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Articles 1 - 30 of 162
Full-Text Articles in Medicine and Health Sciences
Glun2b Protein Deficits In The Left, But Not The Right, Hippocampus In Schizophrenia, Amy Geddes, Xu-Feng Huang, Kelly Newell
Glun2b Protein Deficits In The Left, But Not The Right, Hippocampus In Schizophrenia, Amy Geddes, Xu-Feng Huang, Kelly Newell
Xu-Feng Huang
Background Increasing evidence indicates that alterations to the function and subunit composition of the glutamatergic NMDA receptor are associated with the pathophysiology of schizophrenia. The GluN2B protein is a structural and functional subunit of the NMDA receptor, with a growing body of evidence indicating it plays a critical role in cognitive functions mediated by the NMDA receptor. The hippocampus plays a key role in cognitive function, with studies suggesting lateralised glutamatergic dysfunction in this region may contribute to the cognitive deficits observed in schizophrenia patients. The present study, for the first time, investigated GluN2B protein and binding density in the …
Gender Differences In Cognitive Deficits In Schizophrenia With And Without Diabetes, Bao Hua J. Zhang, Mei Han, Xiang Yang Zhang, Li Hui, Shu Rong Jiang, Fu-De Yang, Yun Long Tan, Zhi-Ren Wang, Juan Li, Xu-Feng Huang
Gender Differences In Cognitive Deficits In Schizophrenia With And Without Diabetes, Bao Hua J. Zhang, Mei Han, Xiang Yang Zhang, Li Hui, Shu Rong Jiang, Fu-De Yang, Yun Long Tan, Zhi-Ren Wang, Juan Li, Xu-Feng Huang
Xu-Feng Huang
This study investigated gender differences in cognition in schizophrenia with and without diabetes. Cognition was assessed in 263 individuals with schizophrenia with age range (40-68): 67 males and 34 females with schizophrenia with diabetes; and 125 males and 37 females with schizophrenia without diabetes according to the repeatable battery for the assessment of neuropsychological status (RBANS). Fasting glucose, hemoglobin A1c (HbA1c) and lipid levels were measured. Results showed that male individuals performed worse on most cognitive tasks, especially attention, in schizophrenia with than without diabetes. This result was not observed in female individuals. Also, individuals of both genders showed higher …
High Fat Diet-Induced Obesity Increases The Formation Of Colon Polyps Induced By Azoxymethane In Mice, Jiezhong Chen, Xu-Feng Huang
High Fat Diet-Induced Obesity Increases The Formation Of Colon Polyps Induced By Azoxymethane In Mice, Jiezhong Chen, Xu-Feng Huang
Xu-Feng Huang
Background: Obesity has been found to be associated with colon cancer. However, the mechanism of this relationship is unclear and thus a good animal model is required. Our previous research showed that some mice developed diet-induced obesity (DIO) whilst others were diet-resistant (DR) when fed a high-fat diet. Methods: In the present study, we have tested the effects of a high-fat diet on the formation of colon polyps induced by azoxymethane (AOM) in both DIO and DR mice. Results: We found that the DIO mice have developed 2.5 times of polyps compared to the DR mice (P<0.05) and 3.4 …
Effects Of Olanzapine And Betahistine Co-Treatment On Serotonin Transporter, 5-Ht2a And Dopamine D2 Receptor Binding Density, Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Deng
Effects Of Olanzapine And Betahistine Co-Treatment On Serotonin Transporter, 5-Ht2a And Dopamine D2 Receptor Binding Density, Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Deng
Xu-Feng Huang
