Medicine and Health Sciences Commons^™

Multiple Testing And Data Adaptive Regression: An Application To Hiv-1 Sequence Data, Merrill D. Birkner, Sandra E. Sinisi, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Analysis of viral strand sequence data and viral replication capacity could potentially lead to biological insights regarding the replication ability of HIV-1. Determining specific target codons on the viral strand will facilitate the manufacturing of target specific antiretrovirals. Various algorithmic and analysis techniques can be applied to this application. We propose using multiple testing to find codons which have significant univariate associations with replication capacity of the virus. We also propose using a data adaptive multiple regression algorithm to obtain multiple predictions of viral replication capacity based on an entire mutant/non-mutant sequence profile. The data set to which these techniques …

The Provider System For Children's Mental Health: Workforce Capacity And Effective Treatment, Jane Koppelman

National Health Policy Forum

This issue brief examines two issues that are key to meeting children’s unmet needs for mental health care: ensuring that the provider supply is adequate and that the care delivered is effective. It describes the shortage of qualified providers to address children’s mental disorders, as well its possible causes; it describes how managed care, to a certain extent, drives practice patterns; and it discusses the gray areas in deciding which providers are most qualified to deliver what care. In addition, this paper introduces what is known about evidence-based care in children’s mental health, the extent to which it is being …

Myelin Proteolipid Protein-Specific Cd4+ Cd25+ Regulatory Cells Mediate Genetic Resistance To Experimental Autoimmune Encephalomyelitis, Jay Reddy, Zsolt Illés, Xingmin Zhang, Jeffrey Encinas, Jason Pyrdol, Lindsay Nicholson, Raymond A. Sobel, Kai W. Wucherpfennig, Vijay K. Kuchroo, James P. Allison

Jay Reddy Publications

SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139–151, whereas H-2 congenic B10.S mice are resistant. Immunodominance and susceptibility to EAE are associated with a high precursor frequency of PLP 139–151-specific T cells in the naive repertoire of SJL mice. To understand the mechanism of EAE resistance in B10.S mice, we determined the precursor frequency of PLP 139–151-reactive T cells in both strains by using IA^s/PLP 139–151 tetramers. SJL and B10.S mice had similar frequencies of tetramer-reactive T cells in the naive peripheral repertoire. However, in SJL mice, the …

Licensed Electrician Dies When Electrocuted By 480volts, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On July 4, 2003, a 36-year-old male lead electrician died after being electrocuted with 480 volts of electricity. A crew of five licensed electricians were working at an automotive supply manufacturing facility running wires to connect service for two air conditioning units (3-phase; 480 volts; 30 amp and 35 amp) and service for a lighting panel (3-phase; 277/480 volts and 200 amps). The manufacturing facility had been shut down for the holiday, and besides a facilities office worker in the facilities main office, the five men were the only workers at the site and had complete control of the facility …

Cytokines And Synthetic Double-Stranded Rna Augment The T Helper 1 Immune Response Of Swine To Porcine Reproductive And Respiratory Syndrome Virus, William A. Meier, Robert J. Husmann, William M. Schnitzlein, Fernando A. Osorio, Joan K. Lunney, Federico A. Zuckermann

School of Veterinary and Biomedical Sciences: Faculty Publications

Immunization of pigs with a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine initially elicits a weak interferon (IFN)-γ response. To improve the immune response, an adjuvant consisting of plasmid encoding either porcine interleukin (IL)-12 or IFN-α was co-administered during vaccination. In the presence of either adjuvant, at least a threefold increase in the primary virus-specific IFN-γ response was observed. While this enhancement was only transient (1 week) when the IL-12 expressing plasmid was used, the effect was not only still apparent at 6 weeks after vaccination in the presence of the IFN-α expressing plasmid but even after …

Data Adaptive Estimation Of The Treatment Specific Mean, Yue Wang, Oliver Bembom, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

An important problem in epidemiology and medical research is the estimation of the causal effect of a treatment action at a single point in time on the mean of an outcome, possibly within strata of the target population defined by a subset of the baseline covariates. Current approaches to this problem are based on marginal structural models, i.e., parametric models for the marginal distribution of counterfactural outcomes as a function of treatment and effect modifiers. The various estimators developed in this context furthermore each depend on a high-dimensional nuisance parameter whose estimation currently also relies on parametric models. Since misspecification …

Semiparametric Methods For The Binormal Model With Multiple Biomarkers, Debashis Ghosh

The University of Michigan Department of Biostatistics Working Paper Series

Abstract: In diagnostic medicine, there is great interest in developing strategies for combining biomarkers in order to optimize classification accuracy. A popular model that has been used when one biomarker is available is the binormal model. Extension of the model to accommodate multiple biomarkers has not been considered in this literature. Here, we consider a multivariate binormal framework for combining biomarkers using copula functions that leads to a natural multivariate extension of the binormal model. Estimation in this model will be done using rank-based procedures. We also discuss adjustment for covariates in this class of models and provide a simple …

Native Health Database Information Services Project, Indian Health Service 1997-2004, Unm Health Sciences Library & Informatics Center

Native Health Database project records

Report on NHD activities from 1997-2004.

