Medicine and Health Sciences Commons^™

Calcium And Glycolysis Mediate Multiple Bursting Modes In Pancreatic Islets, Richard Bertram, Leslie S. Satin, Min Zhang, Paul Smolen, Arthur Sherman

Pharmacology and Toxicology Publications

Abstract

Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to stimulatory glucose levels. These bursts often have a regular repeating pattern, with a period of 10–60 s. In some cases, however, the bursts are episodic, clustered into bursts of bursts, which we call compound bursting. Consistent with this are recordings of free Ca²⁺ concentration, oxygen consumption, mitochondrial membrane potential, and intraislet glucose levels that exhibit very slow oscillations, with faster oscillations superimposed. We describe a new mathematical model of the pancreatic β-cell that can account for these multimodal patterns. The model includes the feedback of …

A Third Lineage With Two-Piece Tmrna, S. M. Sharkady, K. P. Williams

Pharmaceutical Sciences

No abstract provided.

Intra-Arterial Blood Pressure Characteristics During Submaximal Cycling And Recovery, Julia Orri, S E. Griffin, Robert A. Robergs, David S. James, D R. Wagner, R Quintana

Kinesiology (Formerly Exercise and Sport Science)

The purpose of this study was to measure intra-arterial (IA) blood pressure from rest to steady-state submaximal exercise and immediately post-exercise. Beat-to-beat blood pressure was compared to breath-by-breath VO2 during steady-state and maximal exercise. Fourteen normotensive subjects volunteered. Systolic (SBP), diastolic (DBP) and mean (mBP) blood pressure was measured from rest to steady state during cycling at 45, 60, and 75% maximal power output (POmax). BP was assessed during recovery from VO2peak through 2 min of cycling at 50 W. During the rest to exercise transition, mBP decreased from 103.41 ± 9.4 to 90.1 ± 8.9 mmHg after 11.6 ± …

Estimating The True Prevalence Of Mycobacterium Bovis In Hunter-Harvested White-Tailed Deer In Michigan, Daniel J. O’Brien, Stephen M. Schmitt, Dale E. Berry, Scott D. Fitzgerald, Jolene R. Vanneste, Timothy J. Lyon, Diane Magsig, Jean S. Fierke, Thomas M. Cooley, Laura S. Zwick, Bruce V. Thomsen

Michigan Bovine Tuberculosis Bibliography and Database

Apparent prevalence, although useful as a consistent index, may underestimate the true prevalence of disease. In Michigan, the ability to estimate the true prevalence of bovine tuberculosis (TB; caused by Mycobacterium bovis) in free-ranging white-tailed deer (Odocoileus virginianus) will become increasingly important to accurately assess progress towards eradication. Our objectives were threefold: to estimate the true prevalence of M. bovis in free-ranging deer in Michigan, to evaluate the effectiveness of existing TB surveillance methods, and to indirectly assess whether TB epidemiologic data from captive cervid herds can be meaningfully extrapolated to free-ranging populations. The study population consisted …

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Winter, 2004 edition of the ALHeLa newsletter - Synapse.

Contents include:

• Tracy Powell Recognized
• ALHeLA Executive Committee 2004
• ALHeLA Executive Committee Meeting

International Low Back Pain Guidelines: A Comparison Of Two Research Based Models Of Care For The Management Of Acute Low Back Pain., Benedict Wand, C Bird, James H. Mcauley, Maureen Macdowell, Lorraine H. De Souza

Health Sciences Conference Papers

Evidence based guidelines for the management of acute low back pain (ALBP) have been formulated by numerous countries. There are discrepancies between guidelines regarding physiotherapy treatment.

The aim of this study was to compare two research based models derived from international LBP guidelines. A single-blind randomised controlled trial was undertaken in a physiotherapy outpatients department. Subjects with ALBP were randomly allocated to an ‘assess/advise/treat’ group (n = 50) or an ‘assess/advise/wait’ group (n = 52). The primary outcome measure was the Roland and Morris Disability Questionnaire (RMDQ). Secondary outcome measures of pain (VAS, usual pain intensity) depressive symptoms (MZSRDS) somatic …

Equivalence Study Of A Dental Anatomy Computer-Assisted Learning Program, Russell E. Bogacki, Al M. Best, Louis M. Abbey

Periodontics Publications

Tooth Morphology is a computer-assisted learning program designed to teach the anatomy of the adult dentition. The purpose of this study was to test whether Tooth Morphology could teach dental anatomy to first-year dental students as well as the traditional lecture. A randomized controlled trial was performed with forty-five first-year dental students. The students were randomly assigned to either the Tooth Morphology group (n=23), which used the computer-assisted learning program and did not attend lecture, or the lecture group (n=22), which attended the traditional lecture and did not useTooth Morphology. The Tooth Morphology group had a final exam …

