Medicine and Health Sciences Commons^™

The Impact Of Resistance Training On Obese Perimenopause African American Women In San Antonio, Letesha Nicole Butler

Doctoral Dissertations and Projects

This quantitative randomized controlled trial investigated the impact of resistance training on body fat in obese African American perimenopausal women in San Antonio, Texas. The study aimed to support the World Health Organization's efforts to combat obesity and address the underrepresentation of African American women in research, a population with over half being overweight or obese. Eleven eligible participants completed an intake survey and had their body fat percentage measured using an InBody 270 before and after the intervention. Participants were divided into two groups: one utilizing weights (e.g., dumbbells, barbells, machines, resistance bands) and the other using body weight …

The Effects Of The Menstrual Cycle On Movement Velocity In Female Athletes, Casey M. Krolikowski

Doctoral Dissertations and Projects

This study examined the psychological and physiological impacts of menstrual cycle phase and hormonal contraceptive (HC) use on barbell back squat and bench press velocity, handgrip strength, and countermovement jump height. The aim was to determine whether HC use and premenstrual syndrome (PMS) symptoms affected performance during menstruation, the late follicular phase (LFP), or the mid-luteal phase (MLP). Fourteen college-aged female athletes (N = 14) were divided into HC users (n = 7), and naturally menstruating, eumenorrheic individuals (n = 7). Movement velocity data was assessed using RepOne linear position transducers, jump height with the Just Jump mat, and grip …

An Analysis Of The Health Disparities For Traumatic Brain Injury Care In Urban Vs. Rural Populations, Jeremy R. Russell

Doctoral Dissertations and Projects

The purpose of this quantitative research study was to examine how disparities between urban and rural environments impacted the amount, onset, and duration of care received by patients with mild traumatic brain injury, as well as differences in demographic characteristics such as age and gender. Mild TBIs, often referred to as concussions, involve a temporary disruption in brain function resulting from external force, leading to symptoms like confusion, dizziness, or memory issues. Guided by critical theory, this study explored how systemic structures contributed to unequal healthcare experiences. Since TBIs remained a leading cause of disability and death with potential long-term …

Social Media And Mental Health According To Generation Z: A Health Belief Model-Based Cross-Sectional Evaluation Of Generation Z Adults’ Attitudes And Perceptions Of Problematic Social Media Use And Its Relationship With Depression And Anxiety, Michael Chad Gann

Doctoral Dissertations and Projects

Purpose: This study aimed to examine Generation Z adults’ attitudes and perceptions of problematic social media use (PSMU) as they relate to mental health problems (depression and anxiety) through the lens of the Mental Health Belief Model.

Methods: A cross-sectional, web-based survey gathered data from a convenience sample (N = 353) of Generation Z adults (age 18-30) after receiving approval from the LU IRB. The previously validated instrument battery included the Bergen Social Media Addiction Scale (BSMAS), the Patient Health Questionaire – 9 (PHQ-9), the Generalized Anxiety Disorder – 7 (GAD-7), and the Greene (2012) MHBM subscales for perceived susceptibility …

Evaluating Inclusion Rates Of Oral-Systemic Health Connection Coursework In Dental And Medical Professional Programs' Admissions Requirements, Wendy Marie Carry

Doctoral Dissertations and Projects

Oral systemic health connections (OSHC) are bidirectional, life-threatening, and a significant public health concern. Studies have identified over 200 OSHCs; however, the prevalence of foundational OSHC education in dental and medical professional programs remains unknown. This quantitative descriptive comparative pilot study aimed to explore the prevalence of predictor variables, dental and medical professional programs in the United States, and the criterion variable, including an OSHC admissions requirement for the 2025 academic year. The point-in-time count methodology served as the theoretical framework guiding this study and the development of the PiT-PARCI instrument. The proposed testing was replaced with alternative testing based …

Experiences Of First-Generation Nursing Students After Their First Year At An Hbcu: A Transcendental Phenomenological Study, Ari L. Cuffee

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore the lived experiences of first-generation nursing students (FGNS) after their first year at a Historically Black College or University (HBCU). The central research question asked, “What are the lived experiences of first-generation nursing students who have completed one year at a Historically Black University?” The theoretical framework that guided this study was Banks’ theory of multicultural education. This theory demonstrated how educators taught FGNS using the multicultural education paradigm with strategies and procedures to make provisions for culturally, racially, and ethnically diverse students. Data were analyzed using Moustakas’ interpretive phenomenological …

