Medicine and Health Sciences Commons^™

Registry Screens 02no98, Armin Weinberg

Works on Radiation Effects: 1990-2020

Content and screen shots of development of cancer registrty. See more at Armin Weinberg, PhD Papers and its finding aid.

Cytochalasins Useful In Providing Protection Against Nerve Cell Injury Associated With Neurodegenerative Disorders, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Patents

The present invention relates to novel therapeutic uses of certain compounds to protect nerve cells from injury and death. The compounds include cytochalasin D and related analogs, and cytochalasin E and related analogs.

Classifying Quality Nursing Care Initiatives: Framework For Ambulatory Surgery Nursing Practice, Beth Ann Swan

College of Nursing Faculty Papers & Presentations

The demand for information about quality is greater now than ever. Despite the significance of quality to consumers, providers, and insurers of health care, information related to this phenomenon, although plentiful, has been plagued by the lack of consistent definitions, frameworks, and outcome measurements. This inconsistency leads to the inability to compare and evaluate patient outcomes from study to study and across practice settings. Assessing recovery, including symptom distress and functioning, is increasingly significant because extended operations requiring longer anesthesia are being performed in the ambulatory surgery setting. Outcomes must be linked to specific processes, and outcome information should include …

Trophectoderm Differentiation In The Bovine Embryo: Characterization Of A Polarized Epithelium., L C Barcroft, A Hay-Schmidt, A Caveney, E Gilfoyle, E W Overstrom, P Hyttel, A J Watson

Obstetrics & Gynaecology Publications

Blastocytst formation is dependent on the differentiation of a transporting epithelium, the trophectoderm, which is coordinated by the embryonic expression and cell adhesive properties of E-cadherin. The trophectoderm shares differentiative characteristics with all epithelial tissues, including E-cadherin-mediated cell adhesion, tight junction formation, and polarized distribution of intramembrane proteins, including the Na-K ATPase. The present study was conducted to characterize the mRNA expression and distribution of polypeptides encoding E-cadherin, beta-catenin, and the tight junction associated protein, zonula occludens protein 1, in pre-attachment bovine embryos, in vitro. Immunocytochemistry and gene specific reverse transcription--polymerase chain reaction methods were used. Transcripts for E-cadherin and …

Information Interface - Volume 23, Issue 5 - November/December 1998, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Site Visit To Southern California — Plans And Providers: Risk, Accountability, And Staying Power, Lisa Sprague

National Health Policy Forum

This site visit was the second of two focused on managed care operations and market dynamics in California, a state notable for high HMO market penetration and intense competition. In southern California, large physician groups and independent practice associations were highly visible and influential. They had assumed significant financial risk and care management responsibility for patients in HMO plans. The result was a distinctly different model of managed care than existed in other regions of the country. The visit included meetings with leaders from physician organizations and managed care organizations in San Diego and Orange counties, as well as an …

The Seca Subunit Of Escherichia Coli Preprotein Translocase Is Exposed To The Periplasm, Jerry Eichler, William Wickner

Dartmouth Scholarship

SecA undergoes conformational changes during translocation, inserting domains into and across the membrane or enhancing the protease resistance of these domains. We now show that some SecA bound at SecYEG is accessible from the periplasm to a membrane-impermeant probe in cells with a permeabilized outer membrane but an intact plasma membrane.

Exoy, An Adenylate Cyclase Secreted By The Pseudomonas Aeruginosa Type Iii System, Timothy L. Yahr, Amy J. Vallis, Michael Hancock, Joseph T. Barbieri, Dara W. Frank

Dartmouth Scholarship

The exoenzyme S regulon is a set of coordinately regulated virulence genes of Pseudomonas aeruginosa. Proteins encoded by the regulon include a type III secretion and translocation apparatus, regulators of gene expression, and effector proteins. The effector proteins include two enzymes with ADP-ribosyltransferase activity (ExoS and ExoT) and an acute cytotoxin (ExoU). In this study, we identified ExoY as a fourth effector protein of the regulon. ExoY is homologous to the extracellular adenylate cyclases of Bordetella pertussis (CyaA) and Bacillus anthracis (EF). The homology among the three adenylate cyclases is limited to two short regions, one of which possesses an …

