Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (159)
- Public Health (148)
- Medical Specialties (87)
- Sociology (66)
- International Public Health (65)
-
- Medical Sciences (63)
- Arts and Humanities (56)
- Psychiatry and Psychology (53)
- Demography, Population, and Ecology (52)
- Law (45)
- Life Sciences (43)
- Health Services Research (41)
- Dentistry (39)
- Business (36)
- Education (34)
- Health Law and Policy (34)
- Community Health and Preventive Medicine (32)
- History (32)
- History of Science, Technology, and Medicine (31)
- Nursing (31)
- Diseases (28)
- Family, Life Course, and Society (28)
- Mental and Social Health (28)
- Business and Corporate Communications (26)
- Pharmacy and Pharmaceutical Sciences (26)
- Bioethics and Medical Ethics (24)
- Health Services Administration (24)
- Health and Medical Administration (24)
- Sports Sciences (24)
- Institution
-
- University of Nebraska - Lincoln (69)
- Population Council (68)
- Aga Khan University (37)
- Thomas Jefferson University (35)
- University of Kentucky (30)
-
- Himmelfarb Health Sciences Library, The George Washington University (29)
- University of Wollongong (27)
- American Dental Association (26)
- Dartmouth College (24)
- Washington University School of Medicine (20)
- Marquette University (19)
- Western Kentucky University (16)
- Syracuse University (13)
- University of South Florida (13)
- Nova Southeastern University (11)
- Cedarville University (10)
- Eastern Illinois University (10)
- Sacred Heart University (10)
- Western University (10)
- The Texas Medical Center Library (7)
- University of Tennessee, Knoxville (7)
- Virginia Commonwealth University (7)
- WellBeing International (7)
- Florida International University (6)
- University of Connecticut (6)
- University of Montana (6)
- University of Nevada, Las Vegas (6)
- University of Northern Iowa (6)
- Chapman University (5)
- Singapore Management University (5)
- Keyword
-
- English (56)
- Humans (28)
- Broadsheet (26)
- Newsletter (26)
- Newspaper (26)
-
- Oral health (26)
- Paper (26)
- Professional association (26)
- Animals (23)
- Reproductive Health (22)
- Family Planning (18)
- HIV Prevention (15)
- Genetics (12)
- Contraceptives (11)
- Female (11)
- Metabolism (11)
- Mice (10)
- Amino acid sequence (9)
- Genetic (9)
- Male (9)
- Molecular sequence data (9)
- Cultured (8)
- Kenya (8)
- Spanish (8)
- Women (8)
- Antibodies (7)
- Athletics (7)
- Bacterial (7)
- Cedarville (7)
- Education (7)
- Publication
-
- Reproductive Health (39)
- Department of Psychology: Faculty Publications (31)
- ADA News (26)
- Dartmouth Scholarship (24)
- National Health Policy Forum (19)
-
- Faculty of Science, Medicine and Health - Papers: part A (17)
- Independent Studies and Capstones (16)
- Poverty, Gender, and Youth (15)
- HIV and AIDS (14)
- College of Nursing Faculty Research and Publications (10)
- Sport Management - All Scholarship (10)
- Faculty of Health and Behavioural Sciences - Papers (Archive) (9)
- Masters Theses & Specialist Projects (9)
- College of Population Health Faculty Papers (8)
- Health Professions Divisions Course Catalogs and Course Descriptions (8)
- School of Veterinary and Biomedical Sciences: Faculty Publications (8)
- Other Publications in Zoonotics and Wildlife Disease (7)
- Department of Pathology and Laboratory Medicine (6)
- Faculty Publications and Other Works -- Nursing (6)
- Faculty Research & Creative Activity (6)
- Graduate Research Papers (6)
- Uniformed Services University of the Health Sciences (6)
- Department of Surgery (5)
- FIU Electronic Theses and Dissertations (5)
- Information Interface (1976 - 2009) (5)
- Journal Articles (5)
- Michigan Bovine Tuberculosis Bibliography and Database (5)
- Molecular Medicine Faculty Publications (5)
- Nursing Faculty Publications (5)
- Obstetrics & Gynaecology Publications (5)
- File Type
Articles 1 - 30 of 663
Full-Text Articles in Medicine and Health Sciences
Will Theaters Receive Two Thumbs Up From Individuals With Disabilities?, Joseph H. Huber
Will Theaters Receive Two Thumbs Up From Individuals With Disabilities?, Joseph H. Huber
Movement Arts, Health Promotion and Leisure Studies Faculty Publications
No abstract provided.
Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin
Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin
Graduate Center for Nutritional Sciences Faculty Patents
The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods …
Going Global The Fastest Way To The Top, Rick Burton
Going Global The Fastest Way To The Top, Rick Burton
Sport Management - All Scholarship
No abstract provided.
Effect Of Seeing Tobacco Use In Films On Trying Smoking Among Adolescents: Cross Sectional Study, James D. Sargent, Michael L. Beach, Madeline A. Dalton, Leila A. Mott, Jennifer J. Tickle, M. Bridget Ahrens, Todd F. Heatherton
Effect Of Seeing Tobacco Use In Films On Trying Smoking Among Adolescents: Cross Sectional Study, James D. Sargent, Michael L. Beach, Madeline A. Dalton, Leila A. Mott, Jennifer J. Tickle, M. Bridget Ahrens, Todd F. Heatherton
Dartmouth Scholarship
Objective: To test the hypothesis that greater exposure to smoking in films is associated with trying smoking among adolescents.
Nipple Aspirate Cytology And Pathologic Parameters Predict Residual Cancer And Nodal Involvement After Excisional Breast Biopsy., E R Sauter, H Ehya, A Mammen, G Klein
Nipple Aspirate Cytology And Pathologic Parameters Predict Residual Cancer And Nodal Involvement After Excisional Breast Biopsy., E R Sauter, H Ehya, A Mammen, G Klein
Department of Surgery Faculty Papers
We previously demonstrated that abnormal nipple aspirate fluid (NAF) cytology predicted residual breast cancer (RC) and tumour size after excisional biopsy (EB), although normal NAF cytology did not exclude RC. Tumour size correlates with the risk of lymph node (LN) metastases. LN metastases provide prognostic information allowing medical and radiation oncologists to determine the need for adjuvant therapy. We hypothesized that pathologic factors known after EB, combined with NAF cytology, would predict with a high degree of accuracy the presence of RC and LN spread. NAF cytology and pathologic parameters: tumour distance from biopsy margins, multifocal and multicentric disease, sub-type …
Ada News - 12/10/2001, American Dental Association, Publishing Division
Ada News - 12/10/2001, American Dental Association, Publishing Division
ADA News
Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.
Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky
Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Enhanced formation of reactive oxygen species (ROS), superoxide (O2*-), and hydrogen peroxide (H2O2) may result in either apoptosis or other forms of cell death. Here, we studied the mechanisms underlying activation of the apoptotic machinery by ROS. Exposure of permeabilized HepG2 cells to O2*- elicited rapid and massive cytochrome c release (CCR), whereas H2O2 failed to induce any release. Both O2*- and H2O2 promoted activation of the mitochondrial permeability transition pore by Ca2+, but Ca2+-dependent pore opening was not required for O2*--induced CCR. Furthermore, O2*- alone evoked CCR without damage of the inner mitochondrial membrane barrier, as mitochondrial membrane potential …
Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo
Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo
Department of Psychology: Faculty Publications
Previous work has shown that individual differences in locomotor activity in an inescapable novel environment can predict acquisition of amphetamine self-administration. The current study examined whether individual differences in approach to novelty in a free choice test could also predict amphetamine self-administration. Further, the current study examined whether individual differences in either free choice or inescapable novelty tests could predict responding for a nondrug reinforcer (sucrose) in the presence and absence of amphetamine. Male and female rats were first tested for their response to free choice novelty (playground maze and novelty-induced place preference tests) and inescapable novelty. They were then …
A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting
A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting
Dartmouth Scholarship