Opiate Addiction Crisis In The United States, Autumn Joy Collins

Doctoral Dissertations and Projects

This research investigates how fentanyl has influenced drug trafficking trends and the corresponding response from law enforcement in New York State. It aims to explore the changes in drug trafficking pathways, organizational structures, and methods in this region since fentanyl's emergence and how state law enforcement has adjusted to this new challenge. The study uses a quantitative methodology, analyzing various data from law enforcement records, court documents, and state government reports. The focus is on fentanyl-related drug trafficking cases in New York State over five years. Methods include examining case records and analyzing trafficking patterns statistically. The study will assess …

Passing The Torch: Evaluating Documentation Quality And Its Impact On Nurses’ Perceptions Of Communication Across Va Care Transitions, Shannon Collier Baker

Doctoral Dissertations and Projects

Effective communication during transitions of care is crucial to ensuring patient safety and optimizing outcomes. However, current practices may fall short in supporting clear and comprehensive communication among healthcare providers, particularly during complex care transitions involving Veterans who have received targeted care coordination intervention outside of their primary Patient Aligned Care Team. The absence of standardized tools for handoff documentation exacerbates fragmented communication and ambiguity about the transfer of care management responsibilities, potentially leading to avoidable errors and care coordination failures. This project aimed to investigate nurses' perceptions of the adequacy of communication during the transition of moderate to complex …

Adapt-3d: Accelerated Deep Adaptable Processing Of Tissue For 3-Dimensional Fluorescence Tissue Imaging For Research And Clinical Settings, Daniel D Lee, Kevin A Telfer, Deanna L Davis, Leon C D Smyth, Rahul Ravindran, Rafael S Czepielewski, Christopher G Huckstep, Siling Du, Kento Kurashima, Ajay K Jain, Jonathan Kipnis, Bernd H Zinselmeyer, Gwendalyn J Randolph

2020-Current year OA Pubs

Light sheet microscopy and preparative clearing methods that improve light penetration in 3D tissues have revolutionized imaging in biomedical research. Here we present ADAPT-3D, a streamlined 3-step approach to turn tissues optically transparent while preserving tissue architecture with the versatility to handle diverse tissue sizes and types across species. Unlike extensive lipid removal utilized by existing protocols, ADAPT-3D only partially removes lipids to preserve cell membranes, yet the non-toxic aqueous refractive indexing solution still rapidly turns tissues transparent while preserving the fluorescence of endogenous and antibody conjugated fluorophores. ADAPT-3D prepares whole mouse brains for light sheet microscopy in a 4-hour …

Whf Roadmap On Single Pill Combination Therapies, Enrico G Ferro, Mark Huffman, Orly Vardeny, Et Al.

2020-Current year OA Pubs

Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially …

Prefoldin Complex Promotes Interferon-Stimulated Gene Expression And Is Inhibited By Rotavirus Vp3, Yinxing Zhu, Yanhua Song, Dilip Kumar, Peter K Jackson, B V Venkataram Prasad, Siyuan Ding

2020-Current year OA Pubs

Timely induction of interferons and interferon-stimulated genes (ISGs) is critical for successful host defense against viral infections. VP3 encoded by rotavirus is implicated in interferon antagonism. However, the precise mechanisms remain incompletely understood. By conducting tandem-affinity purification coupled with high-resolution mass spectrometry, we identify the prefoldin complex as the top cellular binding partner of VP3. Rotavirus infection is significantly enhanced in prefoldin subunit knockout cells. Using proteome-wide label-free quantification, we find that prefoldin assists in folding ubiquitin-like-modifier-activating-enzyme-3 (UBA3), both of which positively regulate ISG expression. Through direct and competitive binding, VP3 interferes with the chaperone activity of prefoldin, leading to …

Excitotoxic Neuronal Death Requires Superoxide Entry Into Neurons Through Volume-Regulated Anion Channels, Kate Harris, Seok Joon Won, Gokhan Uruk, Nguyen Mai, Devran Ogut, Yonghui Zhao, Litao Xie, Paul Baxter, Katharina Everaerts, Rajan Sah, Raymond A Swanson

2020-Current year OA Pubs

Neuronal death in stroke and other conditions stems in part from stimulation of

Investigating “Sled Head” Phenomenon And Diurnal Patterns In Team Usa Bobsleigh And Luge Athletes: A Virtual Research Study, Garrett R. Augsburger

Doctoral Dissertations and Projects

This study investigated the relationship between training time, performance, and concussion symptoms among Team USA bobsleigh and luge athletes during a four-week training season. Recognizing the high physical demands and potential risks associated with sledding sports, the study aimed to understand the prevalence of concussion-related experiences and how training schedules might influence athletic performance and symptomology. Repeated measures quantitative design was employed using session-level survey data submitted by athletes following daily training sessions. Data was collected through a structured questionnaire assessing variables such as performance rating, fatigue, alertness, training intensity, sleep quality, and concussion symptoms. A total of 156 sessions …