Staphylococcal Enterotoxin B Primes Cytokine Secretion And Lytic Activity In Response To Native Bacterial Antigens, K. M. Mason, T. D. Dryden, Nancy J. Bigley, P. S. Fink

Neuroscience, Cell Biology & Physiology Faculty Publications

Superantigens stimulate T-lymphocyte proliferation and cytokine production, but the effects of superantigen exposure on cell function within a complex, highly regulated immune response remain to be determined. In this study, we demonstrate that superantigen exposure significantly alters the murine host response to bacterial antigens in an in vitro coculture system. Two days after exposure to the superantigen staphylococcal enterotoxin B, splenocytes cultured with Streptococcus mutans produced significantly greater amounts of gamma interferon (IFN-gamma) and interleukin-12 than did sham-injected controls. The majority of IFN-gamma production appeared to be CD8(+) T-cell derived since depletion of this cell type dramatically reduced the levels …

Moyamoya Disease Presenting With Intracranial Haemorrhage, Ali Akbar, Aftab Qureshi, Rashid Jooma

Section of Neurosurgery

No abstract provided.

The Meeting Of Pain And Depression: Comorbidity In Women, Marta Meana

Psychology Faculty Research

The higher prevalence of depression in women is coupled with a higher prevalence of pain complaints. Growing evidence suggests that the comorbidity of these conditions is also proportionately higher in women than men. This paper critically reviews the empirical findings relating to gender differences in comorbid pain and depression as well as findings in support of hypothesized etiologic factors that could explain why women may be more susceptible than men to comorbidity. The empirical evidence for biogenic, psychogenic, and sociogenic explanatory models is presented, and an integration of these models is proposed as a guideline to both research and clinical …

Preoperative Work Up: Are The Requirements Different In A Developing Country?, K M. Pal, I A. Khan, B Safdar

Department of Surgery

In developing countries there is a tendency to advocate routine testing in asymptomatic healthy patients to identify undocumented significant medical conditions. A retrospective review of pre- operative laboratory investigations undertaken in patients attending the General Surgical department was performed. Three hundred and twenty patients case notes were reviewed, patients were selected on the basis of common general surgical procedures. Two hundred and sixteen patients (67.5%) did not have any associated medical illness on history and physical examination. Analysis of laboratory results showed that 42/216 (19.4%) had low hemoglobin. An abnormal chest X-ray was the next common abnormality 11/103 (10.6%). Mild …

Primary Cutaneous Actinomycosis, Anjum Kanjee, Zamaz Wahid, Shahid Pervez

Department of Pathology and Laboratory Medicine

No abstract provided.

Guidelines For The Responsible Utilization Of Intensive Care, Lawrence University, Wisconsin Health Decisions

Biomedical Ethics Publications and Presentations

These guidelines are the product of five working groups of physicians, administrators, attorneys, ethicists, social workers, nurses, hospital chaplains, and critical care nurses from Wisconsin. Dr. John Stanley, Professor Emeritus, Lawrence University, convened the group in 1994 and they presented this final document to the Wisconsin health care community in October 1998.

These documents are not meant to be strict guidelines to be imposed, but rather resources that present the best thinking and practice at a particular time and place.

Logger Fatally Injured By Falling Limb, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 60-year-old male logger (the victim) was killed when a falling limb struck him on the head. He had been involved in the logging industry all of his life and had been working for a small logging business for six days when the fatal incident occurred. At about 9 a.m. on the day of the incident, the owner of the company went with the victim to where he would be felling trees. The victim was not wearing any personal protective equipment (PPE). They talked for a few minutes then the owner left on the bulldozer. When he returned 20-25 minutes …

Site Visit To Utah And Nevada — Essential Community Health Services On The Frontier, Karen Matherlee, Michael Anzick

