Medicine and Health Sciences Commons^™

What Is The Impact Of Intraperitoneal Surfactant Administration Against Postoperative Intraabdominal Adhesion Formation? An Experimental Study, Şehmus Pala, Tuncay Kuloğlu, Remzi̇ Atilgan, Zehra Sema Özkan, Serhat Hançer

Turkish Journal of Medical Sciences

Background/Aim: Surfactant is a surface-active substance that, in addition to its detergent effect, also has effects that reduce inflammation and fibrosis. Because of these effects, it was aimed herein to investigate the effect of intraperitoneal surfactant application on preventing postoperative peritoneal adhesion formation in a uterine horn adhesion model. Materials and methods: Twenty-one Wistar albino rats were randomly divided into 3 groups (G1-G3), as follows: G1 (n = 7): control group. The abdomen was opened and then closed; G2 (n = 7): adhesion group. The abdomen was opened. Then, a 2-cm linear incision was made over the right uterine horn, …

Long Term Neuroprotective Effects Of Human Adipose-Derived Stem Cells In Neonatal Rats Post Hypoxic Ischemic Encephalopathy, Melissa February, Md, Thomas N. Tulenko, Phd, Barry Weinberger, Md, Alla Kushnir, Md

Cooper Rowan Medical Journal

Background: Hypoxemic ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in the neonatal population. Recent research has shown human adipose stem cells (hASCs) to have neuroprotective effects in animal models of HIE. This study tested the hypothesis that neurodevelopmental outcomes would be improved using hASC therapy in term neonatal HIE rat model.

Methods: Seven day old rats underwent left carotid artery ligation followed by 8% oxygen for 120 minutes, or carotid isolation in shams. Forty-eight hours after surgery half of the rats received hASCs and half normal saline (NS) intravenously. Rota-rod and cylinder tests were used to …

The Role Of Curcumin Against Paclitaxel-Induced Oxidative Stress And Dna Damage In Testes Of Adult Male Rats, Esra Balcioğlu, Özge Göktepe, Fazi̇le Cantürk Tan, Pinar Bi̇lgi̇ci̇, Bi̇rkan Yakan, Sai̇m Özdamar

Turkish Journal of Medical Sciences

Background/aim: Paclitaxel is a widely used drug for the treatment of cancer, but it possesses toxic effects on male reproductive system. Administering paclitaxel with an antioxidant has become a strategy for preventing the side effects of paclitaxel. Although curcumin is an antioxidant, data concerning the effect of curcumin on paclitaxel-induced testis tissue are lacking. The present study was established to examine the protective impact of curcumin against testicular damage induced by paclitaxel. Materials and methods: In the study, 40 Wistar albino male rats were used and randomly divided into 4 groups (n:10). The control group received only saline solution; the …

Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to investigate the use of tissues with multiple traumas, scarred pedicles, and medial scarring as a flap. Materials and methods: Forty-eight rats were randomly divided into four equal groups. The modified McFarlane flap was chosen as the flap model. In Group 1 (control), a dorsal skin flap was elevated and then sutured back into original position. In the other groups, a two-phase procedure was used. In Group 2 (pedicle incision), scar tissue was created with a skin incision at the prospective pedicle site of the flap and then sutured to its original site. …

Pathological And Immunohistochemical Changes In The Liver Of Monocrotaline-Treated Rats, Şevket Soylu, Aydin Çevi̇k, Necati̇ Ti̇murkaan

Turkish Journal of Veterinary & Animal Sciences

Pathological and immunohistochemical changes in livers were investigated in monocrotaline-treated rats. Eighty adult-male Wistar rats were distributed in 5 groups, each containing 16 animals according to monocrotaline dose (Group I: 50 mg/kg, Group II: 100 mg/kg, Group III: 150 mg/kg, and Group IV: 200 mg/kg). The control group was administered with physiological saline. Half of the animals in each group were euthanized at the 18th hour while the remaining half at the 6th week postinoculation. At the end of the 18th hour, the most prominent lesion was hepatocytic apoptosis which was dose-dependent. Apoptotic cells were mostly located in periportal and …

Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş

Turkish Journal of Medical Sciences

Background/aim: Nonalcoholic fatty liver is one of the most common forms of liver disease and role of microRNAs (miRNAs) on this illness is currently unclear. It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. Materials and methods: Twenty-four rats were randomized into three groups: sham (n = 8), experimental fatty liver group (n = 8), and fatty liver + vitamin D3 supplementation group (n = 8). In the treatment group, 10 µg/kg/week of vitamin D3 was given by orogastric tube weekly for …

