Medicine and Health Sciences Commons^™

Apache Ii Score As A Predictor Of Length Of Stay And Outcome In Our Icus, Shahla Siddiqui, Saad Ahmed, Roshan Manasia

Department of Anaesthesia

The APACHE II (acute physiology and chronic health evaluation) is used widely for predicting probability of hospital mortality and length of stay in the ICU. APACHE II forms were available to all ICU residents within 24 hours of admission, and a score was assigned to them. Based on our results the APACHE II score has reliably predicted an outcome of the least amount of length of stay (LOS) in the ICU as well as a 100% probability of being shifted out of the ICU for a score of < 10 (according to international benchmarks). This reliable scoring system can be used for predicting mortality and length of stay and therefore, resource allocation, antibiotic use and ethical decisions regarding counseling families about end of life decisions--all within 24 hours of admissions.

Time To Task Failure Differs With Load Type When Old Adults Perform A Submaximal Fatiguing Contraction, Sandra K. Hunter, Ludovic Rochette, Ashley Critchlow, Roger M. Enoka

Exercise Science Faculty Research and Publications

Young adults exhibit a longer time to task failure when performing a submaximal isometric contraction by pushing against a force transducer (force task) than when supporting an equivalent inertial load (position task). The purpose of this study was to compare the time to failure for old adults when they performed a force task and a position task with the elbow flexor muscles. Eighteen old adults (72 ± 4 years) performed the force and position tasks at 20% maximal voluntary contraction (MVC) force until task failure. The time to task failure was briefer for the position task (10.6 ± 6.1 min) …

Mentoring Staff Members As Patient Safety Leaders: The Clarian Safe Passage Program, Kathryn Rapala

College of Nursing Faculty Research and Publications

We are at a crossroad in patient safety. Patient safety definitions, research, products, and implementation strategies have become as complex as health care itself. Almost every professional and regulatory organization now has a position or strategy to address the estimated 44,000 to 98,000 deaths per year due to health care error[1]. Memorizing and implementing the Joint Commission for Accreditation National Patient Safety Goals is not enough to establish and maintain a culture of safety. Patient safety literature offers few practical solutions on the implementation of an integrated, system wide application of patient safety approaches to clinical practice. It is our …

Attributable Risk Function In The Proportional Hazards Model, Ying Qing Chen, Chengcheng Hu, Yan Wang

UW Biostatistics Working Paper Series

As an epidemiological parameter, the population attributable fraction is an important measure to quantify the public health attributable risk of an exposure to morbidity and mortality. In this article, we extend this parameter to the attributable fraction function in survival analysis of time-to-event outcomes, and further establish its estimation and inference procedures based on the widely used proportional hazards models. Numerical examples and simulations studies are presented to validate and demonstrate the proposed methods.

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Improving The Experience Of Hospitalization For Hawaiian Children On The Mainland Through Cultural Sensitivity To Hawaiian Ways Of Healing, Jane H. Lassetter, Joan H. Baldwin

Faculty Publications

The experience of hospitalization for Hawaiian children on the mainland might be improved through the understanding and development of cultural sensitivity to Hawaiian ways of healing. This article contains a selected review of the literature on meeting the cultural health care needs of Hawaiian children and their families, a discussion of some of the challenges of caring for Hawaiian children in Utah, and suggestions for practice that may improve the experience of hospitalization for Hawaiian children in general.

Endothelial Cell Pseudopods And Angiogenesis Of Breast Cancer Tumors, Ivan L. Cameron, Nicholas Short, Luzhe Sun, W. Elaine Hardman

Biochemistry and Microbiology

Background

A neoplastic tumor cannot grow beyond a millimeter or so in diameter without recruitment of endothelial cells and new blood vessels to supply nutrition and oxygen for tumor cell survival. This study was designed to investigate formation of new blood vessels within a human growing breast cancer tumor model (MDA MB231 in mammary fat pad of nude female mouse). Once the tumor grew to 35 mm³, it developed a well-vascularized capsule. Histological sections of tumors greater than 35 mm³were stained with PAS, with CD-31 antibody (an endothelial cell maker), or with hypoxia inducible factor 1α …

