Medicine and Health Sciences | Open Access Articles

Genetic And Environmental Influences On Offspring Alcoholism: New Insights Using A Children-Of-Twins Design, T. Jacob, Andrew C. Heath, Kathleen K. Bucholz, J. Scherrer, B. Waterman, W. R. True, R. Haber, Q. Fu

Posters

No abstract provided.

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Effects Of Childhood Exposure To Paternal Alcoholism On Substance Use Disorders In Adolescents And Young Adults, A. E. Duncan, Q. Fu, Kathleen K. Bucholz, J. F. Scherrer, T. Jacob, W. R. True

Posters

No abstract provided.

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Does Prenatal Exposure Modify The Response To First Use Of Alcohol And Tobacco?, Valerie S. Knopik, Kathleen K. Bucholz, Michele L. Pergadia, Andrew C. Heath, Pamela A. Madden

Posters

No abstract provided.

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A Mathematical Model Of Immune Response To Tumor Invasion, Lisette De Pillis, Ami Radunskaya

All HMC Faculty Publications and Research

Recent experimental studies by Diefenbach et al. [1] have brought to light new information about how the immune system of the mouse responds to the presence of a tumor. In the Diefenbach studies, tumor cells are modiﬁed to express higher levels of immune stimulating NKG2D ligands. Experimental results show that sufﬁciently high levels of ligand expression create a signiﬁcant barrier to tumor establishment in the mouse. Additionally, ligand transduced tumor cells stimulate protective immunity to tumor rechallenge. Based on the results of the Diefenbach experiments, we have developed a mathematical model of tumor growth to address some of the questions …

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Review Of Cure: A Story Of Cancer And Politics From The Annals Of The Cold War, John Stephen Brantley

Faculty & Staff Research & Creative Activity

No abstract provided.

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Clinical Issues Surrounding Once-Daily Aminoglycoside Dosing In Children, Chad A. Knoderer, Julie A. Everett, William F. Buss

Scholarship and Professional Work – COPHS

Aminoglycoside antibiotics are first-line treatment for many infectious diseases in the pediatric population and are effective in adults. The traditional dosing interval in children is every 8–12 hours. Studies in adults reported equivalent efficacy and equal or less toxicity with once-daily regimens. Despite many studies in the adult population, this approach has yet to become standard practice in most pediatric hospitals. Reasons for lack of acceptance of this strategy in children include rapid aminoglycoside clearance, unknown duration of postantibiotic effect, safety concerns, and limited clinical and efficacy data.

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Pulmonary Embolism As An Adverse Drug Event Of Intravenous Immunoglobulin Therapy, Katasha S. Butler, Deborah S. Zeitlin

Scholarship and Professional Work – COPHS

TO THE EDITOR: Intravenous immunoglobulin (IVIG) therapy has gained popularity for the treatment of neuromuscular diseases (i.e., myasthenia gravis, inflammatory myopathy, chronic inflammatory demyelinating polyneuropathy), although adverse events are associated with high-dose IVIG infusions.^1,2 Common adverse reactions to IVIG therapy are anxiety, headache, fever, chills, chest pain, dyspnea, nausea, and abdominal pain.³ More serious adverse events include anaphylaxis, hemolytic anemia, hepatitis C, and thrombosis.³ Studies have shown documented effects of IVIG on blood rheology. It increases plasma viscosity in a dose-related response and may also activate platelets.^2–4 High-dose IVIG therapy is approximately 24–54 g/d.⁴

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Nsucommuniversity Link - January 2003, Nova Southeastern University

NSU Digital: Communiversity

No abstract provided.

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Early Alcohol Use As A Risk Factor For Drug Use And Dependence, Julia D. Grant, Kathleen K. Bucholz, Michael T. Lynskey, Jeffrey F. Scherrer, Seth A. Eisen, William R. True, Michael J. Lyons, Ming T. Tsuang

Posters

No abstract provided.

