Medicine and Health Sciences Commons^™

Ada Deficiency: Improvement In Immune Function After Enzyme Replacement Therapy, Esosa Adah, Nikita Raje

Posters

Introduction: Adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID) is characterized by severe lymphocytopenia affecting T-, and B-,lymphocytes, with non-immunological manifestations including neurodevelopmental deficits, sensorineural deafness, and skeletal abnormalities. Treatment modalities include enzyme replacement therapy(ERT) and/or autologous gene therapy or hematopoietic stem cell treatment. We report a 9-month-old female with ADA deficient T-B-NK+ SCID treated with ERT while awaiting stem cell treatment. Case Description: A 9-month-old female with a history of failure to thrive, hypotonia and loss of developmental milestones had genetic testing done that showed variants ADA c.911 T>G, c.302G>A. She was admitted for further work up. Lymphocyte …

Bowel Cleanout Prior To Intrathecal Baclofen Pump Implantation: Effects On Acute Post- Operative Gastrointestinal Complications, Amanda Lindenberg, Brittni Walton, Sathya Vadivelu, Matthew J. Mclaughlin

Posters

Background: Intrathecal baclofen (ITB) pumps have been used for management of spasticity and dystonia There is limited data on immediate post-operative complications such as GI adverse events after surgery for ITB pump related procedures. This study aimed to compare patients who underwent a pre-operative bowel cleanout to those who did not and the relationship with post-operative nausea, vomiting and constipation requiring an escalation of their bowel regimen. Design: Retrospective cohort study. Setting: Pediatric acute care hospital. Participants: All patients who underwent new ITB pump and/or catheter placement from January 2015-December 2022. Interventions: Preoperative bowel clean out. Main Outcome Measure: Quantity …

Privacy Preserving Self-Service Degauss Based Geomarker Portal, Harpreet Gill, Kushal Vallambhatla, Mark A. Hoffman, Kevin Power, Catherine Jackson

Posters

DeGAUSS offers a privacy-preserving capability to annotate a list of addresses with geomarker information that is useful for social determinants and other research. The standard delivery of DeGAUSS requires command line proficiency, potentially limiting the group of users. We provide a self-service portal that enables researchers to load a file and receive a downloadable annotated output file. In our pilot phase, the system has processed 481 calls for more than 45,000 addresses at Children’s Mercy.

Increasing Annual Eye Exam Completion For Children With Cystic Fibrosis Receiving Cftr Modulators, Paula Capel, Claire Elson, Stephanie Duehlmeyer, Jessica Haynes, Amanda Conway, Christopher M. Oermann

Posters

Background: CFTR modulators are life-changing therapy for people with CF. During preclinical studies of ivacaftor, cataracts were identified in juvenile rat pups. Subsequently, noncongenital cataracts have been reported in children receiving CFTR modulator therapy [1], so baseline and annual slit lamp eye examinations for cataract development are recommended for children with CF (aged <18). At Children’s Mercy Kansas City (CMKC), our standard practice is to conduct baseline and annual ophthalmologic examinations to assess for cataracts in children with CF prescribed CFTR modulator therapy, but there was no formal process for tracking adherence to this standard and ensuring that examinations were completed. A quality improvement project was undertaken in May 2022 to determine the rate of completion of annual eye exams and increase adherence to our annual monitoring standard.

Methods: To improve adherence to annual monitoring standards, a quality improvement taskforce including CF care team nurses and pharmacists was developed. A database was used to document baseline and follow-up eye examinations. A standardized communication process was developed and deployed that included an eye exam brochure (Figure …

Anticoagulation Therapies And Vte Risk Assessment, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Hyperleukocytosis/Leukapheresis, Children's Mercy Kansas City

Clinical Pathways

Hyperleukocytosis is a life-threatening oncology emergency, defined as a white blood cell (WBC) count ≥ 100,000/µL and can occur in up to 20% of patients with acute myeloid or lymphoid leukemias (Abla et al., 2016). Hyperleukocytosis may lead to leukostasis and subsequent end organ damage, commonly affecting the central nervous system, respiratory and renal systems, and can also cause tumor lysis syndrome (TLS), another oncology emergency, and lead to metabolic derangements and further renal dysfunction (Porcu et al., 2000). Treatment of hyperleukocytosis includes supportive care, early initiation of chemotherapy and/or leukapheresis (Zhang et al., 2021). There are no definitive guidelines …

