Medicine and Health Sciences Commons^™

Tumor Infiltrating Lymphocyte Recruitment After Peri-Lymphatic Irx-2 Cytokine Immunotherapy In Resectable Breast Cancer And Head And Neck Carcinoma, Joanna Pucilowska, Venkatesh Rajamanickam, Nikki Moxon, Monil Shah, Maritza Martel, Alison Conlin, James E. Egan, David B. Page

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: The IRX-2 biologic is a subcutaneous injectable immunotherapy composed of IL-2 and other cytokines derived from stimulated lymphocytes. Preclinically, IRX-2 activates T cells, natural killer cells, macrophages, and dendritic cells, and facilitates maturation of antigen-presenting cells.Tumor-infiltrating lymphocytes (TILs) are associated with improved outcomes in many cancers including early stage breast cancer (ESBC) and head and neck squamous cell carcinoma (HNSCC). We report data on TIL recruitment associated with pre-operative IRX-2 in a phase Ib ESBC trial, as well as phase Ib and IIa HNSCC trials.

Methods: The pre-operative IRX-2 regimen was evaluated in both ESBC and HNSCC trials for …

Single Cell Sequencing To Identify Tcrs That Recognize Autologous Tumor Cells After Vaccination With Allogeinic Dribble Vaccine, Hong-Ming Hu, Christopher C. Paustian, Zhifa Wen, Tarsem L. Moudgil, Traci L. Hilton, Sam Bookhardt, Guangjie Yu, Eric Tran, Venkatesh Rajamanickam, Walter Urba, Rachel E. Sanborn, Bernard A. Fox

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Adoptive immunotherapy with tumor-specific TCR gene-modified T cells has the potential to eradicate bulky disease. Traditional methods of TCR identification require lengthy in vitro culture to generate clonal T-cell populations, which adds time and complexity to this promising therapy. Here we described a simplified and reliable method to identify TCRs by single cell TCR sequencing of cells sorted with antibodies against T-cell surface markers that are up-regulated only when they are stimulated with specific tumor cell antigens.

Methods: A tumor-infiltrating lymphocyte (TIL) culture with T cells reactive against autologous tumor was generated from a brain metastasis of a patients …

Delayed Immune-Related Events After Discontinuation Of Immunotherapy – Dire Syndrome?, Marcus Couey, R. Bryan Bell, Ashish Patel, Marka R Crittenden, Brendan Curti, Rom Leidner

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Although the temporality of immune-related adverse events (irAE) is well-recognized during immunotherapy to be highly variable and often delayed,[1] post-immunotherapy irAE are rarely described and potentially under-recognized. In 2013, two cases were reported in abstract form in Deutschen Dermatologischen Gesellschaft.[2] In July 2018 a case of autoimmune hepatitis eight months post-immunotherapy was reported in The Oncologist[3] and a dermatologic series appeared online in JAMA Dermatology.[4] With expanding indications for IO and an increasing number of clinical trials in the curative-neoadjuvant setting, larger numbers of patients are being treated in earlier stages of disease and often for short courses. Given …

College Of Health Sciences E-Newsletter, November 2018, Irvin B. Harrell (Editor)

Ellmer College of Health Sciences Newsletters

November 2018 issue of Old Dominion University's College of Health Sciences Newsletter.

The Ketogenic Diet: The Effects You’D Yeast Expect, Bryce Edwards, Samantha M. Waters

Dental Hygiene Student Research Posters

This research poster addresses the question: How does the ketogenic diet affect the oral cavity? Ketogenic ‘keto’ diet emphasizes high fat, low carbohydrate consumption and avoids simple carbohydrate and sugars. Sugar substitutes are almost always utilized. Fat heavy diets causes the body to go into ketosis: a process in which the body burns fat for energy because glucose isn’t available. The keto diet has many positive effects for the body, including several specific to the oral cavity: Decreased caries risk, gingival inflammation, and bleeding; reduction of acidity and plaque mutans when paired with the keto approved sugar substitute: erythritol. The …

Air Polishing: A New Look At An Old Technique, Ellen Bosland, Cristina Sevilla

Dental Hygiene Student Research Posters

This research poster addresses the question “What differences exist between erythritol, glycine, and sodium bicarbonate powders in air polishing?” The use of air polishers in the dental field is highly recommended; however, the ability to determine the correct powder and grit for each patient can be vital. The three types of powders have different pros and cons related to their function; though most studies show significant advantages of using air polishing in general. One study compared erythritol powder and the ultrasonic. In the results, pocket depths were decreased but there was no difference in effectiveness between the two; however, a …

The Scoop, Vol. 5 Issue 8, November 2018, Health Sciences Library

Volume 5

Latest news and events from the Health Sciences Library in our monthly newsletter for November 2018.