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Associations Among Parental Alcohol Problems, Trauma, And Depression In A Twin Sample, Vivia V. Mccutcheon, Andrew C. Heath, Elliot C. Nelson, Kathleen K. Bucholz, Pamela A. Madden, Nicholas G. Martin

Posters

No abstract provided.

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Genetic And Environmental Influences On Perceived Peer Alcohol Use During Adolescence, Julia D. Grant, Kathleen K. Bucholz, Pamela A. Madden, Wendy S. Slutske, Andrew C. Heath

Posters

No abstract provided.

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Is Psychosocial Stress Associated With Alcohol Use Among Continuation High School Students?, Raul Caulderon, Jr., Gregory T. Smith, Marilyn Winkleby

Posters

No abstract provided.

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Role Ambiguity In Sport Teams, Mark A. Eys, Albert V. Carron, Mark R. Beauchamp, Steven R. Bray

Kinesiology and Physical Education Faculty Publications

The general purpose of the present study was to examine the nature of role ambiguity in sport teams and to explore the construct validity of the operational definition of role ambiguity developed by Beauchamp, Bray, Eys, and Carron (2002). Role ambiguity was operationalized as a multidimensional construct (Scope of Responsibilities, Behavioral Responsibilities, Evaluation of Performance, and Consequences of Not Fulfilling Responsibilities) that occurs in two contexts, offense and defense. Consistent with the a priori hypothesis, perceptions of role ambiguity exhibited some degree of within-group consistency and group-level variability, but most of the variance in role ambiguity was seen at the …

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Evaluation Of Intra-And Inter-Fraction Motion In Breast Radiotherapy Using Electronic Portal Imaging Cine Loops, Chrison Lee, Edward Yu, Tomas Kron

Oncology Presentations

Parallel tangent breast irradiation is commonly used postbreast conservation surgery for early breast cancer patient without lymph node involvement to improve local disease control. Intra-fractional and inter-fractional variabilities are often presented in daily treatment setup. The present pilot study used Electronic Portal Imaging (EPI) to evaluate intra-and inter-fraction motion in patients undergoing simple breast tangent radiotherapy.

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Relationships Between Human Auditory Cortical Structure And Function, Deborah A Hall, Heledd C Hart, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

The human auditory cortex comprises multiple areas, largely distributed across the supratemporal plane, but the precise number and configuration of auditory areas and their functional significance have not yet been clearly established. In this paper, we discuss recent research concerning architectonic and functional organisation within the human auditory cortex, as well as architectonic and neurophysiological studies in non-human species, which can provide a broad conceptual framework for interpreting functional specialisation in humans. We review the pattern in human auditory cortex of the functional responses to various acoustic cues, such as frequency, pitch, sound level, temporal variation, motion and spatial location, …

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Prevalence Of The Use Of Central Venous Access Devices Within And Outside Of The Intensive Care Unit: Results Of A Survey Among Hospitals In The Prevention Epicenter Program Of The Centers For Disease Control And Prevention, Michael Climo, Dan Diekema, David K. Warren, Loreen A. Herwaldt, Trish M. Perl, Lance Peterson, Theresa Plaskett, Connie Price, Kent Sepkowitz, Steve Solomon, Jerry Tokars, Victoria J. Fraser, Edward Wong

Open Access Publications

No abstract provided.

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Differential Requirement For The Nonhelical Tailpiece And The C Terminus Of The Myosin Rod In Caenorhabditis Elegans Muscle, Pamela E. Hoppe, Rebecca C. Andrews, Payal D. Parikh

Open Access Publications

No abstract provided.

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Osteopontin Deficiency Produces Osteoclast Dysfunction Due To Reduced Cd44 Surface Expression, M. A. Chellaiah, N. Kizer, R. Biswas, U. Alvarez, J. Strauss-Schoenberger, L. Rifas, S. R. Rittling, D. T. Denhardt, K. A. Hruska

Open Access Publications

No abstract provided.

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Lens Connexins Α3cx46 And Α8cx50 Interact With Zonula Occludens Protein-1 (Zo-1), Peter A. Nielsen, Amos Baruch, Valery I. Shestopalov, Ben N.G. Giepmans, Irene Dunia, E. Lucio Benedetti, Nalin M. Kumar

Open Access Publications

No abstract provided.