Serine-Threonine Kinases And Transcription Factors Active In Signal Transduction Are Detected At High Levels Of Phosphorylation During Mitosis In Preimplantation Embryos And Trophoblast Stem Cells, Jian Liu, Elizabeth E. Puscheck, Fangfei Wang, Anna Trostinskaia, Dusan Barisic, Gordon Maniere, Dana Wygle, W Zhong, Edmond Hhm Rings, Daniel A. Rappolee

Department of Obstetrics and Gynecology Research Publications

Serine-threonine kinases and transcription factors play important roles in the G1-S phase progression of the cell cycle. Assays that use quantitative fluorescence by immunocytochemical means, or that measure band strength during Western blot analysis, may have confused interpretations if the intention is to measure G1-S phase commitment of a small subpopulation of phosphorylated proteins, when a larger conversion of the same population of proteins can occur during late G2 and M phases. In mouse trophoblast stem cells (TSC), a human placental cell line (HTR), and/or mouse preimplantation embryos, 8/19 ser- ine-threonine and tyrosine kinases, 3/8 transcription factors, and 8/14 phospho …

Cancer Among Arab Americans In The Metropolitan Detroit Area, Kendra L. Schwartz, Anahid Kulwicki, Linda K. Weiss, Haifa Fakhouri, Wael Sakr, Gregory Kau, Richard K. Severson

FMPHS Faculty Publications

Detroit is home to one of the largest populations of Arab Americans outside of the Middle East, yet little is known about the cancer distribution in this ethnic group. The authors of this study created an Arab/Chaldean surname list and matched it with the Detroit SEER Registry to identify cancer cases of probable Arabic descent. We then determined proportional incidence ratios (PIR) for specific cancer sites among metropolitan Detroit Arab Americans as compared to non-Arab Whites, and contrasted the results with Middle Eastern data. Arab/Chaldean men had greater proportions of leukemia (29%), multiple myeloma (46%), liver (64%), kidney (33%), and …

Value-Based Nursing Education, Nancy L. Fahrenwald, Susan D. Bassett, Lois Tschetter, Paula P. Carson, Lani White, Venita J. Winterboer

Bush Project Anthology

Curriculum guidelines from the American Association of Colleges of Nursing ( [ AACN], 1998) espouse that baccalaureate programs facilitate the development of professional values. The five core nursing values include human dignity, integrity, autonomy, altruism, and social justice. Behaviors that reflect these values characterize the caring, professional nurse (AACN, 1998). Teaching attitudes and actions that facilitate caring is a curriculum challenge. Caring is a multi-dimensional nursing concept that can be actualized through purposeful teaching and student-centered learning of core nursing values. This scholarly paper presents an innovative and integrative approach to value-based education in the baccalaureate nursing program at South …

Palifermin For Oral Mucositis After Intensive Therapy For Hematologic Cancers, Ricardo Spielberger, Patrick Stiff, William Bensinger, Teresa Gentile, Daniel Weisdorf, Tarun Kewalramani, Thomas Shea, Saul Yanovich, Keith Hansen, Stephen Noga, John Mccarty, C. Frederick Lemaistre, Eric C. Sung, Bruce R. Blazar, Dieter Elhardt, Mon-Gy Chen, Christos Emmanouilides

Internal Medicine Publications

BACKGROUND: Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment. We tested the ability of palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy. METHODS: This double-blind study compared the effect of palifermin with that of a placebo on the development of oral mucositis in 212 patients with hematologic cancers; 106 patients received palifermin (60 microg per kilogram of body weight per day) and 106 received a placebo intravenously for three consecutive days immediately before the initiation of conditioning therapy (fractionated total-body irradiation plus high-dose chemotherapy) and after autologous …

Ten Years’ Experience With Alendronate For Osteoporosis In Postmenopausal Women, Henry G. Bone, David Hosking, Jean-Pierre Devogelaer, Joseph R. Tucci, Ronald D. Emkey, Richard P. Tornino, Jose A. Rodriguez-Portales , M.D., Robert W. Downs, Jayanti Gupta, Arthur C. Santora, Uri A. Liberman

Internal Medicine Publications

Background

Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized, double-blind study, in which postmenopausal women with osteoporosis were treated with alendronate for up to 10 years.

Methods

The initial three-year phase of the study compared three daily doses of alendronate with placebo. Women in the original placebo group received alendronate in years 4 and 5 and then were discharged. Women in the original active-treatment groups continued to receive alendronate during the initial extension (years 4 and 5). In two further extensions (years 6 and 7, and 8 through 10), women who had …

Public-Access Defibrillation And Survival After Out-Of-Hospital Cardiac Arrest, Alfred Hallstrom, Joseph P. Ornato

VCU Health Publications

BACKGROUND

The rate of survival after out-of-hospital cardiac arrest is low. It is not known whether this rate will increase if laypersons are trained to attempt defibrillation with the use of automated external defibrillators (AEDs).