Cime Newsletter : November 2018, Cime

Centre for Innovation in Medical Education (CIME) Archives

-A Knowledge Enhancement and Skills Updating Workshop For 75 Infection Control Nurses and Staff
-Acquiring Skills, Knowledge and Confidence in Transurethral Resection of the Prostate and Transurethral Resection of Bladder – A Simulation Workshop
-A Pioneering Simulation Session for Nursing Year III Students
-A First Interdisciplinary Tracheostomy Workshop for AKU
-SimWars 2019
-The Department of Surgery holds a Mini Breast Surgery Symposium
-Staff in Action!

Open-Source Digital Image Analysis Of Whole-Slide Multiplex Immunohistochemistry, Nikhil Lonberg, Carmen Ballesteros-Merino, Shawn Jensen, Bernard A Fox

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Successful digital image analysis (DIA) of cancer tissue is accurate and reproducible. These points of emphasis have brought procedures like the tissue microarray (TMA) and hotspot regions of interest (ROI) under scrutiny. The nature in which a pathologist selects TMAs and ROIs is conducive to bias. Whole Slide Imaging (WSI) offers a solution in its unbiased region selection and consideration of a larger tissue sample. However, options for softwares that can handle such large throughput are scarce. Additionally, while multiplex immunohistochemistry (mIHC) is becoming popular [1], documentation of its digital analysis tools remains minimal [2]. The combination of these …

Inducible T Cell Co-Stimulator (Icos) Is Upregulated On Lymphocytes Following Radiation Of Tumors And Icos Agonism In Combination With Radiation Results In Enhanced Tumor Control, Michael J. Gough, Shelly Bambina, Monica Gostissa, Christopher Harvey, David Friedman, Marka R Crittenden

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Radiation and co-stimulatory ligands or checkpoint inhibitors have demonstrated improved anti-tumor immunity and overall survival in preclinical animal studies. However, the results of human trials suggest we have not yet found the optimal combination. Here we demonstrate upregulation of ICOS expression on T cells following focal tumor radiation and test the hypothesis that ICOS agonism in combination with radiation will enhance the immunologic effect of radiation resulting in increased survival.

Methods: BALB/c mice bearing CT26 tumors or C57BL/6 mice bearing Panc02 tumors were treated at d14 with 20Gy CT guided radiation therapy and anti-ICOS antibody or isotype control antibody …

Intratumoral Delivery Of Mdna55, An Interleukin-4 Receptor Targeted Immunotherapy, By Mri-Guided Convective Delivery For The Treatment Of Recurrent Glioblastoma, Achal Achrol, Manish Aghi, Krystof Bankiewicz, Martin Bexon, Sotirios Bisdas, Steven Brem, Andrew Brenner, Nicholas Butowski, Melissa Coello, Seunggu Jude Han, Santosh Kesari, Fahar Merchant, Dina Randazzo, Diana Roettger, Michael Vogelbaum, Frank Vrionis, Miroslaw Zabek, John Sampson

Books, Presentations, Posters, Etc.

No abstract provided.

November 2018, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

Healthier Dishes to Serve This Thanksgiving

This year, why not make Thanksgiving not only delicious but also a health-boosting experience that’s truer to the origins of the holiday? For most of us, our traditional Thanksgiving meal has shifted away from the natural foods enjoyed by the 17th-century celebrants. But it’s not that difficult to get back to preparing delicious food that is fresh from the harvest…and packed with nutrition.

What's Happening: October 29, 2018, Maine Medical Center

What's Happening

No abstract provided.

Week Of October 29, 2018, New York Medical College

InTouch

• Class of 2022 Robes Up for White Coat Ceremony
• Student Clubs Provide Wide Array of Extracurricular Activities
• Graduate School of Basic Medical Sciences and School of Medicine Forge New Agreement

Hotspotting Without A Patient, Mirna Rezkalla, Bs, Pharmd Candidate, Nicole Lenegan, Bsn, Rn, Elena Umland, Pharmd

College of Pharmacy Posters

Introduction

• Interprofessional (IP) teamwork is the foundation for successful patient care outcomes. Numerous issues can arise from poor teamwork stemming from the lack of acknowledgment and appreciation of the roles of each healthcare provider.
• Throughout our training in school, students often become focused on their own profession and develop biases or perceptions of the other members of other healthcare disciplines.
• The Hotspotting program provides students the opportunity to eliminate biases and clarify perceptions.

