Medicine and Health Sciences Commons^™

Phosphoglycan Messengers And Their Medical Uses (Sle), Khalid M. Elased, Khalid A. Gumaa, Hassan Rahmoune, Thomas Rademacher, J. B. De Souza

Pharmacology and Toxicology Faculty Publications

PPhosphoglycan messengers (PGMs) which are carbohydrate derivatised phosphatidyl cyclitols are disclosed, together with the finding that these substances are biologically active, especially in modulating plasma cholesterol, plasma triglycerides and/or high density lipoprotein levels and/or modulating the LDL:HDL ratio, and for the treatment of lipodystrophy or dyslipidemia. These compounds are distinct from GPI-anchors disclosed in the prior art as these GPI-anchors are protein linked and are not biologically active.

Using Controversial Mock Trials In “Psychology And Law” Courses: Suggestions From Participants, James L. Werth, James Harvey, Rebecca Mcnamara, Andrea Svoboda, Raina Gulbrandson, Jennifer Hendren, Tiffany Greedy, Christie Leybold

Department of Psychology: Faculty Publications

We discuss the use of a mock trial of the controversial Jack Kevorkian euthanasia case in an undergraduate psychology and law course. We provide an overview of the project, student feedback, and recommendations for improving the exercise. Based on feedback from students, we conclude that constructing a trial around a controversial topic with psychosocial issues as the foundation of a course can increase the utility of a mock trial and make the course a better learning experience.

The Challenges Of College-Age Drinking Brochure

Brochure

No abstract provided.

A Hybrid Expert System Supporting Diagnosis Of Heart Diseases, Rania Hodhod

Faculty Bibliography

In this paper, we have developed a hybrid expert system prototype used for supporting diagnosis of heart diseases. The system merges uncertainty management techniques and case-based reasoning. The system is able to give appropriate diagnosis for 4 heart diseases namely; mitral stenosis, left-sided heart failure, stable angina pectoris and essential hypertension with the corresponding certainty factor. The system has been implemented in visual prolog for windows and has trained set of 42 cases for Egyptian cardiac patients and has been tested by another 13 different cases. Each case contains 33 significant attributes resulted from the statistical analysis performed to 110 …

Accessible Electronic And Information Technology: A New Era For People With Disabilities, Joseph H. Huber, A. Blinn, J. L. Mackool

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

No abstract provided.

Ritalin And Adhd: Recent Developments, Joseph H. Huber, P. Dubois

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

No abstract provided.

Healthnet News V.17:No.4 Winter 2002, Judith S. Kronick, Alberta Richetelle

Articles - Patient Care

A newsletter for public librarians and others interested in consumer health information services.

Differential Diagnosis And Management Of Spinal Nerve Root- Related Pain, P. Sizer, V. Phelps, G. S. Dedrick, O. Mattijs

Physical Therapy

No abstract provided.

How Can We Best Measure Fundamental Movement Skills?, Beth P. Hands

Health Sciences Conference Papers

The assessment of movement skill is a critical component of many disciplines and professions. In particular, the effectiveness of movement programs hinges on accurate information about the skill level of participants. This information should be based on assessment that is valid, comprehensive, educative, fair and explicit. The chosen process is matched to the assessment purpose. In this paper, the advantages and disadvantages of quantitative and qualitative strategies will be presented and the areas for future research highlighted.

What Do We Really Know About The Constraints And Enablers Of Physical Activity Levels In Young Children?, Beth P. Hands, Helen Parker, Dawne Larkin

Health Sciences Conference Papers

Ample evidence exists to support the benefits of habitual physical activity levels on long term health and well-being for adults, youth and, more recently, children. However information about factors that impact on young children’s choices to be active or inactive is limited because the accurate measurement of physical activity in young children is difficult. Consequently, many statements found in the literature about young children’s physical activity levels are not founded on empirically validated information. Some conclusions are extrapolated to younger children from findings in studies of older children.