Full Text of Background...

METHODS

We conducted a prospective, community-based, multicenter clinical trial in which we randomly assigned community units (e.g., shopping malls and apartment complexes) to a structured and monitored emergency-response system involving lay volunteers trained in cardiopulmonary resuscitation (CPR) alone or in CPR and the use of AEDs. The primary outcome was survival to hospital discharge.

Full Text of Methods...

RESULTS

More than …

Meeting The Challenges And Opportunities Of Aging With Lifelong Disabilities: The Area Planning And Services Committee, Allison Wilder, Edward F. Ansello

Case Studies from Age in Action

Educational Objectives

1. To generate awareness of needs and capacities of aging adults with lifelong disabilities and their effect upon human services

2. To understand the challenges and opportunities facing aging adults with lifelong disabilities in accessing appropriate community supports and services.

3. To illustrate the benefits of intersystem collaboration among human services providers through the vehicle of an Area Planning and Services Committee.

Mental Fitness And The Lifelong Learning Movement, Jane F. Stephan, Debbie Leidheiser, Edward F. Ansello

Case Studies from Age in Action

Educational Objectives

1. To identify the functional benefits of continued mental activity

2. To examine the role of Lifelong Learning Institutes in later life

3. To describe the motivations of participants in lifelong learning

Law Enforcement And Adult Protective Services Working Together: A Team Approach To Elder Abuse Cases, Anne Douglas Palmer

Case Studies from Age in Action

Educational Objectives

1. Familiarize readers with the different roles and responsibilities of Adult Protective Services and law enforcement in elder abuse cases.

2. Demonstrate the benefits of working collaboratively to resolve complex elder abuse and domestic violence cases.

Congregate Nutrition Programs Can Alleviate Loneliness And Isolation, Carol Cooper Driskill

Case Studies from Age in Action

Educational Objectives

1. Familiarize readers with the Older Americans Act congregate nutrition services provided to community-residing older adults.

2. Demonstrate how congregate nutrition services can alleviate isolation and loneliness in community-residing older adults.

The Surgical Infection Society Guidelines On Antimicrobial Therapy For Intra-Abdominal Infections: An Executive Summary, John E. Mazuski, Robert G. Sawyer, Avery B. Nathens, Joseph T. Dipiro, Moshe Schein, Kenneth A. Kudsk, Charles Yowler

Publications from the Office of the Dean

The Surgical Infection Society last published guidelines on antimicrobial therapy for intra-abdominal infections in 1992 (Bohnen JMA, et al., Arch Surg 1992;127:83-89). Since then, an appreciable body of literature has been published on this subject. Therefore, the Therapeutics Agents Committee of the Society undertook an effort to update the previous guidelines, primarily using data published over the past decade. An additional goal of the Committee was to characterize its recommendations according to contemporary principles of evidence-based medicine. To develop these guidelines, the Committee carried out a systematic search for all English language articles published between 1990 and 2000 related to …

Aminoglycosides For Intra-Abdominal Infection: Equal To The Challenge?, John A. Bailey, Katherine S. Virgo, Joseph T. Dipiro, Avery B. Nathens, Robert G. Sawyer, John E. Mazuski

Publications from the Office of the Dean

Background: Aminoglycosides, combined with antianaerobic agents, have been used widely for the treatment of intra-abdominal infection. However, some prospective randomized controlled trials and other data suggested that aminoglycosides were less efficacious than newer comparators for the treatment of these infections. We therefore performed a meta-analysis of all prospective randomized controlled trials utilizing aminoglycosides to reevaluate the efficacy of these agents for the treatment of intra-abdominal infection.

Methods: Published English-language prospective randomized controlled trials comparing aminoglycosides with other agents for treatment of intra-abdominal infection were identified by MEDLINE search. For each study, data were collected regarding the number of …

The Surgical Infection Society Guidelines On Antimicrobial Therapy For Intra-Abdominal Infections: Evidence For The Recommendations, John E. Mazuski, Robert G. Sawyer, Avery B. Nathens, Joseph T. Dipiro, Moshe Schein, Kenneth A. Kudsk, Charles Yowler

Publications from the Office of the Dean

Revised guidelines for the use of antimicrobial therapy in patients with intra-abdominal infections were recently developed by the Therapeutic Agents Committee of the Surgical Infection Society (Mazuski et al., Surg Infect2002;3:161-173). These were based, insofar as possible, on evidence published over the past decade. The objective of this document is to describe the process by which the Committee identified and reviewed the published literature utilized to develop the recommendations and to summarize the results of those reviews. English-language articles published between 1990 and 2000 related to antimicrobial therapy for intra-abdominal infections were identified by a systematic MEDLINE search and …

Communicating Severity Of Hazard With The Signal Word On A Safety Sign, Roger C. Jensen, Andrew M. Mccammack

Safety Health & Industrial Hygiene

An experiment examined five signal words on safety signs for effectiveness at communicating information about severity of a hazard. Perceived severity was rated by 59 college students for the signal words Deadly, Danger, Warning, Caution, and Notice. Results indicated that Deadly communicated the highest ratings for severity. Danger was second. Warning and Caution were tied for third. The lowest ratings were for Notice.