Enhancing Collaborative Care: A Training Manual For Improving Veterans Affairs Mental Health Chaplaincy, Eddie L. Jones

Doctoral Dissertations and Projects

In 2010, the U.S. Department of Veterans Affairs (VA) and the Department of Defense (DoD) launched a study to investigate the integration of chaplains in mental health care. This research expands on that study by focusing on the critical need for enhanced collaboration between chaplaincy and mental health services at local VA facilities. While existing literature affirms the integral role of chaplains in addressing the spiritual and emotional needs of individuals, significant gaps in awareness and effective collaboration practices were identified at the Marion, IL VA Health Care System (VHCS). This study aimed to assess and address the specific training …

Exploring The Effectiveness Of Wearable Devices For Early Disease Detection, Chinonso Iwummadu

Doctoral Dissertations and Projects

The purpose of this qualitative interpretive phenomenological study was to explore the perceived effectiveness of wearable devices in facilitating early disease detection among patient groups, healthcare professionals, and healthcare administrators in the outpatient care setting. The central phenomenon investigated, involved the experiences, perceptions, and behavioral responses toward real-time monitoring and diagnostic engagement enabled by wearable devices. The theory that guided the study was the Health Technology Acceptance Model (HTAM), which supported inquiry into how perceived usefulness, perceived ease of use, and perceived health outcomes shaped adoption behavior and clinical integration of digital tools. Data were collected from a purposive sample …

Dynamics And Malleability Of Plant Dna Methylation During Abiotic Stresses, Niraj Lodhi, Rakesh Srivastava

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Epigenetic regulation, particularly DNA methylation, plays a crucial role in plant adaptation to environmental stresses by modulating gene expression without altering the underlying DNA sequence. In response to major abiotic stresses such as salinity, drought, heat, cold, and heavy metal toxicity, plants undergo dynamic changes in DNA methylation patterns. These modifications are orchestrated by DNA methyltransferases and demethylases with variations depending on plant species, genetic background, and ontogenic phase. DNA methylation affects the expression of key genes involved in cellular, physiological, and metabolic processes essential for stress tolerance. Furthermore, it contributes to the establishment of stress memory, which can be …

Identifying Factors Associated With Subsequent Diagnosis Of Adrenal Adenoma: A Population-Based Historical Case-Control Study, Ashley J Han, Sara J Achenbach, Elizabeth J Atkinson, Irina Bancos

Faculty, Staff and Students Publications

Objective: The objective of this study is to identify social/metabolic risk factors associated with subsequent diagnosis of adrenal adenoma.

Design: The design is a population-based historical case-control study.

Methods: Cases were adult patients diagnosed with an adrenal adenoma between 2005 and 2017 with no overt hormone excess. Controls were age- and sex-matched individuals with (1) no diagnosis of adrenal adenoma and (2) no diagnosis of adrenal adenoma with cross-sectional imaging of the chest/abdomen performed within 5 years prior to index date. The frequency of various social/metabolic risk factors present 5-10 years prior to index date and odds ratios (ORs) for …

Risk Of Major Depression In Partners Of People With Alzheimer's Disease: A National Cohort Study, Casey Crump, Jingkai Wei, Barbara G Vickrey, Alexis C Edwards, Paul E Schulz, Weiva Sieh, Jan Sundquist, Kristina Sundquist

Faculty, Staff and Student Publications

Background: Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown.

Methods: A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden during 1998-2017, and 1 300 561 population-based controls. Cox regression was used to compute hazard ratios (HRs) for subsequent risk of major depression identified from nationwide outpatient and inpatient diagnoses through 2018, adjusting for sociodemographic factors and prior mental …

Self-Efficacy And Burnout Of Nursing Faculty: The Mediating Role Of Fear Of Negative Evaluation, Sarah Murray Kelly

Doctoral Dissertations and Projects

The contents of this manuscript include a dissertation of a survey research study using the theoretical models of self-efficacy and burnout. The quantitative study used mediation analysis to explore the relationship between self-efficacy and burnout, with fear of negative evaluation as a mediator. Fear of negative evaluation was measured using the Brief Fear of Negative Evaluation Scale-Revised; self-efficacy was calculated using the General Self-Efficacy Scale; and burnout was measured using the Oldenburg Burnout Inventory. The study drew a sample of 98 academic nurse educators (N = 98) who were evaluated by student evaluations of teaching. The sample included educators who …

