Medicine and Health Sciences Commons^™

Factors Associated With Depression Among Type 2 Diabetes Mellitus Patients At A Tertiary Hospital During The Covid-19 Pandemic, Muhammad Ikhsan Mokoagow, Dian Pitawati, Ditya Nona Arisandy, Nadya Magfira, Pratiwi Indah Palupi, Jerry Nasarudin, Marina Epriliawati, Ida Ayu Kshanti

Kesmas

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that can cause various complications, economic burdens, and psychosocial issues that eventually lead to depression. This study aimed to describe the prevalence of depression among type 2 diabetes mellitus patients in the Internal Medicine Outpatient Clinic of a South Jakarta tertiary hospital during the COVID-19 pandemic. This cross-sectional study was conducted from May to July 2021. The data were collected consecutively from 100 patients aged 18 years or older who came for regular consultation. The instrument used for determining depression is Beck Depression Inventory-II. The prevalence of depression, a correlation …

Cognitive Function In Type 2 Diabetes Mellitus Patients Taking Metformin And Metformin-Sulfonylurea, Abu Rachman, Rani Sauriasari, Nadia Farhanah Syafhan, Pukovisa Prawiroharjo, Hindun Wilda Risni

Kesmas

The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the …

Prognostic Value Of Coronary Computed Tomography Angiography In Asymptomatic Diabetic Patients, Abdalla Mostafa, Ahmed Abdalla, Ahmed Gaafar, Mahmoud Z. Attia, Waleed Abdou

Menoufia Medical Journal

Objectives To study the prognostic value of coronary computed tomography (CT) angiography in asymptomatic diabetic patients. Background Diabetic patients have a higher prevalence of coronary artery disease (CAD) and are more likely to have silent myocardial ischemia and myocardial infarction than nondiabetics and are characterized by multivessel disease and calcified, diffuse, and distal lesions. CT coronary angiography is a safe, accurate, and reliable technique of high ability to detect CAD and estimate the degree of obstruction, number of affected arteries, and the pattern of their affection and a reliable modality for exclusion of CAD. Patients and methods This study was …

Long Noncoding Rna As A Diagnostic Tool In Vascular Complication Of Diabetes, Mohamed El Sayed Sakr, Nabil A. El Kafrawy, Shaimaa K. Zewain, Shimaa A. Refaat, Shimaa A. Hassanein

Menoufia Medical Journal

Background At present, there is really no unique biomarker for detecting diabetes-related vascular complications. As a result, it is critical to investigate specific biomarkers for diagnosing, detecting, and catching the early stages of disease progression. Objectives To analyze the relationship of long noncoding RNA in patients with asymptomatic atherosclerotic diabetic. Patients and methods This case–control study included 312 participants recruited from Menoufia University Hospitals' Internal Medicine Outpatient Clinics and Inpatient Departments and divided into two groups: group I was the diabetic with subclinical atherosclerosis group, which included 176 patients with type 2 diabetes mellitus, with the carotid intima-media thickness assessed …

Fat Mass And Obesity-Associated Gene Polymorphisms Rs9939609 And Rs17817449 In Type 2 Diabetic Egyptians, Gehan K. El Saeed, Marwa M. Omar, Shaza E. Ahmed, Thoria A. Omar, Walid A. Shehab-Eldin

Menoufia Medical Journal

Background Individual predisposition to obesity and type 2 diabetes mellitus (T2DM) is determined by the interaction between genetic and environmental factors. The fat mass and obesity-associated gene (FTO) is an obesity-susceptibility gene identified to have a huge effect on obesity and DM in different populations. Objectives To investigate the association between FTO gene polymorphisms rs9939609 and rs17817449 and prediction of T2DM in Egyptian obese patients. Patients and methods In this case–control study, PCR–restriction fragment length polymorphism was used for investigating allele and genotype frequencies of FTO rs9939609 and rs17817449 in 90 participants divided into two groups: diabetic group …

Indicators Of Cardiac Autonomic Dysfunction Associated With Chronic Hyperglycemia: Implications On Vascular Surrogates And Heart Failure, Yap-Hang Chan, Bernard Man-Yung Cheung, Hung-Fat Tse

Journal of the Hong Kong College of Cardiology

Background: Limited data exist on the role of chronic hyperglycemia-related cardiac autonomic dysfunction in incident heart failure (HF). We investigated the relations of resting heart rate (HR) and PR interval with chronic hyperglycemia, and effects on new-onset HF.