The Effect Of Low-Level Laser Therapy On Rat Unicortical Femoral Defect, Latif Emrah Yanmaz, Ugur Ersoz, Sitkican Okur, Betul Apaydin Yildirim, Selim Comakli, Yavuz Selim Sağlam, Elif Dogan, Ozhan Karatas, Ferda Turgut, Zafer Okumuş

The Thai Journal of Veterinary Medicine

The aim of this study was to determine the effectiveness of low-level laser therapy (LLLT) in the healing of experimentally created unicortical defect (UCD) of rat femurs. Twenty-four adult Wister rats were randomly divided into 2 groups: UCD and UCD+LLLT. The animals were subdivided into 3 groups (each group had 4 animals) and then they sacrificed at day 8, 15 and 22 for radiological, pathological and biochemical analysis. Bone healing was significantly different between the groups at day 15 and 22 (P < 0.05), while bone formation was significantly increased in the UCD+LLLT group at day 22 compared to the UCD group (P < 0.05). On histopathological examination, significant difference was found between the UCD and UCD+LLLT groups on the 22nd day (P < 0.05) while there was no difference on the 8th and 15th day. In the UCD group, the plasma Alkaline phosphatase activity decreased on the 15th and 22nd days, Calcium on the 15th day and Phosphorus on the 8th and 22nd days compared to the UCD+LLLT group. In addition, Glutathione levels, Plasma Catalase, Glutathione Peroxidase and Superoxide Dismutase activity significantly reduced in the UCD group compared with UCD+LLLT on the 8th, 15th and 22nd day (P < 0.05). In conclusion, LLLT applied at a dose of 904µm accelerates fracture healing in UCD of a rat’s femur. However, this effect shows an increase after the 22nd day of LLLT application.

Chemical Castration Using An Intratesticular Injection Of Mannitol: A Preliminary Studyin A Rat Model, Mohammad-Ali Maadi, Mehdi Behfar, Amir Rasaei, Ali Shalizar-Jalali, Gholamreza Najafi, Vahid Mohammadi

Turkish Journal of Veterinary & Animal Sciences

This study was aimed to evaluated chemical sterilization using an intra-testicular injection of mannitol 20% in rats. Fifty male Wistar rats were divided into five groups, including 1) intact, 2) surgical castration and, 3 to 5) intra-testicular injections of normal saline, hypertonic saline, and mannitol, respectively. The baseline testosterone levels were measured. Surgical castration was performed in group 2. Intra-testicular injections were performed in groups 3, 4, and 5. On day 60, the testosterone level was evaluated. Then, sperm count, viability, motility, morphological abnormalities and DNA damage were studied. Gonadosomatic index was recorded on day 60. Serum testosterone level was …

Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney

Turkish Journal of Medical Sciences

Aim: The aim of this study is to determine the effects of different concentrations of albendazole and lansoprazole, which were benzimidazole derivatives, on endocrinologic and biochemical parameters in experimental type 2 diabetic (T2D) rats. Materials and methods: In this study, 46 male Wistar Albino rats were used. Animals were divided as healthy control (0.1 mL/rat/day saline, s.c, n = 6), diabetes control (0.1 mL/rat/day saline, s.c, n = 8), diabetes+low-dose albendazole (5 mg/kg, oral, n = 8), diabetes+highdose albendazole (10 mg/kg, oral n = 8), diabetes+low-dose lansoprazole (15 mg/kg, subcutaneous, n = 8), and diabetes+high-dose lansoprazole (30 mg/kg, subcutaneous, n …

The Protective Effects Of Anakinra In A Neonatal Rat Model Of Necrotizing Enterocolitis, Hati̇ce Güneş, Sevcan İpek, Sadik Yurttutan, Tuncay Kuloğlu, Fatma İnanç Tolun, Ülkü Kazanci, Adem Doğaner

Turkish Journal of Medical Sciences

Background/aim: Necrotizing enterocolitis (NEC) is a commonly seen life-threatening condition in newborns characterized by ischemic necrosis. This study aimed to investigate anakinra's effects, an interleukin-1 receptor antagonist, on oxidative stress, inflammation, and tissue necrosis in an NEC rat model. Materials and methods: Forty Wistar albino pups were divided into four groups randomly as follows; group 1, control group; group 2, anakinra-treated control group; group 3, NEC group; and group 4, NEC and anakinra treatment group. The rats were given hyperosmolar formula feeding, and they were exposed to hypoxia after cold stress at +4 °C and oxygen in order to create …

