Medicine and Health Sciences Commons^™

Doctor Of Health Science Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Response Of Dark-Adapted Retinal Rod Photoreceptors, H. Khanal, V. Alexiades, E. Dibenedetto

Publications

The process of phototransduction, whereby light is converted into an electrical response, in rod and cone photoreceptors in the retina, involves as a key setp, the diffusion of the cytoplasmic, signaling molecules cGMP (cyclic guanosime monophosphate) and Ca²+ diffuse in the cytoplasm (the fluid surrounding the discs). the complex geometry of the rod creates computational difficulties. We present spatio-temporal compuational models for interacctions and diffusion of cGMP and Ca²+ in the cytoplasm of vertebrate rod photoreceptors, as well as numerical simulations fo the response to light of dark-adapted Salamander rods.

Impact Of Extra-Curricular Activities On Adolescents' Connectedness And Cigarette Smoking: Annual Report, Donna Cross, Greg Hamilton, Rob Mcgee, Margaret Hall

Research outputs pre 2011

Cigarette smoking is the primary cause of preventable death in Australia, killing approximately 19,000 people every year.⁸ Up to 90% of smokers begin smoking by 18 years of age.^9,10 In spite of the obvious public health burden, current approaches have led to very modest decreases in adolescent smoking in the past 10 years. ¹¹ The Smoking Cessation for Youth Project (SCYP)⁴ was a cluster randomised control trial that resulted in lower cigarette smoking among Year 10 students who received a harm minimisation intervention over two years. This project also led to the identification of connectedness as a …

Manganese Toxicokinetics At The Blood-Brain Barrier, Robert A. Yokel, Janelle S. Crossgrove

Pharmaceutical Sciences Reports

Increased manganese (Mn) use in manufacturing and in gasoline has raised concern about Mn-induced parkinsonism. Previous research indicated carrier-mediated brain entry but did not assess brain efflux.

Using in situ rat brain perfusion, we studied influx across the blood-brain barrier (BBB) of three predominant plasma Mn species available to enter the brain: Mn²⁺, Mn citrate, and Mn transferrin. Our results suggested transporter-mediated uptake of these species. The uptake rate was greatest for Mn citrate. Our results using the brain efflux index method suggested that diffusion mediates distribution from rat brain to blood.

To characterize the carriers mediating brain …

Validation Of A New Method For Estimating Vo2max Based On Vo2 Reserve, David P. Swain, James A. Parrott, Anna R. Bennett, J. David Branch, Elizabeth A. Dowling

Human Movement Studies & Special Education Faculty Publications

Purpose: The American College of Sports Medicine's (ACSM) preferred method for estimating maximal oxygen consumption (V̇O_2max) has been shown to overestimate V̇O_2max, possibly due to the short length of the cycle ergometry stages. This study validates a new method that uses a final 6-min stage and that estimates V̇O_2max from the relationship between heart rate reserve (HRR) and V̇O₂ reserve. Methods: A cycle ergometry protocol was designed to elicit 65–75% HRR in the fifth and sixth minutes of the final stage. Maximal workload was estimated by dividing the workload of the final stage by …

Maximum Tolerable Dose Of Cyclophosphamide And Azathioprine In Pakistani Patients With Primary Renal Disease, S S. Ali, M A. Rabbani, S S M Moinuddin, Salim S. Virani, F Farooque, A Salam, A Ahmad

Section of Nephrology

Objective: The immunosuppressive regimens, at present, mainly rely on western guidelines that were derived from studies conducted in western populations. No such study exists for South Asian population, which is home to almost two billion people different in both genetics and environment from west. Locally derived thresholds for side effects markedly different from western figures may warrant re-adjustment of current local immunosuppressive regimens that are at present based largely on western guidelines. In order to define optimum dose for Cyclophosphamide (CYC) and Azathioprine (AZA) based immunosuppressive therapy, we conducted this study to find out maximum tolerable doses of azathioprine (AZA) …

Therapeutic Efficacy Of Sulfadoxine-Pyrimethamine And Prevalence Of Resistance Markers In Tanzania Prior To Revision Of Malaria Treatment Policy: Plasmodium Falciparum Dihydrofolate Reductase And Dihydropteroate Synthase Mutations In Monitoring In Vivo Resistance, K. Mugittu, M. Ndejembi, A. Malisa, M. Lemnge, Zul Premji, A. Mwita, W. Nkya, J. Kataraihya, S. Abdulla, H.-P. Beck, H. Mshinda