This paper is based on an extensive review of literature and the …

Estimating Causal Parameters In Marginal Structural Models With Unmeasured Confounders Using Instrumental Variables, Tanya A. Henneman, Mark Johannes Van Der Laan, Alan E. Hubbard

U.C. Berkeley Division of Biostatistics Working Paper Series

For statisticians analyzing medical data, a significant problem in determining the causal effect of a treatment on a particular outcome of interest, is how to control for unmeasured confounders. Techniques using instrumental variables (IV) have been developed to estimate causal parameters in the presence of unmeasured confounders. In this paper we apply IV methods to both linear and non-linear marginal structural models. We study a specific class of generalized estimating equations that is appropriate to these data, and compare the performance of the resulting estimator to the standard IV method, a two-stage least squares procedure. Our results are applied to …

Two Concepts Of Immortality: Reframing Public Debate On Stem-Cell Research, Frank Pasquale

Faculty Scholarship

Regenerative medicine seeks not only to cure disease, but also to arrest the aging process itself. So far, public attention to the new health care has focused on two of its methods: embryonic stem-cell research and therapeutic cloning. Since both processes manipulate embryos, they alarm those who believe life begins at conception. Such religious objections have dominated headlines on the topic, and were central to President George W. Bush's decision to restrict stem-cell research.

Although they are now politically potent, the present religious objections to regenerative medicine will soon become irrelevant. Scientists are fast developing new ways of culturing the …

Parenting In The Face Of Prejudice: The Need For Representation For Parents With Mental Illness, Leigh S. Goodmark

Faculty Scholarship

No abstract provided.

Peginterferon Alfa-2a Plus Ribavirin For Chronic Hepatitis C Virus Infection., Michael W. Fried , M.D., Mitchell L. Shiffman , M.D., K. Rajender Reddy , M.D., Coleman Smith , M.D., George Marinos , M.D., Fernando L. Gonçales , Jr., M.D., Dieter Häussinger , M.D., Moises Diago , M.D., Giampiero Carosi , M.D., Daniel Dhumeaux , M.D., Antonio Craxi , M.D., Amy Lin , M.S., Joseph Hoffman , M.D., Jian Yu , M.D., Ph.D.

Internal Medicine Publications

BACKGROUND

Treatment with peginterferon alfa-2a alone produces significantly higher sustained virologic responses than treatment with interferon alfa-2a alone in patients with chronic hepatitis C virus (HCV) infection. We compared the efficacy and safety of peginterferon alfa-2a plus ribavirin, interferon alfa-2b plus ribavirin, and peginterferon alfa-2a alone in the initial treatment of chronic hepatitis C.

METHODS

A total of 1121 patients were randomly assigned to treatment and received at least one dose of study medication, consisting of 180 μg of peginterferon alfa-2a once weekly plus daily ribavirin (1000 or 1200 mg, depending on body weight), weekly peginterferon alfa-2a plus daily placebo, …

Ventricular Pacing Or Dual-Chamber Pacing For Sinus-Node Dysfunction, Gervasio A. Lamas , M.D., Kerry L. Lee ,Ph. D., Michael O. Sweeney , M.D., Russell Silverman , M.D., Angel Leon , M.D., Raymond Yee , M.D., Roger A. Marinchak , M.D., Greg Flaker , M.D., Eleanor Schron , M.S., R.N., E. John Orav , Ph.D., Anne S. Hellkamp, Lee Goldman , M.D., Stephen Greer , M.D., John Mcanulty , M.D., Kenneth Ellenbogen , M.D., Frederick Ehlert , M.D., Roger A. Freedman , M.D., N.A. Mark Estes Iii, M.D., Arnold Greenspon , M.D.

Internal Medicine Publications

BACKGROUND

Dual-chamber (atrioventricular) and single-chamber (ventricular) pacing are alternative treatment approaches for sinus-node dysfunction that causes clinically significant bradycardia. However, it is unknown which type of pacing results in the better outcome.