National Health Policy Forum

From the opening dinner to the closing summary, this site visit explored the delivery and financing of essential community services for vulnerable populations in the frontier West. A sequel to the Forum's March 30-31, 1998, urban-centered site visit to Philadelphia, Providing Community-Based Primary Care: Nursing Centers, CHCs, and Other Initiatives, the visit spanned 493 miles. It included overview presentations, bus briefings, facility tours, telehealth demonstrations, panel discussions, and wrap-up reviews. Topics included the Utah health marketplace, the demands of emergency preparedness, the development of a patchwork of services along a continuum ranging from preventive care to tertiary referrals and follow-up, …

Your Personal Specific Spinal Rehabilitation Program, Richard S. Koch

Koch Collection, Papers of Richard S Koch, DO

General description of Dr Koch's spinal rehabilitation program with hand-out for his patients on their specific rehab program.

Chimeric Isoprenoid Synthases And Uses Thereof, Joseph Chappell, Kyoungwhan Back

Pharmaceutical Sciences Faculty Patents

Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an assymetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring …

53-Year-Old Dies In Tricycle Tractor Overturn While Transporting Round Bale, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 53-year-old full-time farmer (the victim) was crushed to death when the tractor he was operating overturned. At 1:45 pm, the victim was moving a large round bale of hay with a hay spike mounted on the front of a tractor. The tractor was not equipped with a rollover protective structure (ROPS) or a seatbelt. The farmer, who was sharecropping, was moving rolled hay from a field to a wagon in preparation for transportation to his farm. Hydraulics were used to lift the approximately 1500-pound spiked bale, and the farmer began driving toward the wagon. He proceeded along a tobacco …

Thiazolidinediones Inhibit Lipoprotein Lipase Activity In Adipocytes, Subramanian Ranganathan, Philip A. Kern

Clinical and Translational Science Faculty Publications

The thiazolidinediones troglitazone and BRL 49653 improve insulin sensitivity in humans and animals with insulin resistance. Adipose tissue lipoprotein lipase is an insulin-sensitive enzyme. We examined the effects of thiazolidinediones on lipoprotein lipase expression in adipocytes. When added to 3T3-F442A, 3T3-L1, and rat adipocytes in culture, troglitazone and BRL 49653 inhibited lipoprotein lipase activity. This inhibition was observed at concentrations as low as 0.1 μM and within 2 h after addition of the drug. Lipoprotein lipase activity was inhibited in differentiated adipocytes as well as the differentiating cells. Despite this decrease in enzyme activity, these drugs increased mRNA levels in …

Mid-Atlantic Ethics Committee Newsletter, Fall-Winter 1998

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Animal Organs In Humans: Uncalculated Risks And Unanswered Questions, Gillian R. Langley, Joyce D'Silva

Biomedicine and Animal Models in Research Collection

This report, produced jointly by the British Union for the Abolition of Vivisection and Compassion in World Farming, fills a number of significant gaps in the current debate about xenotransplantation.

In this report we also summarise the ethical and welfare issues concerning experiments on animals for xenotransplant research and their possible use as source animals for organs. Both these aspects are responsible for much pain and distress caused to many animals. We prefer the term “source animals” to “donor animals”, because animals do not choose to donate their organs for xenotransplantation.

Nurses Alumni Association Bulletin, Fall 1998, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers

Nursing Alumni Bulletins

1998-1999 Meeting Date Calendar

1999 Annual Luncheon & Meeting Notice

Fall Social

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

News About Our Graduates

Highlight Of 1998

Operation Smile

Scholarship Funds At Work

Romania Trip

Double Honors

Doris Bowman

Memorial Service For Janet Hindson "A time for everything"

On the Lighter Side

Twenty Ways to Kill an Organization

Happy Birthday

Fiftieth Anniversary

Resume Alumni Association Meetings

Alumni Office News

Committee Reports

• Bulletin
• By-Laws
• Relief Fund
• Social
• Scholarship
• Development
• Nominating

Luncheon Photos

In Memoriam, Names of Deceased Graduates

Class News

Certification Reimbursement Application

Relief Fund Application

Scholarship …

Assessing The Accuracy Of A New Diagnostic Test When A Gold Standard Does Not Exist, Todd A. Alonzo, Margaret S. Pepe