Olanzapine is widely used in treating multiple domains of schizophrenia symptoms but induces serious metabolic side-effects. Recent evidence has showed that co-treatment of betahistine (a histaminergic H1 receptor agonist and H3 receptor antagonist) is effective for preventing olanzapine-induced weight gain/obesity, however it is not clear whether this co-treatment affects on the primary therapeutic receptor binding sites of olanzapine such as serotonergic 5-HT2A receptors (5-HT2AR) and dopaminergic D2 receptors (D2R). Therefore, this study investigated the effects of this co-treatment on 5-HT2AR, 5-HT transporter (5-HTT) and D2R bindings in various brain regions involved in antipsychotic efficacy. Female Sprague Dawley rats were administered …
Effects Of Olanzapine On The Elevation Of Macrophage Infiltration And Pro-Inflammatory Cytokine Expression In Female Rats, Qingsheng Zhang, Meng He, Chao Deng, Hongqin Wang, Xu-Feng Huang
Effects Of Olanzapine On The Elevation Of Macrophage Infiltration And Pro-Inflammatory Cytokine Expression In Female Rats, Qingsheng Zhang, Meng He, Chao Deng, Hongqin Wang, Xu-Feng Huang
Xu-Feng Huang
The metabolic side-effects of olanzapine have undermined drug compliance and increased concern for this otherwise-effective treatment for schizophrenia. As obesity and type 2 diabetes are associated with low-grade inflammation, and olanzapine-induced weight gain has three typical stages, the current study investigated the inflammatory effects of olanzapine in three treatment stages. Female Sprague-Dawley rats were treated orally with olanzapine (1 mg/kg three times daily) or vehicle for one week, two weeks, and five weeks. Olanzapine significantly increased body weight and white visceral fat deposition in all three treatment stages compared to control. Olanzapine enhanced average adipocyte size and level of macrophage …
Early Antipsychotic Treatment In Childhood/Adolescent Period Has Long-Term Effects On Depressive-Like, Anxiety-Like And Locomotor Behaviours In Adult Rats, Michael De Santis, Jiamei Lian, Xu-Feng Huang, Chao Deng
Early Antipsychotic Treatment In Childhood/Adolescent Period Has Long-Term Effects On Depressive-Like, Anxiety-Like And Locomotor Behaviours In Adult Rats, Michael De Santis, Jiamei Lian, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
Childhood/adolescent antipsychotic drug (APD) use is exponentially increasing worldwide, despite limited knowledge of the long-term effects of early APD treatment. Whilst investigations have found that early treatment has resulted in some alterations to dopamine and serotonin neurotransmission systems (essential to APD efficacy), there have only been limited studies into potential long-term behavioural changes. This study, using an animal model for childhood/adolescent APD treatment, investigated the long-term effects of aripiprazole, olanzapine and risperidone on adult behaviours of male and female rats. Open-field/holeboard, elevated plus maze (EPM), social interaction and forced swim (FS) tests were then conducted in adult rats. Our results …
Effects Of Pharmacological Blockade Of Lingo - 1 Signaling Pathways In A Phencyclidine Rat Model For Schizophrenia, Jessica L. Andrews, Ryan Sullivan, Kelly Newell, Xu-Feng Huang, Francesca Fernandez-Enright
Effects Of Pharmacological Blockade Of Lingo - 1 Signaling Pathways In A Phencyclidine Rat Model For Schizophrenia, Jessica L. Andrews, Ryan Sullivan, Kelly Newell, Xu-Feng Huang, Francesca Fernandez-Enright
Xu-Feng Huang
Abstract of a poster presentation at the 2014 Society for Neuroscience Meeting, Washington, DC, 15-19 November.