Pathology, East Africa

Prior to the 2001 malarial treatment policy change in Tanzania, we conducted trials to assess the efficacy of sulfadoxine-pyrimethamine (SP) and the usefulness of molecular markers in monitoring resistance. A total of 383 uncomplicated Plasmodium falciparum malaria patients (between 6 and 59 months old) were treated with SP and their responses were assessed. Mutations in the P. falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) genes in admission day blood samples were analyzed. Results indicated that 85.6% of the patients showed an adequate clinical response, 9.7% an early treatment failure, and 4.7% a late treatment failure. The quintuple mutant genotype …

Detection And Confirmation Of Ractopamine And Its Metabolites In Horse Urine After Paylean® Administration, A. F. Lehner, C. G. Hughes, J Daniel Harkins, C. Nickerson, B. Mollett, L. Dirikolu, Jeffrey M Bosken, Fernanda C. Camargo, J. Boyles, A. Troppmann, W. Karpiesiuk, W. E. Woods, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

We have investigated the detection, confirmation, and metabolism of the beta-adrenergic agonist ractopamine administered as Paylean to the horse. A Testing Components Corporation enzyme-linked imunosorbent assay (ELISA) kit for ractopamine displayed linear response between 1.0 and 100 ng/ml, with an 1-50 of 10 ng/ml, and an effective screening limit of detection of 50 ng/mL. The kit was readily able to detect ractopamine equivalents in unhydrolyzed urine up to 24 h following a 300-mg oral dose. Gas chromatography-mass spectrometry (GC-MS) confirmation comprised glucuronidase treatment, solid-phase extraction, and trimethylsilyl derivatization, with selected-ion monitoring of ractopamine-tris(trimethylsilane) (TMS) m/z 267, 250, 179, and 502 …

Description Of A Program For Social Language Intervention: “If You Can Have A Conversation, You Can Have A Relationship, Lee Robinson, Bonnie Brinton, Martin Fujiki

Faculty Publications

Adolescents with impaired language comprehension and formulation skills often experience difficulty keeping up with the linguistic and social demands of peer interaction. This clinical exchange describes an individualized treatment program designed to increase the conversational skill of an adolescent male with language impairment. Treatment focused on increasing awareness of the listener’s needs and on balancing the exchange of conversational turns. Clinical performance, parent report, and client report were used to assess outcomes.

Phosphorylation Of Vesicular Stomatitis Virus Phosphoprotein P Is Indispensable For Virus Growth†, Subash C. Das, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

The phosphoprotein (P) of vesicular stomatitis virus (VSV) is an essential subunit of the viral RNAdependent RNA polymerase (RdRp) complex. It is phosphorylated at two different domains. Using defective interfering (DI) RNA or minigenomic RNA templates, we previously demonstrated that phosphorylation within the amino-terminal domain I is essential for transcription, whereas phosphorylation within the carboxyterminal domain II is necessary for replication. For the present study, we examined the role of the phosphorylation of residues in these domains in the life cycle of VSV. Various mutant P coding sequences were inserted into a full-length cDNA clone of VSV, and the virus …

Glycosyltransferases Encoded By Viruses, Nicolas Markine-Goriaynoff, Laurent Gillet, James L. Van Etten, Haralambos Korres, Naresh Verma, Alain Vanderplasschen

James Van Etten Publications

Studies of cellular biology in recent decades have highlighted the crucial roles of glycans in numerous important biological processes, raising the concept of glycomics that is now considered as important as genomics, transcriptomics and proteomics. For millions of years, viruses have been co-evolving with their hosts. Consequently, during this co-evolution process, viruses have acquired mechanisms to mimic, hijack or sabotage host processes that favour their replication, including mechanisms to modify the glycome. The importance of the glycome in the regulation of host–virus interactions has recently led to a new concept called ‘glycovirology’. One fascinating aspect of glycovirology is the study …

Ic079: Headlines Newsletters, Vol. 7, Nos. 1-3, March-May, Summer, Fall/Winter 2004, John P. Mcgovern Museum Of Health And Medical Science

Museum Publications (1998-2009)

McGovern Museum of Health and Medical Science March-May 2004, Summer 2004 and Fall/Winter 2004 bulletin featuring news and information on upcoming museum events, exhibits, and programs.

Chronic Pain: The Extra Burden On Canadian Women, Marta Meana, Robert Cho, Marie Desmeules

Psychology Faculty Research

Health Issue: Chronic pain is a major health problem associated with significant costs to both afflicted individuals and society as a whole. These costs seem to be disproportionately borne by women, who generally have higher prevalence rates for chronic pain than do men.