Specific Functions Of Synaptically Localized Potassium Channels In Synaptic Transmission At The Neocortical Gabaergic Fast-Spiking Cell Synapse, Ethan Goldberg, Shigeo Watanabe, Su Ying Chang, Rolf Joho, Z Josh Huang, Christopher S. Leonard, Bernardo Rudy

NYMC Faculty Publications

Potassium (K+) channel subunits of the Kv3 subfamily (Kv3.1-Kv3.4) display a positively shifted voltage dependence of activation and fast activation/deactivation kinetics when compared with other voltage-gated K+ channels, features that confer on Kv3 channels the ability to accelerate the repolarization of the action potential (AP) efficiently and specifically. In the cortex, the Kv3.1 and Kv3.2 proteins are expressed prominently in a subset of GABAergic interneurons known as fast-spiking (FS) cells and in fact are a significant determinant of the fast-spiking discharge pattern. However, in addition to expression at FS cell somata, Kv3.1 and Kv3.2 proteins also are expressed prominently at …

Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang

Pharmaceutical Sciences Faculty Patents

Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.

Association Between Archaeal Prolyl- And Leucyl-Trna Synthetases Enhances TrnaPro Aminoacylation, Mette Praetorius-Ibba, Theresa E. Rogers, Rachel Samson, Zvi Kelman, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Aminoacyl-tRNA synthetase-containing complexes have been identified in different eukaryotes, and their existence has also been suggested in some Archaea. To investigate interactions involving aminoacyl-tRNA synthetases in Archaea, we undertook a yeast two-hybrid screen for interactions between Methanothermobacter thermautotrophicus proteins using prolyl-tRNA synthetase (ProRS) as the bait. Interacting proteins identified included components of methanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS). The association of ProRS with LeuRS was confirmed in vitro by native gel electrophoresis and size exclusion chromatography. Determination of the steady-state kinetics of tRNA^Pro charging showed that the catalytic efficiency (k_cat/K_m) of ProRS increased 5-fold …

Female Breast Cancer Incidence And Survival In Utah According To Religious Preference, 1985-1999, Ray M. Merrill, Jeffrey A. Folsom

Faculty Publications

Female breast cancer incidence rates in Utah are among the lowest in the U.S. The influence of the Church of Jesus Christ of Latter-day Saint (LDS or Mormon) religion on these rates, as well as on disease-specific survival, will be explored for individuals diagnosed with breast cancer in Utah from 1985 through 1999. Methods: Population-based records for incident female breast cancer patients were linked with membership records from the LDS Church to determine religious affiliation and, for LDS Church members, level of religiosity. Incidence rates were age-adjusted to the 2000 U.S. standard population using the direct method. Cox proportional hazards …

Prognosis Of Stage Ii Colon Cancer By Non-Neoplastic Mucosa Gene Expresssion Profiling, Alain Barrier, Sandrine Dudoit, Et Al.

U.C. Berkeley Division of Biostatistics Working Paper Series

Aims. This study assessed the possibility to build a prognosis predictor, based on non-neoplastic mucosa microarray gene expression measures, in stage II colon cancer patients. Materials and Methods. Non-neoplastic colonic mucosa mRNA samples from 24 patients (10 with a metachronous metastasis, 14 with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. The k-nearest neighbor method was used for prognosis prediction using microarray gene expression measures. Leave-one-out cross-validation was used to select the number of neighbors and number of informative genes to include in the predictor. Based on this information, a prognosis predictor was proposed and its accuracy estimated by …

Colon Cancer Prognosis Prediction By Gene Expression Profiling, Alain Barrier, Sandrine Dudoit, Et Al.

U.C. Berkeley Division of Biostatistics Working Paper Series

Aims. This study assessed the possibility to build a prognosis predictor, based on microarray gene expression measures, in stage II and III colon cancer patients. Materials and Methods. Tumour (T) and non-neoplastic mucosa (NM) mRNA samples from 18 patients (9 with a recurrence, 9 with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. The k-nearest neighbour method was used for prognosis prediction using T and NM gene expression measures. Six-fold cross-validation was applied to select the number of neighbours and the number of informative genes to include in the predictors. Based on this information, one T-based and one NM-based …

Ada News - 05/16/2005, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Mesure Des Émissions De Monoxyde De Carbone Des Générateurs D'Air Chaud Utilisés Sur Les Chantiers De Construction, Stéphane Brunet

Rapports de recherche scientifique

No abstract provided.