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Down-Regulation Of Cd46 By Piliated Neisseria Gonorrhoeae, Darcy B. Gill, Michael Koomey, Janne G. Cannon, John P. Atkinson

Open Access Publications

No abstract provided.

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Mere And Partial Means: The Full Range Of The Objectification Of Women, Carolyn Mcleod

Philosophy Publications

No abstract provided.

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Differences In Percutaneous Injury Patterns In A Multi-Hospital System, Hilary M. Babcock, Victoria Fraser

Open Access Publications

No abstract provided.

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Targeted Inactivation Of The Il-4 Receptor Α Chain I4r Motif Tromotes Allergic Airway Inflammation, Frank Blaeser, Paul J. Bryce, Nga Ho, Vidya Raman, Fatma Dedeoglu, Debra D. Donaldson, Raif S. Geha, Hans C. Oettgen, Talal A. Chatila

Open Access Publications

No abstract provided.

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Interferon-Producing Cells Fail To Induce Proliferation Of Naive T Cells But Can Promote Expansion And T Helper 1 Differentiation Of Antigen-Experienced Unpolarized T Cells, Anne Krug, Ravi Veeraswamy, Andrew Pekosz, Osami Kanagawa, Emil R. Unanue, Marco Colonna, Marina Cella

Open Access Publications

No abstract provided.

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Targeted Chemical Disruption Of Clathrin Function In Living Cells, Howard S. Moskowitz, John Heuser, Timothy E. Mcgraw, Timothy A. Ryan

Open Access Publications

No abstract provided.

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Dispositional Hardiness And Women’S Well-Being Relating To Gender Discrimination: The Role Of Minimization, Mindi D. Foster, Kenneth L. Dion

Psychology Faculty Publications

Three studies examined whether personality-based hardiness would be associated with mental health benefits in contexts of gender discrimination. Hardy women encountering both a laboratory simulation and a hypothetical scenario of discrimination showed greater self-esteem and less negative affect than low hardy women. However, these benefits were mediated by the use of specific attributions, suggesting that the well-being in hardy women may have been achieved through minimizing the pervasiveness of discrimination. Study three showed this mediation pattern occurred only for participants exposed to higher threat scenarios versus lower threat scenarios of discrimination. Thus, minimizing the pervasiveness of discrimination may have been …

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Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

One often develops stochastic ecologic simulation models based on local interactions between individuals or groups and bases systemic conclusions on trends summarized over multiple data sets generated from the model. In many cases, such models generate data sets (“realizations”) each violating the usual assumptions associated with traditional statistical tests of goodness-of-fit, most notably that of independent observations. Monte Carlo hypothesis tests applied to multiple realizations from such models provide appropriate goodness-of-fit tests regardless of within-model peculiarities. The Monte Carlo tests address the question “Do the observed data appear consistent with the model?” in contrast to the usual question “Does the …

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Abundant PrpCwd In Tonsil From Mule Deer With Preclinical Chronic Wasting Disease, Katherine I. O'Rourke, Dongyue Zhuang, Amy Lyda, Gabriel Gomez, Elizabeth S. Williams, Wenbin Tuo, Michael W. Miller

Zoonotics and Wildlife Disease: Publications

A monoclonal antibody dot-blot assay was used to evaluate detergent lysates of tonsil tissue from mule deer to detect PrP^CWD, the marker for the cervid transmissible spongiform encephalopathy chronic wasting disease (CWD). Samples of formalin-fixed brain and tonsil tissues from mule deer were examined for PrP^CWD using immunohistochemistry (IHC) with Mab F99/97.6.1, the gold standard for diagnosis of preclinical CWD. The contralateral tonsil from each of the 143 deer was prepared for confirmatory IHC and as a 10% (wt/vol) detergent lysate without purification or enrichment steps for monoclonal antibody dot-blot assay. PrP^CWD was detected by dot-blot …