Birth Brachial Plexus Injury (Bbpi): Management Of Shoulder Subluxation/Dislocation, Children's Mercy Kansas City

Clinical Pathways

BBPI most often, but not always, occurs during the delivery process as the infant descends through the birth canal and the shoulder becomes lodged on the mother’s pelvic bone. As contraction begins, the infant’s neck and shoulder are stretched which can cause tears or ruptures of the nerves within the brachial plexus thus impacting the sensation and movement of the affected upper extremity. Incidence of brachial plexus injuries in the United States is 0.4 to 4 in 1,000 live births (Abzug, et al., 2018; Foad et al., 2008; Hoeksma et al., 2004; Waters, 1997). Although many of these infants will …

Breastfeeding Support In Your Pocket: Evaluating The Impact Of A Mobile App On Maternal Success, Maygan Brandt

Nursing | Student Research Posters

No abstract provided.

The Effect Of Nursing Education On The Utilization Of Kangaroo Mother Care And Weight Gain Of Preterm And Low Birth Weight Infants, Jhenalynn Valete

Nursing | Student Research Posters

Kangaroo Mother Care (KMC), often referred to as skin-to-skin contact, is an intervention for preterm and low birth weight infants, involving the practice of the mother or caregiver holding the newborn against their bare chest (Cleveland Clinic, 2023). This is a cost-effective and natural way to enhance health outcomes such as temperature regulation, weight gain, respiratory function, pain mitigation, and facilitation of breastfeeding for the neonate (Jefferies et al., 2012).

Nursing staff may have limited knowledge regarding KMC which creates challenges in effectively educating parents. This information prompts the following question: “Can Nurse Education about the Importance of Kangaroo Mother …

Furry Friends & Brighter Futures: Enhancing The Life Skills Of Toddlers With Autism Through Animal Assisted Therapy, Abigail Tolentino

Nursing | Student Research Posters

No abstract provided.

Investigating The Association Between Mast Cell Activation Syndrome And Irritable Bowel Syndrome, Ishaan Jakhar, Maggie Urschler, Medha Singh, Suman Sahil, Hassan Ahmad

Posters

Investigating the Association between Mast Cell Activation Syndrome and Irritable Bowel Syndrome Introduction Mast Cell Activation Syndrome (MCAS) involves the inappropriate release of chemical mediators resulting in varied episodic symptoms. Irritable Bowel Syndrome (IBS) is a common functional abdominal disorder where mucosal immune alterations play a key role. Since mast cells function as gatekeepers for the intestinal interface, we examined what proportion of patients diagnosed with MCAS also had IBS along with comorbid risk factors. Methods All patients in our study were 18 years of age or older. We used Cerner Healthfacts to gather our cohorts of patients with MCAS, …

The Scoop, Vol. 10 Issue 8, November 2023, Health Sciences Library

Volume 10

Latest news and updates from the Health Sciences Library in our monthly newsletter for November 2023.

Evaluating A Newborn Infant With Pancytopenia For Whim Syndrome, Shayan Sazdar, Thao Le, Nikita Raje

Posters

Introduction Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare immunodeficiency caused by a gain-of-function mutation in CXCR4. A complication of WHIM syndrome is severe neutropenia, which can result in fatal bacterial infections. Given the rarity of the disease and variability of clinical presentations, WHIM syndrome can be difficult to diagnose and manage. Case Description A full term male infant was hospitalized for hypoxic ischemic encephalopathy after delivery. Physical exam was unremarkable. During his hospitalization, he was found to have progressive pancytopenia. Initial lymphocyte subsets showed a significant T cell lymphopenia of 1325 mm3 CD3+, 920 mm3 CD4+, 390 …

Evaluating Patients With Recurrent Fever And Elevated Igd, Thao Le, Nikita Raje

Posters

Introduction: Hyperimmunoglobulinemia D with periodic fever syndrome (HIDS) often presents within the first year of life. Symptoms include fevers, chills, headache, lymphadenopathy, and abdominal pain. Patients may be misdiagnosed as other autoinflammatory syndromes, resulting in delay of treatment. Case: A 16-year-old female presented for evaluation of recurrent fever. Her fevers started at two months of age, occurred one to two times a month, and were associated with headache, abdominal pain, and fatigue . At 18-months, she was diagnosed with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA). She was treated with prednisone and an adenotonsillectomy but her fevers persisted. . At …