Methods: We prospectively studied 550 patients with prior coronary disease, ischemic stroke and/ or type 2 diabetes. Incident HF was ascertained. Heart rate-PR interval dissociation was defined as counter-physiological co-occurrence of increased PR interval (>mean; 173.3ms) and increased resting HR (>mean; 64.4 beats/min).

Results: Over 63 ±11 months, 6.7% patients developed new-onset HF. Resting HR³75bpm was independently predictive of new-onset …

The Association Between Adherence To Oral Antihyperglycemic Agent And Hba1c Level, Indana Ayu Soraya, Rani Sauriasari, Pukovisa Prawiroharjo, Hindun Wilda Risni

Pharmaceutical Sciences and Research

Adherence to taking medication is essential for patients with chronic diseases such as Type 2 Diabetes Mellitus (T2DM). There have been many studies about the association between medication adherence and HbA1c levels, but few have used Adherence Refills and Medications Scale (ARMS) questionnaire and Proportion of Days Covered (PDC) method to measure adherence in Indonesian population. The aim of this study were to assess the association of medication adherence to HbA1c levels and compare two methods of adherence measurements. This research was conducted at Pasar Minggu Public Health Center, Jakarta using a cross-sectional design. The adherence assessment was conducted using …

An Overlooked Problem: A Qualitative Meta-Synthesis From Experience Of Men With Diabetic Erectile Dysfunction, Junjira Seesawang, Pulawit Thongtaeng

Journal of Health Research

Background: ED is negatively associated with men’s sexual function capacity, emotional, intimate relationship and particularly psychological well-being. The purpose of this study was to synthesize qualitative findings which explain the experiences of men with diabetes who have erectile dysfunction.

Method: A meta-synthesis was performed. A search for qualitative studies published in English from 2010 to 2020 was conducted using PubMed, CINAHL, PsycInfo, and Science Direct databases. The main key words included: experience, men/male patient, erectile dysfunction, diabetes, diabetic erectile dysfunction, and qualitative research. Inductive and interpretative technique was used to analyze and synthesize findings from qualitative studies and reviewed by …

Assessment Of Retinal Ganglion-Cell Complex Using Spectral-Domain Optical Coherence Tomography In Diabetic Patients Without Retinopathy, Asmaa M. Ibrahim, Mustafa K. Nassar, Shaimaa S. Helal

Menoufia Medical Journal

Background Diabetic retinopathy (DR) consists of microvascular changes, although recent investigations have demonstrated that neurodegeneration may occur earlier. Objectives To assess ganglion-cell complex thickness using spectral-domain optical coherence tomography in diabetic patients without retinopathy. Patients and methods This was a cross-sectional case–control study conducted at Shebin El kom Ophthalmology Hospital and Tiba Ophthalmological Center on 200 patients divided into two groups: group A involves 100 diabetic patients without DR. Group B involves 100 healthy controls. All participants underwent full ophthalmological and medical history, ophthalmological examination with measurement of the macular ganglion-cell layer–inner-plexiform layer (GCL–IPL) thickness, and retinal nerve-fiber-layer (RNFL) thickness …

Correlation Of Anterior Ocular-Segment Biometry With Glycated Hemoglobin Level In Type-2 Diabetic Patients, Gehan A. A. Elsabrout, Hatem M. G. Marey, Marwa A. Zaky

Menoufia Medical Journal

Background Diabetic retinopathy (DR), nephropathy, and peripheral neuropathy are the common complications of diabetes mellitus. DR is one of the causes of blindness worldwide. Although diabetic-eye disease is often thought to refer merely to the retina, the anterior segment of the eye has also been shown to be affected in diabetes. Objective To compare the anterior ocular-segment biometry among type-2 diabetes mellitus with no DR, nonproliferative diabetic retinopathy (NPDR), and evaluate the correlation of anterior ocular-segment biometry with glycosylated hemoglobin (HbA1c) level. Patients and methods A cross-sectional study was conducted on 48 patients. The patients were randomly selected from the …

Macular Thickness Assessment In Diabetic Patients Without Retinopathy, Adel G. Zaky, Amin F. Ellakwa, Asmaa A. Askria, Moatz F. Elsawy, Saber H. El Sayed

Menoufia Medical Journal

Objective A comparative study of macular thickness measurements with optical coherence tomography (OCT) in patients with diabetes mellitus without diabetic retinopathy (DR) versus healthy controls. Background DR is one of the most common causes of deterioration of vision in the adult population. Recently, some studies showed that the degeneration of the retinal neuronal cells starts before the microvascular changes appear clinically. Patients and methods Sixty-five patients with diabetes mellitus (without DR underwent full ophthalmic examination; colored fundus photography, fluorescin fundus angiography, and OCT. Mean macular thickness measured by OCT was calculated for the central fovea, the perifoveal, and the parafoveal …