Localization of ion channels and transporters to the correct membrane of polarized epithelia is important for vectorial ion movement. Prior studies have shown that the cytoplasmic carboxyl terminus of the cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the apical localization of this protein. Here we show that the C-terminal tail alone, or when fused to the green fluorescent protein (GFP), can localize to the apical plasma membrane, despite the absence of transmembrane domains. Co-expression of the C terminus with full-length CFTR results in redistribution of CFTR from apical to basolateral membranes, indicating that both proteins interact with the …
Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen
Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen
Department of Psychology: Faculty Publications
Presumably, anger is a common experience of parenting. Although practitioners and researchers recognize the role of anger in various parenting situations, objective and standardized measures of parental anger have been notably lacking in the field. This study examined the Parental Anger Inventory (PAI), a measure developed specifically to assess parental anger in response to child misbehavior. A diverse sample of 98 parents participated in the study, including (a) physically abusive or neglectful parents, or both, n = 44; (b) nonmaltreating clinic parents seeking assistance for child behavior problems, n = 24; and (c) nonmaltreating, non–help-seeking community parents, n = 30. …
Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton
Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton
Dartmouth Scholarship
We purified microtubules from a mammalian mitotic extract and obtained an amino acid sequence from each microtubule-associated protein by using mass spectrometry. Most of these proteins are known spindle-associated components with essential functional roles in spindle organization. We generated antibodies against a protein identified in this collection and refer to it as astrin because of its association with astral microtubule arrays assembled in vitro. Astrin is approximately 134 kDa, and except for a large predicted coiled-coil domain in its C-terminal region it lacks any known functional motifs. Astrin associates with spindle microtubules as early as prophase where it concentrates at …
Predictors Of Injury From Fighting Among Adolescent Males, B J. Hammig, L L. Dahlberg, Monica H. Swahn
Predictors Of Injury From Fighting Among Adolescent Males, B J. Hammig, L L. Dahlberg, Monica H. Swahn
Public Health Faculty Publications
Objectives: To identify violence related behaviors associated with injuries among adolescent males involved in fights.
Methods: Data from the National Longitudinal Study of Adolescent Health were used to develop weighted estimates of injury prevalence and associations between injury and violence related behaviors.
Results: Forty seven per cent injured others and 18% were themselves injured in a fight among adolescent males in the preceding 12 months. Group fighting, fighting with strangers, and weapon use were predictive of injury in this sample.
Conclusions: These findings suggest that injuries associated with fighting are a health risk among adolescent males. Certain behaviors, such as …
Effects Of Maternal Employment And Prematurity On Child Outcomes In Single Parent Families, Joanne M. Youngblut, Dorothy Brooten, Lynn T. Singer, Theresa Standing, Haejung Lee, Willard L. Rodgers
Effects Of Maternal Employment And Prematurity On Child Outcomes In Single Parent Families, Joanne M. Youngblut, Dorothy Brooten, Lynn T. Singer, Theresa Standing, Haejung Lee, Willard L. Rodgers
Nicole Wertheim College of Nursing and Health Sciences
Background
Effects of maternal employment for preschool children vary based on specific characteristics of the mother’s employment, the family’s economic status, and the mother’s attitudes about employment. However, there is limited research on a growing group of children at developmental risk—those born prematurely and living in a single-parent family.
Objective
To examine the effects of maternal employment and prematurity on child cognition and behavior in single-parent families.