Decreasing The Incidence Of Healthcare Associated Presure Injuries In The Acute Care Setting, Amanda R. Nichols

Doctoral Dissertations and Projects

Healthcare-associated pressure injuries (HAPIs) can cause great harm to vulnerable patients. Acquiring a HAPI during hospitalization can result in delayed wound treatment, prolonged hospitalization, risk for infection, reimbursement issues for the facility, and delayed patient discharge. Avoiding these injuries is essential to improve patient outcomes. Research reveals that the implementation of nurse education and two registered nurse skin assessments on admission, instead of one nurse skin assessment, can decrease the incidence of healthcare-associated pressure injuries. Using the Iowa model, the goal of this scholarly project is to implement evidence-based research to change the current process and decrease the incidence of …

Evaluating Mental Health Providers’ Knowledge And Attitudes Towards Stigma Among Teenagers Aged 13 To 19 Years With Mental Illness, Fredrica Murray-Johnson

Doctoral Dissertations and Projects

Limited knowledge and poor attitudes among mental health providers contribute to stigma towards individuals with mental illness, adversely affecting treatment experience and outcomes. This study evaluated the effectiveness of an educational intervention in improving mental health providers’ knowledge and attitudes toward stigma-based practices. The clinical question stated: Among mental health providers, does an educational intervention, compared to standard practice, improve knowledge and attitudes of stigma and promote evidence-based care delivery to teenagers aged 13 to 19 with mental illness within six weeks? The Iowa Model of Evidence-Based Practice (EBP) was used as a framework for implementing this study. The quasi-experimental …

The Efficacy Of Mindfulness, Breathwork, And Neurofeedback: A Holistic Approach To Healing, Cheryl Moore-Whidby

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to explore the holistic impact of mindfulness, breathwork, and neurofeedback on individuals experiencing a range of emotional and physical health conditions, including PTSD, anxiety, depression, chronic pain, cardiovascular symptoms, and other chronic illnesses. This investigation is grounded in multiple theoretical frameworks, including the Polyvagal Theory (Porges, 2009), Cognitive Theory (Beck, 1963), Maslow’s Hierarchy of Needs (Maslow et al., 1943), Mindfulness-Based Stress Reduction (Kabat-Zinn, 1990), and Dialectical Behavior Therapy (Linehan, 1993). A total of 28 participants, approved through IRB review, engaged in 24 sessions across 30 days, divided between in-person and virtual formats. Breathwork …

An Analysis Of Sport Science Practices And Standards In Collegiate Football, Corey F. Fitzgerald

Doctoral Dissertations and Projects

This dissertation presents the findings of a survey that identifies the sport science practices and standards utilized in National Collegiate Athletic Association (NCAA) football programs. In total a fifty-two item survey instrument was administered that examines seven sections, including (i) demographics, (ii) current sport science practices, (iii) advanced technology, (iv) decision-making processes, (v) health and wellness, (vi) budget and resources, and (vii) comments. All generated numerical data was organized into a statistical analysis program, SPSS Statistics v 29.0.2.0 (© IBM Corporation). Correlations were conducted on data gathered from Likert Scale questions, using Spearman test. Additionally, comprehensive non-numerical subjective data was …

Beyond The Screening: Enhancement Of The Patient Experience Through Biophilic Interventions In A Controlled Mammography Environment, Sarah J. Morris

Doctoral Dissertations and Projects

This study was intended to significantly contribute to the body of research focused on biophilic design within the healthcare setting while expanding the application to the diagnostic imaging setting. This study’s purpose was to improve the mammography experience through the implementation of biophilic design for the enhancement of the patient experience, while successfully reducing negative perceptions during mammography procedures. The intervention of biophilic design has been shown to positively impact relaxation, wellness, and health through the reduction of stress. A randomized controlled trial with utilization of a quantitative design was utilized for the collection of data on the patient experience. …

Enhancing Parental Knowledge Of Functional Medicine Interventions For Adhd: An Educational Initiative To Improve Caregiver Competency, Julie Gammer

Doctoral Dissertations and Projects

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent pediatric psychiatric condition often managed with stimulant medications that carry potential side effects and may not address underlying causes. Research findings indicate a significant gap in caregiver knowledge and confidence in treating their child's ADHD with functional medicine strategies. This project develops an evidence-based educational initiative designed to enhance caregiver knowledge and confidence in applying functional medicine interventions—such as dietary modifications, targeted supplementation, and gut health restoration—as natural, root-cause approaches to managing ADHD symptoms. The project utilized a 30-minute audiovisual presentation and was evaluated using pre- and post-intervention competency tests, as well as a …