Key findings: Data obtained from 125,574 respondents to the Canadian Community Health Survey (2000–2001) indicated that 18% of Canadian women suffered from chronic pain, compared to 14% of men. This gender discrepancy, however, seemed to be linked primarily to differences in age, income, and education between adult men and women in this large sample. Age, income, depression …

Bibliotherapy For Hospital Patients, P. S. Mcmillen, D. Pehrsson

Library Faculty Research

The purpose of this paper is to provide an overview of bibliotherapy in relation to hospital patients. It includes a brief history as well as discussion of practitioners, patients and problems, methodology and effectiveness. It also offers recommendations for those who provide bibliotherapy within the hospital context. The focus is on the use of bibliotherapy by professionals other than mental health practitioners. Coverage includes common literary genres that can be used for bibliotherapy addressing patients’ affective issues.

Development Of Dose Coefficients For Radionuclides Produced In Spallation Targets, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

Dose coefficients permit simple determination of radiation dose associated with various exposure scenarios, and ultimately permit radiation safety personnel to assess the health risks to workers in a nuclear facility. Specifically, radiation safety personnel use dose coefficients to determine the radiation dose incurred to a tissue or organ system from a given exposure. These parameters are often expressed in terms of Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs).

Results from this study will be used to produce ALIs and DACs for these rare radionuclides created by spallation target systems that are not included in Federal Guidance Report …

Inside Unlv, Gian Galassi, Jennifer Vaughan, Carol C. Harter, Richard Flaherty, Rebecca Mills

Inside UNLV

No abstract provided.

Income And The Use Of Prescription Drugs By The Elderly: Evidence From The Notch Cohorts, John R. Moran, Kosali Ilayperuma Simon

Center for Policy Research

We use exogenous variation in Social Security payments created by the Social Security benefits notch to estimate how retirees' use of prescription medications responds to changes in their incomes. In contrast to estimates obtained using ordinary least squares, instrumental variables estimates based on the notch suggest that lower-income retirees exhibit considerable income sensitivity in their use of prescription drugs. Our estimates are potentially useful for thinking about the health implications of changes in transfer payments to the elderly and for evaluating the benefits of the recently enacted Medicare prescription drug benefit.

Men's Basketball Media Guide 2004-2005, Indiana State University

Intercollegiate Athletics

No abstract provided.

Women's Basketball Media Guide 2004-2005, Indiana State University

Intercollegiate Athletics

No abstract provided.

Using Incentives To Encourage Aids Programs And Policies In The Workplace: A Study Of Feasibility And Impact In Thailand, Simon Baker, Srisuman Sartsara, Patchara Rumakom, Philip Guest, Katie D. Schenk, Anthony Pramualratana, Suparat Suksakulwat, Surachai Panakitsuwan, Sikarat Moonmeung

HIV and AIDS

A recently completed Horizons study in Thailand examined the question of how to encourage the private sector to become actively involved in developing and improving workplace HIV/AIDS programs. The study found that the AIDS-response Standard Organization (ASO) initiative mobilized a moderate proportion of different types of companies to develop and improve HIV/AIDS workplace policies and programs. The data also reveal that companies that were eligible for the insurance discount made the greatest improvements. Thus a financial incentive combined with efforts to tap into managers’ willingness to respond to the epidemic can be important motivators for certain companies to improve their …

Challenges Faced By Households In Caring For Orphans And Vulnerable Children, Population Council

HIV and AIDS

South Africa has seen a rapid increase in HIV prevalence among the general population over the past ten years, from less than 1 percent in 1990 to 20 percent in 2001. As the HIV/AIDS epidemic increases, so do the number of orphans and vulnerable children (OVC). In 2002, an estimated five million people were living with HIV/AIDS. Because of the average 10-year period between infection and death, even if HIV prevalence declined rapidly, South Africa would still experience an increasing orphan burden for many years to come. By 2010, 16 percent of all children in South Africa will be orphans …

A Gc-Ms Method For The Determination Of Isoxsuprine In Biological Fluids Of The Horse Utilizing Electron Impact Ionization, Jeffrey M Bosken, A. F. Lehner, C. G. Hughes, W. E. Woods, F. C. Camargo, J. D. Harkins, J. Boyles, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Isoxsuprine is used to treat navicular disease and other lower-limb problems in the horse. Isoxsuprine is regulated as a class 4 compound by the Association of Racing Commissioners, International (ARCI) and, thus, requires regulatory monitoring. A gas chromatography-mass spectrometry method utilizing electron impact ionization was developed and validated for the quantitation of isoxsuprine in equine plasma or equine urine. The method utilized robotic solid-phase extraction and tri-methyl silyl ether products of derivatization. Products were bis-trimethylsilyl (TMS) isoxsuprine and tris-TMS ritodrine, which released intense quantifier ions m/z 178 for isoxsuprine and m/z 236 for ritodrine that were products of C-C cleavage. …

