Medicine and Health Sciences Commons^™

Hearing Screening With Otoacoustic Emissions In Pediatric Outpatient Facilities : Ages Birth Through Five, Jordan King

Independent Studies and Capstones

This paper discusses the use of otoacoustic emissions (OAEs) in performing outpatient hearing screening for children, birth to age five.

Diagnosis And Management Of Auditory Neuropathy/Dys-Sychrony, Erika Knox

Independent Studies and Capstones

This paper discusses auditory neuropathy (AN) and auditory dys-sychrony (AD), and means of testing and diagnosis.

Understanding Cochlear Implants: A Guide For Parents And Educators, Lauren Pfaender

Independent Studies and Capstones

This paper discusses the development of a guidebook for parents and teachers of children with cochlear implants.

Central Auditory Processing: A Current Literature Review And Summary Of Interviews With Researchers On Controversial Issues Related To Auditory Processing Disorders, Anne E. Matson

Independent Studies and Capstones

This paper discusses issues related to Auditory Processing Disorders (ADP) evaluation and management, focusing mainly on the disorder in children.

Comparative Study Of The Gaze Stabilization Test (Gst) And The Dynamic Visual Acuity Test (Dvat) For Detecting Patients With Unilateral Vestibular Dysfunction, Jaime Carmody

Independent Studies and Capstones

This paper compares the use of two diagnostic tests, Gaze Stabilization Test (GST) and the Dynamic Visual Acuity Test (DVAT) to detect unilateral vestibular dysfunction.

Objective Validation Of Behavioral Maps In Children With Advanced Bionics Cochlear Implants, Jamie Hayden Cadieux

Independent Studies and Capstones

This paper studies the relationship between behavioral and objective measures used to program cochlear implants in pre-linguistically deafened children.

Occurence Of Autism Spectrum Disorder In The Hearing-Impaired Population: How To Achieve Earlier Diagnosis, Laura Elizabeth Saia

Independent Studies and Capstones

This paper discusses the incidence of hearing impaired children with Autism Spectrum Disorder and methods of diagnosis.

The Relationship Of Language Development To Theory Of Mind Understanding In Young Deaf Children, Bethany Lyn Gehrlein

Independent Studies and Capstones

This paper studies cognitive development in young deaf children, specifically Theory of Mind development and its link to language abilities.

Emotion Perception In Pre-Kindergarten School Children At Central Institute For The Deaf, Amanda Ruth Shinall

Independent Studies and Capstones

This paper studies the ability of pre-kindergarten students with both normal hearing and impaired hearing to identify emotions in speech through audition only. In addition, the study assesses whether a listener's familiarity with a speaker's voice has an effect on his/her ability to identify the emotion of the speaker.

Phonological Awareness In Children Who Are Deaf/Hard Of Hearing, Susan Corine Theobald

Independent Studies and Capstones

This paper examines the phonological awareness skills of young children who are hearing impaired through rime identification and onset detection.

Identification Of Factors Predicting Spoken Language Development In Young Children With A Cochlear Implant, Dena Michele Witkin

Independent Studies and Capstones

This paper examines the factors that are significant predictors of spoken language acquisition in children with cochlear implants. Factors identified include age of cochlear implantation, age of diagnosis, age started hearing aid use, parent educational level, and family income.

Newborn Hearing Screening: Examining The Presence Of Risk Factors For Hearing Loss, Andrea Marie Golfin

Independent Studies and Capstones

This paper identifies risk factors associated with hearing loss in newborns, including family history, craniofacial abnormalities, and ototoxic medications.

Mitochondrial Dna Mutations, Apoptosis, And The Misfolded Protein Response., Justin L. Mott, Dekui Zhang, Hans Peter Zassenhaus

Journal Articles: Biochemistry & Molecular Biology

Studies of transgenic mice with accelerated accumulation of mtDNA mutations specifically in the heart lead us to propose that apoptotic signaling and cell death is central to the pathogenesis of mtDNA mutations in aging. It is the cellular response to that apoptotic signaling and the organ?s compensatory response to a loss of cells that specify the phenotype of an accumulation of mtDNA mutations. In the heart, cardiomyocytes induce a vigorous anti-apoptotic, pro-survival response to counteract mitochondrial apoptotic signaling. The heart up-regulates contractility of remaining myocytes in order to maintain cardiac output. We hypothesize that mutant mitochondrial proteins originate apoptotic signaling …

Enhancing The Geriatric Competence Of Urologic Nurses, Karen A. Karlowicz

Ellmer School of Nursing Faculty Publications

Editorial. Provides strategies for enhancing the geriatric competence of urologic nurses. Improvements in nursing practice and in other health care professions; Considerations in caring for older adults; Implications for nursing practice.