Methods
Sixty preterm and 61 full-term preschool children were recruited through NICU admission records and birth records. Data were collected with the Kaufmann Assessment Battery for Children, Peabody Picture Vocabulary Test, Child Behavior …
Anatomy And Three-Dimensional Reconstructions Of The Brain Of A Bottlenose Dolphin (Tursiops Truncatus) From Magnetic Resonance Images, Lori Marino, Keith D. Sudheimer, Timothy L. Murphy, Kristina K. Davis, D. Ann Pabst, William A. Mclellan, James K. Rilling, John I. Johnson
Anatomy And Three-Dimensional Reconstructions Of The Brain Of A Bottlenose Dolphin (Tursiops Truncatus) From Magnetic Resonance Images, Lori Marino, Keith D. Sudheimer, Timothy L. Murphy, Kristina K. Davis, D. Ann Pabst, William A. Mclellan, James K. Rilling, John I. Johnson
Veterinary Science and Medicine Collection
Cetacean (dolphin, whale, and porpoise) brains are among the least studied mammalian brains because of the formidability of collecting and histologically preparing such relatively rare and large specimens. Magnetic resonance imaging offers a means of observing the internal structure of the brain when traditional histological procedures are not practical. Furthermore, internal structures can be analyzed in their precise anatomic positions, which is difficult to accomplish after the spatial distortions often accompanying histological processing. In this study, images of the brain of an adult bottlenose dolphin, Tursiops truncatus, were scanned in the coronal plane at 148 antero-posterior levels. From these scans …
Inside Unlv, Diane Russell, Jennifer Vaughan, Richard Jensen, Mae Worthey-Flennoy
Inside Unlv, Diane Russell, Jennifer Vaughan, Richard Jensen, Mae Worthey-Flennoy
Inside UNLV
No abstract provided.
Anti-Class Ii Monoclonal Antibody-Targeted Vibrio Cholerae Tcpa Pilin: Modulation Of Serologic Response, Epitope Specificity, And Isotype, Jia-Yan Wu, Ronald K. Taylor, William F. Wade
Anti-Class Ii Monoclonal Antibody-Targeted Vibrio Cholerae Tcpa Pilin: Modulation Of Serologic Response, Epitope Specificity, And Isotype, Jia-Yan Wu, Ronald K. Taylor, William F. Wade
Dartmouth Scholarship
Toxin-coregulated pilus (TCP) is a colonization factor required for cholera infection. It is not a strong immunogen when delivered in the context of whole cells, yet pilus subunits or TcpA derivative synthetic peptides induce protective responses. We examined the efficacy of immunizing mice with TCP conjugated to anti-class II monoclonal antibodies (MAb) with or without the addition of cholera toxin (CT) or anti-CD40 MAb to determine if the serologic response to TcpA could be manipulated. Anti-class II MAb-targeted TCP influenced the anti-TCP peptide serologic response with respect to titer and isotype. Responses to TcpA peptide 4 were induced with class …
Evaluation Of A Tetracycline-Inducible Promoter In Staphylococcus Aureus In Vitro And In Vivo And Its Application In Demonstrating The Role Of Sigb In Microcolony Formation, B. T. Bateman, N. P. Donegan, T. M. Jarry, M. Palma
Evaluation Of A Tetracycline-Inducible Promoter In Staphylococcus Aureus In Vitro And In Vivo And Its Application In Demonstrating The Role Of Sigb In Microcolony Formation, B. T. Bateman, N. P. Donegan, T. M. Jarry, M. Palma
Dartmouth Scholarship
An inducible promoter system provides a powerful tool for studying the genetic basis for virulence. A variety of inducible systems have been used in other organisms, including pXyl-xylR-inducible promoter, the pSpac-lacI system, and the arabinose-inducible PBAD promoter, but each of these systems has limitations in its application to Staphylococcus aureus. In this study, we demonstrated the efficacy of a tetracycline-inducible promoter system in inducing gene expression in S. aureus in vitro and inside epithelial cells as well as in an animal model of infection. Using the xyl/tetO promoter::gfpuvr fusion carried on a shuttle …
Evaluation Of Cholera Vaccines Formulated With Toxin-Coregulated Pilin Peptide Plus Polymer Adjuvant In Mice, Jia-Yan Wu, William F. Wade, Ronald K. Taylor
Evaluation Of Cholera Vaccines Formulated With Toxin-Coregulated Pilin Peptide Plus Polymer Adjuvant In Mice, Jia-Yan Wu, William F. Wade, Ronald K. Taylor
Dartmouth Scholarship
