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Full-Text Articles in Medicine and Health Sciences
The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane. Materials and methods: Rats were divided into five groups: Group S (sham), saline solution; Group B, bupivacaine; Group BD, bupivacaine + dexmedetomidine; Group BC, bupivacaine + clonidine; and Group BE, bupivacaine + epinephrine. For each group, 0.2 mL of local anesthetic was injected into the sciatic nerve bifurcation …
Comparison Of Intraarticular Bupivacaine And Levobupivacaine Injection In Rat Synovial Inflammation, Beki̇r Suat Kürkçüoğlu, Melahat Dönmez, Seher Altinel, Seda Banu Akinci, Fatma Saricaoğlu, Ülkü Aypar
Comparison Of Intraarticular Bupivacaine And Levobupivacaine Injection In Rat Synovial Inflammation, Beki̇r Suat Kürkçüoğlu, Melahat Dönmez, Seher Altinel, Seda Banu Akinci, Fatma Saricaoğlu, Ülkü Aypar
Turkish Journal of Medical Sciences
Both bupivacaine and levobupivacaine are local anesthetics with strong analgesic efficacy that can be used intraarticularly. The aim of this study was to compare the effects of intraarticular bupivacaine and levobupivacaine injection on inflammation in articular cartilage and the synovium of the rat knee joint. Materials and methods: Twenty Sprague-Dawley rats were injected in the right knee joint with 0.2 mL of bupivacaine, while 0.2 mL of levobupivacaine was injected into the left knee joint. Groups of 5 were sacrificed on days 1, 7, 14, and 21 after bupivacaine and levobupivacaine administration and knee joints were examined for subintimal fibrosis, …
A Comparison Of The Effects Of Hyperbaric And Isobaric Bupivacaine Spinal Anesthesia On Hemodynamics And Heart Rate Variability, Mehmet Toptaş, Si̇nan Uzman, İlke İşi̇temi̇z, Tümay Uludağ Yanaral, İbrahi̇m Akkoç, Gülşen Bi̇can
A Comparison Of The Effects Of Hyperbaric And Isobaric Bupivacaine Spinal Anesthesia On Hemodynamics And Heart Rate Variability, Mehmet Toptaş, Si̇nan Uzman, İlke İşi̇temi̇z, Tümay Uludağ Yanaral, İbrahi̇m Akkoç, Gülşen Bi̇can
Turkish Journal of Medical Sciences
To compare the effects of hyperbaric and isobaric bupivacaine spinal anesthesia on hemodynamics and heart rate variability (HRV) in nonobstetric surgery. Materials and methods: Sixty patients were randomly allocated to 2 groups. Group I (n = 30) received 15 mg (3 mL) of hyperbaric bupivacaine and Group II (n = 30) received 15 mg (3 mL) of isobaric bupivacaine for spinal anesthesia. Hemodynamic parameters were recorded before and after spinal anesthesia over 30 min. Analyses of HRV were performed on the day of surgery, after volume loading, and 20 min after spinal injection. Low frequency (LF) values, high frequency (HF) …
The Effect Of Addition Of Lidocaine To Bupivacaine On Anesthesia Beginning Time, Block Time, And Block Quality In Lateral Sagittal Infraclavicular Block, Özgür Özmen, Haci Ahmet Alici, Mi̇ne Çeli̇k, Ayşenur Dostbi̇l, Mehmet Cesur
The Effect Of Addition Of Lidocaine To Bupivacaine On Anesthesia Beginning Time, Block Time, And Block Quality In Lateral Sagittal Infraclavicular Block, Özgür Özmen, Haci Ahmet Alici, Mi̇ne Çeli̇k, Ayşenur Dostbi̇l, Mehmet Cesur
Turkish Journal of Medical Sciences
To investigate whether a 2% lidocaine addition to 0.5% bupivacaine that is used in a lateral sagittal infraclavicular block, when administered in an upper extremity surgery, decreases the block onset time, drug effect time, and drug activity when compared with bupivacaine alone. Materials and methods: This study was performed on 120 American Society of Anesthesiology classification I-II patients who were 18–65 years old and scheduled to undergo an upper extremity surgery. The group testing in the study was as follows: 20 mL (5 mg/mL) bupivacaine, 10 mL (5 mg/mL) bupivacaine + 10 mL (20 mg/mL) lidocaine, and 20 mL (20 …