UW Biostatistics Working Paper Series

Often the accuracy of a new diagnostic test must be assessed when a perfect gold standard does not exist. Use of an imperfect test biases the accuracy estimates of the new test. This paper reviews existing approaches to this problem including discrepant resolution and latent class analysis. Deficiencies with these approaches are identified. A new approach is proposed that combines the results of several imperfect reference tests to define a better reference standard. We call this the composite reference standard (CRS). Using the CRS, accuracy can be assessed using multistage sampling designs. Maximum likelihood estimates of accuracy and expressions for …

1998 Scholars And Artists Bibliography, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library

Scholars and Artists Bibliographies

This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti

Transient Expression Of A Translation Initiation Factor Is Conservatively Associated With Embryonic Gene Activation In Murine And Bovine Embryos., P A De Sousa, A J Watson, R M Schultz

Obstetrics & Gynaecology Publications

In the present study the abundance of mRNAs for eukaryotic translation initiation factors eIF-1A (formerly known as eIF-4C), -2alpha, -4A, -4E, and -5 was examined in in vivo-derived mouse embryos throughout preimplantation development using a semiquantitative reverse transcription-polymerase chain reaction assay. Although the mRNA profile for each gene is unique, only mRNA for eIF-1A transiently increases during embryonic gene activation (EGA) at the 2-cell stage, and this was confirmed by an independent hybridization-based assay. In in vitro-developed bovine embryos, mRNA for eIF-1A was transiently detected at the 8-cell stage, when the major activation of the genome occurs in this species. …

The State Children's Health Insurance Program: How Much Latitude Do The States Really Have?, Richard Hegner

National Health Policy Forum

The State Children's Health Insurance Program (CHIP) — a major program to cover low-income, uninsured children — was passed as part of the Balanced Budget Act of 1997. Its passage was part of a trend of a shifting balance of power between the federal and state governments, particularly in the policy areas of health and social welfare. This issue brief explores the degree of freedom afforded the states by CHIP, the factors guiding state decision making and planning, and the factors influencing the states' various decisions about CHIP. It also discusses state options in four basic areas: participation or nonparticipation …

Social Support In Marriage: Translating Research Into Practical Applications For Clinicians, Kieran T. Sullivan, Lauri A. Pasch, Kathleen A. Eldridge, Thomas N. Bradbury

Psychology

How spouses support one another may be important in understanding and preventing marital distress, but has received relatively little attention. Instead, the behavioral model of marriage and corresponding treatment protocols have focused on the importance of good conflict management skills in preventing and treating marital distress. This paper outlines recent research indicating that couples social support skills predict marital outcome two years later, above and beyond conflict management skills. These results indicate that successful prevention and treatment programs may need to incorporate support skills training as well as conflict management training. Practical implications of this research are outlined, and specific …

A Protein Encoded By The Latency-Related Gene Of Bovine Herpesvirus 1 Is Expressed In Trigeminal Ganglionic Neurons Of Latently Infected Cattle And Interacts With Cyclin-Dependent Kinase 2 During Productive Infection, Yunquan Jiang, Ashfaque Hossain, Mariah Teresa Winkler, Todd Holt, Alan R. Doster, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Despite productive viral gene expression in the peripheral nervous system during acute infection, the bovine herpesvirus 1 (BHV-1) infection cycle is blocked in sensory ganglionic neurons and consequently latency is established. The only abundant viral transcript expressed during latency is the latency-related (LR) RNA. LR gene products inhibit S-phase entry, and binding of the LR protein (LRP) to cyclin A was hypothesized to block cell cycle progression. This study demonstrates LRP is a nuclear protein which is expressed in neurons of latently infected cattle. Affinity chromatography indicated that LRP interacts with cyclin-dependent kinase 2 (cdk2)-cyclin complexes or cdc2-cyclin complexes in …

Pathogenicity Of An Enterotoxigenic Escherichia Coli Hemolysin (Hlya) Mutant In Gnotobiotic Piglets, Rodney A. Moxley, Emil M. Berberov, David H. Francis, Jun Xing, Mahtab Moayeri, Rodney A. Welsch, Diane R. Baker, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Pigs infected with hemolytic F4⁺ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4⁺ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.