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Hybridomas Derived From Murine Gut Associated Lymphoid Tissue, Robert Staszewski

Yale Medicine Thesis Digital Library

The clinical potential of specific passive mucosal immunity is discussed and it is proposed that bulk quantities of hybridoma produced specific dimeric IgAs could be clinically useful as made to order super colostrums. SIgAs function on mucosal surfaces to prevent the adherence of pathogens. They are poor opsonins and do not activate complement except by the alternate pathway. In principle mesenteric lymph note (MLN) or Peyer's patch (PP) lymphocytes aseptically harvested from enterically immunized and boostered mice displaying blastogenic anamnestic response might be fused with log phase cells of a non secreting murine myeloma to generate specific dimeric IgA (+J) …