The Mare Reproductive Loss Syndrome And The Eastern Tent Caterpillar Ii: A Toxicokinetic/Clinical Evaluation And A Proposed Pathogenesis: Septic Penetrating Setae, Thomas Tobin, J. Daniel Harkins, John Ford Roberts, Patricia W. Vanmeter, Tara A. Fuller

Maxwell H. Gluck Equine Research Center Faculty Publications

Reviewing the mare reproductive loss syndrome (MRLS), it is proposed that the fundamental mechanism of this syndrome, which includes early fetal loss, late fetal loss, uveitis, pericarditis, and encephalitis, is tissue penetration by septic barbed setal fragments (septic penetrating setae) from Eastern tent caterpillars (Malacosoma americanum). Once ingested, these barbed setal fragments migrate through moving tissues, followed by rapid hematogenous spread of bacteria, bacterial emboli, and/or septic fragments of setae (septic penetrating setal emboli), collectively referred to as septic materials. Pathogenic bacteria, therefore, enter the horse as hitchhikers on or in the caterpillar setal fragments, and MRLS is caused by …

Book Review. From Anarchy To Allottopia, David P. Fidler

Articles by Maurer Faculty

No abstract provided.

2004 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

Relationship Between Static Mobility Of The First Ray And First Ray, Midfoot, And Hindfoot Motion During Gait, Mary K. Allen, Tyler J. Cuddeford, Ward M. Glasoe, Lisa M. Dekam, Pamela J. Lee, Kelli J. Wagner, H. John Yack

Faculty Publications - College of Physical Therapy

The relationship between a static measure of dorsal first ray mobility and dynamic motion of the first ray, midfoot, and hindfoot during the stance phase of walking was investigated in healthy, asymptomatic subjects who represented the spectrum of static flexibility. Static first ray mobility of 15 subjects was measured by a load cell device and ranged from stiff (3.1 mm) to lax (8.0 mm). Using three-dimensional motion analysis, mean first ray dorsiflexion/eversion and mid-/hindfoot eversion peak motion, time-to-peak, and eversion excursion were evaluated. Subjects with greater static dorsal mobility of the first ray demonstrated significantly greater time-topeak hindfoot eversion and …

Use Of Mechanical Patient Lifts Decreased Musculoskeletal Symptoms And Injuries Among Health Care Workers, J. Li, L. Wolf, Bradley A. Evanoff

Occupational and Health Faculty Publications

No abstract provided.

Integrating Adolescent Livelihood Activities Within A Reproductive Health Programme For Urban Slum Dwellers In India, Mary Philip Sebastian, Monica J. Grant, Barbara Mensch

Poverty, Gender, and Youth

This project, whose collaborators included CARE, the Centre for Operations Research and Training, and the Population Council, tested the impact of economic skills training among girls in a slum in Allahabad, India. Recognizing the relative disadvantage of adolescent girls, the study aimed to build an evidence base for adolescent livelihoods programs. Participating girls and their parents welcomed the program, and the baseline survey clearly indicated the appropriateness of an intervention that addresses the capabilities and opportunities available to adolescent girls—including both vocational training and savings schemes. However, few girls turned their new skills into economic gain, in part because of …

Involving Men In Maternity Care In India, Leila Caleb-Varkey, Anurag Mishra, Anjana Das, Emma Ottolenghi, Dale Huntington, Susan E. Adamchak, M.E. Khan, Rick Homan

Reproductive Health

The Men in Maternity study investigated the feasibility, acceptability, and cost of a new, more comprehensive model of maternity care that encouraged husbands’ participation in their wives’ antenatal and postpartum care. The study was conducted in India, in collaboration with the Employees’ State Insurance Corporation (ESIC), Delhi Directorate at their primary health facilities called dispensaries. The study found that men accompanied their wives to the clinics and participated actively in the intervention. There were significant changes in family planning knowledge and behaviors of both men and women; although there was little acknowledgement of STI risk, knowledge and use of dual …

Opiniones Y Respuestas: Resultados De Una Encuesta De Opinión A Médicos Mexicanos Sobre El Aborto, Diana K. Lara, Lisa Goldman, Michelle Firestone

Reproductive Health

En México es incuestionable el papel crucial que los médicos juegan en la oferta de servicios seguros de aborto legal y en la atención a las mujeres con abortos en evolución, espontáneos o inducidos, y abortos complicados. Sin embargo, ningún estudio dirigido a personal de salud, y específicamente a médicos, se había realizado con una muestra representativa a nivel nacional. Una brecha de ese tipo en la literatura científica justificó la realización, entre julio y agosto de 2002, de una encuesta nacional en la cual se recopiló información sobre los conocimientos y las opiniones de médicos gíneco-obstetras, médicos familiares y …