Melatonin Has Favorable Preventive Effects On Experimental Chronic Pancreatitis Rat Model, Esra Guzel Tanoglu, Alpaslan Tanoğlu, Makbule Çi̇sel Aydin Meri̇çöz, Muhammed Fevzi̇ Esen

Turkish Journal of Medical Sciences

Background/aim: Currently, there is not any specific treatment for chronic pancreatitis (CP). It was aimed to investigate the effects of melatonin administration on endoplasmic reticulum (ER) stress, oxidative stress, fibrosis, biochemical and histopathological parameters, and Abcc2,Abcc5, and Abcg2 gene levels in an experimental rat CP model. Materials and methods: Forty rats were randomized into five groups: Sham, CP, CP+25 mg/kg melatonin, CP+50 mg/kg melatonin, and CP+placebo. In all rats, except the sham group, a model of chronic pancreatitis was accomplished with intraperitoneal caerulein administration. In treatment groups, melatonin was used as a therapeutic agent. Serum TGF-ß, TNF-α, MDA and GPx …

The Effects Of Iloprost And Beta3 Receptor Agonist On Trpa1 And Trpc1 Immunreactivityin An Experimental Lower Extremty Ischemia-Reperfusion Injury Model, Lati̇f Üstünel, İbrahi̇m Murat Özgüler

Turkish Journal of Medical Sciences

Background/aim: In this study, we aimed to investigate the effects of antioxidant iloprost (ILO) and ß3 adrenergic receptor agonist (BRL) on transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential canonical 1 (TRPC1) ion channels on an experimental ischemia and reperfusion injury model in 30 male Wistar albino rats aged 8-10 weeks. Materials and methods: Wistar Albino rats aged were divided into 5 equal groups. Group I Sham operation, Group II IR (ischemiareperfusion) procedure, Group III IR + intravenous ILO administration, Group IV IR + intraperitoneal BRL administration, and Group V IR + intravenous ILO + intraperitoneal BRL administration …

Transient Receptor Potential Melastatin 2 Ion Channel Activity In Ovarianhyperstimulation Syndrome Physiopathology, Cengi̇z Şanli, Remzi̇ Atilgan, Tuncay Kuloğlu, Şehmus Pala, Bi̇lge Aydin Türk, Hasan Burak Keser, Nevi̇n İlhan

Turkish Journal of Medical Sciences

Background/aim: Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with increased vascular endothelial growth factor (VEGF) and vascular permeability in the ovarian tissue. Transient receptor potential melastatin 2 (TRPM2) is known to be associated with angiogenesis and vascular permeability. In this experimental study, we aimed to investigate the activity of TRPM2 in the development of OHSS. Materials and methods: Fourteen immature female rats were divided into two groups. Group 1 was the control group, and Group 2 was the OHSS group that was exposed to 10 IU of subcutaneous application of FSH for four days and 30 IU …

Sodium Valproate Improves Sensorimotor Gating Deficit Induced By Sleep Deprivation Atlow Doses, Muhammet Teki̇n, Fatma Duygu Kaya Yertutanol, Burcu Çevreli̇, Asi̇l Ali̇ Özdoğru, Hamza Kulaksiz, İsmai̇l Tayfun Uzbay

Turkish Journal of Medical Sciences

Background/aim: Sleep deprivation disrupts prepulse inhibition of acoustic startle reflex and can be used to mimic psychosis in experimental animals. On the other hand, it is also a model for other disorders of sensory processing, including migraine. This study aims to assess the effects of sodium valproate, a drug that is used in a variety of neuropsychiatric disorders, on normal and disrupted sensorimotor gating in rats. Materials and methods: Sixty-two Wistar albino rats were randomly distributed into 8 groups. Subchronic and intraperitoneal sodium valproate were administrated to the sleep-deprived and nonsleep-deprived rats by either 50-100 or 200 mg/kg/day. Prepulse inhibition …

Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk

Turkish Journal of Medical Sciences

Background/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angiotensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein. Although it is expressed in many places in the kidney, its function is uncertain. TRPC1 is involved in regulating Ca2+ homeostasis, and its upregulation increases ER Ca2+ level, activates the unfolded protein response, which leads to cellular damage in the kidney. This study investigated the role of TRPC1 in …

The Effect Of The Metabolic Syndrome On The Histological Structure Of The Testes Tissue And The Sperm Morphology In The Rats, Ayşe Alkandurur, Şadi̇ye Kum

Turkish Journal of Veterinary & Animal Sciences

In this study, we aimed to investigate the effect of metabolic syndrome on spermatozoon morphology and histological, histochemical, histomorphometric changes in the testes. Twenty-four male Sprague Dawley rats (60 day-olds) were used for this purpose. The rats in the control group were fed only water and rat food, while the rats in the experimental group were fed with water containing 20% D-fructose and rats food for 16 weeks with ad libitum. At the end of the experimental period, the testes and epididymis of the rats were removed. The testes were embedded in paraffin by performing the necessary histological procedure. In …

Therapeutic Effect Of Tarantula Cubensis Extract On Indomethacin Induced Gastric Ulcers In Rats, Mustafa Makav, Volkan Gelen, Semin Gedi̇kli̇, Gözde Atila Uslu, Hamit Uslu, Hüseyin Avni Eroğlu

The Thai Journal of Veterinary Medicine

Non-steroid anti-inflammatory drugs (NSAIDs) have widely been used in patients but side-effects associated with NSAID are also common. Tarantula cubensisextract (TCE) is an antiphlogistic, demarcative, homeopathic and necrotizing drug with wound healing effects in farm animals. However, the therapeutic effects ofTCEon gastric ulcers has not been investigated. The aim of this study was to investigate the gastroprotective effects of TCE against indomethacin-induced gastric injury in rats. A total of 28 female, Wistar albino rats were divided into four groups: (i) the control group, (ii) the indomethacin (Indo) group, (iii) the TCE + Indo group, and (iv) the ranitidine + Indo …

Effect Of Diabetes Mellitus On Cementum Periodontal Interface In Streptozotocin-Induced Diabetic Rat Model, Medhat Ahmed El-Zainy, Ahmed Mahmoud Halawa, Fatma Adel Saad

Future Dental Journal

Objective: Diabetes Mellitus is well known to be associated with several oral complications. Thus, this study investigated the effect of diabetes on the cementum-periodontal interface by light and scanning electron microscopy. Methodology: This investigation was carried out on twenty eight male albino rats weighing from 200 to 220 gm; rats were divided into two groups: group I (control): fourteen animals received intraperitoneal single dose of 1 ml Citrate buffer, group II (diabetic): fourteen animals that were rendered diabetic by intraperitoneal single dose of streptozotocin 40 mg/kg body weight dissolved in 1 ml Citrate buffer and sacrificed 3 weeks after detection …

The Effects Of Pumpkin Seed Oil On Carbon Tetrachloride Induced Chronic Hepatic Damage In Rats, Ayhan Atasever, Meryem Senturk, Gorkem Ekebas, Duygu Yaman Gram, Meryem Eren

The Thai Journal of Veterinary Medicine

The present study determined the possible protective effect of pumpkin seed oil (PSO) on histopathological changes in liver tissue and serum alanine aminotransferase (ALT) activity, glucose, Non-Esterified Fatty Acids (NEFA) and triglyceride (TG) levels on chronic liver injury induced by carbon tetrachloride (CCl4) in rats. A total of 80 Wistar rats were divided into eight groups of ten rats each: the first group served as the control, group II was given intraperitoneal 0.2 mL/kg CCl4, twice a week for 8 weeks. Groups III-V were treated daily with PSO for 8 weeks (1, 2 and 3 mL/kg respectively). Groups (VI-VIII) were …

Effect Of Fermented Red Radish (Raphanus Sativus L) In Carbon Tetrachloride-Induced Liver Injury In Rats, Ayhan Atasever, Duygu Yaman Gram, Gorkem Ekebas, Nurhan Ertas Onmaz, Meryem Senturk, Meryem Eren, Lutfiye Ekici