Cholera is an acute diarrheal disease that is caused by the gram-negative bacterium Vibrio cholerae. The low efficacy of currently available killed-whole-cell vaccines and the reactinogenicity coupled with potential reversion of live vaccines have thus far precluded widespread vaccination for the control of cholera. Recent studies on the molecular nature of the virulence components that contribute to V. cholerae pathogenesis have provided insights into possible approaches for the development of a defined subunit cholera vaccine. Genetic analysis has demonstrated that the toxin-coregulated pilus (TCP) is the major factor that contributes to colonization of the human intestine by V. cholerae. In …
Immune Response Genes Modulate Serologic Responses To Vibrio Cholerae Tcpa Pilin Peptides, Michael D. Meeks, Terri K. Wade, Ronald K. Taylor, William F. Wade
Immune Response Genes Modulate Serologic Responses To Vibrio Cholerae Tcpa Pilin Peptides, Michael D. Meeks, Terri K. Wade, Ronald K. Taylor, William F. Wade
Dartmouth Scholarship
Cholera is an enteric disease caused by Vibrio cholerae. Toxin-coregulated pilus (TCP), a type 4 pilus expressed by V. cholerae, is a cholera virulence factor that is required for host colonization. The TCP polymer is composed of subunits of TcpA pilin. Antibodies directed against TcpA are protective in animal models of cholera. While natural or recombinant forms of TcpA are difficult to purify to homogeneity, it is anticipated that synthesized TcpA peptides might serve as immunogens in a subunit vaccine. We wanted to assess the potential for effects of the immune response (Ir) gene that could complicate a peptide-based …
Access To Pediatric Services Under Medicaid Managed Care In The District Of Columbia, Karen Shaw, Sara J. Rosenbaum
Access To Pediatric Services Under Medicaid Managed Care In The District Of Columbia, Karen Shaw, Sara J. Rosenbaum
Health Policy and Management Faculty Publications
No abstract provided.
Rumination And Cigarette Smoking: A Bad Combination For Depressive Outcomes?, Malia Richmond, Bonnie Spring, Beth Kaplan Sommerfeld, Dennis E. Mcchargue
Rumination And Cigarette Smoking: A Bad Combination For Depressive Outcomes?, Malia Richmond, Bonnie Spring, Beth Kaplan Sommerfeld, Dennis E. Mcchargue
Department of Psychology: Faculty Publications
Ruminative coping has been shown to heighten the risk and severity of depression. The authors hypothesized that ruminators who smoke would experience greater depressive symptoms than ruminators who do not. The rationale is that, by heightening attentional focus, nicotine may increase ruminators' ability to focus on negative thoughts, augmenting depressed mood. Participants (N = 145) self-reported smoking status, rumination, and current and lifetime depressive symptoms, including depressed mood. Results showed that rumination accounted for a larger amount of variance in current and past depressed mood and severity of lifetime depressive symptoms among smokers than nonsmokers. Noncorrelational, experimental research should …
Multimodal Assessment Of The Effect Of Chewing Gum On Nicotine Withdrawal, Lee M. Cohen, Dana M. Britt, Frank L. Collins, Mustafa Al-Absi, Dennis E. Mcchargue
Multimodal Assessment Of The Effect Of Chewing Gum On Nicotine Withdrawal, Lee M. Cohen, Dana M. Britt, Frank L. Collins, Mustafa Al-Absi, Dennis E. Mcchargue
Department of Psychology: Faculty Publications
The present study was designed to evaluate the usefulness of chewing gum to reduce nicotine withdrawal, craving, and salivary cortisol concentrations during temporary nicotine deprivation. A total of 20 male smokers were studied under conditions when gum was and was not accessible during a 4-hour deprivation period. All subjects smoked an initial cigarette shortly after arrival for the two experimental sessions and were informed that they would be unable to smoke for the remainder of each session. The sessions consisted of each subject watching a movie, then waiting in the lab for two consecutive 30-min intervals. Self-reported nicotine withdrawal and …
The Pizzi Holistic Wellness Assessment, Michael Pizzi
The Pizzi Holistic Wellness Assessment, Michael Pizzi
Occupational Therapy Faculty Publications
This paper describes the Pizzi Holistic Wellness Assessment tool. Using theory from the field of health promotion and expertise gained in his private home health practice, the author developed and pilot tested this assessment on a variety of individuals. The assessment is designed to be used with different populations in a variety of settings to help clients self assess their health and well-being.