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Genealogical Relationships Influence The Probability Of Infection With Bovine Tuberculosis And Microgeographic Genetic Structure In Free-Ranging White-Tailed Deer, Julie Anne Blanchong

Michigan Bovine Tuberculosis Bibliography and Database

Zoonoses are of increasing importance to wildlife conservation and human health. It has become increasingly recognized that wildlife ecology plays a key role in disease transmission in wildlife populations. In domestic populations, contacts among individuals are controlled by humans and disease transmission is often density dependent. Unlike domestic animals, wildlife populations often have complex social systems in whch contacts among individuals are not solely density dependent, and can play an important role in the transmission and maintenance of disease.

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Factor Structure Of The Coaching Behavior Questionnaire And Its Relationship To Athlete Variables, Jean M. Williams, Gerald J. Jerome, Laura J. Kenow, Tracie Rogers, Tessa A. Sartain, Greg Darland

Faculty Publications

Little research exists to identify optimal coaching behaviors and factors that influence the effectiveness of particular behaviors. The present study tested 484 athletes in order to determine sub-scales on the Coaching Behavior Questionnaire (CBQ). The CBQ measures athletes’ perceptions of coaching behaviors and evaluates their effectiveness in helping athletes play better and maintain optimal mental states and focus. A confirmatory factor analysis (CFA) supported the two-factor model (negative activation, supportiveness/emotional composure) derived from an exploratory factor analysis (EFA). Correlational analyses indicated that athletes with higher anxiety and lower self-confidence and compatibility with the coach were more likely to negatively evaluate …

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Full-Text Articles in Medicine and Health Sciences

Genetic And Environmental Influences On Offspring Alcoholism: New Insights Using A Children-Of-Twins Design, T. Jacob, Andrew C. Heath, Kathleen K. Bucholz, J. Scherrer, B. Waterman, W. R. True, R. Haber, Q. Fu

Posters

Effects Of Childhood Exposure To Paternal Alcoholism On Substance Use Disorders In Adolescents And Young Adults, A. E. Duncan, Q. Fu, Kathleen K. Bucholz, J. F. Scherrer, T. Jacob, W. R. True

Posters

Does Prenatal Exposure Modify The Response To First Use Of Alcohol And Tobacco?, Valerie S. Knopik, Kathleen K. Bucholz, Michele L. Pergadia, Andrew C. Heath, Pamela A. Madden

Posters

A Mathematical Model Of Immune Response To Tumor Invasion, Lisette De Pillis, Ami Radunskaya

All HMC Faculty Publications and Research

Review Of Cure: A Story Of Cancer And Politics From The Annals Of The Cold War, John Stephen Brantley

Faculty & Staff Research & Creative Activity

Clinical Issues Surrounding Once-Daily Aminoglycoside Dosing In Children, Chad A. Knoderer, Julie A. Everett, William F. Buss

Scholarship and Professional Work – COPHS

Pulmonary Embolism As An Adverse Drug Event Of Intravenous Immunoglobulin Therapy, Katasha S. Butler, Deborah S. Zeitlin

Scholarship and Professional Work – COPHS

Nsucommuniversity Link - January 2003, Nova Southeastern University

NSU Digital: Communiversity

Early Alcohol Use As A Risk Factor For Drug Use And Dependence, Julia D. Grant, Kathleen K. Bucholz, Michael T. Lynskey, Jeffrey F. Scherrer, Seth A. Eisen, William R. True, Michael J. Lyons, Ming T. Tsuang

Posters

Associations Among Parental Alcohol Problems, Trauma, And Depression In A Twin Sample, Vivia V. Mccutcheon, Andrew C. Heath, Elliot C. Nelson, Kathleen K. Bucholz, Pamela A. Madden, Nicholas G. Martin

Posters

Genetic And Environmental Influences On Perceived Peer Alcohol Use During Adolescence, Julia D. Grant, Kathleen K. Bucholz, Pamela A. Madden, Wendy S. Slutske, Andrew C. Heath

