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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Dox Inducible Idh2 R140q Expression In Stem Cells Results In Cell Death, Opposite Of Cancerous Overgrowth, Reuben Hogan
Dox Inducible Idh2 R140q Expression In Stem Cells Results In Cell Death, Opposite Of Cancerous Overgrowth, Reuben Hogan
Undergraduate Research Symposium Posters
Mutations in isocitrate dehydrogenase (IDH) 1 or 2 are found in about 23% of acute myeloid leukemia (AML) samples and about 90% of gliomas. Mutations result in neomorphic function of the IDH enzyme that yields the novel molecule 2-hydroxyglutarate (2HG) instead of alpha-ketoglutarate (aKG). 2HG is known to be associated with hypermethylation of DNA and histones, a phenotype seen in AML. Our lab intends to study the mechanism by which hypermethylation is achieved and how this mechanism relates to the onset of cancer. In this experiment, we utilized a line of H9 stem cells which we had developed. These cells …
Characterizing The Role Of Cpsa In Mycobacterial Pathogenesis, Amir Hassan
Characterizing The Role Of Cpsa In Mycobacterial Pathogenesis, Amir Hassan
Undergraduate Research Symposium Posters
Mycobacterium tuberculosis infects one-third of the world’s population and causes an estimated 2 million deaths per year, more than any other single bacterial pathogen. The inadequacies of existing tuberculosis therapies demand the discovery of novel agents to treat M. tuberculosis infection, which requires mechanistic insight into the pathways involved in mycobacterial pathogenesis. We identified an unanticipated role of the M. tuberculosis protein CpsA in preventing phago-lysosome fusion by host macrophages, resulting in enhanced intracellular survival of bacteria within the host. Strains of M. tuberculosis lacking cpsA are severely attenuated in both macrophage and mouse models, thus establishing CpsA as a …
Significance Of The Feminization Of Male Eating Disorders, Rachel Rothman
Significance Of The Feminization Of Male Eating Disorders, Rachel Rothman
Undergraduate Research Symposium Posters
Today, many individuals develop eating disorders; however, eating disorders are typically associated with women. In this paper, I declare that male eating disorders are stigmatized due to the feminization of eating disorders. I explain why this stigma exists and how this bias inhibits professionals from conducting objective research on male eating disorders and diagnosing them correctly. I illustrate how the stigma prevents men from recognizing their own unhealthy behaviors and can deter individuals from recognizing eating disorder-related behaviors in other men. Throughout the essay, I provide my own analysis regarding how to combat the stigmatization of eating disorders. By writing …