Comparison Of Student Versus Employee Test Populations For Warning Sign Research Based On Severity Ratings For Signal Words, Scott Thomas, Roger C. Jensen

Safety Health & Industrial Hygiene

Most studies of warning signs involve undergraduate students as subjects. This paper reports a direct comparison of findings from an undergraduate population and an employed population. The 48 employed subjects from this study were compared with 59 undergraduate subjects from a companion study. Subjects from both populations were shown the same signs and asked to rate the severity level connoted by each sign. The signs differed only in signal word. Results for each population indicated that signal word had a highly significant effect on severity ratings. When the two populations were compared for ratings of each signal word, the only …

Does Spiritual Care Really Help? A Study Of Patient’S Perceptions, Charlotte Stephenson, Kaye Wilson-Anderson

Faculty Publications - College of Nursing

Microwaves, drive-through windows, cell phones, e-mail, Internet high-ways- fast, faster, fastest. These gadgets reflect the world of the 21st century in which we live. Nursing, too, has moved with these changing cultural norms, becoming compressed and high speed. However, the essence of people, the clients we care for, has remained that of heart-felt needs and a thirst for spiritual peace. How do we as nurses meet the demands of today’s increased patient care loads, unending paperwork and longer hours, yet still meet our clients’ spiritual needs?

Information Interface - Volume 32, Issue 1 - January/February 2004, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on offsite journals, added features to MEDLINE/PubMed, new journal titles, and database search tips.

Women Who Gamble, Hannah Rb Heritage

Graduate Research Papers

Understanding the differences between the male compulsive gambler and the female compulsive gambler can play an important role in the healing process of the female compulsive gambler. This manuscript describes these differences and discusses treatment methods and issues specific to the female pathological gambler including the Twelve Step program for gamblers and cognitive treatment methods. The co-occurrence of other addictions and mental health issues are also examined.

Comparison Of Surface Electromyography And Myotonometric Measurements During Voluntary Isometric Contractions, Charles Leonard, Jason S. Brown, Timothy R. Price, Susan A. Queen, Eugene L. Mikhailenok

Physical Therapy and Rehabilitation Science Faculty Publications

Objectives: Muscle stiffness increases during muscle contraction.The purpose of this study was to determine the strength of the correlation between myotonometric measurements of muscle stiffness and surface electromyography (sEMG) measurements during various levels of voluntary isometric contractions of the biceps brachii muscle. Subjects: Eight subjects (four female; four male), with mean age of 30:6 ± 8:23 years, volunteered to participate in this study. Methods: Myotonometer and sEMG measurements were taken simultaneously from the right biceps brachii muscle.Data were obtained: (1) at rest, (2) while the subject held a 15 lb (6.8 kg) weight isometrically and, (3) during a maximal voluntary …

Occupational Therapy Program 2004, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Fluorometric Measurements Of Conformational Changes In Glutamate Transporters, H. Peter Larsson, Anastassios V. Tzingounis, Hans-Peter Koch, Michael Kavanaugh

Biomedical and Pharmaceutical Sciences Faculty Publications

Glutamate transporters remove glutamate from the synaptic cleft to maintain efficient synaptic communication between neurons and to prevent extracellular glutamate concentrations from reaching neurotoxic levels (1). It is thought that glutamate transporters mediate glutamate transport through a reaction cycle with conformational changes between the two major access states that alternatively expose glutamate-binding sites to the extracellular or to the intracellular solution. However, there is no direct real-time evidence for the conformational changes predicted to occur during the transport cycle. In the present study, we used voltage-clamp fluorometry to measure conformational changes in the neuronal excitatory amino acid transporter …

I Don't Care If I Ever Get Back: Marathons Lasting 20 Or More Innings, Phil Lowry, Darren B. Glass

Math Faculty Publications

This article looks at marathon games of baseball. For purposes of this article, a marathon is defined as a game lasting 20 or more innings. In my research I have discovered 341 marathons. These games are hard to find. Leagues either keep no records, or keep track only of their longest game; only the Texas League keeps records on all marathons. Nobody has ever before explored such questions as: What is the probability a game will go x number of innings? How often should we expect a marathon of 20 or more innings, or 40 or more innings? What is …

College Of Pharmacy Student Handbook June 2004, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.