Posters

Is Psychosocial Stress Associated With Alcohol Use Among Continuation High School Students?, Raul Caulderon, Jr., Gregory T. Smith, Marilyn Winkleby

Posters

Role Ambiguity In Sport Teams, Mark A. Eys, Albert V. Carron, Mark R. Beauchamp, Steven R. Bray

Kinesiology and Physical Education Faculty Publications

Evaluation Of Intra-And Inter-Fraction Motion In Breast Radiotherapy Using Electronic Portal Imaging Cine Loops, Chrison Lee, Edward Yu, Tomas Kron

Oncology Presentations

Relationships Between Human Auditory Cortical Structure And Function, Deborah A Hall, Heledd C Hart, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

Open Access Publications

Differential Requirement For The Nonhelical Tailpiece And The C Terminus Of The Myosin Rod In Caenorhabditis Elegans Muscle, Pamela E. Hoppe, Rebecca C. Andrews, Payal D. Parikh

Open Access Publications

Osteopontin Deficiency Produces Osteoclast Dysfunction Due To Reduced Cd44 Surface Expression, M. A. Chellaiah, N. Kizer, R. Biswas, U. Alvarez, J. Strauss-Schoenberger, L. Rifas, S. R. Rittling, D. T. Denhardt, K. A. Hruska

Open Access Publications

Lens Connexins Α3cx46 And Α8cx50 Interact With Zonula Occludens Protein-1 (Zo-1), Peter A. Nielsen, Amos Baruch, Valery I. Shestopalov, Ben N.G. Giepmans, Irene Dunia, E. Lucio Benedetti, Nalin M. Kumar

Open Access Publications

Down-Regulation Of Cd46 By Piliated Neisseria Gonorrhoeae, Darcy B. Gill, Michael Koomey, Janne G. Cannon, John P. Atkinson

Open Access Publications

Mere And Partial Means: The Full Range Of The Objectification Of Women, Carolyn Mcleod

Philosophy Publications

Differences In Percutaneous Injury Patterns In A Multi-Hospital System, Hilary M. Babcock, Victoria Fraser

Open Access Publications

Targeted Inactivation Of The Il-4 Receptor Α Chain I4r Motif Tromotes Allergic Airway Inflammation, Frank Blaeser, Paul J. Bryce, Nga Ho, Vidya Raman, Fatma Dedeoglu, Debra D. Donaldson, Raif S. Geha, Hans C. Oettgen, Talal A. Chatila

Open Access Publications

Interferon-Producing Cells Fail To Induce Proliferation Of Naive T Cells But Can Promote Expansion And T Helper 1 Differentiation Of Antigen-Experienced Unpolarized T Cells, Anne Krug, Ravi Veeraswamy, Andrew Pekosz, Osami Kanagawa, Emil R. Unanue, Marco Colonna, Marina Cella

Open Access Publications

Targeted Chemical Disruption Of Clathrin Function In Living Cells, Howard S. Moskowitz, John Heuser, Timothy E. Mcgraw, Timothy A. Ryan

Open Access Publications

Dispositional Hardiness And Women’S Well-Being Relating To Gender Discrimination: The Role Of Minimization, Mindi D. Foster, Kenneth L. Dion

Psychology Faculty Publications

Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Abundant PrpCwd In Tonsil From Mule Deer With Preclinical Chronic Wasting Disease, Katherine I. O'Rourke, Dongyue Zhuang, Amy Lyda, Gabriel Gomez, Elizabeth S. Williams, Wenbin Tuo, Michael W. Miller

Zoonotics and Wildlife Disease: Publications

Genealogical Relationships Influence The Probability Of Infection With Bovine Tuberculosis And Microgeographic Genetic Structure In Free-Ranging White-Tailed Deer, Julie Anne Blanchong

Michigan Bovine Tuberculosis Bibliography and Database

Factor Structure Of The Coaching Behavior Questionnaire And Its Relationship To Athlete Variables, Jean M. Williams, Gerald J. Jerome, Laura J. Kenow, Tracie Rogers, Tessa A. Sartain, Greg Darland

Faculty Publications