Duration Of Streptozotocin-Induced Diabetes Differentially Affects P38-Mitogen-Activated Protein Kinase (Mapk) Phosphorylation In Renal And Vascular Dysfunction, H. Chen, S. Brahmbhatt, A. Gupta, Avadhesh C. Sharma

PCOM Scholarly Works

Background: In the present study we tested the hypothesis that progression of streptozotocin (STZ)-induced diabetes (14-days to 28-days) would produce renal and vascular dysfunction that correlate with altered p38- mitogen-activated protein kinase (p38-MAPK) phosphorylation in kidneys and thoracic aorta. Methods: Male Sprague Dawley rats (350-400 g) were randomized into three groups: sham (N = 6), 14-days diabetic (N = 6) and 28-days diabetic rats (N = 6). Diabetes was induced using a single tail vein injection of STZ (60 mg/kg, I.V.) on the first day. Rats were monitored for 28 days and food, water intake and plasma glucose levels were …

The Use Of Time-Resolved Fluorescence Imaging In The Study Of Protein Kinase C Localisation In Cells., Christopher D Stubbs, Stanley W Botchway, Simon J Slater, Anthony W Parker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Two-photon-excitation fluorescence lifetime imaging (2P-FLIM) was used to investigate the association of protein kinase C alpha (PKCalpha) with caveolin in CHO cells. PKCalpha is found widely in the cytoplasm and nucleus in most cells. Upon activation, as a result of increased intracellular Ca2+ and production of DAG, through G-protein coupled-phospholipase C signalling, PKC translocates to a variety of regions in the cell where it phosphorylates and interacts with many signalling pathways. Due to its wide distribution, discerning a particular interaction from others within the cell is extremely difficult. RESULTS: Fluorescence energy transfer (FRET), between GFP-PKCalpha and DsRed-caveolin, was used …

Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel, N. B. O'Mara

School of Pharmacy Faculty Articles

No abstract provided.

Seasonal Affective Disorder (Sad) Light Therapy, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Isosorbide Dinitrate Plus Hydralazine In Blacks With Heart Failure, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Association Between Coinfection Of Porphyromonas Gingivalis, Actinobacillus Actinomycetemcomitans And Treponema Denticola And Periodontal Tissue Destruction In Chronic Periodontitis, L. L. Chen, Y. M. Wu, J. Yan, W. L. Sun, Y. Z. Sun, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

No abstract provided.

Global Gene Expression Profiling Of Cells Overexpressing Smc3., Giancarlo Ghiselli, Chang-Gong Liu

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: The Structural Maintenance of Chromosome 3 protein (SMC3) plays an essential role during the sister chromatid separation, is involved in DNA repair and recombination and participates in microtubule-mediated intracellular transport. SMC3 is frequently elevated in human colon carcinoma and overexpression of the protein transforms murine NIH3T3 fibroblasts. In order to gain insight into the mechanism of SMC3-mediated tumorigenesis a gene expression profiling was performed on human 293 cells line stably overexpressing SMC3. RESULTS: Biotinylated complementary RNA (cRNA) was used for hybridization of a cDNAmicroarray chip harboring 18,861 65-mer oligos derived from the published dEST sequences. After filtering, the hybridization …

Etiology Of Oral Disease In View Of Microbial Complexity, Anne C. R. Tanner, Jacques Izard

Department of Food Science and Technology: Faculty Publications

The number of different microorganisms recognized in the oral cavity using molecular methods has more than doubled compared with the number isolated using cultural techniques. This finding necessitates a reevaluation of which species may be pathogens in dental infections. Molecular methods used to determine microbial diversity include broad range target Polymerase Chain Reaction with ‘universal primers,’ and cloning amplicons or denaturing gradient gel electrophoresis to separate DNA fragments before sequencing. These molecular methods have clarified and expanded the taxonomy of oral microbial species. Discrepancies between comprehensive molecular and cultural methods suggest that neither method alone can adequately evaluate associations of …

Antigenicity And Immunogenicity Of A Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein, Feng Gao, Eric A. Weaver, Zhongjing Lu, Yingying Li, Hua-Xin Liao, Benjiang Ma, S. Munir Alam, Richard M. Scearce, Laura L. Sutherland, Jae-Sung Yu, Julie M. Decker, George M. Shaw, David C. Montefiori, Bette T. Korber, Beatrice H. Hahn, Barton F. Haynes

Nebraska Center for Virology: Faculty Publications

Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine development. To decrease the genetic distances between candidate immunogens and field virus strains, we have designed and synthesized an artificial group M consensus env gene (CON6 gene) to be equidistant from contemporary HIV-1 subtypes and recombinants. This novel envelope gene expresses a glycoprotein that binds soluble CD4, utilizes CCR5 but not CXCR4 as a coreceptor, and mediates HIV-1 entry. Key linear, conformational, and glycan-dependent monoclonal antibody epitopes are preserved in CON6, and the glycoprotein is recognized equally well by sera from individuals infected with different HIV-1 …

Antigenicity And Immunogenicity Of A Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein, Feng Gao, Eric A. Weaver, Zhongjing Lu, Yingying Li, Hua-Xin Liao, Benjiang Ma, S. Munir Alam, Richard M. Scearce, Laura L. Sutherland, Jae-Sung Yu, Julie M. Decker, George M. Shaw, David C. Montefiori, Bette T. Korber, Beatrice H. Hahn, Barton F. Haynes