Effects Of A Dynamic Handgrip Exercise On Left Ventricular Diastolic Functions In Diabetes Mellitus Patients: A Preliminary Clinical Data, Pott Pongpaopattanakul, Thamonwan Imerbtham, Juthamat Kitimala, Suphavech Phatthanawayu, Phattarasuda Kaewkong

Chulalongkorn Medical Journal

Background: A diabetes mellitus (DM) patients sometimes exhibit a pseudo-normal diastolic relaxation during echocardiography examination, which may lead to an incorrect diagnosis. Exercise echocardiography help uncover this hidden alteration, but conventional exercise techniques contain movement artifacts. Recently, an isotonic handgrip exercise was introduced and caused hemodynamic and diastolic changes with less movement. Objective: To investigate hemodynamic and left ventricular diastolic that responses to a dynamic handgrip exercise (DHE) in DM patients. Methods: 12 controls and 12 DM patients were recruited and evaluated for hemodynamic and diastolic functions at rest and 3 minutes after performing DHE. Results: DHE increased systolic blood …

Treatment Adherence And Incidence Of Coronary Heart Disease In Type 2 Diabetes Mellitus Patients, Ahmad Sahlan Baniu, Rani Sauriasari, Woro Riyadina, Pradana Soewondo

Kesmas

Previous studies showed that uncontrolled blood sugar and long-term use of several types of antidiabetic could increase the risk of coronary heart disease (CHD). This study aimed to compare the incidence of CHD in type 2 diabetes mellitus (T2DM) patients showing treatment adherence and non-adherence behavior over four years. This was a retrospective cohort study with data sets obtained from the Bogor Cohort Study of Non-Communicable Disease Risk Factors. All study subjects were not diagnosed with CHD at the beginning of the study. The sample was divided into two groups; one had adhered to treatment from health centers and followed …

Diabetes Mellitus And Mortality Among Covid-19 Patients In Jakarta, March-August 2020, Endang Widuri Wulandari, Sudarto Rotnoatmodjo, Ngabila Salama

Kesmas

Diabetes mellitus (DM) comorbidity is one of the risk factors for coronavirus disease 2019 (COVID-19) mortality. This study aimed to determine the association of comorbid DM and mortality among COVID-19 confirmed cases in DKI Jakarta Province, controlled with confounding variables from March to August 2020. The study design was a retrospective cohort using cox proportional hazard regression, with a total sample of 1,480. The data consisted of 740 COVID-19 cases with and 740 without comorbid DM. The inclusion criteria were COVID-19 confirmed cases with polymerase chain reaction (PCR) laboratory testing reported to the DKI Jakarta Provincial Department of Health, and …

Prevalence And Risk Factors Of Hypertension And Diabetes Mellitus Among The Indonesian Elderly, Prisilia Oktaviyani, Salman Salman, Marlynda Happy Nurmalita Sari, Melisa Frisilia, Munazar Munazar, Ana Satria, Maretalinia Maretalinia

Makara Journal of Health Research

Background: Epidemiological and demographic transitions lead to the emergence of non-communicable diseases (NCD) among the elderly. This study aimed to examine the risk factors of hypertension and diabetes mellitus (DM) among the elderly by using secondary data (Basic Health Research 2018).

Methods: Secondary data from Basic Health Research (N = 88,911) were used. Cut-off values for measurement were WHO standard of 126 mg/dl for fasting and 200 mg/dl for non-fasting for DM and 140 mmHg for systole and 90 mmHg for diastole for hypertension. Univariate, bivariate, and multivariate (binary logistic regression) analyses were conducted using STATA version 15. …

Vascular Endothelial Growth Factor With Genetic Variants Rs3025020 And Rs3025039 In Diabetic Microvascular Complications, Alaa A. Dawood, Asmaa M. Elshemy, Belal A. Montaser, Gehan K. Elsaeed, Reda A. Ibrahem, Sara M. S. El-Deeb, Seham A. Khodeer, Thoria A. Omar

Menoufia Medical Journal

Background Vascular end othelial growth factor (VEGF) is a heparin-binding homodimeric glycoprotein. It plays a key role in the pathogenesis of diabetes mellitus (DM) and its complications, particularly those linked with poor vascularization and hypoxia. The VEGFA gene encodes VEGF, and several genetic variants have been identified in the VEGFA gene, some of which affect VEGF secretions. Objectives To investigate the association between serum levels of VEGF and VEGFA gene variants, −583C>T(rs3025020) and +936 C/T (rs3025039), with microvascular complications in type 2 diabetics. Patients and methods This cross-sectional study was conducted on 104 patients with type 2 DM who …