Investigating The Causes Of Low Birth Weight In Contrasting Ovine Paradigms., J M Wallace, Timothy Regnault, S W Limesand, W W Hay, R V Anthony

Paediatrics Publications

Intrauterine growth restriction (IUGR) still accounts for a large incidence of infant mortality and morbidity worldwide. Many of the circulatory and transport properties of the sheep placenta are similar to those of the human placenta and as such, the pregnant sheep offers an excellent model in which to study the development of IUGR. Two natural models of ovine IUGR are those of hyperthermic exposure during pregnancy, and adolescent overfeeding, also during pregnancy. Both models yield significantly reduced placental weights and an asymmetrically growth-restricted fetus, and display altered maternal hormone concentrations, indicative of an impaired trophoblast capacity. Additionally, impaired placental angiogenesis …

Activation Of Src Kinase Lyn By The Kaposi Sarcoma-Associated Herpesvirus K1 Protein: Implications For Lymphomagenesis, Om Prakash, O Rama Swamy, Xiochang Peng, Zhen-Ya Tang, Li Li, J Craig Cohen, Gist Farr, Suizhao Wang, Felipe Samaniego

Faculty, Staff and Student Publications

The K1 gene of Kaposi sarcoma-associated herpesvirus (KSHV) encodes a transmembrane glycoprotein bearing a functional immunoreceptor tyrosine-based activation motif (ITAM). Previously, we reported that the K1 protein induced plasmablastic lymphomas in K1 transgenic mice, and that these lymphomas showed enhanced Lyn kinase activity. Here, we report that systemic administration of the nuclear factor kappa B (NF-kappaB) inhibitor Bay 11-7085 or an anti-vascular endothelial growth factor (VEGF) antibody significantly reduced K1 lymphoma growth in nude mice. Furthermore, in KVL-1 cells, a cell line derived from a K1 lymphoma, inhibition of Lyn kinase activity by the Src kinase inhibitor PP2 decreased VEGF …

Juror Reactions To Jury Duty: Perceptions Of The System And Potential Stressors, Brian H. Bornstein, Monica Miller, Robert J. Nemeth, Gregory L. Page, Sarah Musil

Department of Psychology: Faculty Publications

Jurors were surveyed on their general perceptions of the court system and factors that may cause stress immediately after trial, after participating in a post-trial debriefing, and a month after trial. Jurors had an overall positive view of the court system but did report some perceived inequities. The two most stressful elements of jury duty were related to the complexity of the trial and the decision-making involved in the trial, although jurors reported low levels of stress overall. Women reported more stress than men, and trial characteristics such as trial length also affected stress levels. The debriefing intervention was perceived …

“You Would If You Loved Me”: Toward An Improved Conceptual And Etiological Understanding Of Nonphysical Male Sexual Coercion, Sarah A. Degue, David Dilillo

Department of Psychology: Faculty Publications

This paper reviews current research regarding the prevalence and possible etiological factors associated with male sexual coercion, defined here as a class of inappropriate male behaviors in which nonphysical tactics (e.g., verbal pressure, lying, deceit, and continual arguments) are utilized to obtain sexual contact with an unwilling adult female. This form of sexual misconduct is contrasted with sexual aggression (i.e., forcible rape), in which the threat or use of physical force is utilized to gain sexual contact. A conceptual framework for understanding and examining sexual coercion within the broader context of male sexual misconduct is offered. This model consists of …

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.

Évaluation De L'Exposition Humaine Aux Organophosphorés Et Des Risques Associés À L'Aide De Biomarqueurs Urinaires, Gaétan Carrier, Robert C. Brunet, Michèle Bouchard, Nathalie H. Gosselin, Marie-Josée Dumoulin, Yvette Bonvalot

Rapports de recherche scientifique

Les travaux exécutés dans le cadre de cet ouvrage proposent aux intervenants de la santé des outils pour aider à prévenir les risques des humains exposés à trois insecticides de la famille des organophosphorés, le parathion, le malathion et le chlorpyrifos et un phytocide, le triclopyr largement utilisé comme herbicide. Il s’agit du développement de biomarqueurs pouvant servir des tests de dépistage pour estimer l’exposition individuelle et le risque associé à ces substances toxiques.