Differential Effects Of Short- And Long-Term Antipsychotic Treatment On The Expression Of Neuregulin-1 And Erbb4 Receptors In The Rat Brain, Chao Deng, Bo Pan, Chang-Hua Hu, Mei Han, Xu-Feng Huang
Differential Effects Of Short- And Long-Term Antipsychotic Treatment On The Expression Of Neuregulin-1 And Erbb4 Receptors In The Rat Brain, Chao Deng, Bo Pan, Chang-Hua Hu, Mei Han, Xu-Feng Huang
Xu-Feng Huang
Neuregulin-1 (NRG1) and ErbB4 genes have been identified as candidate genes for schizophrenia. Post-mortem studies indicated that NRG1-ErbB4 signalling is impaired in schizophrenia subjects. This study investigated whether short- or long-term antipsychotic treatment has different effects on the expression of NRG1 and ErbB4 receptors. Female Sprague-Dawley rats were treated orally with either aripiprazole (0.75 mg/kg), haloperidol (0.1 mg/kg), olanzapine (0.5 mg/kg), or vehicle, 3 times/day for 1 or 12 weeks. Western blotting was performed to examine the expression of NRG1 isoforms (135 kDa, 70 kDa and 40 kDa) and ErbB4 receptors. Both 1-week haloperidol and olanzapine treatment increased NRG1-70 kDa …
Dha Prevents Altered 5-Ht1a, 5-Ht2a, Cb1 And Gabaa Receptor Binding Densities In The Brain Of Male Rats Fed A High-Saturated-Fat Diet, Yinghua Yu, Yizhen Wu, Craig Patch, Zhixiang Wu, Alexander Szabo, Duo Li, Xu-Feng Huang
Dha Prevents Altered 5-Ht1a, 5-Ht2a, Cb1 And Gabaa Receptor Binding Densities In The Brain Of Male Rats Fed A High-Saturated-Fat Diet, Yinghua Yu, Yizhen Wu, Craig Patch, Zhixiang Wu, Alexander Szabo, Duo Li, Xu-Feng Huang
Xu-Feng Huang
Low levels of docosahexaenoic acid (DHA) have been linked to a number of mental illnesses such as memory loss, depression and schizophrenia. While supplementation of DHA is beneficial in improving memory and cognition, the influence of dietary fats on the neurotransmitters and receptors involved in cognitive function is still not known. The aim of this study was to investigate serotonin receptor (5-HT1A and 5-HT2A), cannabinoid receptor (CB1) and gamma-aminobutyric acid type A (GABAA) receptor binding densities in the brain of male rats fed a high-saturated-fat (HF) diet, as well as the effect of DHA supplementation on HF diet. Alterations of …
Dyslipidemia Awareness, Treatment, Control And Influence Factors Among Adults In The Jilin Province In China: A Cross-Sectional Study, Huan He, Yaqin Yu, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Chang Wang, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, Yawen Liu
Dyslipidemia Awareness, Treatment, Control And Influence Factors Among Adults In The Jilin Province In China: A Cross-Sectional Study, Huan He, Yaqin Yu, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Chang Wang, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, Yawen Liu
Xu-Feng Huang
Background In China, even though the prevalence of dyslipidemia among adults increased yearly and dyslipidemia being an important risk factor for cardiovascular diseases among the Chinese population, however, the awareness, treatment and control of dyslipidemia are at low levels, and only limited studies on the influence factors associated with the awareness, treatment and control dyslipidemia in China have been carried out. Methods The analysis was based on a representative sample of 7138 adult subjects aged 18 ~ 79 years recruited from a cross-sectional study of chronic disease and risk factors among adults in the Jilin province in 2012. Chi-square test …
Comment On: Oleanolic Acid Co-Administration Alleviates Ethanol-Induced Hepatic Injury Via Nrf-2 And Ethanol-Metabolizing Modulation (Sic) In Rats, Danielle Camer, Xu-Feng Huang