The Thai Journal of Veterinary Medicine

In this study, the possible protective effect of red radish containing total phenolic content and antioxidant components on histopathological and immuno histochemical active caspase-3, TNF-α and Iba-1, serum ALT activity, triglyceride, total cholesterol, LDL-cholesterol, liver malondialdehyde (MDA) and nitric oxide (NO) levels were evaluated in CCl4induced liver injury in Wistar rats. The rats were randomly divided into six groups (n= 12 to each group). The first group was used as a control which was given only intraperitoneal 0.9% NaCl (0.2 mL / kg / bw); while fermented red radish (FRR) at a dose of 250 mg/kg or 500 mg/kg was …

Research On The Protective Effect Of Caffeic Acid Phenethyl Ester On Testicular Damagecaused By Cisplatin, Tayfun Ceylan, Emi̇n Kaymak, Fazi̇le Cantürk Tan, Bi̇rkan Yakan

Turkish Journal of Medical Sciences

Background/aim: Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells, and Leydig cells in rat testicles. It was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, in eliminating CP-induced testicular damage. Materials and methods: Group 1 (control group) was given physiological saline solution intraperitoneally (IP) throughout the experiment. Group 2 (CP group) was given a single dose of CP (7 mg/kg) IP on the day 7. Group 3 (CP + CAPE group), was given CAPE (10 μmol/kg/day) IP for 12 days and a single dose …

Evaluation Of The Effects Of Bone Morphogenetic Protein-2 On The Healing Of Bonecalvarial Defects In Ovariectomized Rats, Ela Tules Kadi̇roğlu, Fati̇h Karayürek, Mehmet Erdem Akbalik

Turkish Journal of Veterinary & Animal Sciences

Bone morphogenetic proteins (BMPs) are often used with bone grafts for bone regeneration. The aim of this study was to evaluate the effect of demineralized freeze-dried bone allografts and externally applied rhBMP-2 on bone healing in experimentally generated defects in the calvarium of ovariectomized and nonovariectomized rats via histological and immunohistochemical assays. The current study was carried out on 42 female Wistar rats. After ovariectomy was performed in half of the rats, the rats were divided into three groups: control, allograft, and allograft + BMP. An experimental defect with a diameter of 4 mm was created unilaterally in the parietal …

Comparison Of The Efficacy Between Bilateral Proximal Tubal Occlusion And Total Salpingectomy On Ovarian Reserve And The Cholinergic System: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu, Cengi̇z Şanli, Şeyda Yavuzkir, Zehra Sema Özkan

Turkish Journal of Medical Sciences

Background and aim: To compare the effects of bilateral proximal tubal occlusion and bilateral total salpingectomy on ovarian reserve and the cholinergic system via rat experiment. Materials and methods: Twenty-one adult female rats were randomly divided into the following three groups: G1 (n = 7), sham group; G2 (n = 7), bilateral total salpingectomy group; and G3 (n = 7), bilateral proximal tubal occlusion group. Four weeks later, the abdomen of the rats was opened. The right ovarian tissues were stored in 10% formaldehyde, whereas the left ovarian tissues were stored at ?80 °C in aluminum foil. Serum samples were …

What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga

Turkish Journal of Medical Sciences

Background/aim: To evaluate the effects of hysterectomy on rat ovaries and the possible protective role of peroxisome proliferator-activated receptor gamma (PPAR-?) agonist-rosiglitazone against ovarian reserve decrement.Materials and methods: Forty-five adult Wistar albino rats were randomly divided into three groups. Hysterectomy was performed (n = 15) in group 1 [H]; 1 mg/kg/day PPAR-? agonist/rosiglitazone was used for 50 days after hysterectomy (n = 15) in group 2 [H + R]; a sham operation was performed (n = 15) in group 3 [control, C]. Blood samples were collected for anti-Müllerian hormone (AMH) evaluation in all groups and simultaneous ovarian Doppler examination was …

The Effects Of Different Doses Of Diclofenac Sodium On Newborn Rat Hippocampus Exposed During The Third Trimester, Ebru Eli̇bol, Süleyman Kaplan, Gamze Altun, Abdurrahman Aksoy, Berri̇n Zuhal Altunkaynak

Turkish Journal of Veterinary & Animal Sciences

The main aim of the present study was to examine the neurotoxic effects of prenatal exposure to varying doses of diclofenac sodium (DS) on the rat hippocampus. Twenty-eight Wistar albino adult female rats weighing 280-300 g were initially used for pregnancy. When vaginal plaques were seen in female rats, it was accepted as the 0th day of pregnancy. Female rats were divided into five main groups; pure control, saline, low dose DS (3.6 mg/kg), moderate dose DS (9 mg/kg), and high dose DS (18 mg/kg). They were exposed to these treatments during their gestation. After birth, all newborn male rats …