METHODS

We randomly assigned a total of 2010 patients with sinus-node dysfunction to dual-chamber pacing (1014 patients) or ventricular pacing (996 patients) and followed them for a median of 33.1 months. The primary end point was death from any cause or nonfatal stroke. Secondary end points included the composite of death, stroke, or hospitalization for heart failure; atrial fibrillation; heart-failure score; the pacemaker syndrome; and the quality of …

Voriconazole Compared With Liposomal Amphotericin B For Empirical Antifungal Therapy In Patients With Neutropenia And Persistent Fever, Thomas J. Walsh, Peter Pappas, Drew J. Winston, Hillard M. Lazarus, Finn Petersen, John Raffalli, Saul Yanovich, Patric Stiff, Richard Greenberg, Gerald Donowitz, Jeanette Lee

VCU Health Publications

Background

Patients with neutropenia and persistent fever are often treated empirically with amphotericin B or liposomal amphotericin B to prevent invasive fungal infections. Antifungal triazoles offer a potentially safer and effective alternative.

Methods

In a randomized, international, multicenter trial, we compared voriconazole, a new second-generation triazole, with liposomal amphotericin B for empirical antifungal therapy.

Results

A total of 837 patients (415 assigned to voriconazole and 422 to liposomal amphotericin B) were evaluated for success of treatment. The overall success rates were 26.0 percent with voriconazole and 30.6 percent with liposomal amphotericin B (95 percent confidence interval for the difference, –10.6 …

Using Validation As A Consultant In A Richmond, Virginia Continuing Care Retirement Community, John Colletti

Case Studies from Age in Action

Educational Objectives

1. Familiarize readers with the intricacies of setting up a behavioral program for persons diagnosed with Alzheimer's type dementia in a long term care facility.

2. Exemplify importance of interdisciplinary work.

3. Outline the future of the Validation Method in Virginia.

Older Adults, Social Techniques, And Memory, Karla K. Ziegenbalg

Case Studies from Age in Action

Educational Objectives

1. To use a social psychological perspective to examine memory abilities of older adults.

2. To understand in what ways the social environment, through direct social interaction, affects the memory performance of older adults.

3. To find out what, if any, social factors support memory performance in older adults.

Older Homeless Women: Beneath The Safety Net, Anne J. Kisor, Lynne Kendal-Wilson

Case Studies from Age in Action

Educational Objectives

1. Discuss how there is no stereotypical experience of, or explanation for, homelessness among older women.

2. Discuss why it is important to study the experiences of older homeless women.

3. Discuss policy and practice recommendations and specific ways to bridge efforts of aging and homeless service providers.

Are You At Risk For Blindness? Don't Keep Glaucoma A Family Secret! Older Age Is A Risk Factor, Mary Price

Case Studies from Age in Action

Educational Objectives

1. Raise awareness of risk factors for glaucoma.

2. Encourage health care providers to educate the patient about glaucoma risk factors.

3. Educate glaucoma patients to encourage family members to seek a glaucoma examination.

Serratia Marcescens Bacteremia Traced To An Infused Narcotic, Belinda E. Ostrowsky , M.D., M.P.H., Cynthia Whitener , M.D., Helen K. Bredenberg , M.D., Loretta A. Carson , M.S., Stacey Holt , B.S., Lori Hutwagner , M.S., Matthew J. Arduino , Dr., Ph.D, William R. Jarvis , M.D.

Family Medicine and Population Health Publications

BACKGROUND

From June 30, 1998, through March 21, 1999, several patients in the surgical intensive care unit of a hospital acquired Serratia marcescens bacteremia. We investigated this outbreak.

METHODS

A case was defined as the occurrence of S. marcescens bacteremia in any patient in the surgical intensive care unit during the period of the epidemic. To identify risk factors, we compared patients with S. marcescens bacteremia with randomly selected controls. Isolates from patients and from medications were evaluated by pulsed-field gel electrophoresis. The hair of one employee was tested for fentanyl.

RESULTS

Twenty-six patients with S. marcescens bacteremia were identified; …

Effectiveness Of Colors Used On Safety And Health Signs For Communicating Severity Of Injury, Andrew M. Mccammack, Roger C. Jensen

Safety Health & Industrial Hygiene

Signs are used extensively in workplaces and on products to identify hazards and provide instructions for appropriate behavior. A fundamental element of these signs is the signal-word panel located at the top of the sign. The colors and words in this panel are intended to convey information about the hazard identified. One type of hazard information concerns the severity of injury/illness associated with the hazard. The standard of the American National Standards Institute (ANSI) for facility signs uses three severity categories: 1) death or serious injury, 2) minor or moderate injury, and 3) property damage. The standard specifies which signal-word …

Case Study Of An Ergonomics Training Program For Nursing Home Workers, Roger C. Jensen

Safety Health & Industrial Hygiene

This paper describes a case study of a labor-based ergonomics-training program that makes use of some effective worker training methods. The program focus was on ergonomics awareness and back injury prevention for nursing home workers. It was developed and conducted by a not-for-profit organization affiliated with the Service Employees International Union. Training methods included the train-the-trainer model and the small group activity method. The investigation also compared the program components with those identified by the Occupational Safety and Health Administration (OSHA) as being key elements in effective safety training.