Laparoscopic Hysterectomy Versus Abdominal Hysterectomy In Diabetic Patients With Benign Uterine Pathologies: A Randomized Controlled Study, Abdelghaffar S. Dawood, Ahmed M. Elkhyat, Ayman Shehata Dawood, Mohamed Khedr

Menoufia Medical Journal

Objective To compare surgical outcomes of abdominal hysterectomy (AH) versus total laparoscopic hysterectomy (TLH) in diabetic patients. Background Diabetes mellitus is considered a multisytemic disease affecting mainly the small vessels (diabetic vasculopathy). Diabetes mellitus and comorbidities associated with it are well-known factors that negatively affect surgical outcomes. Hysterectomy is one of the most frequent gynecological surgical procedure, having different routes, either abdominal, vaginal, or laparoscopic. AH is correlated to more complications such as wound infection and longer postoperative hospital stay in diabetic patients. However, TLH may be particularly well suited to diabetic women as they can avoid the postoperative complications …

Mucormycosis: Covid-19 And Corticosteroids, Mittal Savaliya, Nivedita Jha, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Decrease Of Cardiovascular Risk In Obese Patients Who Participated In A Lifestyle Medicine Program, Eymard Torres-Rodriguez, Lucy Perla Gulliana Cedillo Ramírez

Revista de la Facultad de Medicina Humana

Lifestyle Medicine in the management of chronic diseases such as obesity is essential to reduce cardiovascular risk and to reverse the disease process (1). Objective: To determine if a Lifestyle Medicine program can reduce cardiovascular risk in obese adults in Colombia. Material and methods: Descriptive observational study cases series type followed for 6 months in a Lifestyle Medicine Clinic. 9 patients were included taking into account 2 measures of cardiovascular risk as a parameter to complete the program. The following measurements were taken: cardiovascular risk using the Pan American Health Organization (PAHO) calculator, Body Mass Index (BMI), lipid profile, history …

The Lifestyle Associated With The Control Of Arterial Hypertension And Diabetes Mellitus In A Care Center In Lima, During The Covid-19 Pandemic, Mariana Callapiña-De Paz, Yoshie Z. Cisneros-Núñez, Norka R. Guillén-Ponce, Jhony A. De La Cruz-Vargas

Revista de la Facultad de Medicina Humana

Introduction: Hypertension and diabetes mellitus 2 are prevalent diseases. The COVID-19 pandemic has changed lifestyle and disease control, potentially triggering serious complications. Objectives: To determine the association between lifestyle and the control of chronic non-communicable diseases: arterial hypertension and diabetes mellitus 2 during the COVID-19 pandemic in patients of an Urgent Care Center. Materials and methods: Observational, cross-sectional, and analytical study. A sample of 158 patients, between 30 and 79 years old, was included. Control files and medical records were analyzed, anthropometric values ​​were measured, and lifestyle was evaluated through surveys. Results: 51.3% were male, an average of 61 years, …

Prevalence Of Endocrine Disorders Among 6078 Individuals With Down Syndrome In The United States, Anne Rivelli, Veronica Fitzpatrick, Danielle Wales, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine

Journal of Patient-Centered Research and Reviews

Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these individuals when compared with age- and sex-matched individuals without DS. This retrospective, descriptive study is a follow-up report documenting prevalence of 21 endocrine disorder conditions, across 28 years of data, from 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large integrated health system. Overall, individuals with DS experienced higher prevalence of adrenal insufficiency and Addison’s disease; …

Modulatory Effect Of Resveratrol And Melatonin On Natural Killer Cell Activity And Adrenomedullin In Diabetic Rats, Fati̇h Özçeli̇k, Fati̇h Hacimustafaoğlu, Alpaslan Tanoğlu

Turkish Journal of Medical Sciences

Background/aim: Epidemiological evidence suggests that diabetes poses a high risk for many chronic diseases, especially cardiovascular diseases, and cancer by stimulating many inflammatory and immunological pathogenic mediators and affecting natural killer (NK)-cell activity. In this study, the effects of melatonin and resveratrol on IL-6, TNF-alpha, oxidant/antioxidant capacity, NK-cell activity, and mid-regional proadrenomedullin (MR-proADM) levels of diabetic rats were investigated. Materials and methods: In the study, 28 Sprague Dawley rats were randomly divided into the control group (group I) and 3 streptozotocin- induced diabetes mellitus (DM) groups (group II, III, and IV), each group consisting of 7 rats. Five mg/kg/day melatonin …