Ada News - 10/18/2004, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Update On Diabetes Mellitus, Murray Korc

Dartmouth Scholarship

Diabetes mellitus is a complex multi-system disorder that may be classified as autoimmune mediated type 1 diabetes, or as insulin resistance associated type 2 diabetes. In type 1 diabetes, there is selective loss of the beta cells within the endocrine islets, as a consequence of T-cell and cytokine mediated destruction of these cells, perhaps in conjunction with destruction of the peri-islet Schwann cells. In type 2 diabetes, the etiology of the resistance ranges from post-receptor defects in the insulin signaling pathway to excessive production of adipocyte derived cytokines that antagonize insulin action to mitochondrial defects that interfere with glucose disposal. …

Electrohydraulic High-Energy Shock-Wave Treatment For Chronic Plantar Fasciitis, John A. Ogden, Richard G. Alvarez, Richard L. Levitt, Jeffrey E. Johnson, Marie E. Marlow

Open Access Publications

No abstract provided.

Ada News - 10/04/2004, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Technology For Humanitarian Action, Kevin M. Cahill, M.D.

Institute of International Humanitarian Affairs

Humanitarian workers around the world struggle under dangerous conditions. Yet many do not have the technological tools readily available elsewhere to help them realize their mission to provide essential services and save lives.

This book, the fruit of a historic conference, is a practical guide to current technologies that can help relief and humanitarian aid workers succeed. Designed to facilitate needed technology transfer to the humanitarian sector, the essays focus on areas where technology is underused and predict where new technological advances may be applied to relief efforts.

The essays cover essential areas: communications technology and infrastructure support and security. …

Healthnet News V.19:No.3/4 Fall/Winter 2004, Judith S. Kronick, Alberta Richetelle

Articles - Patient Care

A newsletter for public librarians and others interested in consumer health information services.

Mainecare Managed Care Performance Report 2003, Catherine Ormond, Stuart Bratesman

Disability & Aging

No abstract provided.

The Association Of Radial Deficiency With Thumb Hypoplasia, Michelle A. James, Hillary D. Green, H. Relton Mccarroll Jr., Paul R. Manske

Open Access Publications

No abstract provided.

Evaluating Uranium Depth Versus Socio-Economic Statistics For Residential Radon Vulnerability In Warren County, Kentucky, Anthony Iovanna

Masters Theses & Specialist Projects

Residences in Warren County, Kentucky, are characterized by high levels of residential radon, which is one of the radioactive daughter products of uranium. According to the United States Environmental Protection Agency (US EPA), radon exposure causes approximately 22,000 lung cancer deaths in the United States per year. The City of Bowling Green, in Warren County, is underlain by karst, an easily soluble limestone subsurface, which allows radon gas to travel easily through cracks and fissures. Carbonate rocks under Bowling Green are underlain by the Devonian Chattanooga Shale, a low-grade uranium ore and a potential source of radon gas. A digital …

Ua61/6 Newsletter Issue 4, Wku Institute For Rural Health Development & Research

WKU Administration Documents

Newsletter created by and about the Institute for Rural Health Development & Research. This issue contains:

• Simpson, Staci. Letter from the Director
• Institute for Rural Health Development & Research Impact Statement
• Mobile Health Unit Conference Attended
• WKU Mobile Health & Wellness Unit
• Kentucky State Fair Project
• Health House of Horrors
• Wilson, Richard. Faculty Presents at American Public Health Association Conference
• New Interdisciplinary Program: WellWorks
• Health Fair Event for Migrant Workers Held
• Local Interventions to Encourage the Enhancement of the Health of the Rural Elderly
• Jones, Susan. Predicting the Use of Personal Respiratory Protection Among Workers in Swine Confinement Buildings
• The …

Ua61 Newsletter, Wku Health & Human Services

WKU Administration Documents

Newsletter created by and about the College of Health & Human Services.

• Bonaguro, John. Letter from the Dean
• WKU Clinical Education Complex Moves Forward
• College Welcomes New Associate Dean – Sylvia Gaiko
• Visiting Scholar from Bournemouth University, England – Mandy Rumley
• Partners Key to Successful Hispanic Health Fair & Screening Event
• Area Health Education Centers (AHEC) 4-H Program
• Hispanic Initiative Gets $700K in Funding
• American Humanics Program Implemented at WKU
• CHHS Focuses on Gerontology
• Gerontologist Dr. John Krout Visits WKU
• Rural Elderly Advocacy Program with Students (REAPS)
• Kentucky Emergency Medical Services Academy Offers EMS Management Workshops
• A Day to Give …

Clinical Presentation Of Thyroid Cancer Patients In Pakistan--Akuh Experience, L M. Zuberi, A Yawar, N Islam, A Jabbar

Section of Diabetes, Endocrinology and Metabolism

Objective: To asses the clinical presentation of patients with thyroid cancer, their preferred diagnostic work-up and preferred surgical procedure.

