Medicine and Health Sciences Commons^™

Pick-Me-Up Newsletter - Issue 1, Volume 2, Nova Southeastern University

Pick Me Up Newsletter

No abstract provided.

Pick-Me-Up Newsletter - Issue 4 , Volume 1, Nova Southeastern University

Pick Me Up Newsletter

No abstract provided.

Predicting The Spatial Dynamics Of Rabies Epidemics On Heterogeneous Landscapes, David L. Smith, Brendan Lucey, Lance A. Waller, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Often as an epidemic spreads, the leading front is irregular, reflecting spatial variation in local transmission rates. We developed a methodology for quantifying spatial variation in rates of disease spread across heterogeneous landscapes. Based on data for epidemic raccoon rabies in Connecticut, we developed a stochastic spatial model of rabies spread through the state’s 169 townships. We quantified spatial variation in transmission rates associated with human demography and key habitat features. We found that large rivers act as semipermeable barriers, leading to a 7-fold reduction in the local rates of propagation. By combining the spatial distribution of major rivers with …

The Federal Role In Regulating Alternative Livestock Operations, Jose R. Diez, Mike Gilsdorf, Robert Werge

Zoonotics and Wildlife Disease: Publications

This paper discusses one aspect of federal regulation for alternative livestock, namely that concerned with the health status of animal agriculture. Federal responsibility for animal health programs rests with Veterinary Services (VS), a unit of the Animal and Plant Health Inspection Service (APHIS), an agency of the United States Department of Agriculture (USDA). The objective of this paper is to briefly describe three aspects ofVS' policy that have a potential to impact alternative livestock as well as free ranging wildlife. These are (1) using cooperative state-federal programs to eliminate diseases in alternative livestock, (2) collaborating on health issues with a …

Preclinical Diagnosis Of Chronic Wasting Disease In Captive Mule Deer (Odocoileus Hemionus) And White-Tailed Deer (Odocoileus Virginianus) Using Tonsillar Biopsy, Margaret A. Wild, Terry R. Spraker, Christina J. Sigurdson, Katherine I. O'Rourke, Michael W. Miller

Zoonotics and Wildlife Disease: Publications

The usefulness of tonsillar biopsy on live deer for preclinical diagnosis of the transmissible spongiform encephalopathy chronic wasting disease (CWD) was evaluated. Disease was tracked in a CWD-endemic herd using serial tonsillar biopsies collected at 6 to 9 month intervals from 34 captive mule deer (Odocoileus hemionus) and five white-tailed deer (O. virginianus). Tonsillar biopsies were examined for accumulation of PrP^CWD, the protein marker for infection, using immunohistochemical (IHC) staining. 26/34 (76%) mule deer and 4/5 (80%) white-tailed deer had PrP^CWD accumulation in tonsillar biopsies; CWD was subsequently confirmed by post-mortem examination in …

Validation Of Monoclonal Antibody F99/97.6.1 For Immunohistochemical Staining Of Brain And Tonsil In Mule Deer (Odocoileus Hemionus) With Chronic Wasting Disease, T. R. Spraker, Katherine I. O'Rourke, A. Balachandran, R. R. Zink, B. A. Cummings, M. W. Miller, B. E. Powers

Zoonotics and Wildlife Disease: Publications

A new monoclonal antibody (MAb), F99/97.6.1, that has been used to demonstrate scrapieassociated prion protein PrP^Sc in brain and lymphoid tissues of domestic sheep with scrapie was used in an immunohistochemistry assay for diagnosis of chronic wasting disease (CWD) in mule deer (Odocoileus hemionus). The MAb F99/97.6.1 immunohistochemistry assay was evaluated in brain and tonsil tissue from 100 mule deer that had spongiform encephalopathy compatible with CWD and from 1,050 mule deer outside the CWD-endemic area. This MAb demonstrated abnormal protease-resistant prion protein (PrP^res) in brains of all of the 100 mule deer and in …

Pregnancy Status And Fetal Prion Genetics Determine PrpSc Accumulation In Placentomes Of Scrapieinfected Sheep, Wenbin Tuo, Katherine I. O'Rourke, Dongyue Zhuang, William P. Cheevers, Terry R. Spraker, Donald P. Knowles

Zoonotics and Wildlife Disease: Publications

Ovine scrapie is a fatal neurodegenerative disorder that may be transmitted through exposure to infected uterine and placental tissues. Susceptibility to scrapie is primarily controlled by polymorphisms in the prion protein (PrP) gene. Scrapie in the U.S. Suffolk breed and in many breeds in Europe occurs in sheep homozygous for glutamine (171QQ), but rarely in sheep heterozygous for glutamine and arginine (171QR) or homozygous for arginine (171RR) at codon 171 of the PrP gene. This study demonstrated that accumulation of PrP^Sc in uterine-placental epithelial cells in the placentome was determined by fetal PrP genotype and the pregnancy status of …

Health Care Organization Managers Beware-Understand Your Ethical Constraints, Ashish Chandra, Andrew Sikula Sr.