Anatomy And Three-Dimensional Reconstructions Of The Brain Of The White Whale (Delphinapterus Leucas) From Magnetic Resonance Images, Lori Marino, Timothy L. Murphy, Amy L. Deweerd, John A. Morris, Archibald J. Fobbs, Nathalie Humbolt, Sam H. Ridgway, John I. Johnson
Anatomy And Three-Dimensional Reconstructions Of The Brain Of The White Whale (Delphinapterus Leucas) From Magnetic Resonance Images, Lori Marino, Timothy L. Murphy, Amy L. Deweerd, John A. Morris, Archibald J. Fobbs, Nathalie Humbolt, Sam H. Ridgway, John I. Johnson
Veterinary Science and Medicine Collection
Magnetic resonance imaging offers a means of observing the internal structure of the brain where traditional procedures of embedding, sectioning, staining, mounting, and microscopic examination of thousands of sections are not practical. Furthermore, internal structures can be analyzed in their precise quantitative spatial interrelationships, which is difficult to accomplish after the spatial distortions often accompanying histological processing. For these reasons, magnetic resonance imaging makes specimens that were traditionally difficult to analyze, more accessible. In the present study, images of the brain of a white whale (Beluga) Delphinapterus leucas were scanned in the coronal plane at 119 antero-posterior levels. Fromthese scans, …
Dextran-Methylprednisolone Succinate As A Prodrug Of Methylprednisolone: Plasma And Tissue Disposition, Xiaoping Zhang, Reza Mehvar
Dextran-Methylprednisolone Succinate As A Prodrug Of Methylprednisolone: Plasma And Tissue Disposition, Xiaoping Zhang, Reza Mehvar
Pharmacy Faculty Articles and Research
Plasma and tissue disposition of a macromolecular prodrug of methylprednisolone (MP), dextran (70 kDa)–methylprednisolone succinate (DMP), was studied in rats. Single 5‐mg/kg doses of DMP or unconjugated MP were administered into the tail veins of different groups of rats (n = 4/group/time point). Blood (cardiac puncture) and tissues (liver, spleen, kidney, heart, lung, thymus, and brain) were collected at various times after DMP (0–96 h) or MP (0–2 h) injections. Concentrations of DMP and MP in samples were analyzed by size‐exclusion chromatography (SEC) and reversed‐phase high‐performance liquid chromatography (HPLC), respectively. Conjugation of MP with 70‐kDa dextran resulted in 22‐, …
A Decentralized, Patient-Centered Approach To Diabetes Disease Management In The Primary Care Setting, Michael Toscani, John P. O'Connor, David B. Nash
A Decentralized, Patient-Centered Approach To Diabetes Disease Management In The Primary Care Setting, Michael Toscani, John P. O'Connor, David B. Nash
College of Population Health Faculty Papers
Although many disease management programs have been developed for diabetes, no single design has proved best for all providers and patient populations. Cost effectiveness is especially relevant to diabetes programs because significant costs of the disease may come from complications that occur later in life, while the costs of the program are incurred immediately. For this reason, diabetes disease management programs with positive outcomes and low implementation costs are of particular importance. We report here on the outcomes of a pilot test of the Steps to Health program developed by Abbott Laboratories. The Steps to Health program was designed to …
From Product Dispensing To Patient Care: The Role Of The Pharmacist In Providing Pharmaceutical Care As Part Of An Integrated Disease Management Approach, Laura T. Pizzi, Jean M. Menz, Geneen R. Graber, Dong-Churl Suh
From Product Dispensing To Patient Care: The Role Of The Pharmacist In Providing Pharmaceutical Care As Part Of An Integrated Disease Management Approach, Laura T. Pizzi, Jean M. Menz, Geneen R. Graber, Dong-Churl Suh