Comment On: Oleanolic Acid Co-Administration Alleviates Ethanol-Induced Hepatic Injury Via Nrf-2 And Ethanol-Metabolizing Modulation (Sic) In Rats, Danielle Camer, Xu-Feng Huang
Xu-Feng Huang
To the Editor: Alcohol induced hepatic oxidative stress and inflammation is known to cause liver injury. An increase in reactive oxidative species (ROS) from alcohol consumption leads to oxidative stress [1]. This can activate the inflammatory cytokines, IL-6 and TNF-α which promote liver injury. Both IL-6 and TNF-α are activated and transcribed by the inflammatory molecule, NFκB [2]. We read the interesting paper by Liu et al., entitled, “Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulating in rats”, published in your journal recently [3]. The authors demonstrated that oleanolic acid can reduce hepatic injury by elevating …
Different Effects Of Bifeprunox, Aripiprazole, And Haloperidol On Body Weight Gain, Food And Water Intake, And Locomotor Activity In Rats, Michael De Santis, Bo Pan, Jiamei Lian, Xu-Feng Huang, Chao Deng
Different Effects Of Bifeprunox, Aripiprazole, And Haloperidol On Body Weight Gain, Food And Water Intake, And Locomotor Activity In Rats, Michael De Santis, Bo Pan, Jiamei Lian, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
Following on the success of Aripiprazole with its high clinical efficacy and minimal side effects, further antipsychotic drugs (such as Bifeprunox) have been developed based on the same dopamine D2 partial agonist pharmacological profile as Aripiprazole. However clinical trials of Bifeprunox have found differing results to that of its predecessor, without the same significant clinical efficacy. This study has therefore investigated the different effects of 10 week treatment with Aripiprazole (0.75 mg/kg, 3 times per day), Bifeprunox (0.8 mg/kg, 3 times per day) and Haloperidol (0.1 mg/kg, 3 times per day) on body weight gain, food and water intake, white …
Differential Cognitive And Behavioural Impacts Of Lps And Polyi:C Prenatal Infections On Adult Female Offspring, Christopher Bell, Hongqin Wang, Xu-Feng Huang, Yinghua Yu
Differential Cognitive And Behavioural Impacts Of Lps And Polyi:C Prenatal Infections On Adult Female Offspring, Christopher Bell, Hongqin Wang, Xu-Feng Huang, Yinghua Yu
Xu-Feng Huang
Abstract of a poster presentation.
Central Administration Of Palmitic Acid Increases Food Intake And Body Temperature In Male Sprague Dawley Rats, Chi H. L Dinh, Alexander M. Szabo, Hongqin Wang, Yinghua Yu, Xu-Feng Huang
Central Administration Of Palmitic Acid Increases Food Intake And Body Temperature In Male Sprague Dawley Rats, Chi H. L Dinh, Alexander M. Szabo, Hongqin Wang, Yinghua Yu, Xu-Feng Huang
Xu-Feng Huang
Abstract of a poster presentation at the World Diabetes Congress 2013
Chronic Betahistine Co-Treatment Reverses Olanzapine's Effects On Dopamine D2 But Not 5-Ht2a/2c Bindings In Rat Brains, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Chronic Betahistine Co-Treatment Reverses Olanzapine's Effects On Dopamine D2 But Not 5-Ht2a/2c Bindings In Rat Brains, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Xu-Feng Huang
Olanzapine is widely prescribed for treating schizophrenia and other mental disorders, although it leads to severe body weight gain/obesity. Chronic co-treatment with betahistine has been found to significantly decrease olanzapine-induced weight gain; however, it is not clear whether this co-treatment affects the therapeutic effects of olanzapine. This study investigated the effects of chronic treatment of olanzapine and/or betahistine on the binding density of the serotonergic 5-HT2A (5-HT2AR) and 5-HT2C (5-HT2CR) receptors, 5-HT transporter (5-HTT), and dopaminergic D2 receptors (D2R) in the brain regions involved in antipsychotic efficacy, including the prefrontal cortex (PFC), cingulate cortex (Cg), nucleus accumbens (NAc), and caudate …