Management Faculty Research

Review of the book Business Ethics in Healthcare: Beyond Compliance.(2001). Leonard J. Weber. Bloomington: Indiana University Press. 196 pp.

Project Towards No Drug Abuse: A Review Of The Findings And Future Directions, Alan W. Stacy, Steve Sussman, Clyde W. Dent

CGU Faculty Publications and Research

Objective: To provide a review of the evidence from 3 experimental trials of Project Towards No Drug Abuse (TND), a senior high-school-based drug abuse prevention program.Methods: Theoretical concepts, subjects, designs, hypotheses, findings, and conclusions of these trials are presented. A total of 2,468 high school youth from 42 schools in southern California were surveyed.Results: The Project TND curriculum shows reductions in the use of cigarettes, alcohol, marijuana, hard drugs, weapon carrying, and victimization. Most of these results were replicated across the 3 trials. Conclusion: Project TND is an effective drug and violence prevention program for older teens, at least for …

Medtextus: An Ontology-Enhanced Medical Portal, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

In this paper we describe MedTextus, an online medical search portal with dynamic search and browse tools. To search for information, MedTextus lets users request synonyms and related terms specifically tailored to their query. A mapping algorithm dynamically builds the query context based on the UMLS ontology and then selects thesaurus terms that fit this context. Users can add these terms to their query and meta-search five medical databases. To facilitate browsing, the search results can be reviewed as a list of documents per database, as a set of folders into which all the documents are automatically categorized based on …

Regulation Of Cardiomyocyte Cell Death In Culture, Deanna Lund

All Volumes (2001-2008)

Heart failure is the inability of body's cardiac output to keep pace with its demand for supplies and waste removal. It is characterized by systolic and diastolic ventricular dysfunction, cardiac remodeling, myocyte loss and fibrosis (Nyquist-Battie et al, 1996). It is accompanied by an increase in sympathetic activity with measurable increases in circulating plasma norepinephrine levels (Hasegawa et al. 2001; Kaye et al., 1995). Previous studies have suggested that adrenergic agonists play a role in myocardial cell death. Mann et al. (1992) have shown that increased activation of the adrenergic signaling pathway causes necrotic as well as apoptotic death in …

College Of Optometry Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Accuracy Of Predictive Methods To Estimate Resting Energy Expenditure Of Thermally-Injured Patients, Roland N. Dickerson, Jane M. Gervasio, Marti L. Riley, James E. Murrell, William L. Hickerson, Kenneth A. Kudsk, Rex O. Brown

Scholarship and Professional Work – COPHS

Background

The purpose of this study was to evaluate the bias and precision of 46 methods published from 1953 to 2000 for estimating resting energy expenditure (REE) of thermally injured patients.

Methods

Twenty-four adult patients with ≥20% body surface area burn admitted to a burn center who required specialized nutrition support and who had their REE measured via indirect calorimetry (IC) were evaluated. Patients with morbid obesity, human immunovirus, malignancy, pregnancy, hepatic or renal failure, neuromuscular paralysis, or those requiring a FiO2 >50% or positive end expiratory pressure (PEEP) ≥10 cm H2O were excluded. One steady-state measured REE measurement (MEE) …

Herbal Product Use Among Anticoagulation Patients, Ilene H. Zuckerman, Eileen K. Steinberger, Priscilla T. Ryder, Stuart Haines

Scholarship and Professional Work – COPHS

Warfarin interacts with many conventional drug products and herbal products,^1-3 Given the incompleteness of information on drug-herbal product interactions and the potential for health care practitioners to be unaware of their patients' utilization of herbal products, we surveyed the use of such products among patients receiving warfarin through an anticoagulation clinic. Patients at the University of Maryland Medical System Anticoagulation Clinic were asked to complete an anonymous written questionnaire during their regularly scheduled appointments over one month.

Pick-Me-Up Newsletter - Issue 5 , Volume 1, Nova Southeastern University

Pick Me Up Newsletter

No abstract provided.

College Of Pharmacy Student Handbook July 2002, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Academic Freedom In Times Of Turmoil, Petr Kolar

Center for the Study of Ethics in Society Papers

Papers presented for the Center of the Study of Ethics in Society Western Michigan University November 5, 2001.

Ua60/5/1 Scrapbook, Junior American Dental Hygienist's Association

Student Organizations

Scrapbook documenting Class of 2002 Junior American Dental Hygienist's Association at WKU.