College of Population Health Faculty Papers
During the past decade, the profession of pharmacy has changed dramatically. The Doctor of Pharmacy degree has replaced the Bachelor of Science degree as the first professional degree offered at most accredited U.S. pharmacy schools. Advanced clinical training is now a mainstay of pharmacy training, and this has enabled pharmacists to contribute to disease management efforts. In addition, technological improvements in prescription processing have afforded pharmacists more time to participate in disease management activities. This paper describes how the role of the pharmacist has changed and reviews the results of programs involving pharmacists as disease management providers in the areas …
Effect Of Nasa Light-Emitting Diode Irradiation On Wound Healing, Harry T. Whelan, Robert L. Smits, Ellen V. Buchmann, Noel T. Whelan, Scott G. Turner, David A. Margolis, Vita Cevenini, Helen Stinson, Ron Ignatius, Todd Martin, Joan Cwiklinski, Alan F. Philippi, William R. Graf, Brian D. Hodgson, Lisa Gould, Mary Kane, Gina Chen, James Caviness
Effect Of Nasa Light-Emitting Diode Irradiation On Wound Healing, Harry T. Whelan, Robert L. Smits, Ellen V. Buchmann, Noel T. Whelan, Scott G. Turner, David A. Margolis, Vita Cevenini, Helen Stinson, Ron Ignatius, Todd Martin, Joan Cwiklinski, Alan F. Philippi, William R. Graf, Brian D. Hodgson, Lisa Gould, Mary Kane, Gina Chen, James Caviness
School of Dentistry Faculty Research and Publications
Objective: The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing.
Background Data: Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans.
Materials and Methods: In vitro and in vivo …
Meeting Medical Terminology Needs: The Ontology-Enhanced Medical Concept Mapper, Gondy Leroy, Hsinchun Chen
Meeting Medical Terminology Needs: The Ontology-Enhanced Medical Concept Mapper, Gondy Leroy, Hsinchun Chen
CGU Faculty Publications and Research
This paper describes the development and testing of the Medical Concept Mapper, a tool designed to facilitate access to online medical information sources by providing users with appropriate medical search terms for their personal queries. Our system is valuable for patients whose knowledge of medical vocabularies is inadequate to find the desired information, and for medical experts who search for information outside their field of expertise. The Medical Concept Mapper maps synonyms and semantically related concepts to a user's query. The system is unique because it integrates our natural language processing tool, i.e., the Arizona (AZ) Noun Phraser, with human-created …
Prognostic Impact Of P53 Status, Tls-Chop Fusion Transcript Structure, And Histological Grade In Myxoid Liposarcoma: A Molecular And Clinicopathologic Study Of 82 Cases, C. R. Antonescu, S. J. Tschernyavsky, R. Decuseara, Denis H. Y. Leung, J. M. Woodruff, M. F. Brennan, J. A. Bridge, J. R. Neff, J. R. Goldblum, M. Ladanyi
Prognostic Impact Of P53 Status, Tls-Chop Fusion Transcript Structure, And Histological Grade In Myxoid Liposarcoma: A Molecular And Clinicopathologic Study Of 82 Cases, C. R. Antonescu, S. J. Tschernyavsky, R. Decuseara, Denis H. Y. Leung, J. M. Woodruff, M. F. Brennan, J. A. Bridge, J. R. Neff, J. R. Goldblum, M. Ladanyi
Research Collection School Of Economics
Purpose: A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS). Three common forms of the TLS-CHOP fusion have been described, differing by the presence or absence of TLS exons 6-8 in the fusion product. Type 5-2 (also known as type II) consists of TLS exons 1-5 fused to CHOP exon 2; type 7-2 (also known as type I) also includes TLS exons 6 and 7 in the fusion, whereas type 8-2 (also known as type III) fuses TLS exons 1-8 to CHOP exon 2. We sought to determine the impact …