Les tests proposés possèdent toutes les qualités recherchées dans un test de dépistage, ils sont facilement applicables, ont un haut degré de …

Traffic Technician Dies From Fall While Changing Traffic Signal Bulb, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On Monday, March 31, 2003, a 39-year-old male (decedent) highway traffic technician, working alone, received fatal head injuries after falling out of the bucket of an aerial boom truck. Injuries sustained in the fall resulted in his death four days later. He was changing a burned-out green traffic bulb in a traffic signal suspended over 2 lanes of traffic. As he worked from the aerial lift suspended over traffic to change the burned out bulb, a cargo truck drove underneath the bucket, striking it, and causing the decedent to fall to the asphalt below. As the worker fell approximately 10 …

Novelty Reward As A Measure Of Anhedonia, Rick A. Bevins, Joyce Besheer

Department of Psychology: Faculty Publications

A decrease in sensitivity to pleasurable stimuli, anhedonia, is a major symptom of depression in humans. Several animal models have been developed to simulate this symptom (e.g. drug withdrawal, learned helplessness) using reward-sensitive procedures such as intracranial self-stimulation and progressive ratio responding as a measure of reward function. Recently, we introduced the use of another procedure, novel-object place conditioning in rats, to measure reward function in an associative learning situation. Withdrawal from chronic nicotine blocked a place preference conditioned by access to novel objects. This blockade was not due to impairment of object interaction, general activity, novelty detection, environmental familiarization, …

Hospital Oversight In Medicare: Accreditation And Deeming Authority, Lisa Sprague

National Health Policy Forum

To be eligible to receive payment from Medicare, hospitals must be certified to meet certain conditions. Hospitals may gain such credentials by choosing to be reviewed by a state certification agency under contract to the Centers for Medicare & Medicaid Services or to be accredited by either the Joint Commission on Accreditation of Healthcare Organizations or the American Osteopathic Association. This issue brief looks at how accreditation of hospitals developed and how it continues to change. It considers the legal and practical reasons that a majority of hospitals choose accreditation and why some hospitals do not, along with broader consideration …

Preparing For A Lonely Day, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Kinetics Of Exocytosis Is Faster In Cones Than In Rods., Katalin Rabl, Lucia Cadetti, Wallace B. Thoreson

Journal Articles: Ophthalmology

Cone-driven responses of second-order retinal neurons are considerably faster than rod-driven responses. We examined whether differences in the kinetics of synaptic transmitter release from rods and cones may contribute to differences in postsynaptic response kinetics. Exocytosis from rods and cones was triggered by membrane depolarization and monitored in two ways: (1) by measuring EPSCs evoked in second-order neurons by depolarizing steps applied to presynaptic rods or cones during simultaneous paired whole-cell recordings or (2) by direct measurements of exocytotic increases in membrane capacitance. The kinetics of release was assessed by varying the length of the depolarizing test step. Both measures …

Ada News - 05/02/2005, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Information Interface - Volume 33, Issue 2 - May/June 2005, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on the humanities and health collection, course reserves, and database search tips.

Early Quadriceps Strength Loss After Total Knee Arthroplasty : The Contributions Of Muscle Atrophy And Failure Of Voluntary Muscle Activation, Ryan L. Mizner, Stephanie C. Petterson, Jennifer E. Stevens, Krista Vandenborne, Lynn Snyder-Mackler

Physical Therapy and Rehabilitation Science Faculty Publications

While total knee arthroplasty reduces pain and provides a functional range of motion of the knee, quadriceps weakness and reduced functional capacity typically are still present one year after surgery. The purpose of the present investigation was to determine the role of failure of voluntary muscle activation and muscle atrophy in theearly loss of quadriceps strength after surgery.

Bush, Thomas (Sc 1421), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and typescript (Click on "Additional Files" below) for Manuscripts Small Collection 1421. Civil War letter written by Thomas Bush, Louisville, Kentucky, to his brother, commenting on the poor hospital care he is receiving for consumption. He notes his doctor's opinion that the man who enlisted him should be sent to the penitentiary.