Understanding Macrophage Phagocytosis In Pediatric Leukemia, Molly Leyda, Jacqelyn Nemechek, John Szarejko, Fang Tao, Tykeem Manor, Douglas Myers, John M. Perry

Posters

Macrophages are a diverse and widespread type of innate immune cell which play an important role in homeostasis and defense. In a process called phagocytosis, macrophages engulf dying cells, foreign substances, and pathogens. Importantly, macrophages can present antigens from phagocytosed cells allowing them to initiate an adaptive immune response against remaining cells of the same type. Despite the immunosuppressive nature of the tumor microenvironment, macrophages often infiltrate tumors where they can either promote or inhibit cancer development, though the specific conditions influencing their pro- vs anti-cancer activity remain enigmatic. Recently, macrophages have been brought into the spotlight of immunotherapy research …

A Case Report Of A 48-Year-Old Female With Cauda Equina Syndrome In The Setting Of Disseminated Mrsa Infection, Aimee Lambeth, Sarah Eickmeyer, Stephanie Fortune

Posters

To present an interesting case of cauda equina syndrome due to disseminated MRSA, where inpatient EMG was useful in diagnosis and treatment planning.

November 2023, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

Eat Right, Every Bite

An Apple a Day …

Staff and faculty MASSAGES

Five Tips for Exercising Safely in Cold Weather

Inspire : Vol 6, Issue 11, Department Of Medicine

INSPIRE – Department of Medicine Archives

• Message from the Chair
• Medicine at National and International Forums
• PSR Seminar By Dr Muhammad Zain Mushtaq
• The Brain Attack team wins recognition! By Prof Ayesha Kamran Kamal
• Dermatology Residents Shine on the National Stage By Prof Sadia Masood
• Appreciation by Dr Rabeea Azmat
• Poem
• What Academics are Reading

Effectiveness Of Occupational Therapy Interventions To Enhance Occupational Performance For Survivors Of Domestic Abuse: A Systematic Review, Mackenzie R. Post, Aubrianna Hohensee, Taylor Fisher, Amanda Malashock

Student Systematized Reviews: Occupational Therapy

TITLE: Effectiveness of Occupational Therapy Interventions to Enhance Occupational Performance for Survivors of Domestic Abuse: A Systematic Review

PURPOSE: An average of 20 people per minute experience domestic abuse in the United States (Black et al., 2011). People who experience abuse have poor physical and mental health outcomes which can include depressive symptoms, substance use, developing chronic disease, chronic mental illness, and injury (Coker et al., 2002). Occupational practitioners are equipped to address this issue because they have specific training on life skills, lifestyle management, adaptive coping strategies, time management, and personal values, which can help minimize the negative health …

Occupational Therapy Interventions To Improve Functional Cognition In Older Adults After Stroke: A Systematic Review, Brady A. Harrison, Alexa A. Preissler, Emilea R. Rogers, Allison D. Singh

Student Systematized Reviews: Occupational Therapy

PURPOSE Cerebral vascular accidents (CVA) are a leading cause of cognitive impairment in the United States, and 80% of CVA survivors experience new or worsening impairment (Knight-Greenfield et al., 2019; Zhang et al., 2021). Functional cognition is vital to an individual’s participation in occupations that are necessary and meaningful to them. Occupational therapy practitioners play a unique role in addressing functional cognition through intervention planning and implementation. The purpose of this study is to understand the most effective occupational therapy interventions addressing functional cognition in older adults post CVA.

DESIGN We conducted a systematized review of articles pertaining to occupational …

Occupational Therapy Interventions That Influence Quality Of Life Of Care Partners Of Children With Developmental Disabilities: A Systematic Review, Alaina Akey, Maggie Alsup, Madison Cockerill, Sydney Wondra

Student Systematized Reviews: Occupational Therapy

TITLE: Occupational Therapy Interventions that Influence Quality of Life of Care Partners of Children with Developmental Disabilities: A Systematic Review

PURPOSE: In the United States, 1 in 6 children have one or more developmental disabilities (Center for Disease Control and Prevention, 2022). Children with developmental disabilities require a higher level of care and support in comparison to their typically developing peers (Akyurek et al., 2023). Due to this increased need for assistance, care partners may experience greater psychological, physical, social, and financial hardships that can impact their overall quality of life (Murphy et al., 2006). Although the scope of occupational …

The Santa Clara, 2023-10-31, Santa Clara University

The Santa Clara

No abstract provided.

