical examination) and of chlamydial infection (estimated by DNA amplification tests), although neither result was statistically significant.

CONCLUSION: …

The Drama Of Dysfunction: Value Conflict In Us Managed Care, Diana D. Mrotek

WCBT Faculty Publications

The transformation of the American health care environment from retrospective fee-for-service to managed care has been both rapid and chaotic. This period of change has been infected by value conflict, evoking unconscious processes in system participants as they have attempted to cope with personally threatening situations. This article attempts to elucidate this process by presenting an account of events and accompanying value conflict as it occurred over time. It also includes a systems analysis of the rapidly changing mosaic of unconscious processes that resulted from the divergent values held by the public and health care professionals, using various organization behavior …

Characterization Of Sarr, A Modulator Of Sar Expression In Staphylococcus Aureus, Adhar Manna, Ambrose L. Cheung

Dartmouth Scholarship

The expression of virulence determinants in Staphylococcus aureus is controlled by global regulatory loci (e.g., sar and agr). The sar locus is composed of three overlapping transcripts (sar P1, P3, and P2 transcripts from P1, P3, and P2 promoters, respectively), all encoding the 372-bp sarA gene. The level of SarA, the major regulatory protein, is partially controlled by the differential activation of sar promoters. We previously partially purified a ∼12 kDa protein with a DNA-specific column

Living In A House Of Cards: Family Experiences With Long-Term Childhood Technology Dependence, Maureen O'Brien

College of Nursing Faculty Research and Publications

Families' experiences of providing long-term home care for the child who is technology dependent were explored via parental interviews. Families identified frequent change, uncertainty, and unpredictability in their lives, a phenomenon described as "living in a house of cards." Attempts to increase stability involved the use of vigilance, advocacy, and reframing. Areas of challenge, change, and growth included making sense of life, managing daily life with technology, and maintaining a functioning family. Increased understanding of family experiences with long-term childhood technology dependence can provide nurses with additional strategies for providing optimal care to this population.

Research News: 2001, No. 1, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Ada News - 01/22/2001, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Where Is The Prophetic Minority That Can See The Future, Rick Burton

Sport Management - All Scholarship

No abstract provided.

Ada News - 01/08/2001, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Strategic Plan, Steve Konkel, Joe E. Beck, Eric Barker

Environmental Health Science Faculty and Staff Research

The Kentucky Association of Counties (KACo) strategic effort was organized under the aegis of Robert Arnold, the Executive Director of KACo. Strategic Focus, a strategic planning and facilitation organization, was selected to facilitate the meetings and provide consultation regarding development of the plan.

Healthnet News V.16:No.4 Winter 2001, Judith S. Kronick, Alberta Richetelle

Articles - Patient Care

A newsletter for public librarians and others interested in consumer health information services.

2001, Kathe Gable

UNISON

No abstract provided.

Tobacco Use Among Latinos, Gerardo Marín

Psychology

No abstract provided.