The Contextual Approach In Health Research: Two Empirical Studies, Anita Kothari

Health Studies Publications

Researchers are being encouraged to consider contextual influences on health-related outcomes. To support this perspective, two context-sensitive studies were conducted. The first study explored the utilization of a research report by Ontario public health units, and examined whether utilization differed by involvement in the research process. Research utilization was conceptualized as a three stage process (reading, information processing and application). Using a case study design, results from three "involved" public health units and three "uninvolved" units demonstrated that inclusion in the research process led to a greater understanding of the analysis and increased the value associated with the report. Involvement …

Substance Abuse Among Urban Aboriginals, Kahá:Wi J. Jacobs, Kathryn J. Gill

Aboriginal Policy Research Consortium International (APRCi)

This paper reports findings of a study of mental health among urban Aboriginal peoples. Both qualitative and quantitative techniques were used to explore the relationship between substance abuse and physical/sexual abuse in a sample of Aboriginal peoples living in an urban community. Open-ended interviews were conducted in a sample of 30 Aboriginals that included Aboriginal social service providers (from health, legal and family services). Forty percent of the sample had been abused and many experienced social, psychological and emotional prob- lems associated with abusive experiences. Content analysis of the interviews revealed common themes in violence discourse including loss of identity …

Endocrine Surgery: Thyroid, Parathyroid, Adrenal, Vivian Mcalister

Data and Test Instruments

The goal of this seminar is to understand the elements and processes that make up the knowledge required by the curriculum. These questions are designed to take you in a sequential fashion through the topic. By that I mean that the answer of one question will inform the next. Try to answer the questions before you come to the seminar. Use all resources available to you including textbooks, experts and Wikipedia. We will discuss our answers. Remember that our goal is to understand - there is no such thing as a stupid question or a foolish answer. Learning by rote …

The Effect Of Repeated Experience On Children’S Suggestibility Across Two Question Types, Martine B. Powell, Kim P. Roberts

Psychology Faculty Publications

There is a discrepancy in the literature regarding the effect of repeated experience on children’s suggestibility. Some researchers have concluded that repeated experience increases children’s suggestibility for variable details whereas others have reported no detrimental effect. This study demonstrated that the type of question used to test memory (cued-recall vs. yes/no questions) could account for the different reported conclusions. Children aged 5-6 years took part in an event either once or four times. Three or 21 days later, they were given a suggestive interview about the single/final occurrence of the event during which half of the event details were inaccurately …

Children's Ability To Distinguish Between Memories From Multiple Sources: Implications For The Quality And Accuracy Of Eyewitness Statements, Kim P. Roberts

Psychology Faculty Publications

Identifying the sources of memories (e.g., who carried out an action, whether an event happened or was suggested, when an instance of a repeated event occurred) is an important skill in providing accurate accounts of events in forensic investigations. Sensitivity to the nature and development of children’s source-monitoring skills can inform interviewing practices. Five perspectives addressing alternate aspects of the development of children’s source monitoring are outlined (source-monitoring theory, fuzzy-trace theory, schema theory, the person-based perspective, and the mental-state reasoning model). Six main areas of empirical research stemming from these theories are then discussed with emphasis on how the findings …

Personal Growth Groups For Therapists, Vicky A. Knapp

Graduate Research Papers

Since the birth of psychotherapy, the need for therapists to attend to their own personal healing and growth has been recognized. This tradition of personal therapy has been incorporated into many current programs that train therapists/helpers in this country. Freud and a large number of subsequent practitioners have also advocated periodic or ongoing personal therapy throughout the therapist's career span. Self-exploration groups can be an excellent means to keep helpers in touch with their humanness, to further their personal and professional growth, and to reduce toxic consequences of practicing therapy.

Active Surveillance For Scrapie By Third Eyelid Biopsy And Genetic Susceptibility Testing Of Flocks Of Sheep In Wyoming, Katherine I. O'Rourke, John V. Duncan, James R. Logan, Anne K. Anderson, Dianne K. Norden, Elizabeth S. Williams, Bret A. Combs, Robert H. Stobart, Gary E. Moss, Diane L. Sutton

Zoonotics and Wildlife Disease: Publications

Control of scrapie, an ovine transmissible spongiform encephalopathy or prion disorder, has been hampered by the lack of conventional antemortem diagnostic tests. Currently, scrapie is diagnosed by postmortem examination of the brain and lymphoid tissues for PrP^Sc, the protein marker for this group of disorders. For live, asymptomatic sheep, diagnosis using tonsil or third-eyelid lymphoid tissue biopsy and PrP^Sc assay has been described. To evaluate the feasibility and efficacy of third-eyelid testing for identification of infected flocks and individual infected sheep, 690 sheep from 22 flocks were sampled by third-eyelid lymphoid tissue biopsy and immunohistochemistry. Sheep were …