The Assassin Bug, Lola Alao '20, Harsha Nalam '19, Dwanne Colobong '19, Trisha Sudhakar '19

Human Diseases Graphic Novels

No abstract provided.

Diseases At Work, Alice Liu '19, Nicholas Opiola '19, Gunnar Bergmann '19, Femi Durodola '20, Suraj Sunkara '19

Human Diseases Graphic Novels

No abstract provided.

In The Office, Theo Heilman '19, Nathan Lee '19, Prachi Patil '19, Katie Si '19

Human Diseases Graphic Novels

No abstract provided.

Kidney Stones, Bopo Taiwo '20, Ishanpepe Jagusah '20

Human Diseases Graphic Novels

No abstract provided.

The Blue Baby, Lola Alao, Harsha Nalam '19, Dwanne Colobong '19, Trisha Sudhakar '19

Human Diseases Graphic Novels

No abstract provided.

Navigating Health Care Transition: An Exploration Into The Experiences Of Parents And Their Adolescents With Special Health Care Needs Utilizing A Transitional Care Service, Jane Tobias, Dnp, Crnp

College of Nursing Posters

Abstract

Adolescents with special health care needs encounter barriers and challenges during transition to adult health care that have the potential to impact health outcomes and satisfaction with the experience. The use of transitional care services can provide resources and support throughout the transition process to the adolescent and their parent/caregiver. This descriptive survey study was conducted to evaluate adolescent and/or parent/caregiver satisfaction with the transitional care services provided by an urban, academic, pediatric health care facility. Nineteen of 39 (49%) eligible participants completed the survey. Findings indicate that adolescents and their parent/caregiver were satisfied with the resources and support …

The Santa Clara, 2018-10-25, Santa Clara University

The Santa Clara

No abstract provided.

2018 Celebration Of Scholarship, Creativity And Engagement, Eastern Illinois University

Programs

Scholarship, creativity, innovation, and the many forms of collaborative engagement that shape faculty life and student learning are central to the mission of Eastern Illinois University. For that reason, our faculty, department chairs, college deans, the provost, and the entire campus community celebrate the achievements and outstanding contributions of our colleagues and students to their disciplines and professions every year.

And, as the following pages illustrate, faculty engaged in continuing scholarly and creative activities provide outstanding mentoring experiences for our undergraduate and graduate students.

In addition to recognizing faculty performances, shows, publications, grants and other professional efforts, the University will …

What's Happening: October 22, 2018, Maine Medical Center

What's Happening

No abstract provided.

Digital Literacy In An Urban Cancer Population: Who Are We Leaving Out?, A. Petok, Msw, Mph, G. Garber, Msw, L. Waldman, Ba, A. Leader, Phd, A. Dicker, Md, Phd, L. Capparella, Mss

Department of Medical Oncology Posters

Background

• With an increase in and rapid development of health care applications, as well as electronic medical records and patient portals, patients have more access to health information than ever.
• Previous research has found an association between integration of electronic patient reported outcomes (ePROs) with increased survival for patients with metastatic cancer compared to usual care.
• Although greater access to health information as well as personal health records and patient portals can be shown to have positive effects on patient outcomes, the digital divide that is pervasive in the general population extends to oncology as well.
• This project aimed to …

Effect Of Positive Patient Identification On Wrong Blood In Tube Errors: A Single Center Experience, Faisal Huq Ronny, Md, Phd, Mary Harach, Bs, Mt(Ascp), Cqa(Asq), Ssgb, Jay H. Herman, Md, Fcap

Department of Pathology, Anatomy, and Cell Biology Posters

No abstract provided.

Week Of October 22, 2018, New York Medical College

InTouch

• College Supporters Gather for a Festive Evening at the Founder's Dinner
• NYMC Welcomes Bess J. Chazhur, M.S., as Chief Development Officer and Executive Director of Alumni Relations
• Center for Long-Term Care Hosts Colloquium on Aging

The Santa Clara, 2018-10-18, Santa Clara University

The Santa Clara

No abstract provided.

Boonshoft School Of Medicine Central Research Forum Program - 2018, Office Of Research Affairs, Boonshoft School Of Medicine

Central Research Forum

The 63-page program includes a schedule, speaker biographies, and presentation titles from the 2018 Central Research Forum held by the Boonshoft School of Medicine's Office of Research Affairs.

What's Happening: October 15, 2018, Maine Medical Center

What's Happening

No abstract provided.