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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Authoritarian Parenting Predicts Callous-Unemotional Behaviors In Preschoolers, Ara Nazmiyal, Alli Hollender
Authoritarian Parenting Predicts Callous-Unemotional Behaviors In Preschoolers, Ara Nazmiyal, Alli Hollender
Undergraduate Research Symposium Posters
Callous-unemotional behaviors, such as lack of empathy and guilt, are critical in understanding the development of certain mental pathologies. Studies have found that these traits are risk factors for disorders such as sociopathy and psychopathy. Virtually no studies have examined callous behaviors in the preschool period. The purpose of this study was to examine parenting characteristics that predict preschoolers’ greater callous-unemotional behaviors. This study examined data from the PCIT-ED study, a randomized control trial (RCT) of a novel treatment for depression for children aged 3.11-6.11 years old (N = 240). Callous behaviors were assessed by previously validated measures such …
Can Prescribed Fire Reduce Tick Parasitism Of Birds?, Leslie A. Sterling, Kim Medley, Katie Westby, Solný Adalsteinsson
Can Prescribed Fire Reduce Tick Parasitism Of Birds?, Leslie A. Sterling, Kim Medley, Katie Westby, Solný Adalsteinsson
Undergraduate Research Symposium Posters
Tick-borne diseases spread through enzootic transmission cycles that often involve ticks parasitizing bird hosts. Some avian species are competent reservoirs, amplifying the pathogens that cause tick-borne illnesses in humans. Prescribed burns in forests have the potential to reduce tick-borne disease risk if they limit interactions between ticks and infectious wildlife hosts. Although prescribed burns are increasingly being used for a variety of habitat management purposes, little is known about how they affect tick-host interactions. We hypothesize that if prescribed fires reduce tick abundance, then birds in burned forest plots will host fewer ticks than birds in unburned forest plots. Experimental …
Dox Inducible Idh2 R140q Expression In Stem Cells Results In Cell Death, Opposite Of Cancerous Overgrowth, Reuben Hogan
Dox Inducible Idh2 R140q Expression In Stem Cells Results In Cell Death, Opposite Of Cancerous Overgrowth, Reuben Hogan
Undergraduate Research Symposium Posters
Mutations in isocitrate dehydrogenase (IDH) 1 or 2 are found in about 23% of acute myeloid leukemia (AML) samples and about 90% of gliomas. Mutations result in neomorphic function of the IDH enzyme that yields the novel molecule 2-hydroxyglutarate (2HG) instead of alpha-ketoglutarate (aKG). 2HG is known to be associated with hypermethylation of DNA and histones, a phenotype seen in AML. Our lab intends to study the mechanism by which hypermethylation is achieved and how this mechanism relates to the onset of cancer. In this experiment, we utilized a line of H9 stem cells which we had developed. These cells …
Characterizing The Role Of Cpsa In Mycobacterial Pathogenesis, Amir Hassan
Characterizing The Role Of Cpsa In Mycobacterial Pathogenesis, Amir Hassan
Undergraduate Research Symposium Posters
Mycobacterium tuberculosis infects one-third of the world’s population and causes an estimated 2 million deaths per year, more than any other single bacterial pathogen. The inadequacies of existing tuberculosis therapies demand the discovery of novel agents to treat M. tuberculosis infection, which requires mechanistic insight into the pathways involved in mycobacterial pathogenesis. We identified an unanticipated role of the M. tuberculosis protein CpsA in preventing phago-lysosome fusion by host macrophages, resulting in enhanced intracellular survival of bacteria within the host. Strains of M. tuberculosis lacking cpsA are severely attenuated in both macrophage and mouse models, thus establishing CpsA as a …
Significance Of The Feminization Of Male Eating Disorders, Rachel Rothman
Significance Of The Feminization Of Male Eating Disorders, Rachel Rothman
Undergraduate Research Symposium Posters
Today, many individuals develop eating disorders; however, eating disorders are typically associated with women. In this paper, I declare that male eating disorders are stigmatized due to the feminization of eating disorders. I explain why this stigma exists and how this bias inhibits professionals from conducting objective research on male eating disorders and diagnosing them correctly. I illustrate how the stigma prevents men from recognizing their own unhealthy behaviors and can deter individuals from recognizing eating disorder-related behaviors in other men. Throughout the essay, I provide my own analysis regarding how to combat the stigmatization of eating disorders. By writing …
Patterns Of Fecal Progestagens, Estrogens, And Androgens Associated With Reproduction In Blue-Throated Piping Guans (Pipile Cumanensis), Leslie Ann Sterling, Helen Clawitter, Corinne P. Kozlowski, Michael Macek, Anne Tieber
Patterns Of Fecal Progestagens, Estrogens, And Androgens Associated With Reproduction In Blue-Throated Piping Guans (Pipile Cumanensis), Leslie Ann Sterling, Helen Clawitter, Corinne P. Kozlowski, Michael Macek, Anne Tieber
Undergraduate Research Symposium Posters
While fecal hormone analyses are routinely employed to monitor reproduction in mammals, few studies have used these techniques for monitoring reproductive events in birds. This study describes the endocrine patterns associated with reproduction in the blue-throated piping guan (Pipile cumanensis), a less threatened relative of the critically endangered Trinidad piping guan (P. pipile). Fecal samples were collected approximately once a week for 3 years from seven female guans and six male guans at the Saint Louis Zoo. Concentrations of fecal progestagens, estrogens, and androgens were quantified using commercially available enzyme immunoassays. Baseline progestagen concentrations for females …
The Role Of Notch Signaling On Heart Rate And Atrial Conduction, Somya Bhatnagar
The Role Of Notch Signaling On Heart Rate And Atrial Conduction, Somya Bhatnagar
Undergraduate Research Symposium Posters
Heart disease is the leading cause of death worldwide and can result in arrhythmias, or dysregulation in the electrical activation of the heart. Sick Sinus Syndrome (SSS) is characterized by sinus bradycardia (slowed heart rate, HR), slowed conduction through atrial myocardium, and can predispose to the development of atrial fibrillation. A developmental signaling pathway, Notch, regulates cellular identity through differentiation of cardiomyocytes (CMs) into cardiac conduction system-like cells. Previous data show that Notch electrically remodels the right atrium, causing slowed conduction velocity (CV) and hallmarks of SSS including sinus pauses, sinus bradycardia and a predisposition to atrial fibrillation. However, the …
Mu Opioid Receptor Desensitization In Inflammatory Pain, Matthew Bredder
Mu Opioid Receptor Desensitization In Inflammatory Pain, Matthew Bredder
Undergraduate Research Symposium Posters
Due to the epidemic level of opioid overdose deaths in the United States, improving the treatment of chronic pain has become a pressing concern. Opioid treatments such as fentanyl and morphine activate mu opioid receptors (MORs), causing an increase in dopamine release. Long term use of opioids, even as prescribed by a physician, can desensitize the MORs and lead to the appearance of withdrawal symptoms when the receptors are no longer stimulated. Since pain increases endogenous opioid release, we hypothesized that this increase may cause MOR desensitization and the appearance of withdrawal syndrome upon blockade of MORs, as seen in …