The Caribbean American Dementia And Aging Study: Protocol For A Population-Based Study Of Older Adult Health And Dementia In Cuba, The Dominican Republic, And Puerto Rico, Mao-Mei Liu, Jorge Llibre-Guerra, Chris Soria, Jing Li, Tania Zayas Llerena, Guillermina Rodriguez, Daisy Acosta, Ivonne Jiménez Velázquez, Juan J Llibre-Rodriguez, William H Dow

2020-Current year OA Pubs

BACKGROUND: The Hispanic Caribbean region is rapidly aging but national population-based aging surveys are rare. The Caribbean American Dementia and Aging Study (CADAS) is a multi-purpose household study of aging with a particular focus on the life course determinants and consequences of health and dementia in three countries with many similarities but divergent recent histories: Puerto Rico, Dominican Republic, and Cuba. METHODS: CADAS will survey population-based samples of adults ages 65 and over. In Puerto Rico and Dominican Republic these will be nationally representative samples of 1,500 adults each; the Cuban survey will include 1,500 adults from purposively selected urban …

Staged Reconstruction And Salvage Of A Small Finger With A Corticocancellous Distal Radius Autograft: A Case Report, Emmanuel Franco, Zayd Ayas, Frank Gerold

School of Medicine Publications

Finger reconstruction in the aftermath of severe trauma poses significant challenges in restorative surgery, particularly when addressing extensive soft tissue damage, comminuted fractures, and simultaneous neurovascular complications. This study presents a case of a patient with a complicated proximal phalangeal fracture who pursued digit salvage.

A 31-year-old Hispanic woman sustained severe injury to her right fifth digit during an all-terrain vehicle (ATV) rollover resulting in an exposed, comminuted fracture of the proximal phalanx with extensive structural and neurovascular compromise. She pursued digit salvage despite a high risk of failure and complication. The patient underwent four operations over a six-month period, …

Ras-Membrane Interaction And Oligomerization: There Is More Than Meets The Eye, Abraham C Sianoya, Vijay K Bhardwaj, Alemayehu A Gorfe

Faculty, Staff and Student Publications

Membrane association is fundamental to Rat sarcoma (RAS) function, driving both its physiologic signaling and oncogenic transformation. This review consolidates recent advances in the study of RAS-membrane interactions, emphasizing the molecular mechanisms underlying its membrane engagement and oligomerization. We first discuss the roles of RAS lipid modification and conformational diversity of its intrinsically disordered C-terminus in these processes, and we then examine the debate surrounding RAS dimerization and its potential role in the formation of higher-order oligomers. By integrating emerging insights into these issues, we offer our own perspectives on the driving forces of RAS oligomerization and propose potential new …

Epigenetic Modulation Of Bard1 To Enhance Anti-Vegf Therapy, Emine Bayraktar, Cristian Rodriguez-Aguayo, Elaine Stur, Sudhir Kumar, Lingegowda S Mangala, Nicholas B Jennings, Nazende Nur Bayram, Sara Corvigno, Amma Asare, Cristina Ivan, Mark S Kim, Thanh Chung Vu, Pahul Hanjra, Sangbae Kim, Adrian Lankenau Ahumada, Weichem Wu, Sanghoon Lee, Anna Szymanowska, Hulya Oztatlici, Marcos R Estecio, Ju-Seog Lee, Abhinav K Jain, Nidhi Sahni, John P Hagan, Stephen Baylin, Jinsong Liu, Gabriel Lopez-Berestein, Sunila Pradeep, Anil K Sood

Faculty, Staff and Student Publications

Despite the clinical use of anti-vascular endothelial growth factor (VEGF) antibodies (AVAs) in cancer therapy, resistance frequently develops, leading to disease progression. To address this, we identify a previously unknown role for breast cancer type 1 susceptibility protein (BRCA1)-associated RING domain 1 (BARD1) in modulating AVA sensitivity. Epigenetic modulation-via global and targeted DNA methylation-reveals BARD1 as a key regulator of angiogenesis. Sequential treatment with azacytidine overcomes AVA resistance in vivo. To enable precise epigenetic reactivation, we develop a liposomal CRISPR-deactivated Cas9 (dCas9)-TET1 system guided by BARD1-targeting single-guide RNAs (sgRNAs). This platform achieves CpG-specific demethylation of the BARD1 promoter, restores expression, …

Editorial: Endocrine Imbalances Of Mineral Ions And Vitamins In Chronic Disease Pathogenesis, Mor-Li Hartman, Hosam G. Abdelhady, Mohammed S. Razzaque

School of Medicine Publications

No abstract provided.