Cognitive Differences In Schizophrenia On Long-Term Treatments With Clozapine, Risperidone And Typical Antipsychotics, Mei Han, Xiang Yang Zhang, Da Chun Chen, Yun Long Tan, Chong Sheng Song, Yinghua Yu, Xu-Feng Huang
Cognitive Differences In Schizophrenia On Long-Term Treatments With Clozapine, Risperidone And Typical Antipsychotics, Mei Han, Xiang Yang Zhang, Da Chun Chen, Yun Long Tan, Chong Sheng Song, Yinghua Yu, Xu-Feng Huang
Xu-Feng Huang
Cognitive deficits are a core feature of schizophrenia. There is ongoing debate on whether cognition is affected by antipsychotic drugs (APDs). This study examined the effect of long-term treatment with APDs on cognition in schizophrenia. Cognitive function was assessed in 418 patients with schizophrenia on long-term treatment with APDs (215 on clozapine, 91 on risperidone and 112 on typical APDs) and 159 healthy controls using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Schizophrenia symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). We found that cognitive test scores were significantly lower in all patients compared …
Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu
Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu
Xu-Feng Huang
Purpose: Leptin inhibits feeding and increases energy expenditure through the central nervous system. High-fat diet with saturated fatty acids (SFA) or n-6 polyunsaturated fatty acids (n-6 PUFA) has been reported to induce central leptin resistance and obesity. However, little is known if central administration of SFA or n-6 PUFA can reduce central leptin sensitivity. This study examined the central leptin sensitivity in response to intracerebroventricular (i.c.v.) injection of SFA, palmitic acid (PA) and n-6 PUFA, arachidonic acid (ARA) in mice. Methods: After overnight fasting, C57BL/6J male mice (n=24/group) were i.c.v. injected with either PA (50pmol/2ul), ARA (50pmol/2ul) or vehicle (saline, …
Central Inflammation And Leptin Resistance Are Attenuated By Ginsenoside Rb1 Treatment In Obese Mice Fed A High-Fat Diet, Yizhen Wu, Yinghua Yu, Alexander Szabo, Mei Han, Xu-Feng Huang
Central Inflammation And Leptin Resistance Are Attenuated By Ginsenoside Rb1 Treatment In Obese Mice Fed A High-Fat Diet, Yizhen Wu, Yinghua Yu, Alexander Szabo, Mei Han, Xu-Feng Huang
Xu-Feng Huang
A low-grade pro-inflammatory state is at the pathogenic core of obesity and type 2 diabetes. We tested the hypothesis that the plant terpenoid compound ginsenoside Rb1 (Rb1), known to exert anti-inflammatory effects, would ameliorate obesity, obesity-associated inflammation and glucose intolerance in the high-fat diet-induced obese mouse model. Furthermore, we examined the effect of Rb1 treatment on central leptin sensitivity and the leptin signaling pathway in the hypothalamus. We found that intraperitoneal injections of Rb1 (14 mg/kg, daily) for 21 days significantly reduced body weight gain, fat mass accumulation, and improved glucose tolerance in obese mice on a HF diet compared …
Bardoxolone Methyl: A Potential Therapeutic For The Prevention Of Anti-Psychotic Drug-Induced Obesity?, Danielle Camer, Christopher Bell, Yinghua Yu, Alexander M. Szabo, Francesca Fernandez-Enright, Hoang Lan Chi Dinh, Xu-Feng Huang
Bardoxolone Methyl: A Potential Therapeutic For The Prevention Of Anti-Psychotic Drug-Induced Obesity?, Danielle Camer, Christopher Bell, Yinghua Yu, Alexander M. Szabo, Francesca Fernandez-Enright, Hoang Lan Chi Dinh, Xu-Feng Huang
Xu-Feng Huang
Abstract of a presentation.