Comparison Of The Effects Of Epidural 0.5% Bupivacaine And 0.5% Levobupivacaine Administration On Anesthesia Quality, Side Effect Incidence, And Analgesia Requirement Times In Hip And Lower Extremity Surgery, Fesi̇h Kara, Hüsnü Kürşad, Mi̇ne Çeli̇k, Ayşenur Dostbi̇l, İlker İnce, Ahmet Faruk Gi̇ren, Haci Ahmet Alici
Comparison Of The Effects Of Epidural 0.5% Bupivacaine And 0.5% Levobupivacaine Administration On Anesthesia Quality, Side Effect Incidence, And Analgesia Requirement Times In Hip And Lower Extremity Surgery, Fesi̇h Kara, Hüsnü Kürşad, Mi̇ne Çeli̇k, Ayşenur Dostbi̇l, İlker İnce, Ahmet Faruk Gi̇ren, Haci Ahmet Alici
Turkish Journal of Medical Sciences
To compare the anesthetic effectiveness of epidural levobupivacaine and bupivacaine without adjuvant medication in patients who were to have elective operations on the lower extremities and hips. Materials and methods: This study was conducted on a total of 70 ASA I-II patients aged between 30 and 70 years, who underwent elective hip and lower extremity operations. The patients that received bupivacaine were assigned to Group B (n = 35) and those that received levobupivacaine to Group L (n = 35). Results: No statistically significant difference was found between the groups in terms of the onset and regression times of the …
Final Baricity Of Ropivacaine Or Bupivacaine Combined With Fentanyl For Intrathecal Administration, Berri̇n Günaydin, İrfan Güngör, Seval İzdeş
Final Baricity Of Ropivacaine Or Bupivacaine Combined With Fentanyl For Intrathecal Administration, Berri̇n Günaydin, İrfan Güngör, Seval İzdeş
Turkish Journal of Medical Sciences
We determined the baricity of fentanyl-added bupivacaine or ropivacaine with or without dextrose by analyzing the specific gravity for a better understanding of the final baricity of the intrathecal drug combinations that are supposed to be used for surgery.
Effects On Hypotension Incidence: Hyperbaric, Isobaric, And Combinations Of Bupivacaine For Spinal Anesthesia In Cesarean Section, Bülent Serhan Yurtlu, Volkan Hanci, Rahşan Di̇lek Okyay, Seli̇me Evri̇m Bostankolu, Gülay Erdoğan Kayhan, Sedat Haki̇moğlu, Hi̇lal Ayoğlu, İnan İlker Arikan, Ülkü Bayar, Işil Özkoçak Turan
Effects On Hypotension Incidence: Hyperbaric, Isobaric, And Combinations Of Bupivacaine For Spinal Anesthesia In Cesarean Section, Bülent Serhan Yurtlu, Volkan Hanci, Rahşan Di̇lek Okyay, Seli̇me Evri̇m Bostankolu, Gülay Erdoğan Kayhan, Sedat Haki̇moğlu, Hi̇lal Ayoğlu, İnan İlker Arikan, Ülkü Bayar, Işil Özkoçak Turan
Turkish Journal of Medical Sciences
To determine if hypotension frequency changes when hyperbaric or isobaric formulations of bupivacaine, or their sequential administrations, are used for cesarean section. Hypotension after spinal anesthesia for cesarean section is common. Materials and methods: A total of 144 patients who were to undergo cesarean section with spinal anesthesia were allocated into 4 groups. Spinal anesthesia was achieved with 10 mg of hyperbaric bupivacaine in Group H10, sequential 5-mg administrations of hyperbaric and isobaric bupivacaine in Group H5P5, sequential 5-mg administrations of isobaric and hyperbaric bupivacaine in Group P5H5, and 10 mg of isobaric bupivacaine in Group P10. Hemodynamic parameters were …
The Effects Of Local Anaesthesia With Bupivacaine And Botulinum Toxin-A After Thoracotomy On Stress Hormone Levels, Makbule Ergi̇n, Ali̇ Yegi̇nsu, İsmai̇l Kürşat Gürlek
The Effects Of Local Anaesthesia With Bupivacaine And Botulinum Toxin-A After Thoracotomy On Stress Hormone Levels, Makbule Ergi̇n, Ali̇ Yegi̇nsu, İsmai̇l Kürşat Gürlek
