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Full-Text Articles in Medicine and Health Sciences
An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell
An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell
Xu-Feng Huang
Purpose: Metabotropic glutamate receptors (mGluRs) are proposed novel therapeutic targets for a variety of brain disorders such as schizophrenia (SZ), bipolar disorder (BP) and major depression (MD). Despite their potential, the involvement of these receptors in these pathological processes is uncertain. This information is crucial to understand the efficiency of drugs that target these receptors. Methods: Using post-mortem human brains, mGluR2/3 and mGluR5 binding densities were measured in the anterior cingulate cortex of SZ, BP, MD and matched controls (CT) (n=15/group) by receptor autoradiography. Results: Whilst preliminary analyses indicated no diagnostic effect in mGluR2/3 or mGluR5 binding densities, mGluR2/3 binding …
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Xu-Feng Huang
The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia,particularly with regards to auditory hallucinations. In this study, using in situ quantitative autoradiography in postmortem tissue, we investigated the binding of the [3H]ketanserin to 5-HT2A receptors and [3H] mesulergine to 5-HT2C receptors in the left STG of 8 male schizophrenic patients compared to 8 control subjects. A strong [3H]ketanserin binding was observed in the STG, however there was a very weak [3H] mesulergine binding in the STG. A significant decrease in binding of [3H]ketanserin was clearly observed in schizophrenia patients in comparison with control subjects. There were …
No Changes In Densities Of Cannabinoid Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng, Mei Han
No Changes In Densities Of Cannabinoid Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng, Mei Han
Xu-Feng Huang
Objective: In recent years, abnormal changes in the endocannabinoid system have been found in schizophrenia. The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. In this study, we investigated the binding density of cannabinoid CB1 receptors in the STG of schizophrenia patients compared to control subjects. Methods: Quantitative autoradiography was used to investigate the binding densities of [3H] SR141716A (a selective antagonist) and [3H]CP-55940 (an agonist) to the CB1 receptors in the STG. Post-mortem brain tissue was obtained from the NSW Tissue Resource Centre (Australia). Results: Contrasting to previous findings …
Increased Density Of Gabaa Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Increased Density Of Gabaa Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
Decreased Density Of Muscarinic Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Decreased Density Of Muscarinic Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
Perinatal Pcp Treatment Alters The Developmental Expression Of Prefrontal And Hippocampal Muscarinic Receptors, Kelly Newell, Xu-Feng Huang, Chao Deng, Teresa Du Bois, Mei Han
Perinatal Pcp Treatment Alters The Developmental Expression Of Prefrontal And Hippocampal Muscarinic Receptors, Kelly Newell, Xu-Feng Huang, Chao Deng, Teresa Du Bois, Mei Han
Xu-Feng Huang
Perinatal phencyclidine (PCP) treatment has been used to model brain pathological processes that may be present in schizophrenia such as increased apoptosis during early brain development, and long-term alterations in expression of parvalbumin-containing interneurons and glutamatergic N-methyl-d-aspartate (NMDA) receptors. We report that this treatment also affects receptor expression of another excitatory neurotransmitter receptor, the muscarinic receptor. Female rat pups received injections of the NMDA receptor antagonist PCP (10 mg/kg, s.c.) or saline on postnatal days (PN)7, 9 and 11. [3H]Pirenzepine binding to M1/4 receptors was examined at four time-points (PN12, 18, 32 and 96) following treatment cessation. Significant effects of …
Effects Of Typical And Atypical Antipsychotic Drugs On Rat Brain Muscarinic Receptors, Van Nguyen, Xu-Feng Huang, Katerina Zavitsanou, Mei Han
Effects Of Typical And Atypical Antipsychotic Drugs On Rat Brain Muscarinic Receptors, Van Nguyen, Xu-Feng Huang, Katerina Zavitsanou, Mei Han
Xu-Feng Huang
No abstract provided.