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The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane. Materials and methods: Rats were divided into five groups: Group S (sham), saline solution; Group B, bupivacaine; Group BD, bupivacaine + dexmedetomidine; Group BC, bupivacaine + clonidine; and Group BE, bupivacaine + epinephrine. For each group, 0.2 mL of local anesthetic was injected into the sciatic nerve bifurcation …