10.30.2023 Orsp Connect, Liz Williamson

ORED Newsletter

No abstract provided.

Intouch Week Of October 30, 2023, New York Medical College

InTouch

• NYMC Applauds Esteemed Leaders and Educators at Annual Founder’s Dinner
• Dr. Mitchell Cairo Awarded Grant to Support Osteosarcoma Research
• SOM Establishes Psychiatry Residency Program at Saint Joseph’s Medical Center
• New Area in Concentration in Health Equity Leadership Introduced
• NYMC Goes Orange for National Physical Therapy Month
• Pumpkins Under the Knife: The Winners of the NYMC Pumpkin Carving Contest
• NYMC and TU Hosts “Ninety Minutes: The Medical Magazine of the Web”
• NYMC Research | Eva Chorna, SOM Class of 2024

Learning Health Center Leadership Makes The Case For Quality In Reducing Hospital Acquired Pressure Injury, Shea Polanich Phd, Rn, Faan, Shannon Layton Dnp, Rn, Rebecca Miltner Phd, Rn, Faan

School of Nursing Professional Posters

No abstract provided.

Quality Matters: Nurse Staffing And Clinical Outcomes, Shea Polancich Phd, Rn, Faan, Tracey Dick Phd, Rn, Terry Poe Dnp, Rn, Rebecca Miltner Phd, Rn, Faan, Aoyjai Montgomery Phd, Bsn, Patricia Patrician Phd, Rn, Faan

School of Nursing Professional Posters

No abstract provided.

Patient Involvement And Communication Council, Angela Murphy, Laura Gooseberry, Becca Austin, Rob Behrendt, Lara Miskevich

2023 Patient Advisor Retreat

Patient-Centered Care (nothing about me without me) is the best approach to improve outcomes and provide value to each patient. The Council is involved in the following: Act as champions of patient experience andbring ideas, thoughts, and opinions on various topics and processes. Review patient and family communications to ensure engagement in health care services. Provide feedback regarding communication gaps between patients and providers. Revise and improve materials to be understood by patients and their caregivers.

Using Storytelling To Share Lived Experiences With Maternal Mental Health (Mama), Sara Santarossa, Amy Loree, Courtney Latimer, Wendy Corriveau, Sara Mertz, Hailey Maddox, Leah M. Copeland, Dana Murphy, Ashley B. Redding

2023 Patient Advisor Retreat

Mental health conditions are a top medical complication of pregnancy and childbirth and are associated with a range of adverse maternal and child outcomes. Approximately 1 in 7 to 1 in 4 birthing people experience symptoms of a mental health condition during pregnancy or postpartum, yet few are diagnosed or treated. There remain critical knowledge gaps and significant challenges to adequately addressing maternal mental health. Project aims to use storytelling to share diverse perspectives on MAternal MentAl health (MAMA), build capacity and engagement for patient centered research by sharing these stories in a Storytelling Symposium, and with the aid of …

Bump: Burnout Mitigation In Physician Trainees, Jacqueline Pflaum-Carlson, Sara Santarossa, Lisa Mclean, Julie A. Hamilton, Dana Murphy, Ashley B. Redding

2023 Patient Advisor Retreat

Physician burnout affects healthcare organizations at every level and has been associated with higher self-reported errors, increased turnover, and has a negative impact on patient care; it is estimated that tens of thousands of Americans die each year as a result ofpreventable medical errors. This project seeks to reduce the symptoms of physician burnout by exploring Acceptance Commitment Therapy (ACT) compared to Body Mapping as effective interventions in preventing and mitigating burnout in physician trainees at Henry Ford Health (HFH) in Detroit, Michigan.

Our Contributions To The Hermelin Brain Tumor Center (Hbtc), Megan Sauer, Marc Betman, Ron Leach, Mike Coughlin, Jeni Barry, Dominik Mackowski, Lisa Scarpace, Nestelynn Gay

2023 Patient Advisor Retreat

The Hermelin Brain Tumor Center Patient and Family Advisory Council is comprised of patients and care partners who have generously agreed to come together to share their experiences and ideas. Mission Statement: Our goal is to drive patient and caregiver education, innovation, research, and success to continue to be a center of excellence. We aim to amplify the strengths of the Hermelin Brain Tumor Center by sharing our combined experience as patients, caregivers, and clinicians to its continual improvement and development.