Evaluation Of The Early Term Healing Effects Of Resveratrol On Corneal Wounds In Rats, Hati̇ce Çi̇lem Perçi̇n, Zülfükar Kadi̇r Saritaş

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the effects of resveratrol (RES) treatment on corneal wound healing. Randomly divided into 2 groups were 26-week-old male Wistar albino rats. Group 1 was the control group (C) and group 2 was the RES group. A 2-3-mm-long vertical incision was made centrally in the right cornea of each rat to the descemet membrane using loupe magnification (2.5X) and the wounds were sutured using 10/0 nylon material. In the RES group, the rats were fed 30 mg/kg/day RES via oral gavage; the C and RES groups were provided food and water ad libitum …

A Review Of Rat Lungworm Infection And Recent Data On Its Definitive Hosts In Hawaii, Chris N. Niebuhr, Susan I. Jarvi, Shane R. Siers

Human–Wildlife Interactions

Rat lungworm (Angiostrongylus cantonensis) is a zoonotic nematode that causes rat lungworm disease (angiostrongyliasis), a potentially debilitating form of meningitis, in humans worldwide. The definitive hosts for rat lungworm are primarily members of the genus Rattus, with gastropods as intermediate hosts. This parasite has emerged as an important public health concern in the United States, especially in Hawaii, where the number of human cases has increased in the last decade. Here we discuss the current knowledge of the rat lungworm, including information on the life cycle and host species, as well as updates on known infection levels. Three …

Investigation Of Treatment Efficacy Of 10% Povidone-Iodine Sclerotherapy On Ovarian Cyst Diameter: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was toinvestigate the effects of 10% povidone-iodine (PI) sclerotherapyon ovarian cyst diameter through an experimental study.Materials and methods: To be able to create ovarian cysts, right unilateral salpingectomy was performed on 20 Wistar albino rats. One month after the operation, the abdomens of all rats were reopened. Sixteen rats with macroscopic ovarian cysts were divided randomly into 2 groups consisting of 8 rats. Group 1 (G1): the cyst content was only aspirated. Group 2 (G2): the ovarian cyst was aspirated and then the cystic cavity was irrigated with PI. Abdomens of all rats were …

Effects Of Phenytoin Injection On Vocal Cord Healing After Mechanical Trauma: An Experimental Study, Si̇bel Ali̇cura Tokgöz, Cem Saka, İstemi̇han Akin, Fatma Fulya Köybaşioğlu, Saffet Kiliçaslan, Murat Çalişkan, Ömer Beşalti, Emel Çadalli Tatar

Turkish Journal of Medical Sciences

Background/aim: Phenytoin is an anticonvulsant drug which causes fibroblast proliferation, collagen synthesis, and an increase in epidermal growth factor. Therefore, the aim of the present study is to evaluate the effect of phenytoin injection on the wound healing process in rats with vocal cord injury by histopathological methods. Materials and methods: The vocal cords of 10 albino Wistar rats were damaged bilaterally; the left vocal cord was kept as the control group. Phenytoin was injected in the right vocal cord. Ten rats were sacrificed. The thickness of the lamina propria and density of the fibroblast and collagen were evaluated histopathologically.Results: …

Antinociceptive Effect Of Liposomal Bupivacaine Formulations After Intrathecal Administration In Rats, İlker Yi̇ği̇t, Berri̇n Günaydin, Ömer Hakan Emmez, Meci̇t Orhan Uludağ, Nur Banu Bal, İsmai̇l Tuncer Deği̇m

Turkish Journal of Medical Sciences

Background/aim: Based on our previous in vitro study with multilamellar liposomal bupivacaine (MLB) versus bupivacaine alone in artificial cerebrospinal fluid, we aimed to investigate in vivo antinociceptive effect of intrathecal MLB by determining tail flick latency (TFL) time after thermal stimulation in rats. Materials and methods: After preparing MLB and high-yield drug entrapment in liposome (HYDEL) bupivacaine, 18 female Wistar rats were assigned to 3 groups as control (bupivacaine) and study groups (MLB and HYDEL bupivacaine) including 6 rats in each group to administer these drugs intrathecally. Antinociceptive activity was determined in terms of TFL time after thermal stimulation. Maximum …