Turkish Journal of Medical Sciences
To investigate the effects of local and systemic analgesics on stress hormone levels, which increase after thoracotomy. Materials and methods: Sixty-three male rats were divided into 9 groups (n = 7). In the control animals, only a blood sample was taken. In the thoracotomy group, a retractor was inserted for 1 h. In the local anaesthesia group, intercostal nerve block was performed with bupivacaine or botulinum toxin-A. In the systemic analgesia group, blockade was performed with bupivacaine and diclofenac sodium was given intraperitoneally. Blood samples were taken twice 4 h and 24 h after thoracotomy. Results: At 4 h, stress …
A Comparison Of The Effects Of Intrathecal Ropivacaine And Bupivacaine During Cesarean Section*, Nuray Camgöz Eryilmaz, Berri̇n Günaydin
A Comparison Of The Effects Of Intrathecal Ropivacaine And Bupivacaine During Cesarean Section*, Nuray Camgöz Eryilmaz, Berri̇n Günaydin
Turkish Journal of Medical Sciences
To compare the effects of intrathecal plain bupivacaine or ropivacaine with those of opioids on sensory and motor block characteristics during cesarean section (C/S). Materials and methods: Fifty-two ASA I or II women were randomly allocated into 2 groups to administer either 10 mg of 0.5% plain bupivacaine (Group B), or 15 mg of 0.75% plain ropivacaine (Group R) with 25 \mug fentanyl and 100 µg morphine for spinal anesthesia. Characteristics of the sensory and motor block were recorded. Results: The time to achieve sensory block at T_6 was significantly faster in Group B than in Group R (2.7 ± …
Adjuncts (Tramadol And Magnesium) Potentiate Impulse Inhibition By A Local Anaesthetic In Isolated Frog Siatic Nerves?, Belgi̇n Büyükakilli, Nurcan Doruk, Ülkü Çömelekoğlu, Handan Çamdevi̇ren, Sevgi̇ Güneş
Adjuncts (Tramadol And Magnesium) Potentiate Impulse Inhibition By A Local Anaesthetic In Isolated Frog Siatic Nerves?, Belgi̇n Büyükakilli, Nurcan Doruk, Ülkü Çömelekoğlu, Handan Çamdevi̇ren, Sevgi̇ Güneş
Turkish Journal of Medical Sciences
Aim: In clinical use, the addition of adjuncts (magnesium or tramadol) to local anesthetic agents is used for different reasons. However, reports about the effect of magnesium plus bupivacaine and of tramadol plus bupivacaine on in vitro preparations are scarce. The aim of this study was to examine the ability of local anesthetics to reduce the amplitude of compound nerve action potentials of the isolated frog sciatic nerve in the absence and presence of adjuncts (magnesium and tramadol). Materials and Methods: The experiments were done on frog sciatic nerves, using an extracellular recording technique. Isolated frog sciatic nerves were bathed …
Reversible Conduction Block In Frog Sciatic Nerve For Three Different Concentrations Of Bupivacaine, Belgi̇n Büyükakilli, Ülkü Çömelekoğlu, Oya Öğenler
Reversible Conduction Block In Frog Sciatic Nerve For Three Different Concentrations Of Bupivacaine, Belgi̇n Büyükakilli, Ülkü Çömelekoğlu, Oya Öğenler
Turkish Journal of Medical Sciences
We examined the effects of various concentrations of the bupivacaine commonly used for spinal anaesthesia on the reversibility of conduction block in isolated frog sciatic nerves measured by the extracellular recording technique. Seventy-two isolated nerves were divided into 3 groups (n = 24), each of which was bathed in a different bupivacaine solution in a range of concentrations (10, 20 or 30 mM for 20 min). In each group, the extracellular action potentials were recorded before exposure to the bupivacaine solution to provide the control data. The extracellular action potentials were recorded after 20 min exposure to the drug by …