Methods: A retrospective chart review of patients that underwent partial or total thyroidectomy for thyroid cancer at AKUH between 1989 and 2002. SPSS was used to analyze data. Pearson's chi square and likelihood ratios used to calculate tests of significance.

Results: A total of 97 patients were included in this review. Solitary thyroid nodule was the initial presentation in three. Majority (58.7%) presented with "neck swelling" or enlarging goiter. One out of every 3 patients showed evidence of lymph …

The Review - Fall 2004

Jefferson Review

In This Issue

• 3 - Message From the Dean
• 4 - Special Occasions
• 4 - Supporting JCHP Through Online Giving
• 5 - Check Out The New Jefferson Bookstore
• 6 - Jefferson Welcomes New President
• 10 - Staff Changes at JCHP
• 11 - JCHP Dean Named Honorary Professor
• 12 - 30 Years of Nursing at JCHP
• 14 - Nursing Memories
• 15 - Nursing Faculty Member Awarded Nightingale Award
• 15 - JCHP Grad Student Wins Award
• 16 - Summer Science Camp Called a Success
• 17 - OT Helps Children with Sensory Integration
• 18 - Jefferson Debuts DPT
• 18 - RS Student Takes …

Nurses Alumni Association Bulletin, Fall 2004, Paula Levine, Elizabeth K. Prisnock, Sally H. Wagner, John J. Wagner

Nursing Alumni Bulletins

2004 - 2005 Meeting Date Calendar

2005 Annual Luncheon & Meeting Notice

Officers, Committee Chairs, Satellite and Volunteers

Bulletin Publication Committee

The President's Message

Treasurer's Report

Resume of Minutes

Other Scholarships Awarded

Office News

Committee Reports

• Bulletin
• Satellite - Harrisburg Satellite Area
• Relief Trust Fund
• Scholarship
• Nominating
• Development

Annual Giving

Janet C. Hindson Award Recipients and Nominees

Janet C. Hindson Award Qualifications

News About Graduates

Headache Research

Memoirs

Odds & Ends

My Aunt

Bacone College

Mother's Letter

Happy Birthday, To Be 80 or more

Madeline M. Ullom Dedication

50th Anniversary Class

Center page

Luncheon Attendees

Class News

Scholarship Fund Application …

New And Improved Micromedex Poster

Library Posters

No abstract provided.

Workers Crushed By Vehicles, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

To prevent motor vehicle repair injuries:

• Ensure that vehicles are positively restrained from moving with chocks.
• Do not place jack stands under potential moving vehicle parts.
• The space under a jack-suspended vehicle should not be entered unless suitable vehicle support stands are utilized.

Trabajadores Aplastados Por Vehículos, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

Para prevenir lesiones relacionadas con la reparación de automotores:

1. Asegúrese de que los vehículos estén firmemente inmovilizados con tacos.
2. No coloque los soportes bajo partes del vehículo que se puedan mover.
3. No se debe ocupar el espacio entre un vehículo suspendido con gato y el suelo a menos que se haga uso de bases de soporte adecuadas para el mismo.

Cystic Breast Lymphangioma, S N. Waqar, H Khan, S F. Mekan, N Kayani, A J. Raja

Department of Biological & Biomedical Sciences

No abstract provided.

Fall 2004, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Fall 2004

Relationship Of Serum Prolactin With Severity Of Drug Use And Treatment Outcome In Cocaine Dependence., Ashwin A. Patkar, Paolo Mannelli, Kenneth M. Certa, Kathleen Peindl, Heather Murray, Michael J. Vergare, Wade H. Berrettini

Department of Psychiatry and Human Behavior Faculty Papers

RATIONALE: Alteration in serum prolactin (PRL) levels may reflect changes in central dopamine activity, which modulates the behavioral effects of cocaine. Therefore, serum PRL may have a potential role as a biological marker of drug severity and treatment outcome in cocaine dependence.

OBJECTIVE: We investigated whether serum PRL levels differed between cocaine-dependent (CD) subjects and controls, and whether PRL levels were associated with severity of drug use and treatment outcome in CD subjects.

METHODS: Basal PRL concentrations were assayed in 141 African-American (AA) CD patients attending an outpatient treatment program and 60 AA controls. Severity of drug use was assessed …

Inside Unlv, Diane Russell, Carol C. Harter, Cate Weeks, Cayrn Key

Inside UNLV

No abstract provided.

Felix Platter: A Sixteenth-Century Medical Student, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.