Bardoxolone Methyl Prevents Fat Deposition And Inflammation In Brown Adipose Tissue And Enhances Sympathetic Activity In Mice Fed A High-Fat Diet, Chi H. L Dinh, Alexander M. Szabo, Yinghua Yu, Danielle Camer, Qingsheng Zhang, Hongqin Wang, Xu-Feng Huang
Bardoxolone Methyl Prevents Fat Deposition And Inflammation In Brown Adipose Tissue And Enhances Sympathetic Activity In Mice Fed A High-Fat Diet, Chi H. L Dinh, Alexander M. Szabo, Yinghua Yu, Danielle Camer, Qingsheng Zhang, Hongqin Wang, Xu-Feng Huang
Xu-Feng Huang
Obesity results in changes in brown adipose tissue (BAT) morphology, leading to fat deposition, inflammation, and alterations in sympathetic nerve activity. Bardoxolone methyl (BARD) has been extensively studied for the treatment of chronic diseases. We present for the first time the effects of oral BARD treatment on BAT morphology and associated changes in the brainstem. Three groups (n = 7) of C57BL/6J mice were fed either a high-fat diet (HFD), a high-fat diet supplemented with BARD (HFD/BARD), or a low-fat diet (LFD) for 21 weeks. BARD was administered daily in drinking water. Interscapular BAT, and ventrolateral medulla (VLM) and dorsal …
Bardoxolone Methyl Prevents Mesenteric Fat Deposition And Inflammation In High-Fat Diet Mice, Chi H. L Dinh, Alexander M. Szabo, Yinghua Yu, Danielle Camer, Hongqin Wang, Xu-Feng Huang
Bardoxolone Methyl Prevents Mesenteric Fat Deposition And Inflammation In High-Fat Diet Mice, Chi H. L Dinh, Alexander M. Szabo, Yinghua Yu, Danielle Camer, Hongqin Wang, Xu-Feng Huang
Xu-Feng Huang
Mesenteric fat belongs to visceral fat. An increased deposition of mesenteric fat contributes to obesity associated complications such as type 2 diabetes and cardiovascular diseases. We have investigated the therapeutic effects of bardoxolone methyl (BARD) on mesenteric adipose tissue of mice fed a high-fat diet (HFD). Male C57BL/6J mice were administered oral BARD during HFD feeding (HFD/BARD), only fed a high-fat diet (HFD), or fed low-fat diet (LFD) for 21 weeks. Histology and immunohistochemistry were used to analyse mesenteric morphology and macrophages, while Western blot was used to assess the expression of inflammatory, oxidative stress, and energy expenditure proteins. Supplementation …
Awareness, Treatment, Control Of Diabetes Mellitus And The Risk Factors: Survey Results From Northeast China, Chang Wang, Yaqin Yu, Xiang Yang Zhang, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Huan He, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, Yawen Liu
Awareness, Treatment, Control Of Diabetes Mellitus And The Risk Factors: Survey Results From Northeast China, Chang Wang, Yaqin Yu, Xiang Yang Zhang, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Huan He, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, Yawen Liu
Xu-Feng Huang
Background The awareness, treatment and control of diabetes mellitus (DM) can effectively reflect on the social status of diabetes conditions. Although several researchers have investigated the awareness, treatment and control rates of diabetes mellitus in China, little is known about their association with risk factors. This study aims to examine the relationship between risk factors and awareness, treatment and control of diabetes mellitus in northeast China. Methods A cross-sectional survey was conducted in 2012. Multistage stratified random cluster sampling design was used to select participants aged 18 to 79 years old. The analysis was based on a representative sample of …
Bardoxolone Methyl Prevents High-Fat Diet-Induced Alterations In Prefrontal Cortex Signalling Molecules Involved In Recognition Memory, Danielle Camer, Yinghua Yu, Alexander M. Szabo, Francesca Fernandez-Enright, Hoang Lan Chi Dinh, Xu-Feng Huang