Safety And Health Sign Colors And Signal Words For Communicating Information On Likelihood And Imminence Of Threat, Roger C. Jensen, Andrew M. Mccammack

Safety Health & Industrial Hygiene

Signs are used extensively in workplace facilities and on products to identify hazards and provide instructions and safety information. A fundamental component of these signs is a signal-word panel located at the top of the sign. Certain colors and signal words in this panel are intended to convey information about a hazard, including likelihood of harm and imminence of the threat. The purpose of this study was to determine if young adults without prior training on safety signs associate signal words and color with likelihood of harm and imminence of the threat. The sample population consisted of 59 college students. …

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Winter, 2002 edition of the ALHeLa newsletter - Synapse.

Contents include:

• News from NN/LM
• Photos Anyone?
• ALHeLA Member named MLA Academic Librarian of 2002
• ALHeLA Executive Committee Members (2002)
• ALHeLA Executive Board Meeting (January 25, 2002)

Information Interface - Volume 30, Issue 1 - January/February 2002, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Glutamine Uptake By Neurons: Interaction Of Protons With System A Transporters, Farrukh A. Chaudhry, Dietmar Schmitz, Richard J. Reimer, Peter Larsson, Andrew T. Gray, Roger Nicoll, Michael Kavanaugh, Robert H. Edwards

Biomedical and Pharmaceutical Sciences Faculty Publications

Astrocytes provide the glutamine required by neurons to synthesize glutamate and GABA. However, the mechanisms involved in glutamine transfer from glia to neurons have remained poorly understood. Recent work has implicated the System N transporter SN1 in the efflux of glutamine from astrocytes and the very closely related System A transporters SA1 and SA2 in glutamine uptake by neurons. To understand how these closely related proteins mediate flux in different directions, we have examined their ionic coupling. In contrast to the electroneutral exchange of H⁺ for Na⁺ and neutral amino acid catalyzed by SN1, we now show that …

Dynamic Equilibrium Between Coupled And Uncoupled Modes Of A Neuronal Glutamate Transporter, Lars Borre, Michael Kavanaugh, Baruch I. Kanner

Biomedical and Pharmaceutical Sciences Faculty Publications

In the brain, the neurotransmitter glutamate is removed from the synaptic cleft by (Na⁺ + K⁺)-coupled transporters by an electrogenic process. Moreover, these transporters mediate a sodium- and glutamate-dependent uncoupled chloride conductance. In contrast to the wild type, the uptake of radiolabeled substrate by the I421C mutant is inhibited by the membrane-impermeant [2-(trimethylammonium)ethyl]methanethiosulfonate and also by other sulfhydryl reagents. In the wild-type and the unmodified mutant, substrate-induced currents are inwardly rectifying and reflect the sum of the coupled electrogenic flux and the anion conductance. Remarkably, the I421C mutant modified by sulfhydryl reagents exhibits currents that are non-rectifying …

College Of Pharmacy Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Concentrations Of Hair Minerals Determined By Inductively Coupled Plasma-Mass Spectrometry In People With Headaches, Joel R. Mundall

Capstone Research Projects

Calculations were made to determine what relationships exist between headaches and hair mineral levels of 1,995 hair tissue mineral analyses by inductively coupled plasma-mass spectrometry. Of the 1,995 samples (1,089 females, 906 males), 163 (100 females, 63 males) were taken from patients who had been diagnosed with headaches. Above average hair levels of bismuth and the earth metals were found among the both the males and females of the headache group. An age correlation analyses showed highest headache incidence in teens and early forties. A direct correlation was also found between calcium and magnesium levels, which peaked in the late …