Comparison Of Histological Lesions And Immunohistochemical Staining Of Proteinase-Resistant Prion Protein In A Naturally Occurring Spongiform Encephalopathy Of Free-Ranging Mule Deer (Odocoileus Hemionus) With Those Of Chronic Wasting Disease Of Captive Mule Deer, T. R. Spraker, R. R. Zink, B. A. Cummings, M. A. Wild, M. W. Miller, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

In this investigation, the nature and distribution of histologic lesions and immunohistochemical staining (IHC) of a proteinase-resistant prion protein were compared in free-ranging mule deer (Odocoileus hemionus) dying of a naturally occurring spongiform encephalopathy (SE) and captive mule deer dying of chronic wasting disease (CWD). Sixteen free-ranging deer with SE, 12 free-ranging deer without SE, and 10 captive deer with CWD were examined at necropsy. Tissue sections were stained with hematoxylin and eosin, and duplicate sections were stained with a monoclonal antibody (F89/160.1.5). Histological lesions in the freeranging deer with SE and captive deer with CWD were found …

A New Class Of Lipid Desaturase Central To Sphingolipid Biosynthesis And Signalling, Johnathan A. Napier, Louise V. Michaelson, Teresa M. Dunn

Uniformed Services University of the Health Sciences

Sphingolipids and their phosphorylated metabolites play crucial roles in intracellular signaling in animals, and evidence is emerging for analogous situations in fungi and plants. Central to this signaling pathway is the phosphorylation of the sphingoid long chain base, sphingosine, which yields sphingosine-1-phosphate. Until recently, the enzyme responsible for the biosynthesis of sphingosine was unknown, but the Δ4-long chain base desaturase that carries out this reaction has now been identified. Orthologues are present in animals, plants and fungi, raising the possibility of using reverse genetics to determine the contribution of sphingosine-1-phosphate to signaling networks.

A Saccharomyces Cerevisiae Gene Required For Heterologous Fatty Acid Elongase Activity Encodes A Microsomal Β-Keto-Reductase, Frédéric Beaudoin, Ken Gable, Olga Sayanova, Teresa Dunn, Johnathan A. Napier

Uniformed Services University of the Health Sciences

A number of Saccharomyces cerevisiae membranebound oxidoreductases were examined for potential roles in microsomal fatty acid elongation, by assaying heterologous elongating activities in individual deletion mutants. One yeast gene, YBR159w, was identified as being required for activity of both the Caenorhabditis elegans elongase PEA₁ (F₅₆H_11.4) and the Arabidopsis thaliana elongase FAE₁. Ybr159p shows some limited homology to human steroid dehydrogenases and is a member of the short-chain alcohol dehydrogenase superfamily. Disruption of YBR159w is not lethal, in contrast to previous reports, although the mutants are slow growing and display high temperature sensitivity. Both …

The Saccharomyces Cerevisiae Ybr159w Gene Encodes The 3-Ketoreductase Of The Microsomal Fatty Acid Elongase, Gongshe Han, Ken Gable, Sepp D. Kohlwein, Frédéric Beaudoin, Johnathan A. Napier, Teresa M. Dunn

Uniformed Services University of the Health Sciences

The YBR159w gene encodes the major 3-ketoreductase activity of the elongase system of enzymes required for very long-chain fatty acid (VLCFA) synthesis. Mutants lacking the YBR159w gene display many of the phenotypes that have previously been described for mutants with defects in fatty acid elongation. These phenotypes include reduced VLCFA synthesis, accumulation of high levels of dihydrosphingosine and phytosphingosine, and accumulation of medium-chain ceramides. In vitro elongation assays confirm that the ybr159Δ mutant is deficient in the reduction of the 3-ketoacyl intermediates of fatty acid elongation. The ybr159Δ mutant also displays reduced dehydration of the 3-OH acyl intermediates of fatty …

Cell Surface-Localized Nucleolin Is A Eukaryotic Receptor For The Adhesin Intimin-Γ Of Enterohemorrhagic Escherichia Coli O157:H7, James F. Sinclair, Alison D. O'Brien

Uniformed Services University of the Health Sciences

Intimin-γ is an outer membrane protein of enterohemorrhagic Escherichia coli (EHEC) O157:H7 that is required for the organism to adhere tightly to HEp-2 cells and to colonize experimental animals. Another EHEC O157:H7 protein, the Transferred intimin receptor (Tir), is considered the primary receptor for intimin-γ. Nevertheless, Tir-independent binding of intimin-γ to HEp-2 cells has been reported. This observation suggests the existence of a eukaryotic receptor(s) for intimin-γ. In this study, we sought to identify that receptor(s). First, we determined by equilibrium binding titration that the association of purified intimin-γ with HEp-2 cells was specific and consistent …