Bardoxolone Methyl Prevents High-Fat Diet-Induced Alterations In Prefrontal Cortex Signalling Molecules Involved In Recognition Memory, Danielle Camer, Yinghua Yu, Alexander M. Szabo, Francesca Fernandez-Enright, Hoang Lan Chi Dinh, Xu-Feng Huang
Xu-Feng Huang
High fat (HF) diets are known to induce changes in synaptic plasticity in the forebrain leading to learning and memory impairments. Previous studies of oleanolic acid derivatives have found that these compounds can cross the blood-brain barrier to prevent neuronal cell death. We examined the hypothesis that the oleanolic acid derivative, bardoxolone methyl (BM) would prevent diet-induced cognitive deficits in mice fed a HF diet. C57BL/6J male mice were fed a lab chow (LC) (5% of energy as fat), a HF (40% of energy as fat), or a HF diet supplemented with 10 mg/kg/day BM orally for 21 weeks. Recognition …
Bardoxolone Methyl Prevents Insulin Resistance And The Development Of Hepatic Steatosis In Mice Fed A High-Fat Diet, Danielle Camer, Yinghua Yu, Alexander M. Szabo, Hoang Lan Chi Dinh, Hongqin Wang, Licai Cheng, Xu-Feng Huang
Bardoxolone Methyl Prevents Insulin Resistance And The Development Of Hepatic Steatosis In Mice Fed A High-Fat Diet, Danielle Camer, Yinghua Yu, Alexander M. Szabo, Hoang Lan Chi Dinh, Hongqin Wang, Licai Cheng, Xu-Feng Huang
Xu-Feng Huang
High-fat (HF) diet-induced obesity is a major risk factor for the development of insulin resistance and hepatic steatosis. We examined the hypothesis that bardoxolone methyl (BM) would prevent the development of insulin resistance and hepatic steatosis in mice fed a HF diet. C57BL/6J male mice were fed a lab chow (LC), HF (40% fat), or HF diet supplemented with 10 mg/kg/day BM orally for 21 weeks. Glucose metabolism was assessed using a glucose tolerance test (GTT) and insulin sensitivity test (IST). Signalling molecules involved in insulin resistance, inflammation, and lipid metabolism were examined in liver tissue via western blotting and …
Aripiprazole And Haloperidol Activate Gsk3Β-Dependent Signalling Pathway Differentially In Various Brain Regions Of Rats, Bo Pan, Xu-Feng Huang, Chao Deng
Aripiprazole And Haloperidol Activate Gsk3Β-Dependent Signalling Pathway Differentially In Various Brain Regions Of Rats, Bo Pan, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
Aripiprazole, a dopamine D2 receptor (D2R) partial agonist, possesses a unique clinical profile. Glycogen synthase kinase 3β (GSK3β)-dependent signalling pathways have been implicated in the pathophysiology of schizophrenia and antipsychotic drug actions. The present study examined whether aripiprazole differentially affects the GSK3β-dependent signalling pathways in the prefrontal cortex (PFC), nucleus accumbens (NAc), and caudate putamen (CPu), in comparison with haloperidol (a D2R antagonist) and bifeprunox (a D2R partial agonist). Rats were orally administrated aripiprazole (0.75 mg/kg), bifeprunox (0.8 mg/kg), haloperidol (0.1 mg/kg) or vehicle three times per day for one week. The levels of protein kinase B (Akt), p-Akt, GSK3β, …
Arachidonic Acid Impairs Hypothalamic Leptin Signaling And Hepatic Energy Homeostasis In Mice, Licai Cheng, Yinghua Yu, Qingsheng Zhang, Alexander M. Szabo, Hongqin Wang, Xu-Feng Huang
Arachidonic Acid Impairs Hypothalamic Leptin Signaling And Hepatic Energy Homeostasis In Mice, Licai Cheng, Yinghua Yu, Qingsheng Zhang, Alexander M. Szabo, Hongqin Wang, Xu-Feng Huang
Xu-Feng Huang
Epidemiological evidence suggests that the consumption of a diet high in n-6 polyunsaturated fatty acids (PUFA) is associated with the development of leptin resistance and obesity. We aim to examine the central effect of n-6 PUFA, arachidonic acid (ARA) on leptin sensitivity and leptin-regulated hepatic glucose and lipid metabolism. We found that intracerebroventricular injection of ARA (25 nmol/day) for 2.5 days reversed the effect of central leptin on hypothalamic JAK2, pSTAT3, pAkt, and pFOXO1 protein levels, which was concomitant with a pro-inflammatory response in the hypothalamus. ARA also attenuated the effect of central leptin on hepatic glucose and lipid metabolism …