Nebraska Center for Virology: Faculty Publications

Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine development. To decrease the genetic distances between candidate immunogens and field virus strains, we have designed and synthesized an artificial group M consensus env gene (CON6 gene) to be equidistant from contemporary HIV-1 subtypes and recombinants. This novel envelope gene expresses a glycoprotein that binds soluble CD4, utilizes CCR5 but not CXCR4 as a coreceptor, and mediates HIV-1 entry. Key linear, conformational, and glycan-dependent monoclonal antibody epitopes are preserved in CON6, and the glycoprotein is recognized equally well by sera from individuals infected with different HIV-1 …

Cutting Edge: Cd4+Cd25+ Regulatory T Cells Contribute To Gender Differences In Susceptibility To Experimental Autoimmune Encephalomyelitis, Jay Reddy, Hanspeter Waldner, Xingmin Zhang, Zsolt Illes, Kai W. Wucherpfennig, Raymond A. Sobel, Vijay K. Kuchroo

Jay Reddy Publications

Female B10.S mice are highly resistant to proteolipid protein (PLP) 139–151-induced experimental autoimmune encephalomyelitis (EAE) and depletion of PLP 139–151- reactive CD4+CD25+regulatory T (Treg) cells can slightly increase their EAE susceptibility. Although male B10.S mice are moderately susceptible to EAE, we report that depletion of Treg cells in male B10.S mice before immunization with PLP 139–151 renders them highly susceptible to severe EAE with more CNS neutrophil infiltrates than nondepleted controls. Increased susceptibility is associated with an enhanced PLP 139–151-specific T cell response and greater production of IFN-γ, IL-6, and IL-17. Male CD4+CD25+ effector cells depleted of Treg cells proliferate …

Serologic Survey Of Select Infectious Diseases In Coyotes And Raccoons In Nebraska, Richard Bischof, Douglas G. Rogers

School of Veterinary and Biomedical Sciences: Faculty Publications

To obtain data about select zoonotic and other infectious diseases in free-ranging predators in five ecoregions in Nebraska, sera were collected from 67 coyotes (Canis latrans) and 63 raccoons (Procyon lotor)) from November 2002 through January 2003. For coyotes, antibodies were detected against canine distemper virus (CDV, 61%), Francisella tularensis) (32%), Rickettsia rickettsi) (13%), and flaviviruses (48%). None of the coyote sera had antibodies to Borrelia burgdorferi, Brucella canis), or six serovars of Leptospira interrogans). Because serologic cross-reactivity exists among flaviviruses, 14 sera from flavivirus-positive coyotes were also tested for St. Louis …

Omega-3 Fatty Acid Consumption And Food Sources Differ Among Elderly Men Living In Coastal And Internal Regions Of Saudi Arabia, Khalid Al-Numair, Nancy M. Lewis, Sharon Evans

Department of Nutrition and Health Sciences: Faculty Publications

Research suggests that omega-3 fatty acids (n-3 FAs) play an important role in reducing the risk of heart diseases. The objectives of the current study were to investigate the consumption and the food sources of n-3 FAs in two samples of elderly men living in different geographic locations (coastal and internal regions) of Saudi Arabia. Sixty men from each of the coastal and the internal regions provided a 24-hour recall and 2-day food record and a food frequency questionnaire. Food Processor Plus computer program software (ESHA Version 0.7; Salem, Oregon, 2002) was used to analyze the dietary intake. The intake …

The Pervasive Triad Of Food Security, Gender Inequity And Women's Health: Exploratory Research From Sub-Saharan Africa, A.A. Hyder, S. Maman, J.E. Nyoni, S.A. Khasiani, N. Teoh, Zul Premji, S. Sohani

Pathology, East Africa

Objectives: This study was designed to explore the interactions between food securing activities, health and gender equity from the perspective of rural east African women. The specific objectives were to document the critical interaction among these three issues - food security, gender inequity, women's health within the context of sub-Saharan Africa; to describe the nature of this triad from the perspective of women farmers in Africa; and to propose a framework for linking available interventions to the vicious nature of this triad.

Setting: In-depth interviews and focus group discussions were conducted with rural women farmers in Kwale District, Kenya and …

Anaphylactic Reaction After Intramuscular Injection Of Cyanocobalamin (Vitamin B12): A Case Report, Fareena Bilwani, Salman Adil, Usman Sheikh, Ayesha Humera, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

We report a case of anaphylactic reaction to intramuscular injection of cyanocobalamin. This 52-year-old lady was diagnosed as a case of megaloblastic anemia secondary to dietary vitamin B12 deficiency. She had severe anaphylactic reaction after the parenteral administration of cyanocobalamine. Later she received oral vitamin B12 with no adverse effects. The purpose of this case report is to draw attention to the hypersensitive reaction to injectable vitamin B12, which is rarely seen. This could be due to sensitization to the vitamin B12 molecule itself or an IgE mediated reaction. We concluded that anaphylactic reaction to vitamin B12 is a rare …