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Full-Text Articles in Medicine and Health Sciences
Comparison Of Thermal Effect With Ultrasound In Rat Calf Muscles After The Application Of Five Non-Steroidal Anti-Inflammatory Drugs, Yueh-Ling Hsieh, Chen-Chia Yang, Hui-Wen Kuo
Comparison Of Thermal Effect With Ultrasound In Rat Calf Muscles After The Application Of Five Non-Steroidal Anti-Inflammatory Drugs, Yueh-Ling Hsieh, Chen-Chia Yang, Hui-Wen Kuo
Rehabilitation Practice and Science
Background and Purposes: Phonophoresis has been defined as the migration of drugs through the skin under influence of ultrasound (US). The phonophoresis of nonsteroidal anti-inflammatory drugs (NSAIDs) was studied in vivo through hairless rat skin to determine the temperature changes in superficial and deep tissues in response to NSAID phonophoresis.Study Design and Objectives: To measure and compare the temperature changes in tissues in response to five NSAIDs under phonophoresis. Methods: Male Wistar rats weighing 250 to 350 g had one of five drugs; i.e., piroxicam (Feldene), indomethacin (Indocin), etofenamate (Rheumon), methylsalicylate (Salomethyl), or diclofenac (Voren) applied to one hindlimb followed …
Reversal Of Endotoxin-Induced Hypotension By Inhibition Of Inducible Nitric Oxide Synthase Activity Is Associated With Improved Oxidative Status In Rat Heart, Aorta And Mesenteric Artery, Bahar Tunçtan, Belma Korkmaz, Hati̇ce Yildirim, Lülüfer Tamer, Uğur Ati̇k, C. Kemal Buharalioğlu
Reversal Of Endotoxin-Induced Hypotension By Inhibition Of Inducible Nitric Oxide Synthase Activity Is Associated With Improved Oxidative Status In Rat Heart, Aorta And Mesenteric Artery, Bahar Tunçtan, Belma Korkmaz, Hati̇ce Yildirim, Lülüfer Tamer, Uğur Ati̇k, C. Kemal Buharalioğlu
Turkish Journal of Medical Sciences
Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and decreased total antioxidant capacity, which is responsible for high mortality from several diseases such as endotoxic shock. Nitric oxide (NO) produced by inducible NO synthase (iNOS) during endotoxemia is the major cause of vascular hyporeactivity, hypotension and multiple organ failure. We investigated whether NO-mediated oxidative stress in rat heart, aorta and mesenteric artery is involved in the attenuation of endotoxin-induced hypotension by inhibition of iNOS. In conscious male Wistar rats, injection of endotoxin (10 mg/kg, i.p.) caused a gradual fall in mean arterial pressure (MAP) for 4 hours …
Effects Of Excess Vitamin B_6 Intake On Serum Lipid Profile And Cerebral Cortex In Rats, Göksemi̇n Acar, Leyla Sati, Yasemi̇n Seval, Aysel Ağar, Ramazan Demi̇r
Effects Of Excess Vitamin B_6 Intake On Serum Lipid Profile And Cerebral Cortex In Rats, Göksemi̇n Acar, Leyla Sati, Yasemi̇n Seval, Aysel Ağar, Ramazan Demi̇r
Turkish Journal of Medical Sciences
Aim: The present study was undertaken to investigate the effects of dietary excess of vitamin B_6 on certain blood parameters [serum total cholesterol, high density lipoprotein (HDL) cholesterol and total lipid] and the cerebral cortex. Materials and Methods: A total of 36 albino rats were included in the study. Saline solution was administered to control groups (CG-10, n = 6 for 10 days; CG-15, n = 6 for 15 days; CG-20, n = 6 for 20 days). The experimental groups (EG-10, n = 6; EG-15, n = 6; EG-20, n = 6) received 5 mg/kg vitamin B_6 daily for 10 …