Alterations Of P75 Neurotrophin Receptor And Myelin Transcription Factor 1 In The Hippocampus Of Perinatal Phencyclidine Treated Rats, Jessica L. Andrews, Kelly A. Newell, Natalie Matosin, Xu-Feng Huang, Francesca Fernandez-Enright
Alterations Of P75 Neurotrophin Receptor And Myelin Transcription Factor 1 In The Hippocampus Of Perinatal Phencyclidine Treated Rats, Jessica L. Andrews, Kelly A. Newell, Natalie Matosin, Xu-Feng Huang, Francesca Fernandez-Enright
Xu-Feng Huang
Postnatal administration of phencyclidine (PCP) in rodents causes major disturbances to neurological processes resulting in severe modifications to normal behavioral traits into adulthood. It is routinely used to model psychiatric disorders such as schizophrenia, producing many of the dysfunctional processes in the brain that are present in this devastating disorder, including elevated levels of apoptosis during neurodevelopment and disruptions to myelin and plasticity processes. Lingo-1 (or Leucine-rich repeat and immunoglobulin domain-containing protein) is responsible for negatively regulating neurite outgrowth and the myelination of axons. Recent findings using a postmortem human brain cohort showed that Lingo-1 signaling partners in the Nogo …
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Xu-Feng Huang
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) …
A High-Dose Shiitake Mushroom Increases Hepatic Accumulation Of Triacylglycerol In Rats Fed A High-Fat Diet: Underlying Mechanism, Dian Handayani, Barbara J. Meyer, Jiezhong Chen, Simon H. J Brown, Todd W. Mitchell, Xu-Feng Huang
A High-Dose Shiitake Mushroom Increases Hepatic Accumulation Of Triacylglycerol In Rats Fed A High-Fat Diet: Underlying Mechanism, Dian Handayani, Barbara J. Meyer, Jiezhong Chen, Simon H. J Brown, Todd W. Mitchell, Xu-Feng Huang
Xu-Feng Huang
Shiitake mushroom have been shown to have health benefits including lowering plasma lipids and preventing body weight gain. However, their underlying mechanisms are largely unknown. The study aim was to assess the potential underlying mechanism of Shiitake mushrooms in lowering plasma triacylglycerol (TAG) in rats fed a high fat diet (HFD). Forty Wistar rats were divided into control group were given HFD and treatment group were fed HFD, enriched with Shiitake mushroom powder at a low dose (LD-M): 0.7%, medium dose (MD-M): 2%, or high dose (HD-M): 6% (wt:wt) for six weeks. Diets were isocaloric containing ~50% energy from fat. …
Alterations Of Mglur5 And Its Endogenous Regulators Norbin, Tamalin And Preso1 In Schizophrenia: Towards A Model Of Mglur5 Dysregulation, Natalie Matosin, Francesca Fernandez-Enright, Samantha J. Fung, Jeremy S. Lum, Martin Engel, Jessica L. Andrews, Xu-Feng Huang, Cynthia S. Weickert, Kelly A. Newell
Alterations Of Mglur5 And Its Endogenous Regulators Norbin, Tamalin And Preso1 In Schizophrenia: Towards A Model Of Mglur5 Dysregulation, Natalie Matosin, Francesca Fernandez-Enright, Samantha J. Fung, Jeremy S. Lum, Martin Engel, Jessica L. Andrews, Xu-Feng Huang, Cynthia S. Weickert, Kelly A. Newell
Xu-Feng Huang
Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explored mGluR5 dysfunction at the molecular level in the postmortem schizophrenia brain. We assessed mGluR5 mRNA and protein levels in the dorsolateral prefrontal cortex (DLPFC) using a large cohort of schizophrenia and control subjects (n = 37/group), and additionally measured protein levels of recently discovered mGluR5 endogenous regulators, Norbin (neurochondrin), Tamalin (GRASP-1), and Preso1 (FRMPD4), which regulate mGluR5 localization, …